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51. 发明授权

US5959075A Testis-specific insulin homolog polypeptides 失效
标题翻译：睾丸特异性胰岛素同源多肽
公开(公告)号：US5959075A
公开(公告)日：1999-09-28
申请号：US905267
申请日：1997-08-01
申请人： Si Lok , Darrell C. Conklin , Robyn L Adams , Anna C. Jelmberg , Catherine E. Lofton-Day , Stephen R. Jaspers
发明人： Si Lok , Darrell C. Conklin , Robyn L Adams , Anna C. Jelmberg , Catherine E. Lofton-Day , Stephen R. Jaspers
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/28 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P15/00 , A61P15/08 , A61P15/16 , A61P15/18 , A61P43/00 , C07K14/62 , C07K14/625 , C07K14/64 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/16 , C12N15/17 , C12P21/02
CPC分类号： C07K14/62 , C07K14/64 , A61K38/00
摘要： The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
摘要翻译：本发明提供了睾丸特异性胰岛素同源物多肽和编码多肽的多核苷酸，以及相关的组合物和方法。多肽和多核苷酸可以用于增强冷冻保存的精子的活力的方法，用于增强精子活力，增强辅助生殖方法中的受精作为避孕药具和其他相关用途。

52. 发明授权

US09388241B2 Anti-human IL-21 antibodies 有权
标题翻译：抗人IL-21抗体
公开(公告)号：US09388241B2
公开(公告)日：2016-07-12
申请号：US13492315
申请日：2012-06-08
申请人： Pallavur V. Sivakumar , Stephen R. Jaspers
发明人： Pallavur V. Sivakumar , Stephen R. Jaspers
IPC分类号： A61K39/395 , C07K16/22 , C07K16/24 , C07K16/18 , A61K39/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2319/30 , Y10S530/809
摘要： Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and inflammatory diseases such as pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, diverticulosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, osteoarthritis, atopic dermatitis, vitiligo, graft vs. host disease (GVHD), cutaneous T cell lymphoma (CTCL), Sjogren's syndrome, glomerulonephritis, IgA nephropathy, transplant rejection, atopic dermatitis, anti-phospholipid syndrome, and asthma, and other autoimmune diseases.
摘要翻译：鉴定结合IL-21蛋白的单克隆抗体。这些抗体用于鉴定结合中和IL-21活性的IL-21蛋白的区域。描述了杂交瘤和产生抗IL-21单克隆抗体的方法。单克隆抗体可用于治疗IL-21介导的疾病，其可能包括自身免疫性和炎性疾病如胰腺炎，I型糖尿病（IDDM），格雷夫斯病，炎性肠病（IBD），克罗恩病，溃疡性结肠炎，肠易激综合征综合征，多发性硬化症，类风湿性关节炎，憩室病，系统性红斑狼疮，牛皮癣，强直性脊柱炎，硬皮病，系统性硬化症，银屑病关节炎，骨关节炎，特应性皮炎，白癜风，移植物抗宿主病（GVHD），皮肤T细胞淋巴瘤，干燥综合征，肾小球性肾炎，IgA肾病，移植排斥反应，特应性皮炎，抗磷脂综合征，哮喘和其他自身免疫性疾病。

53. 发明授权

US08496936B2 Antagonists of IL-17A, IL-17F, and IL-23P19 有权
公开(公告)号：US08496936B2
公开(公告)日：2013-07-30
申请号：US13534019
申请日：2012-06-27
申请人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , Robert Mabry , Stephen R. Jaspers , Monica J. Huber
发明人： Katherine E. Lewis , Scott R. Presnell , Steven D. Levin , Robert Mabry , Stephen R. Jaspers , Monica J. Huber
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.

54. 发明授权

US08481288B2 Polynucleotides encoding antibodies that bind both IL-17A and IL-17F 有权
公开(公告)号：US08481288B2
公开(公告)日：2013-07-09
申请号：US13539534
申请日：2012-07-02
申请人： Stephen R. Jaspers , Scott R. Presnell , Monica J. Huber
发明人： Stephen R. Jaspers , Scott R. Presnell , Monica J. Huber
IPC分类号： C12N15/09 , C12N15/13
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, hybridomas that produce the antibodies, and methods of using the same in inflammation.

55. 发明申请

US20110318350A1 ANTIBODIES THAT BIND BOTH IL-17A AND IL-17F AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：US20110318350A1
公开(公告)日：2011-12-29
申请号：US13198933
申请日：2011-08-05
申请人： Stephen R. Jaspers , Scott R. Presnell
发明人： Stephen R. Jaspers , Scott R. Presnell
IPC分类号： A61K39/395 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/244 , C07K2317/20 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/76
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, as well as methods of using the same in inflammation.

56. 发明申请

US20110097331A1 ANTIBODIES THAT BIND BOTH IL-17A AND IL-17F AND METHODS OF USING THE SAME 审中-公开
标题翻译：与IL-17A和IL-17F两个结合的抗体及其使用方法
公开(公告)号：US20110097331A1
公开(公告)日：2011-04-28
申请号：US12617078
申请日：2009-11-12
申请人： Stephen R. Jaspers , Scott R. Presnell
发明人： Stephen R. Jaspers , Scott R. Presnell
IPC分类号： A61K39/395 , C07K16/24 , G01N33/68 , A61P29/00 , A61P17/06 , A61P19/02 , A61P31/00 , A61P3/10 , A61P25/00 , A61P37/08 , A61P11/06 , A61P11/00 , A61P37/06
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/244 , C07K2317/20 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/76
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, as well as methods of using the same in inflammation.
摘要翻译：本发明涉及阻断，抑制，降低，拮抗或中和IL-17A和IL-17F的活性。 IL-17A和IL-17F是参与炎症过程和人类疾病的细胞因子。本发明包括结合IL-17A和IL-17F的抗体以及在炎症中使用它们的方法。

57. 发明申请

US20110081340A1 METHODS FOR TREATING DISEASE USING AN ANTI-IL-21 RECEPTOR ANTIBODY 有权
标题翻译：使用抗IL-21受体抗体治疗疾病的方法
公开(公告)号：US20110081340A1
公开(公告)日：2011-04-07
申请号：US12941354
申请日：2010-11-08
申请人： Pallavur V. Sivakumar , Stephen R. Jaspers
发明人： Pallavur V. Sivakumar , Stephen R. Jaspers
IPC分类号： A61K39/395 , A61P29/00 , A61P37/02 , A61P17/06 , A61P19/02 , A61P37/06 , A61P25/28 , A61P1/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/76 , C07K2319/30 , Y10S530/809
摘要： Monoclonal antibodies to the IL-21 receptor and multimeric complexes comprising the IL-21 receptor; including monoclonal antibodies to the heterodimeric receptor, IL-21/IL-2Rγ; have been prepared. The invention also describes a method of producing said antibodies. And, the invention also describes a method of treatment comprising using said antibodies to suppress an immune response.
摘要翻译： IL-21受体的单克隆抗体和包含IL-21受体的多聚复合物; 包括对异二聚体受体的单克隆抗体，IL-21 / IL-2Rγ; 已经准备好了本发明还描述了产生所述抗体的方法。而且，本发明还描述了一种包括使用所述抗体抑制免疫应答的治疗方法。

58. 发明授权

US07655447B2 ZSIG33-like polynucleotides 有权
标题翻译： ZSIG33样多核苷酸
公开(公告)号：US07655447B2
公开(公告)日：2010-02-02
申请号：US12239535
申请日：2008-09-26
申请人： Stephen R. Jaspers , Paul O. Sheppard
发明人： Stephen R. Jaspers , Paul O. Sheppard
IPC分类号： C12N9/00 , C12N15/00 , C07H21/04 , C12Q1/00 , C12P21/04
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译：本发明涉及与zsig33肽相关的多核苷酸，包括激动剂，拮抗剂和抗体。还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。

59. 发明申请

US20100008915A1 METHODS FOR TREATING DISEASE USING AN ANTI-IL-21 RECEPTOR ANTIBODY 审中-公开
标题翻译：用抗IL-21受体抗体治疗疾病的方法
公开(公告)号：US20100008915A1
公开(公告)日：2010-01-14
申请号：US12541544
申请日：2009-08-14
申请人： Pallavur V. Sivakumar , Stephen R. Jaspers
发明人： Pallavur V. Sivakumar , Stephen R. Jaspers
IPC分类号： A61K39/395 , A61P37/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/76 , C07K2319/30 , Y10S530/809
摘要： Monoclonal antibodies to the IL-21 receptor and multimeric complexes comprising the IL-21 receptor; including monoclonal antibodies to the heterodimeric receptor, IL-21/IL-2Rγ; have been prepared. The invention also describes a method of producing said antibodies. And, the invention also describes a method of treatment comprising using said antibodies to suppress an immune response.
摘要翻译： IL-21受体的单克隆抗体和包含IL-21受体的多聚复合物; 包括针对异二聚体受体的单克隆抗体，IL-21 / IL-2Rγ; 已经准备好了本发明还描述了产生所述抗体的方法。而且，本发明还描述了一种包括使用所述抗体抑制免疫应答的治疗方法。

60. 发明申请

US20090270333A1 Methods of using motilin homologs 有权
标题翻译：使用胃动素同系物的方法
公开(公告)号：US20090270333A1
公开(公告)日：2009-10-29
申请号：US12075821
申请日：2008-03-13
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
IPC分类号： A61K38/10 , C07H21/04 , C12N15/63 , C12N5/10 , C07K7/08 , C07K14/00 , C07K16/00 , C12P21/00 , A61P1/00
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译：本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。

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