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51. 发明授权

US4946005A Apparatus and method for charging a lubricant into a marine engine outdrive 失效
标题翻译：将润滑剂装入船用发动机的装置和方法超速传动
公开(公告)号：US4946005A
公开(公告)日：1990-08-07
申请号：US407834
申请日：1989-09-15
申请人： Paul A. Levine
发明人： Paul A. Levine
IPC分类号： F01M11/04 , F02B61/04 , F16N31/00
CPC分类号： F01M11/0458 , F01M11/0408 , F16N31/00 , F02B61/045 , F16N2210/06
摘要： An apparatus that facilitates the filling of a marine engine lower unit reservoir with gear lube. A squeezable container having a conical spout with a threaded base is modified by cutting off a substantial part of the spout, leaving only a truncated, unthreaded part above the threaded base. The threads at the base of the spout engage complementally formed threads in a fitting member having an axial bore disposed in fluid communication with a first end of an elongate flexible tube that carries a clamp member operable to selectively open and close the tube to fluid flow. The opposite end of the tube is confluent with an axial bore formed in another fitting that is adapted to engage either a drain opening or a vent opening in a lower unit. The lower unit is filled by elevating and inverting the squeezable gear lube container when the clamp is open and the proper fitting is engaged with the drain opening. The clamp is closed when an empty tube is removed and a new squeezable tube is engaged with the fitting having the swivel head. The clamp is reopened and the process is repeated until the required amount of gear lube has been introduced into the engine outdrive. The same apparatus also has utility in connection with draining and flushing the lubrication reservoir.
摘要翻译：一种便于用齿轮润滑剂填充船用发动机下部单元储存器的装置。具有带有螺纹底座的圆锥形喷口的可挤压容器通过切断喷嘴的大部分而被修改，在螺纹底座上方仅留下截断的无螺纹部分。在喷嘴底部的螺纹在配合构件中接合互补形成的螺纹，该配合构件具有轴向孔，该轴向孔设置成与细长柔性管的第一端流体连通，所述细长柔性管承载可操作以选择性地打开和关闭管到流体流动的夹紧构件。管的相对端与形成在另一配件中的轴向孔融合，其适于接合下部单元中的排放开口或通风口。当夹具打开并且适当的配件与排水口接合时，下部单元通过升高和翻转可挤压齿轮润滑油容器来填充。当空管被移除并且新的可挤压管与具有旋转头的配件接合时，夹具关闭。重新打开夹具，重复该过程，直到所需量的齿轮润滑剂已经被引入发动机超速传动。相同的设备也可用于排放和冲洗润滑油箱。

52. 发明授权

US08515539B2 Remote follow-up automaticity with intelligent data download restrictions 有权
标题翻译：远程后续自动化具有智能数据下载限制
公开(公告)号：US08515539B2
公开(公告)日：2013-08-20
申请号：US13169928
申请日：2011-06-27
申请人： Paul A. Levine
发明人： Paul A. Levine
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/37211 , A61N1/37252 , A61N1/37282
摘要： An implanted device is equipped with a flag that indicates to a remote monitoring unit that an event such as a patient medical emergency or device failure has occurred. The remote monitoring unit is configured in some embodiments to maintain a low power communication link with the implanted device when they are within range. When the flag indicates an event has occurred, the remote monitoring unit quickly downloads sensed data collected by the implanted device and transfers it over a network so that it can be utilized by a medical practitioner. The remote monitoring unit is further configured in some embodiments to query the implanted device at regular intervals. The remote monitoring unit may read a subset of the data stored by the implanted device and, based on that data, determine whether to complete a full or partial download.
摘要翻译：植入装置配备有向远程监视单元指示发生诸如患者医疗紧急情况或装置故障的事件的标志。在一些实施例中，远程监视单元被配置为当植入设备在范围内时保持与植入设备的低功率通信链路。当标志指示事件已经发生时，远程监视单元快速地下载由植入的设备收集的感测数据，并通过网络传送，以便医疗人员可以使用它。在一些实施例中，进一步配置远程监视单元以规则的间隔查询植入的设备。远程监视单元可以读取植入设备存储的数据的子集，并且基于该数据确定是否完成全部或部分下载。

53. 发明授权

US08498706B2 Capture threshold and lead condition analysis 有权
公开(公告)号：US08498706B2
公开(公告)日：2013-07-30
申请号：US12496539
申请日：2009-07-01
申请人： Xing Pei , Robert E. Smith , Paul A. Levine
发明人： Xing Pei , Robert E. Smith , Paul A. Levine
IPC分类号： A61N1/37
CPC分类号： A61N1/08 , A61N1/056 , A61N1/0563 , A61N1/368 , A61N1/3682 , A61N1/3702 , A61N1/371 , A61N1/3712 , A61N1/372 , A61N1/3962 , A61N2001/083
摘要： An exemplary method includes performing a capture threshold assessment using a bipolar electrode configuration, deciding if capture occurred for a maximum energy value of the capture threshold assessment and, if capture did not occur, then performing a lead impedance test for the lead associated with the bipolar electrode configuration. Such a test may aim to detect an insulation defect and/or a conductor defect. Other exemplary methods, devices, systems, etc., are also disclosed.

54. 发明申请

US20120108987A1 IMPLANTABLE SYSTEMIC BLOOD PRESSURE MEASUREMENT SYSTEMS AND METHODS 审中-公开
标题翻译：可植入系统血压测量系统和方法
公开(公告)号：US20120108987A1
公开(公告)日：2012-05-03
申请号：US13342864
申请日：2012-01-03
申请人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine , Anders Björling
发明人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine , Anders Björling
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/02116 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0452 , A61B5/6846 , A61B2562/0219 , A61N1/36564 , A61N1/36578 , A61N1/36585
摘要： Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.
摘要翻译：本文提供了可植入系统及其使用方法，用于长期监测动脉血压。使用植入电极和植入的传感器获得指示患者心脏的电活动的第一信号和指示患者心脏的机械活动的第二信号。通过测量第一信号的各个特征相对于第二信号的特征之间的时间，可以确定指示收缩压和舒张压的值。在具体实施例中，这些特征用于确定峰值脉冲到达时间（PPAT），其用于确定指示收缩压的值。此外，可以使用在第二信号的最大峰值处的峰 - 峰幅度和指示收缩压的值来确定指示舒张压的值。

55. 发明授权

US08162841B2 Standalone systemic arterial blood pressure monitoring device 有权
标题翻译：独立的全身动脉血压监测装置
公开(公告)号：US08162841B2
公开(公告)日：2012-04-24
申请号：US12474276
申请日：2009-05-29
申请人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
发明人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/02125 , A61B5/0295 , A61B5/0452 , A61B5/1459 , A61B2562/0219 , A61N1/36557 , A61N1/36564 , A61N1/36585 , G06F19/00
摘要： Certain embodiments of the present invention are related to an implantable monitoring device to monitor a patient's arterial blood pressure, where the device is configured to be implanted subcutaneously. The device includes subcutaneous (SubQ) electrodes and a plethysmography sensor. Additionally, the device includes an arterial blood pressure monitor configured to determine at least one value indicative of the patient's arterial blood pressure based on at least one detected predetermined feature of a SubQ ECG and at least one detected predetermined feature of a plethysmography signal. Alternative embodiments of the present invention are directed to a non-implantable monitoring device to monitor a patient's arterial blood pressure based on features of a surface ECG and a plethysmography signal obtained from a non-implanted sensor.
摘要翻译：本发明的某些实施例涉及一种用于监测患者的动脉血压的可植入监测装置，其中该装置被配置为被皮下植入。该装置包括皮下（SubQ）电极和体积描记传感器。另外，该装置包括动脉血压监测器，其被配置为基于至少一个检测到的SubQ ECG的预定特征和至少一个检测到的体积描记信号的预定特征来确定指示患者的动脉血压的至少一个值。本发明的替代实施例涉及一种非植入式监测装置，用于基于从非植入传感器获得的表面ECG和体积描记信号的特征来监测患者的动脉血压。

56. 发明申请

US20110257700A1 REMOTE FOLLOW-UP AUTOMATICITY WITH INTELLIGENT DATA DOWNLOAD RESTRICTIONS 有权
标题翻译：远程自动化智能数据下载限制
公开(公告)号：US20110257700A1
公开(公告)日：2011-10-20
申请号：US13169928
申请日：2011-06-27
申请人： Paul A. Levine
发明人： Paul A. Levine
IPC分类号： A61N1/362
CPC分类号： A61N1/37211 , A61N1/37252 , A61N1/37282
摘要： An implanted device is equipped with a flag that indicates to a remote monitoring unit that an event such as a patient medical emergency or device failure has occurred. The remote monitoring unit is configured in some embodiments to maintain a low power communication link with the implanted device when they are within range. When the flag indicates an event has occurred, the remote monitoring unit quickly downloads sensed data collected by the implanted device and transfers it over a network so that it can be utilized by a medical practitioner. The remote monitoring unit is further configured in some embodiments to query the implanted device at regular intervals. The remote monitoring unit may read a subset of the data stored by the implanted device and, based on that data, determine whether to complete a full or partial download.
摘要翻译：植入装置配备有向远程监视单元指示发生诸如患者医疗紧急情况或装置故障的事件的标志。在一些实施例中，远程监视单元被配置为当植入设备在范围内时保持与植入设备的低功率通信链路。当标志指示事件已经发生时，远程监视单元快速地下载由植入的设备收集的感测数据，并通过网络传送，以便医疗人员可以使用它。在一些实施例中，进一步配置远程监视单元以规则的间隔查询植入的设备。远程监视单元可以读取植入设备存储的数据的子集，并且基于该数据确定是否完成全部或部分下载。

57. 发明授权

US08005546B1 Remote follow-up automaticity with intelligent data download restrictions 有权
标题翻译：远程后续自动化具有智能数据下载限制
公开(公告)号：US08005546B1
公开(公告)日：2011-08-23
申请号：US11838781
申请日：2007-08-14
申请人： Paul A. Levine
发明人： Paul A. Levine
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/37211 , A61N1/37252 , A61N1/37282
摘要： An implanted device is equipped with a flag that indicates to a remote monitoring unit that an event such as a patient medical emergency or device failure has occurred. The remote monitoring unit is configured in some embodiments to maintain a low power communication link with the implanted device when they are within range. When the flag indicates an event has occurred, the remote monitoring unit quickly downloads sensed data collected by the implanted device and transfers it over a network so that it can be utilized by a medical practitioner. The remote monitoring unit is further configured in some embodiments to query the implanted device at regular intervals. The remote monitoring unit may read a subset of the data stored by the implanted device and, based on that data, determine whether to complete a full or partial download.
摘要翻译：植入装置配备有向远程监视单元指示发生诸如患者医疗紧急情况或装置故障的事件的标志。在一些实施例中，远程监视单元被配置为当植入设备在范围内时保持与植入设备的低功率通信链路。当标志指示事件已经发生时，远程监视单元快速地下载由植入的设备收集的感测数据，并通过网络传送，以便医疗人员可以使用它。在一些实施例中，进一步配置远程监视单元以规则的间隔查询植入的设备。远程监视单元可以读取植入设备存储的数据的子集，并且基于该数据确定是否完成全部或部分下载。

58. 发明授权

US07574259B1 Capture threshold and lead condition analysis 有权
标题翻译：捕获阈值和引导条件分析
公开(公告)号：US07574259B1
公开(公告)日：2009-08-11
申请号：US10987731
申请日：2004-11-12
申请人： Xing Pei , Robert E. Smith , Paul A. Levine
发明人： Xing Pei , Robert E. Smith , Paul A. Levine
IPC分类号： A61N1/37
CPC分类号： A61N1/08 , A61N1/056 , A61N1/0563 , A61N1/368 , A61N1/3682 , A61N1/3702 , A61N1/371 , A61N1/3712 , A61N1/372 , A61N1/3962 , A61N2001/083
摘要： An exemplary method includes performing a capture threshold assessment using a bipolar electrode configuration, deciding if capture occurred for a maximum energy value of the capture threshold assessment and, if capture did not occur, then performing a lead impedance test for the lead associated with the bipolar electrode configuration. Such a test may aim to detect an insulation defect and/or a conductor defect. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括使用双极电极配置执行捕获阈值评估，确定捕获阈值评估的最大能量值是否发生捕获，并且如果没有发生捕获，则对与双极性相关联的引线执行引线阻抗测试电极配置。这种测试可能旨在检测绝缘缺陷和/或导体缺陷。还公开了其它示例性方法，装置，系统等。

59. 发明授权

US07551961B1 Cardiac stimulation device with selective atrial pacing on premature ventricular complex detection and method 有权
标题翻译：心脏刺激装置与早期心室复合物检测及方法的选择性心房起搏
公开(公告)号：US07551961B1
公开(公告)日：2009-06-23
申请号：US11401972
申请日：2006-04-10
申请人： Xing Pei , Paul A. Levine
发明人： Xing Pei , Paul A. Levine
IPC分类号： A61N1/39
CPC分类号： A61N1/3622 , A61N1/3702
摘要： An implantable cardiac stimulation device provides selective atrial pacing upon detection of a premature ventricular complex (PVC). The device comprises a premature ventricular complex detector that detects premature complexes of the heart, and a sensing circuit that senses atrial events. The device further comprises a P wave discriminator that identifies an atrial event sensed by the sensing circuit following detection of a premature ventricular complex as one of a retrograde P wave and a normal sinus P wave, and an atrial pulse generator that delivers an atrial pacing pulse responsive to the discriminator identifying an atrial event sensed by the sensing circuit following detection of a premature ventricular complex as a retrograde P wave.
摘要翻译：可植入心脏刺激装置在检测到早期心室复合物（PVC）时提供选择性心房起搏。该装置包括检测心脏过早复合物的早产性心室复合物检测器和感测心房事件的感测电路。该装置还包括P波鉴别器，其识别在检测到过早心室复合体之后由感测电路感测的心房事件，作为逆行P波和正常窦P波之一，以及心房脉搏发生器，其传送心房起搏脉冲响应鉴别器识别在检测到过早心室复合体之后由感测电路感测的心房事件作为逆行P波。

60. 发明申请

US20090082826A1 AUTOMATIC SIGNAL AMPLITUDE MEASUREMENT SYSTEM IN THE SETTING OF ABNORMAL RHYTHMS 有权
标题翻译：自动信号振幅测量系统在异常RHYTHMS的设置
公开(公告)号：US20090082826A1
公开(公告)日：2009-03-26
申请号：US12266441
申请日：2008-11-06
申请人： Paul A. Levine , Amdt Godau
发明人： Paul A. Levine , Amdt Godau
IPC分类号： A61N1/37
CPC分类号： A61N1/3706
摘要： A system for automatically evaluating the sensing and detection of physiological processes by an implantable medical device, such as an implantable cardiac stimulation device. The system includes an automatic testing algorithm which iteratively adjusts at least one of the threshold and gain settings of the device and evaluates the accuracy of the detection for refining the programming of the device. The algorithm can include sampling the physiological process beginning at a relatively low rate to avoid excessive burden on the processing and battery capacity available and progressively increasing the rate to obtain higher resolution data. The algorithm can also evaluate the observed physiological process for periodicity and can determine repetition of an irregular pattern, such as bigeminy, and use the determined pattern for predictive purposes to refine the programming of the device. The algorithm employs observation of a change in observed pattern as indicia for loss of proper detection.
摘要翻译：一种用于通过可植入医疗装置（例如可植入心脏刺激装置）自动评估生理过程的感测和检测的系统。该系统包括自动测试算法，其迭代地调整设备的阈值和增益设置中的至少一个，并评估用于精简设备编程的检测的准确性。该算法可以包括以相对较低的速率开始生理过程的采样，以避免对可用处理和电池容量的过度负担，并逐渐增加速率以获得更高分辨率的数据。该算法还可以评估观察到的生理过程的周期性，并且可以确定诸如bigeminy的不规则图案的重复，并且使用确定的图案进行预测目的来改进设备的编程。该算法使用观察模式的变化观察作为丢失适当检测的标记。

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