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    • 53. 发明申请
    • Hydroxamic acid compounds and methods of use thereof
    • 羟肟酸化合物及其使用方法
    • US20070155785A1
    • 2007-07-05
    • US11710036
    • 2007-02-22
    • Ronald BreslowThomas MillerSandro BelvederePaul MarksVictoria RichonRichard Rifkind
    • Ronald BreslowThomas MillerSandro BelvederePaul MarksVictoria RichonRichard Rifkind
    • A61K31/4709C07D401/02
    • C07D211/02C07D215/38C07D401/12
    • The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through a methylene chain. The hydroxamic acid compounds can be used to treat cancer, for example, brain cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.
    • 本发明涉及一类具有至少两个含芳基基团的异羟肟酸衍生物,其中至少一个是喹啉基,异喹啉基或苄基部分,通过亚甲基链与异羟肟酸基团连接。 异羟肟酸化合物可用于治疗癌症,例如脑癌。 异羟肟酸化合物也可以抑制组蛋白脱乙酰酶,适用于选择性诱导终末分化,阻止肿瘤细胞的细胞生长和/或凋亡,从而抑制这些细胞的增殖。 因此,本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病,例如自身免疫性,过敏性和炎性疾病,以及预防和/或治疗中枢神经系统(CNS)的疾病,例如神经变性 疾病
    • 55. 发明申请
    • Mobile-device directed conference calling
    • 移动设备定向会议呼叫
    • US20070111716A1
    • 2007-05-17
    • US11273163
    • 2005-11-14
    • Randolph LeighThomas MillerDavid GuthrieJ. Tapp
    • Randolph LeighThomas MillerDavid GuthrieJ. Tapp
    • H04M3/42
    • H04M3/56H04L12/1818H04L12/189H04M3/563H04M2203/5054H04M2207/18
    • A method for mobile-device directed conference calling comprises receiving information from a subscriber of a mobile-communication service, communicating an access number and providing executable instructions to the mobile-communication device that expose a conference service to the subscriber, wherein when the subscriber selects an option from the mobile-communication device, the mobile-communication device initiates a call to a conference service that uses automatic number identification to authenticate the subscriber and connect the call with a teleconference bridge. A system comprises a processor, interfaces in communication with the public telephone network and a data network, respectively, and a memory. The system receives information from a subscriber of a mobile-communication service, communicates an access number to the subscriber and configures the mobile-communication device to expose a conference service to the subscriber. When the subscriber selects an option, the subscriber is authenticated and connected to a teleconference bridge.
    • 一种用于移动设备定向会议呼叫的方法,包括从移动通信服务的用户接收信息,传送接入号码并向向用户公开会议业务的移动通信设备提供可执行指令,其中,当用户选择 来自移动通信设备的选项,移动通信设备发起对使用自动号码识别的会议服务的呼叫以认证用户并将呼叫与电话会议桥连接。 系统包括处理器,分别与公共电话网络和数据网络通信的接口以及存储器。 该系统从移动通信服务的用户接收信息,向用户传送接入号码,并配置移动通信设备向用户公开会议服务。 当用户选择选项时,用户被认证并连接到电话会议桥。
    • 57. 发明申请
    • Hand-held portable drop light
    • 手提便携式落地灯
    • US20060250791A1
    • 2006-11-09
    • US11389551
    • 2006-03-23
    • Thomas Miller
    • Thomas Miller
    • F21L4/00
    • F21L14/026F21V19/04
    • A hand-held portable drop-light is provided. The light comprises a handle, a housing, a cover, a novel mounting assembly, and a light bulb. The mounting assembly is configured with a pivoting light bulb socket and positioned within the handle for mounting the light bulb within a housing interior. The housing possesses an aperture through which the container interior and light bulb may be accessed. The cover is reversibly attached to the housing so as to inhibit access to the light bulb through the aperture. When replacing the light bulb, the cover is moved from the aperture and the mounting assembly is pivoted between a retracted position, where the bulb is substantially retained within the housing and an extended position, where a portion of the bulb is positioned outside the housing. In this manner, the light bulb is easily accessed for replacement.
    • 提供手提便携式落地灯。 灯包括手柄,壳体,盖子,新颖的安装组件和灯泡。 安装组件配置有旋转灯泡插座并且定位在手柄内,用于将灯泡安装在壳体内部。 壳体具有孔,可以通过该孔容纳容器内部和灯泡。 盖可逆地附接到壳体,以便禁止通过孔径进入灯泡。 当更换灯泡时,盖子从光圈移动,并且安装组件在缩回位置之间枢转,在缩回位置处,灯泡基本上保持在壳体内并且延伸位置,其中灯泡的一部分位于壳体外部。 以这种方式,灯泡可以方便地进行更换。
    • 58. 发明申请
    • Treatment of decompression sickness with inhaled nitric oxide gas
    • 用吸入一氧化氮气治疗减压病
    • US20060191535A1
    • 2006-08-31
    • US11065748
    • 2005-02-25
    • Thomas ShafferJoseph TuckoshThomas Miller
    • Thomas ShafferJoseph TuckoshThomas Miller
    • A61M16/00A62B7/00F16K31/02
    • A61M16/021A61M2202/0275
    • The present invention includes a method for treating an individual suffering from decompression sickness, a gas mixture that can be used to treat the individual, and an apparatus that can be used to administer the gas mixture. The method includes administering a gas mixture of oxygen and a therapeutically effective amount of nitric oxide gas to the individual. The gas mixture can include a mixture of oxygen, helium and, nitric oxide gases. The gas mixture can be administered using an apparatus that can be worn by the individual. The apparatus includes dispensers for gases, a gas blender to mix the gases, an inspiratory passage, a face mask substantially conformable with the individual's face, and an expiratory passage. When the individual wearing the face mask inhales, the gas mixture travels from the gas blender, through the inspiratory passage to the face mask. The gas mixture is then inhaled by the individual. When the individual exhales a breath, the breath travels from the face mask through the expiratory passage.
    • 本发明包括用于治疗患有减压病的个体的方法,可用于治疗个体的气体混合物,以及可用于施用气体混合物的装置。 该方法包括向个体施用氧气和治疗有效量的一氧化氮气体的气体混合物。 气体混合物可以包括氧气,氦气和一氧化氮气体的混合物。 气体混合物可以使用可由个体佩戴的装置来施用。 该装置包括用于气体的分配器,用于混合气体的气体混合器,吸气通道,基本上与个人脸部相适应的面罩以及呼气通道。 当佩戴面罩的人吸入时,气体混合物从气体搅拌器行进,通过吸气通道进入面罩。 然后气体混合物被个体吸入。 当个人呼气时,呼吸从面罩通过呼气通道行进。
    • 60. 发明申请
    • METHOD AND SYSTEM FOR RESETTING TIRE PRESSURE MONITORING SYSTEM FOR AN AUTOMOTIVE VEHICLE
    • 用于重新安装汽车轮胎压力监测系统的方法和系统
    • US20060139158A1
    • 2006-06-29
    • US10905093
    • 2004-12-15
    • Thomas MillerThomas McQuadeRobert Mince
    • Thomas MillerThomas McQuadeRobert Mince
    • B60C23/00
    • B60C23/0408B60C23/0418B60C23/0462G07C5/085G07C9/00182G07C2009/00793
    • A tire pressure monitoring system (12) for a vehicle (10) includes a vehicle speed sensor (38, 98) that is used to generate a vehicle speed signal. A receiver (28) operates using a first protocol when the vehicle speed signal is below a first speed threshold and operates using a second protocol when the vehicle speed is above the speed threshold. A remote keyless entry system (23) is coupled to the receiver and operates when the vehicle speed is below a speed threshold. The remote keyless entry system (23) receives signals from a keyless entry transmitter (60) using the first protocol. A tire pressure monitoring system (12) has a pressure transmitter (16A-16E) that generates a signal using a first protocol and a second protocol when the speed signal is below the speed threshold and generating the signal using only the second protocol when the speed signal is above the speed threshold.
    • 用于车辆(10)的轮胎压力监测系统(12)包括用于产生车速信号的车速传感器(38,98)。 当车速信号低于第一速度阈值时,接收器(28)使用第一协议操作,并且当车速高于速度阈值时,使用第二协议进行操作。 远程无钥匙进入系统(23)耦合到接收器,并且当车速低于速度阈值时操作。 远程无钥匙进入系统(23)使用第一协议从无钥匙进入发射器(60)接收信号。 轮胎压力监测系统(12)具有压力传感器(16A-16E),其在速度信号低于速度阈值时产生使用第一协议和第二协议的信号,并且仅当第二协议产生信号时 速度信号高于速度阈值。