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    • 57. 发明申请
    • Malononitrile Compounds
    • 丙二腈化合物
    • US20090326012A1
    • 2009-12-31
    • US12158507
    • 2006-12-13
    • Matthias PohlmanMichael HofmannHenricus Maria Martinus BastiaansMichael RackDeborah L. CulbertsonHassan Oloumi-SadeghiTakeo HokamaChristopher PalmerJürgen Langewald
    • Matthias PohlmanMichael HofmannHenricus Maria Martinus BastiaansMichael RackDeborah L. CulbertsonHassan Oloumi-SadeghiTakeo HokamaChristopher PalmerJürgen Langewald
    • A61K31/44C07D271/06C07D271/10C07D277/04A01N43/82A01N43/78C07D401/04
    • C07C323/60A01N37/34A01N43/10A01N43/28A01N43/78A01N43/80A01N43/82C07C255/20C07C255/37C07C317/44C07C317/46C07C323/62C07D213/61C07D235/16C07D261/08C07D271/06C07D277/32C07D333/28
    • Compounds of formula I wherein X is O or S(═O)n; n is 0, 1 or 2; R1 is optionally substituted alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkenyl, halocycloalkenyl, phenyl, hetaryl, phenylalkyl, hetaryl alkyl, optionally fused to phenyl, hetaryl or heterocyclyl; A is —NRb2, —C(=G)GRb, —C(=G)NRb2, —C(═NORb)Rb, C(=G)[N═SRb2], —C(=G)NRb—NR2, C2-C6-alkandiyl, C2-C6-alkenediyl, C1-C3-alkyl-G-C1-C3-alkyl, wherein Rb is as defined in the description, or optionally substituted phenyl, hetaryl, heterocyclyl, optionally fused to phenyl or heterocyclyl; B is an optionally substituted saturated or partially unsaturated hydrocarbon chain with 1 to 3 carbon chain atoms; D is an optionally substituted saturated or partially unsaturated hydrocarbon chain with 1 to 5 carbon chain atoms or C3-C6-cycloalkyl; G is oxygen or sulfur; or the enantiomers or diastereomers or salts or N-oxides thereof, processes for preparing the compounds I, pesticidal compositions and synergistic mixtures comprising compounds I, methods for the control of insects, acarids or nematodes by contacting the pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of compounds formula I, and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises orally, topically or parenterally administering or applying to the animals a parasiticidally effective amount of compounds of formula I.
    • 其中X为O或S(-O)n的式I化合物; n为0,1或2; R1是任选被取代的烷基,卤代烷基,烯基,卤代烯基,炔基,卤代炔基,环烷基,卤代环烷基,环烯基,卤代环烯基,苯基,杂芳基,苯基烷基,杂芳基烷基,任选地稠合到苯基,杂芳基或杂环基; A是-NR b2,-C(= G)GRb,-C(= G)NRb2,-C(-NORb)Rb,C(= G)[N-SRb2],-C(= G)NRb-NR2, C 2 -C 6 - 亚烷基,C 2 -C 6 - 亚烯基,C 1 -C 3烷基-G-C 1 -C 3 - 烷基,其中R b如说明书中所定义,或任选取代的苯基,杂芳基,杂环基,任选地稠合至苯基或杂环基 ; B是具有1至3个碳链原子的任选取代的饱和或部分不饱和烃链; D是具有1至5个碳原子的任选取代的饱和或部分不饱和烃链或C 3 -C 6环烷基; G是氧或硫; 或其对映异构体或非对映异构体或其盐或N-氧化物,制备化合物I的方法,农药组合物和包含化合物I的协同混合物,通过接触害虫或其食物供应,栖息地或昆虫或昆虫的方法来控制昆虫,螨虫或线虫 具有杀虫有效量的式I化合物的繁殖地,以及用于治疗,控制,预防或保护动物免受寄生虫侵扰或感染的方法,其包括口服,局部或肠胃外给予动物杀寄生虫有效量的化合物 公式一