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51. 发明授权

US5840240A Method of making a silicone composite vascular graft 失效
标题翻译：制造硅胶复合血管移植物的方法
公开(公告)号：US5840240A
公开(公告)日：1998-11-24
申请号：US552930
申请日：1995-11-03
申请人： Mark D. Stenoien , William J. Drasler , Robert J. Scott , Mark L. Jenson
发明人： Mark D. Stenoien , William J. Drasler , Robert J. Scott , Mark L. Jenson
IPC分类号： A61L27/00 , A61F2/06 , A61L27/18 , A61L27/34
CPC分类号： A61L27/18 , A61F2/06 , A61L27/34 , Y10S623/926 , Y10T428/1369 , Y10T428/1376 , Y10T428/1393
摘要： A silicone/DACRON polyester composite vascular graft especially well suited as an arteriovenous (A-V) graft fistula for dialysis application. The graft has the ability to seal around needle puncture holes without externally applied pressure, excellent anti-kink, anti-crush and strength properties, and a smooth non-porous inner surface which reduces thrombus deposition and enhances the graft wall compliance or elasticity.
摘要翻译：一种硅胶/ DACRON聚酯复合血管移植物，特别适合作为动静脉（A-V）移植瘘用于透析应用。移植物能够在没有外部施加压力的情况下密封针穿刺孔，具有优异的抗扭结，抗压溃和强度性能，以及平滑的无孔内表面，其减少血栓沉积并增强移植物壁顺应性或弹性。

52. 发明授权

US08932349B2 Cardiac valve, system, and method 有权
公开(公告)号：US08932349B2
公开(公告)日：2015-01-13
申请号：US13214520
申请日：2011-08-22
申请人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
发明人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2230/008
摘要： A cardiac valve with a support frame having a first end member and a second end member opposing the first end member in a substantially fixed distance relationship, and a cover extending over the support frame to allow for unidirectional flow of a liquid through the valve.

53. 发明授权

US07854755B2 Vascular catheter, system, and method 有权
标题翻译：血管导管，系统和方法
公开(公告)号：US07854755B2
公开(公告)日：2010-12-21
申请号：US11049000
申请日：2005-02-01
申请人： Daniel M. Lafontaine , Mark L. Jenson , William J. Drasler
发明人： Daniel M. Lafontaine , Mark L. Jenson , William J. Drasler
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61B17/32075 , A61B90/39 , A61B2017/00243 , A61B2017/22097 , A61F2/958
摘要： A catheter including an elongate body, a first cutting head and a second cutting head both having a blade, where the blades moves relative each other to provide a shearing action for cardiac tissue. The catheter can further include a stent positioned over an inflatable balloon, where the inflatable balloon can deploy the expandable stent over sheared cardiac tissue. The catheter can further be included in a system having a sheath, where at least a part of the catheter resides in the lumen of the sheath. The sheath further includes a cardiac valve and an expandable filter. The sheath can move relative the cardiac valve and the expandable filter to deploy the cardiac valve and at least a portion of the expandable filter proximal the inflatable balloon and the expandable stent.
摘要翻译：一种导管，其包括细长体，第一切割头和具有叶片的第二切割头，其中所述刀片相对于彼此移动以提供用于心脏组织的剪切动作。导管还可以包括定位在可膨胀气球上的支架，其中可充气球囊可以在可剪切的心脏组织上展开可扩张支架。导管可以进一步包括在具有护套的系统中，其中导管的至少一部分位于鞘的内腔中。护套还包括心脏瓣膜和可膨胀过滤器。护套可以相对于心脏瓣膜和可膨胀过滤器移动，以将心脏瓣膜部署，并且可扩张过滤器的至少一部分靠近可充气球囊和可扩张支架。

54. 发明授权

US07780630B2 Perfusion device 有权
标题翻译：灌注装置
公开(公告)号：US07780630B2
公开(公告)日：2010-08-24
申请号：US11693795
申请日：2007-03-30
申请人： Mark L. Jenson , William J. Drasler
发明人： Mark L. Jenson , William J. Drasler
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M25/09 , A61M2025/09091
摘要： A perfusion guidewire is disclosed. The perfusion guidewire includes an elongate core member and a collapsible sheath tightly wrapped around at least the distal portion of the elongate core member such that the wrapped sheath is folded upon itself, forming a plurality of layers of material in a radial direction from the longitudinal axis of the elongate core member. The wrapped sheath is tightly wrapped about the elongate core member such that the wrapped sheath and elongate core member travel as a unit during navigation within the blood vessel of the body of a patient. The wrapped sheath is expandable to a larger diameter in order to allow a perfusate to pass through the lumen of the sheath.
摘要翻译：公开了一种灌注导丝。灌注导丝包括细长的芯部构件和可收缩的护套，其紧密地缠绕在细长的芯构件的至少远侧部分周围，使得包裹的护套自身折叠，从纵向轴线沿径向形成多层材料层的细长芯部件。包裹的鞘被紧密地缠绕在细长的芯部件上，使得包裹的护套和细长的芯部件在导航在患者的身体的血管内时作为一个单元行进。包裹的护套可扩张到更大的直径，以便使灌注液通过护套的内腔。

55. 发明申请

US20080243066A1 PERFUSION AND EMBOLIC PROTECTION 有权
标题翻译：灌注和刺激保护
公开(公告)号：US20080243066A1
公开(公告)日：2008-10-02
申请号：US11693956
申请日：2007-03-30
申请人： Mark L. Jenson , William J. Drasler
发明人： Mark L. Jenson , William J. Drasler
IPC分类号： A61M25/10
CPC分类号： A61B17/22 , A61B2017/22067 , A61B2017/22074 , A61B2090/3954 , A61F2/013 , A61M25/005 , A61M25/10 , A61M2025/0063 , A61M2025/1052 , A61M2025/1081 , A61M2025/1095 , A61M2025/1097
摘要： Disclosed is a combination perfusion and occlusion device that can have a perfusion member, an occlusive member and an elongate member. The perfusion member can be an elongate perfusion member that can have a collapsed configuration and an expanded configuration. In the collapsed configuration, the perfusion member can be disposed around the elongate member. In the expanded configuration, the perfusion member can define a perfusion lumen. The occlusive member can have a collapsed configuration and an expanded configuration. The occlusive member in the collapsed configuration can have a low profile that can facilitate insertion of the occlusive member in a body lumen. In the expanded configuration the occlusive member can be a structure that restricts the flow of fluids through a body vessel, for example a filter or another structure that restricts the flow of fluids. The occlusive member can be disposed on the elongate member, for example on a distal portion of the elongate member.
摘要翻译：公开了可以具有灌注构件，闭塞构件和细长构件的组合灌注和闭塞装置。灌注构件可以是可以具有收缩构型和扩张构型的细长灌注构件。在折叠构造中，灌注构件可以设置在细长构件周围。在扩张构型中，灌注构件可以限定灌注腔。闭塞构件可以具有折叠构型和扩展构型。塌缩构型中的闭塞构件可以具有可以有助于闭塞构件在体腔中的插入的低轮廓。在膨胀构型中，闭塞构件可以是限制流体流过身体容器的结构，例如限制流体流动的过滤器或其他结构。闭塞构件可以设置在细长构件上，例如在细长构件的远侧部分上。

56. 发明申请

US20080146990A1 STROKE INTERVENTION APPARATUS AND METHOD 审中-公开
标题翻译： STROKE干预装置和方法
公开(公告)号：US20080146990A1
公开(公告)日：2008-06-19
申请号：US11956734
申请日：2007-12-14
申请人： Mark L. Jenson , William J. Drasler , Jagjit S. Gill
发明人： Mark L. Jenson , William J. Drasler , Jagjit S. Gill
IPC分类号： A61M1/00
CPC分类号： A61B5/03 , A61M25/003 , A61M25/0032 , A61M2025/0002 , A61M2025/1052
摘要： Disclosed herein is an intrathecal catheter having a lumen adapted to transfer liquid between the proximal end of the catheter and its distal end; a pressure detector; and a first sealer, adapted to seal the catheter against a tissue. Also disclosed herein is a stroke intervention system comprising an intrathecal catheter, an infusate supply chamber in fluid communication with the catheter; a pump in fluid communication with the catheter; and a pressure gauge in fluid communication with the pressure detector. Disclosed are also methods of reducing neural injury in a patient during a stroke comprising introducing a catheter intravenously or into the cerebrospinal fluid (CSF) system of the patient; measuring a baseline pressure; infusing and withdrawing infusate fluid into the cerebral venous vasculature or the CSF system at regular intervals.
摘要翻译：本文公开了一种鞘内导管，其具有适于在导管的近端和其远端之间转移液体的内腔; 压力检测器; 以及适于将导管密封在组织上的第一密封剂。本文还公开了一种中风干预系统，其包括鞘内导管，与导管流体连通的输注供应室; 与导管流体连通的泵; 以及与压力检测器流体连通的压力计。还公开了在中风期间减少患者的神经损伤的方法，包括静脉内或导入患者的脑脊液（CSF）系统中的导管; 测量基线压力; 以固定的间隔将输注液注入脑静脉血管或CSF系统。

57. 发明授权

US08556966B2 Annuloplasty device 有权
标题翻译：瓣膜成形术装置
公开(公告)号：US08556966B2
公开(公告)日：2013-10-15
申请号：US13070059
申请日：2011-03-23
申请人： Mark L. Jenson
发明人： Mark L. Jenson
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2451 , A61F2002/30042 , A61F2002/30583 , A61F2210/0085
摘要： Devices, systems, and methods associated with annuloplasty are described herein. One or more annuloplasty devices include a number of longitudinal filaments moveable between an introductory configuration and a deployed configuration, wherein the number of longitudinal filaments are one or more lengths, and a shell, wherein the shell contains the number of longitudinal filaments and a curable polymer to maintain the annuloplasty device in a deployed configuration.
摘要翻译：本文描述了与瓣环成形术相关联的装置，系统和方法。一个或多个瓣膜成形术装置包括在介绍构型和展开构型之间可移动的多个纵向长丝，其中纵向长丝的数量是一个或多个长度，以及壳，其中壳包含多个纵向长丝和可固化聚合物以将瓣环成形术装置维持在部署的配置中。

58. 发明申请

US20120296349A1 Percutaneous Mitral Annulus Mini-Plication 审中-公开
标题翻译：经皮二尖瓣环微球
公开(公告)号：US20120296349A1
公开(公告)日：2012-11-22
申请号：US13240921
申请日：2011-09-22
申请人： Scott R. Smith , Mark L. Jenson
发明人： Scott R. Smith , Mark L. Jenson
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61B17/00234 , A61B17/0644 , A61B17/1227 , A61B17/1285 , A61B2017/00243 , A61B2017/081 , A61F2/2442
摘要： A plication clip comprises a first end portion; a second end portion; and a central portion connecting the first end portion to the second end portion. The first end portion is curved toward the second end portion, and the second end portion is curved toward the first end portion. The central portion has a curvilinear profile such that when the clip is deployed, a shorter length between the first end portion and the second end portion is formed. A delivery catheter and methods for deploying the plication clip are also provided.
摘要翻译：折叠夹包括第一端部; 第二端部; 以及将第一端部连接到第二端部的中心部。第一端部朝向第二端部弯曲，第二端部朝向第一端部弯曲。中心部分具有曲线轮廓，使得当夹子展开时，在第一端部和第二端部之间形成较短的长度。还提供了输送导管和用于展开折叠夹的方法。

59. 发明申请

US20120265198A1 RENAL NERVE DETECTION AND ABLATION APPARATUS AND METHOD 审中-公开
标题翻译：肾脏神经检测和消融装置及方法
公开(公告)号：US20120265198A1
公开(公告)日：2012-10-18
申请号：US13299932
申请日：2011-11-18
申请人： Loren M. Crow , Mark L. Jenson , Scott Smith
发明人： Loren M. Crow , Mark L. Jenson , Scott Smith
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/36007 , A61N7/022
摘要： Stimulation energy is delivered to one or more renal artery sites in accordance with a predetermined energy delivery protocol. The stimulation energy is sufficient to elicit a physiologic response from the patient but insufficient to ablate renal nerves. Target renal artery sites that elicit a physiologic response are identified, and renal nerve tissue at or proximate the target sites is ablated.
摘要翻译：根据预定的能量递送方案，将刺激能量递送至一个或多个肾动脉部位。刺激能量足以引起患者的生理反应，但不足以消融肾神经。确定引起生理反应的目标肾动脉部位，消除靶点位置或其附近的肾神经组织。

60. 发明申请

US20120123303A1 Minimally Invasive Access for Renal Nerve Ablation 有权
标题翻译：微创获取肾神经消融
公开(公告)号：US20120123303A1
公开(公告)日：2012-05-17
申请号：US13243134
申请日：2011-09-23
申请人： David Sogard , Scott Smith , Mark L. Jenson
发明人： David Sogard , Scott Smith , Mark L. Jenson
IPC分类号： A61B18/18 , A61B18/04 , A61N7/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/0212 , A61N5/062 , A61N7/022 , A61N2005/067 , A61N2007/003
摘要： An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.
摘要翻译：细长的柔性医疗装置通过自然孔插入患者体内，并通过自然孔推进到影响肾交感神经活动的靠近神经组织的位置。医疗装置可以进入身体器官和靠近神经组织的器官内的位置。器官可以包括胃肠道或泌尿道的器官。医疗装置可以前进穿过器官壁中的进入孔并且位于邻近神经组织的位置处。成像和消融能量中的一个或两个从医疗装置的远端传送到神经组织。可以使用各种形式的能量消融内源性肾组织，包括射频能量，超声能量，光能和热能。

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