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51. 发明申请

US20110118326A1 Androgen Receptor Modulator and Uses Thereof 失效
标题翻译：雄激素受体调节剂及其用途
公开(公告)号：US20110118326A1
公开(公告)日：2011-05-19
申请号：US12943163
申请日：2010-11-10
申请人： Prabhakar Kondaji Jadhav , Venkatesh Krishnan
发明人： Prabhakar Kondaji Jadhav , Venkatesh Krishnan
IPC分类号： A61K31/404 , C07D405/06 , A61P19/10 , A61P15/08 , A61P15/00 , A61P21/00 , A61P19/08
CPC分类号： C07D405/06
摘要： The present invention relates to the compound of the formula: to pharmaceutical compositions comprising the compound of Formula (I); and to methods for treating or preventing hypogonadism, osteoporosis, osteopenia, sarcopenia, cachexia, muscle atrophy, sexual dysfunction or erectile dysfunction, comprising administering to a patient in need thereof an effective amount of the compound of Formula (I).
摘要翻译：本发明涉及下式的化合物：包含式（I）化合物的药物组合物; 以及用于治疗或预防性腺机能降低，骨质疏松症，骨质减少症，肌肉减少症，恶病质，肌肉萎缩，性功能障碍或勃起功能障碍的方法，包括向有需要的患者施用有效量的式（I）化合物。

52. 发明申请

US20110082693A1 SYSTEMS, METHODS, AND APPARATUS FOR FRAME ERASURE RECOVERY 有权
标题翻译：用于框架擦除恢复的系统，方法和装置
公开(公告)号：US20110082693A1
公开(公告)日：2011-04-07
申请号：US12966960
申请日：2010-12-13
申请人： Venkatesh Krishnan , Ananthapadmanbhan A. Kandhadai
发明人： Venkatesh Krishnan , Ananthapadmanbhan A. Kandhadai
IPC分类号： G10L19/14
CPC分类号： G10L19/005
摘要： In one configuration, erasure of a significant frame of a sustained voiced segment is detected. An adaptive codebook gain value for the erased frame is calculated based on the preceding frame. If the calculated value is less than (alternatively, not greater than) a threshold value, a higher adaptive codebook gain value is used for the erased frame. The higher value may be derived from the calculated value or selected from among one or more predefined values.
摘要翻译：在一种配置中，检测到持续浊音段的有效帧的擦除。基于前一帧计算已擦除帧的自适应码本增益值。如果计算值小于（或者不大于）阈值，则较高的自适应码本增益值被用于被擦除的帧。较高的值可以从计算值导出或从一个或多个预定义值中选择。

53. 发明申请

US20110039855A1 Tetrahydrocyclopenta[b]indole Androgen Receptor Modulators 有权
标题翻译：四氢环戊二烯[b]吲哚雄激素受体调节剂
公开(公告)号：US20110039855A1
公开(公告)日：2011-02-17
申请号：US12989959
申请日：2009-05-14
申请人： Prabhakar Kondaji Jadhav , Venkatesh Krishnan , Euibong Jemes Kim
发明人： Prabhakar Kondaji Jadhav , Venkatesh Krishnan , Euibong Jemes Kim
IPC分类号： A61K31/404 , C07D209/70 , C07D403/06 , C07D401/06 , A61K31/4439 , A61K31/4985 , A61K31/519 , A61K31/53 , A61P19/08 , A61P19/10 , A61P21/06 , A61P15/00
CPC分类号： C07D209/94 , C07D401/06 , C07D403/06
摘要： The present invention provides a compound of the Formula (I), or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating or preventing physiological disorders, particularly reduced bone mass, osteoporosis, osteopenia, reduced muscle mass or strength, or erectile dysfunction comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐; 包含式（I）化合物与合适的载体，稀释剂或赋形剂组合的药物组合物; 以及用于治疗或预防生理障碍，特别是骨量减少，骨质疏松症，骨质减少，肌肉质量或强度降低或勃起功能障碍的方法，其包括施用式（I）化合物或其药学上可接受的盐。

54. 发明授权

US07829333B2 Modulation of hedgehog-mediated signaling pathway 有权
标题翻译：调节hedgehog介导的信号通路
公开(公告)号：US07829333B2
公开(公告)日：2010-11-09
申请号：US11438933
申请日：2006-05-22
申请人： Philip A. Beachy , Ming-Jer Tsai , Sophia Tsai , Venkatesh Krishnan , Chien-Huan Chen
发明人： Philip A. Beachy , Ming-Jer Tsai , Sophia Tsai , Venkatesh Krishnan , Chien-Huan Chen
IPC分类号： C12N5/07 , C12Q1/68
CPC分类号： C07K14/43577 , C07K14/46 , C07K14/47 , C07K14/4702 , G01N33/573 , G01N33/6872 , G01N2500/00
摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
摘要翻译：本发明提供与通过磷酸酶脱磷酸化调节的刺猬蛋白信号传导途径相关的转录因子。还提供了与脱磷酸化转录因子相互作用的刺猬反应元件（HRE）以及用于鉴定作为磷酸酶抑制剂的化合物的方法。还包括通过调节转录因子的磷酸化来治疗受试者的肿瘤的方法。

55. 发明申请

US20090160211A1 Passive Entry System for Automotive Vehicle Doors 有权
标题翻译：汽车车门被动进入系统
公开(公告)号：US20090160211A1
公开(公告)日：2009-06-25
申请号：US11964028
申请日：2007-12-25
申请人： Venkatesh Krishnan , James Joseph Loschiavo , Kosta Papanikolaou
发明人： Venkatesh Krishnan , James Joseph Loschiavo , Kosta Papanikolaou
IPC分类号： G06K19/00 , H04B1/00 , B60J5/04 , B60R25/10 , G06F17/00 , E05C3/16 , G08B5/22
CPC分类号： B60J5/04 , B60R25/00 , B60R25/2036 , E05B81/78 , Y10T70/5889 , Y10T292/1047 , Y10T292/1053 , Y10T292/1054 , Y10T292/1055 , Y10T292/1057 , Y10T292/1059
摘要： A passive entry system for an vehicle door requires no active operator input to gain entrance to the vehicle. A door module recognizes the signal transmitted by an authorized key fob to identify the operator of the vehicle. The authentication of the operator coupled with the operator touching a sensor on the door to be opened actuates a release actuator that unlatches the selected door. The spring-load provided by the door seal will pop the door open from the closed position. A key cylinder, which can be located substantially anywhere on the door, is coupled mechanically to the release latch for use if the battery is weak and cannot activate the release actuator. An LED signals the state of the opening sequence for the door. The fixed door handle can incorporate a membrane switch or a capacitive sensor to indicate the selection of the door by the operator when touched.
摘要翻译：用于车门的被动进入系统不需要有效的操作员输入来进入车辆。门模块识别由授权密钥卡发送的信号以识别车辆的操作者。操作者的身份认证与操作者接触要打开的门上的传感器，致动释放致动器，该释放致动器使所选择的门解锁。门密封提供的弹簧载荷将从关闭位置弹开门。如果电池较弱并且不能激活释放致动器，则可以大致位于门上的任何位置处的钥匙筒机械地联接到释放闩锁以供使用。 LED指示门的打开顺序的状态。固定门把手可以包括薄膜开关或电容式传感器，以指示操作者在触摸时选择门。

56. 发明授权

US07296265B1 Class loading in a virtual machine for a platform having minimal resources 失效
标题翻译：在具有最少资源的平台的虚拟机中加载类
公开(公告)号：US07296265B1
公开(公告)日：2007-11-13
申请号：US09264756
申请日：1999-03-09
申请人： Venkatesh Krishnan , Geetha Manjunath , Kommarahalli S. Venugopal
发明人： Venkatesh Krishnan , Geetha Manjunath , Kommarahalli S. Venugopal
IPC分类号： G06F9/44
CPC分类号： G06F9/445 , Y10S707/99932 , Y10S707/99953
摘要： A virtual machine with mechanisms for class loading and class structure management in a device having limited file system and/or memory resources. The virtual machine includes a class loader that obtains one or more of a set of predefined classes from a network server, thereby reducing or eliminating the need for a local file system in the device. The class loader stores the predefined classes into a class structure in memory in the device. The virtual machine further includes a memory manager that purges selected ones of the predefined classes from the class structure so as to optimize the use of the memory consumed by the predefined classes in the class structure.
摘要翻译：在具有有限文件系统和/或存储器资源的设备中具有用于加载类和类结构管理的机制的虚拟机。虚拟机包括从网络服务器获取一组预定义类中的一个或多个的类加载器，从而减少或消除对设备中的本地文件系统的需要。类加载器将预定义的类存储在设备内存中的类结构中。虚拟机还包括存储器管理器，其从类结构清除预定义类中的选定的类，以优化在类结构中由预定义类消耗的存储器的使用。

57. 发明申请

US20050061855A1 Spun metal form used to manufacture dual alloy turbine wheel 有权
公开(公告)号：US20050061855A1
公开(公告)日：2005-03-24
申请号：US10980480
申请日：2004-11-03
申请人： Derek Rice , Venkatesh Krishnan , David Waldman , Gary Capek , Devinder Katariya
发明人： Derek Rice , Venkatesh Krishnan , David Waldman , Gary Capek , Devinder Katariya
IPC分类号： B23K20/02 , B23P15/00 , F01D5/04 , F01D5/34 , B23K31/02
CPC分类号： F01D5/34 , B23K20/021 , B23P15/006 , F01D5/048 , Y02T50/673 , Y10T29/4932 , Y10T29/49998 , Y10T29/53961
摘要： A spun metal form used to manufacture a dual alloy turbine wheel. The spun metal form prevents braze alloy contamination of the hub/casting interface by relocating the braze joint away from the interface. The spun metal form allows for the re-working of components after failed vacuum brazing and increases the time to failure of dual alloy turbine wheels.

58. 发明申请

US20050028132A1 Application specific optimization of interpreters for embedded systems 审中-公开
标题翻译：针对嵌入式系统的解释器的特定应用优化
公开(公告)号：US20050028132A1
公开(公告)日：2005-02-03
申请号：US10630913
申请日：2003-07-31
申请人： Venugopal Srinivasamurthy , Geetha Manjunath , Venkatesh Krishnan
发明人： Venugopal Srinivasamurthy , Geetha Manjunath , Venkatesh Krishnan
IPC分类号： G06F9/44 , G06F9/455
CPC分类号： G06F9/45516 , G06F9/45504
摘要： The invention provides a method and apparatus for optimising the performance of interpreter-based runtime systems. The runtime system may include a virtual machine where the virtual machine is adapted to interpret an application in the context of the particular runtime environment. The method comprises augmenting the bytecode set of the virtual machine with application-specific opcodes by reference to the application, thereby constituting an application domain-specific virtual machine. The invention also provides a method and apparatus for embedding semantically enriched code opcodes into an application which is to be run on the embedded runtime environment. The embedding can be done statically or dynamically. The invention may find be used in the Java runtime environment and particular applications of such embedded processors include function-specific devices such as cell-phones, PDAs and the like.
摘要翻译：本发明提供一种用于优化基于解释器的运行时系统的性能的方法和装置。运行时系统可以包括虚拟机，其中虚拟机适于在特定运行时环境的上下文中解释应用。该方法包括通过参考应用程序来增加具有应用专用操作码的虚拟机的字节码集，从而构成应用领域特定的虚拟机。本发明还提供了一种用于将语义丰富的代码操作码嵌入到将在嵌入式运行时环境上运行的应用中的方法和装置。嵌入可以静态或动态地进行。本发明可以在Java运行时环境中使用，并且这种嵌入式处理器的特定应用包括功能特定的设备，如手机，PDA等。

59. 发明申请

US20050011070A1 Spun metal form used to manufacture dual alloy turbine wheel 失效
标题翻译：用于制造双合金涡轮机叶轮的螺旋金属形式
公开(公告)号：US20050011070A1
公开(公告)日：2005-01-20
申请号：US10919833
申请日：2004-08-16
申请人： Derek Rice , Venkatesh Krishnan , David Waldman , Gary Capek , Devinder Katariya
发明人： Derek Rice , Venkatesh Krishnan , David Waldman , Gary Capek , Devinder Katariya
IPC分类号： B23K20/02 , B23P15/00 , F01D5/04 , F01D5/34 , B23P15/04
CPC分类号： F01D5/34 , B23K20/021 , B23P15/006 , F01D5/048 , Y02T50/673 , Y10T29/4932 , Y10T29/49998 , Y10T29/53961
摘要： A spun metal form used to manufacture a dual alloy turbine wheel. The spun metal form prevents braze alloy contamination of the hub/casting interface by relocating the braze joint away from the interface. The spun metal form allows for the re-working of components after failed vacuum brazing and increases the time to failure of dual alloy turbine wheels.
摘要翻译：用于制造双合金涡轮机叶轮的纺织金属模型。纺丝金属形式通过将钎焊接头远离接口来防止钎焊合金对轮毂/铸造界面的污染。纺丝金属形式允许在真空钎焊失败后重新加工组件，并增加双合金涡轮机轮胎的故障时间。

60. 发明授权

US09454974B2 Systems, methods, and apparatus for gain factor limiting 有权
标题翻译：用于增益因子限制的系统，方法和装置
公开(公告)号：US09454974B2
公开(公告)日：2016-09-27
申请号：US11610104
申请日：2006-12-13
申请人： Venkatesh Krishnan , Ananthapadmanabhan A. Kandhadai
发明人： Venkatesh Krishnan , Ananthapadmanabhan A. Kandhadai
IPC分类号： G10L19/14 , G10L21/038 , G10L19/02 , G10L25/18
CPC分类号： G10L21/038 , G10L19/0204 , G10L25/18
摘要： The range of disclosed configurations includes methods in which subbands of a speech signal are separately encoded, with the excitation of a first subband being derived from a second subband. Gain factors are calculated to indicate a time-varying relation between envelopes of the original first subband and of the synthesized first subband. The gain factors are quantized, and quantized values that exceed the pre-quantized values are re-coded.
摘要翻译：所公开的配置的范围包括其中语音信号的子带被分开编码的方法，第一子带的激励是从第二子带导出的。计算增益因子以指示原始第一子带和合成的第一子带的包络之间的时变关系。对增益因子进行量化，并重新编码超过预量化值的量化值。

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