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51. 发明申请

US20050267167A1 Pentanoic acid derivatives 失效
公开(公告)号：US20050267167A1
公开(公告)日：2005-12-01
申请号：US11192002
申请日：2005-07-29
申请人： Shuichi Ohuchida , Kazuo Kishimoto , Narito Tateishi , Hiroyuki Ohno
发明人： Shuichi Ohuchida , Kazuo Kishimoto , Narito Tateishi , Hiroyuki Ohno
IPC分类号： A61K31/20 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/197 , A61K31/22 , A61K31/23 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P25/00 , A61P25/04 , A61P25/28 , A61P43/00 , C07B61/00 , C07C51/06 , C07C51/36 , C07C53/126 , C07C53/128 , C07C53/134 , C07C53/19 , C07C53/21 , C07C53/23 , C07C57/03 , C07C57/30 , C07C59/125 , C07C59/135 , C07C59/68 , C07C67/303 , C07C69/02 , C07C69/22 , C07C69/24 , C07C69/34 , C07C69/533 , C07C69/612 , C07C69/63 , C07C69/708 , C07C231/12 , C07C233/05 , C07C233/07 , C07C233/11 , C07C233/12 , C07C233/22 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/54 , C07C323/52 , C07D213/40 , C07D213/72 , C07D213/75 , C07D295/18 , C07D295/185
CPC分类号： C07D213/75 , A61K31/19 , C07C53/21 , C07C69/612 , C07C69/63 , C07C69/708 , C07C233/05 , C07C233/11 , C07C233/25 , C07C233/47 , C07C233/54 , C07C323/52 , C07D295/185
摘要： Formula (I) compounds: wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl subsituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3 and R4, taken together is a saturated heterocyclic ring or amino acid residue; and non-toxic salts and acid addition salts thereof. Also, Formula (X) compounds: wherein n is 0 or 1, R11 is hydrogen and chlorine, R5 is R7—CH2— or R8, or R5 and R11, taken together is alkylidene; R6 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR9R10, in which R9, R10 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl-substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R9 and R10, taken together is a saturated heterocyclic ring or amino acid residue, R7 is (i) F—(CH2)m— or F3C—CH2—, (ii) alkyl subsstituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; R8 is alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy. Non-toxic and acid addition salts thereof are useful to prevent and/or treat neurodegenerative disease (e.g., Alzheimer's) and neuronal dysfunction by stroke or traumatic injury (e.g., Multiple sclerosis).

52. 发明申请

US20050077498A1 Polymerizable ion-conductive liquid-crystalline composite, anisotropically ion-conductive polymeric liquid-crystal composite, and process for producing the same 审中-公开
标题翻译：可聚合离子导电液晶复合材料，各向异性离子导电聚合液晶复合材料及其制造方法
公开(公告)号：US20050077498A1
公开(公告)日：2005-04-14
申请号：US10501761
申请日：2003-01-22
申请人： Takashi Kato , Kenji Kishimoto , Hiroyuki Ohno
发明人： Takashi Kato , Kenji Kishimoto , Hiroyuki Ohno
IPC分类号： C08F2/44 , C08F2/46 , C09K19/00 , C09K19/12 , C09K19/38 , C09K19/52 , C09K19/58
CPC分类号： C09K19/38 , C09K19/00 , C09K19/12 , C09K19/3852 , C09K19/52 , C09K19/582 , C09K2019/123
摘要： A composite of an organic monomer compound and an organic or inorganic salt, wherein the organic monomer compound comprises an ion-complexing moiety, a mesogen moiety that expresses a liquid crystalline phase and a polymerizable moiety in its molecular structure, is polymerized at the polymerizable moiety of the organic monomer compound, thereby forming an anisotropic ion-conductive polymeric liquid crystalline composite as a novel material having high ion conductivity characteristic of polymeric electrolytes, anisotropy due to orientation of a liquid crystal, and self-supporting properties characteristic of polymeric compounds.
摘要翻译：有机单体化合物和有机或无机盐的复合物，其中有机单体化合物包含离子络合部分，表达液晶相的介晶部分和分子结构中的可聚合部分在可聚合部分聚合的有机单体化合物，从而形成各向异性离子导电聚合物液晶复合材料作为具有高聚合电解质的高离子电导率特性的新型材料，由于液晶取向引起的各向异性以及聚合物的自支撑特性。

53. 发明授权

US06395857B1 Modified organopolysiloxanes, production thereof and compositions 失效
标题翻译：改性有机聚硅氧烷，其制备和组合物
公开(公告)号：US06395857B1
公开(公告)日：2002-05-28
申请号：US09575990
申请日：2000-05-23
申请人： Takanao Suzuki , Daisuke Tsukioka , Hiroyuki Ohno , Natsue Kawahara
发明人： Takanao Suzuki , Daisuke Tsukioka , Hiroyuki Ohno , Natsue Kawahara
IPC分类号： C08G7706
CPC分类号： C08G77/388 , C07F7/0838
摘要： A modified organopolysiloxane in which a carboxyl group of a heterocyclic compound having a carboxyl group and containing a nitrogen atom as a heteroatom is combined with an amino group of an amino-modified silicone is used as a gelling agent for low-viscosity silicone oil, which can allow the low-viscosity silicone oil to stably gel without losing the characteristics thereof.
摘要翻译：将其中具有羧基并含有氮原子作为杂原子的杂环化合物的羧基与氨基改性的硅氧烷的氨基结合的改性有机聚硅氧烷用作低粘度硅油的胶凝剂，其中可以使低粘度硅油稳定地凝胶化而不失去其特性。

54. 发明授权

US6025457A Molten-salt type polyelectrolyte 失效
标题翻译：熔盐型聚电解质
公开(公告)号：US6025457A
公开(公告)日：2000-02-15
申请号：US997047
申请日：1997-12-23
申请人： Hiroyuki Ohno , Kaori Ito
发明人： Hiroyuki Ohno , Kaori Ito
IPC分类号： C08F20/02 , C08F8/30 , C08F8/44 , C08F20/34 , C08F28/02 , H01B1/06 , H01B1/12 , H01M6/18 , H01M10/05 , H01M10/0565 , C08G73/18 , C08K5/00 , C08L33/00
CPC分类号： H01M10/052 , C08F20/34 , C08F8/30 , C08F8/44 , H01M10/0565
摘要： Novel molten-salt type polyelectrolytes are disclosed which contain as an essential ingredient a molten salt polymer obtained by reacting an imidazolium derivative, such as a 1,3-dialkylimidazolium halide, 1,2,3-trialkylimidazolium halide, 1-vinyl-3-alkylimidazolium halide, or 1-vinyl-2,3-alkylimidazolium halide, with an acid monomer, a poly(vinylsulfonamide), trifluoromethanesulfonimide, or the like. The electrolytes show high ionic conductivity at room temperature and have excellent stability to temperature fluctuations and excellent mechanical properties.
摘要翻译：公开了新的熔盐型聚电解质，其包含作为必需成分的熔融盐聚合物，其通过咪唑衍生物如1,3-二烷基咪唑卤化物，1,2,3-三烷基咪唑卤化物，1-乙烯基-3- 烷基咪唑鎓卤化物或1-乙烯基-2,3-烷基咪唑鎓卤化物，与酸单体，聚（乙烯基磺酰胺），三氟甲磺酰亚胺等。电解质在室温下显示出高离子电导率，对温度波动和优异的机械性能具有优异的稳定性。

55. 发明授权

US5998410A Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US5998410A
公开(公告)日：1999-12-07
申请号：US31192
申请日：1998-02-26
申请人： Takahiko Nakae , Masashi Kato , Takehito Fujita , Kazuhito Kawabata , Hiroyuki Ohno
发明人： Takahiko Nakae , Masashi Kato , Takehito Fujita , Kazuhito Kawabata , Hiroyuki Ohno
IPC分类号： C07C311/29 , C07C311/64 , C07D203/24 , C07D207/48 , C07D209/42 , C07D211/96 , C07D235/22 , C07D263/38 , C07D277/56 , C07D295/26 , C07D307/68 , C07D309/10 , C07D333/24 , C07D491/10 , C07D521/00 , C07H5/10 , C07K5/078 , A61K31/38 , A61K31/535 , C07D413/12
CPC分类号： C07D295/26 , C07C311/29 , C07C311/64 , C07D203/24 , C07D207/48 , C07D209/42 , C07D211/96 , C07D231/12 , C07D233/56 , C07D235/22 , C07D249/08 , C07D263/38 , C07D277/56 , C07D307/68 , C07D309/10 , C07D333/24 , C07D491/10 , C07H5/10 , C07K5/06139 , C07K5/06165 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.
摘要翻译：式（I）的磺酰胺衍生物，其对弹性蛋白酶具有抑制作用的无毒盐，其酸加成盐或溶剂合物。

56. 发明授权

US5859243A Silicone derivatives, their production and use 失效
标题翻译：硅胶衍生物，其生产和使用
公开(公告)号：US5859243A
公开(公告)日：1999-01-12
申请号：US929783
申请日：1997-09-15
申请人： Hiroyuki Ohno , Natsue Kawahara , Isaburo Amano , Takanao Suzuki , Koji Chiba
发明人： Hiroyuki Ohno , Natsue Kawahara , Isaburo Amano , Takanao Suzuki , Koji Chiba
IPC分类号： A61K8/895 , A61K8/898 , A61Q19/00 , C08G77/388 , A61K31/495 , C07F5/02 , C07F5/04 , C07F7/02
CPC分类号： A61K8/898 , A61Q19/00 , C08G77/388 , A61K2800/57
摘要： Disclosed are amino silicone derivatives having triazinyl groups or pyrimidinyl groups bound to amino groups of amino silicones, their production and use, said silicone derivatives being able to gel silicone oil or to increase the viscosity thereof stably and homogeneously, and therefore being useful as bases for cosmetics, pharmaceutical preparations and industrial materials.
摘要翻译：公开了具有与氨基硅氧烷的氨基结合的三嗪基或嘧啶基的氨基硅氧烷衍生物，它们的制备和用途，所述硅氧烷衍生物能够凝固硅油或者稳定和均匀地增加粘度，因此可用作化妆品，药物制剂和工业材料。

57. 发明授权

US5401760A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US5401760A
公开(公告)日：1995-03-28
申请号：US8365
申请日：1993-01-22
申请人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
发明人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
IPC分类号： C07D207/08 , C07D277/04 , C07D405/04 , C07D417/06 , A61K31/40
CPC分类号： C07D207/08 , C07D277/04 , C07D405/04 , C07D417/06
摘要： Heterocyclic compounds of the general formula: ##STR1## R represents a general formula:G--E--D--B--A--G represents a carbocyclic or heterocyclic ring which is unsubstituted or substituted, L represents a group of general formula:--CO--COR.sup.2--CO--CH.sub.2 --COR.sup.2--CO--CF.sub.2 --COR.sup.2--CO--CO--NR.sup.5 R.sup.6or--CO--CH.sub.2 --CO--NR.sup.5 R.sup.6and non-toxic salt or hydrate thereof possess an inhibitory activity on propyl endopeptidase, and therefore usefull for prevention and/or treatment of amnesia.
摘要翻译：具有以下通式的杂环化合物：（I）R表示通式：GEDBA-G表示未取代或取代的碳环或杂环，L表示通式-CO-COR 2 -CO-CH 2 -COR2 -CO-CF2-COR2 -CO-CO-NR5R6或-CO-CH2-CO-NR5R6及其无毒盐或水合物对丙基内肽酶具有抑制活性，因此可用于预防和/或治疗健忘症。

58. 发明授权

US5376655A Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as an active ingredient 失效
标题翻译：对胍基苯甲酸的衍生物和含有它们作为活性成分的药剂
公开(公告)号：US5376655A
公开(公告)日：1994-12-27
申请号：US70683
申请日：1993-06-02
申请人： Katsuhiro Imaki , Yoshinobu Arai , Hiroyuki Ohno
发明人： Katsuhiro Imaki , Yoshinobu Arai , Hiroyuki Ohno
IPC分类号： C07C279/18 , C07C309/65 , C07C309/66 , C07C311/08 , C07C311/29 , C07C311/46 , C07C329/10 , C07D213/65 , C07D213/75 , C07D277/04 , C07D277/22 , C07D295/26 , A61K31/535 , A61K31/21 , A61K31/44 , C07C327/16
CPC分类号： C07C279/18 , C07C309/65 , C07C309/66 , C07C311/08 , C07C311/29 , C07C311/46 , C07C329/10 , C07D213/65 , C07D213/75 , C07D277/04 , C07D277/22 , C07D295/26
摘要： A derivative of p-guanidinobenzoic acid of the general formula (IA): ##STR1## wherein Y represents an oxygen atom or a sulfur atom and (a) when Y is an oxygen atom, (R.sup.1).sub.m is selected from the group consisting of: 5-(4-guanidinobenzoyloxy)-3-methoxymethyl, 3,5-dicarboxy, 3,5-bis(isopropoxycarbonyl), 3,5-bistrifluoromethyl, 3-acetyl, 3,5-bis(N-ethylcarbamoyl), and 3,5-bis(N-propylcarbamoyl);(b) when Y is a sulfur atom, (R.sup.1).sub.m is selected from the group consisting of: 2-methyl, 3-methyl, 4-fluoro, 2-chloro, 3-chloro, 2,5-dichloro 2,6-dichloro, 3,4-dichloro, 2-bromo, 2-methoxycarbonyl, and 4-(N,N-diethylaminosulfonyl);or an acid addition salt of said derivative. A method for the treatment or prevention of diseases induced by abnormal enhancing of degradation of proteins by the action of elastase in mammals subject to or suffering therefrom, including the step of administering an effective amount of a p-guanidinobenzoic acid as described herein, is also disclosed.
摘要翻译：通式（IA）的对胍基苯甲酸的衍生物：其中Y表示氧原子或硫原子，（a）当Y是氧原子时，（R1）m选自由5-（4-胍基苯甲酰氧基）-3-甲氧基甲基，3,5-二羧基，3,5-双（异丙氧基羰基），3,5-双三氟甲基，3-乙酰基，3,5-双（N-乙基氨基甲酰基）和3,5-双（N-丙基氨基甲酰基）; （b）当Y是硫原子时，（R1）m选自：2-甲基，3-甲基，4-氟，2-氯，3-氯，2,5-二氯2,6 二氯，3,4-二氯，2-溴，2-甲氧基羰基和4-（N，N-二乙基氨基磺酰基）; 或所述衍生物的酸加成盐。用于治疗或预防由于受到或遭受的哺乳动物中的弹性蛋白酶的作用的蛋白质降解异常增强引起的疾病的方法，包括施用有效量的如本文所述的对胍基苯甲酸的步骤也是披露

59. 发明授权

US5247084A Derivatives of p-guanidinobenzoic acid 失效
标题翻译：对胍基苯甲酸的衍生物
公开(公告)号：US5247084A
公开(公告)日：1993-09-21
申请号：US765749
申请日：1991-09-26
申请人： Katsuhiro Imaki , Yoshinobu Arai , Hiroyuki Ohno
发明人： Katsuhiro Imaki , Yoshinobu Arai , Hiroyuki Ohno
IPC分类号： C07C279/18 , C07C309/65 , C07C309/66 , C07C311/08 , C07C311/29 , C07C311/46 , C07C329/10 , C07D213/65 , C07D213/75 , C07D277/04 , C07D277/22 , C07D295/26
CPC分类号： C07C279/18 , C07C309/65 , C07C309/66 , C07C311/08 , C07C311/29 , C07C311/46 , C07C329/10 , C07D213/65 , C07D213/75 , C07D277/04 , C07D277/22 , C07D295/26
摘要： Compounds presented by the general formula: ##STR1## [wherein when Y is oxygen, R.sup.2 is H, alkyl, alkoxy, alkoxymethyl, --COOR.sup.3, --CH.sub.2 COOR.sup.3, --CH=CH--COOR.sup.3, halogen, --CF.sub.3, --COR.sup.4, --OCOR.sup.4, --CH.sub.2 OCOR.sup.4, --SO.sub.2 R.sup.4, --OSO.sub.2 R.sup.4, --CONR.sup.5 R.sup.6, --OCONR.sup.5 R.sup.6, --SO.sub.2 NR.sup.5 R.sup.6, --CONH--SO.sub.2 NR.sup.5 R.sup.6, --NHSO.sub.2 R.sup.7, --NO.sub.2, --OH, --CH.sub.2 OH, guanidino, benzyloxy, guanidinophenylthiomethyl, morpholinosulfonylphenoxymethyl, pyridyloxymethyl, or (1,1-dioxothiazol-3-yl)carbonyl, or when Y is sulfur, R.sup.2 is H, alkyl, alkoxy, halogen, --COOR.sup.3, --CH.sub.2 COOR.sup.3, --NO.sub.2, or --SO.sub.2 NR.sup.5 R.sup.6, and n represents an integer of one to five, and when n represents more than two, each of R.sup.2 may be the same group or the different group.] and acid addition salts thereof have inhibitory effect on elastase, and, therefore, are useful for the treatment and/or prevention of diseases induced by abnormal enhancing of degradation of proteins such as elastin and the like, by the action of elastase in mammals, especially in human beings.
摘要翻译：由以下通式表示的化合物：其中当Y为氧时，R 2为H，烷基，烷氧基，烷氧基甲基，-COOR 3，-CH 2 COOR 3，-CH = CH-COOR 3，卤素，-CF 3，-COR 4 ，-OCOR4，-CH2OCOR4，-SO2R4，-OSO2R4，-CONR5R6，-OCONR5R6，-SO2NR5R6，-CONH-SO2NR5R6，-NHSO2R7，-NO2，-OH，-CH2OH，胍基，苄氧基，胍基苯硫基甲基，吗啉代磺酰基苯氧基甲基，吡啶氧基甲基或（1,1-二氧代噻唑-3-基）羰基，或者Y为硫时，R2为H，烷基，烷氧基，卤素，-COOR3，-CH2COOR3，-NO2或-SO2NR5R6，n表示1〜 5，当n表示2以上时，R2各自可以相同或不同。]及其酸加成盐对弹性蛋白酶具有抑制作用，因此可用于治疗和/或预防疾病通过弹性蛋白酶在哺乳动物，特别是人类中的弹性蛋白酶的作用，由弹性蛋白等蛋白质的异常增强引起的。

60. 发明授权

US5212191A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US5212191A
公开(公告)日：1993-05-18
申请号：US700299
申请日：1991-05-15
申请人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
发明人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
IPC分类号： C07D207/08 , C07D277/04 , C07D405/04 , C07D417/06
CPC分类号： C07D207/08 , C07D277/04 , C07D405/04 , C07D417/06
摘要： Heterocyclic compounds of the general formula: ##STR1## wherein, Z represents sulfur atom, R represents a general formula:G--E--D--B--A--L represents a group of the general formula: ##STR2## R.sup.3 represents alkyl group of from 1 to 6 carbon atom(s), phenyl group.
摘要翻译：具有以下通式的杂环化合物：其中Z表示硫原子，R表示通式：GEDBA-L表示通式为CH（OR 3）2的基团，R 3表示 1至6个碳原子，苯基。

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