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    • 51. 发明授权
    • Alarm device for informing reduction of pneumatic pressure of tire
    • 用于通知减少轮胎气压的报警装置
    • US4180795A
    • 1979-12-25
    • US859517
    • 1977-12-12
    • Akira MatsudaMakoto TanakaJunichi MurataShigeo YasudaHiroshi Nishino
    • Akira MatsudaMakoto TanakaJunichi MurataShigeo YasudaHiroshi Nishino
    • G01L17/00B60C23/02B60C23/04C07H15/04G08C19/00
    • C07H15/04B60C23/0428
    • An alarm device for informing reduction of pneumatic pressure of vehicle tires by sensing abnormal change of tire internal pressure of a vehicle when running by a pressure sensing switch, by converting the thus sensed abnormal change into an electric signal and by generating an alarm to an operator. This device comprises an oscillator having an oscillation coil fixed on a chassis side of the vehicle; a resonator consisting of a resonance coil and a capacitor fixed to a peripheral portion of the rotating wheel having tire adjacent the oscillation coil and for resonating with an electromagnetic wave radiated from the oscillation coil; a signal processing device containing a sensing means for sensing change in an oscillation condition generated in the oscillator due to a resonant condition of the resonator switched on and off in accordance with abnormal internal pressure of a tire and for processing a signal sensed by this sensing means; and an alarm for generating a warning by the output of this signal processing device.
    • 一种报警装置,用于通过检测由压力传感开关行驶时车辆的轮胎内部压力的异常变化,通过将这样检测到的异常变化转换为电信号并向操作者产生报警来通知车辆轮胎气动压力的降低 。 该装置包括具有固定在车辆的底盘侧上的振荡线圈的振荡器; 谐振器,其由谐振线圈和固定到具有轮胎的旋转轮的周边部分的电容器组成,轮胎与振荡线圈相邻并且与从振荡线圈辐射的电磁波谐振; 一种信号处理装置,包括用于感测由于根据轮胎的异常内部压力而导通和断开的谐振器的谐振条件在振荡器中产生的振荡条件的变化的感测装置,并且用于处理由该感测装置感测到的信号 ; 以及用于由该信号处理装置的输出产生警告的报警。
    • 60. 发明授权
    • 3'-substituted nucleoside derivatives
    • 3'-取代核苷衍生物
    • US5763418A
    • 1998-06-09
    • US693161
    • 1996-08-13
    • Akira MatsudaSasaki Takuma
    • Akira MatsudaSasaki Takuma
    • A61K31/7052A61P35/00C07H19/04C07H19/06C07H19/10C07H19/16C07H19/20A61K31/70
    • C07H19/06C07H19/04C07H19/10C07H19/16C07H19/20Y02P20/55
    • The invention relates to a 3'-substituted nucleoside derivative represented by the following general formula (1): ##STR1## wherein B means a nucleic acid base which may have a substituent, Z represents a lower alkynyl or lower alkenyl group which may be substituted by a group represented by the formula: ##STR2## in which R.sup.a, R.sup.b and R.sup.c are individually a lower alkyl group or a phenyl group, or an oxiranyl group which may have at least one lower alkyl group, R.sup.1 and R.sup.2 individually represent H or an ester-forming residue capable of easily leaving in a living body, and R.sup.3 is H, a mono- or polyphosphoric acid residue, or an ester-forming residue capable of easily leaving in a living body, with the proviso that the sugar moiety is ribose, or a pharmaceutically acceptable salt thereof. The 3'-substituted nucleoside derivative according to the invention has an excellent antitumor activity and is hence useful for treatment for and prevention of cancers.
    • PCT No.PCT / JP95 / 02554 Sec。 371日期:1996年8月13日 102(e)日期1996年8月13日PCT 1995年12月13日PCT PCT。 WO96 / 18636 PCT公开号 日期:1996年6月20日本发明涉及由以下通式(1)表示的3'-取代核苷衍生物:其中B表示可具有取代基的核酸碱基,Z表示低级炔基 或低级链烯基,其可以被下式表示的基团取代:其中Ra,Rb和Rc分别是低级烷基或苯基,或可以具有至少一个的环氧乙烷基 低级烷基,R 1和R 2分别表示H或能够容易地在活体中离开的成酯残基,R3是H,单磷酸或多磷酸残基或能容易地离开的酯形成残基 活体,条件是糖部分是核糖,或其药学上可接受的盐。 根据本发明的3'-取代的核苷衍生物具有优异的抗肿瘤活性,因此可用于治疗和预防癌症。