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51. 发明申请

US20050152982A1 Controlled release multiparticulates formed with dissolution enhancers 审中-公开
标题翻译：用溶解增强剂形成的控制释放多颗粒
公开(公告)号：US20050152982A1
公开(公告)日：2005-07-14
申请号：US11003853
申请日：2004-12-03
申请人： Leah Appel , Roderick Ray , David Newbold , David Lyon , James West , Dwayne Friesen , Scott McCray , Marshall Crew , Julian Lo
发明人： Leah Appel , Roderick Ray , David Newbold , David Lyon , James West , Dwayne Friesen , Scott McCray , Marshall Crew , Julian Lo
IPC分类号： A61K9/14 , A61K9/16 , A61K9/22 , A61K31/7052
CPC分类号： A61K9/1617
摘要： Pharmaceutical compositions of crystalline azithromycin-containing multiparticulates having low concentrations of azithromycin ester degradants and exhibiting controlled release of the drug are achieved by inclusion of dissolution enhancers having low concentrations of acid and ester substituents.
摘要翻译：通过包含具有低浓度的酸和酯取代基的溶解增强剂来实现具有低浓度的阿奇霉素酯降解物并显示药物释放控制的含结晶阿奇霉素的多颗粒的药物组合物。

52. 发明申请

US20050129772A1 Compositions comprising an HIV protease inhibitor 审中-公开
标题翻译：包含HIV蛋白酶抑制剂的组合物
公开(公告)号：US20050129772A1
公开(公告)日：2005-06-16
申请号：US11008325
申请日：2004-12-08
申请人： Scott Smith , Dwayne Friesen , Douglas Lorenz , David Lyon , Rodney Ketner , James West
发明人： Scott Smith , Dwayne Friesen , Douglas Lorenz , David Lyon , Rodney Ketner , James West
IPC分类号： A61K31/425 , C07D277/06 , A61K31/426 , A61K9/14 , C07D277/18
CPC分类号： C07D277/06
摘要： The present invention relates to pharmaceutical compositions comprising amorphous (4R)—N-allyl-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, or a pharmaceutically acceptable salt or solvate thereof, their methods of preparation, their use in inhibiting the HIV protease enzyme, and their use in treating HIV-infected mammals, such as humans.
摘要翻译：本发明涉及包含无定形（4R）-N-烯丙基-3 - {（2S，3S）-2-羟基-3 - [（3-羟基-2-甲基苯甲酰基）氨基] -4-苯基丁酰基} - 5,5-二甲基-1,3-噻唑烷-4-甲酰胺或其药学上可接受的盐或溶剂合物，其制备方法，其用于抑制HIV蛋白酶的用途及其在治疗HIV感染的哺乳动物中的用途，作为人类

53. 发明申请

US20050123627A1 Azithromycin dosage forms with reduced side effects 有权
标题翻译：阿奇霉素剂型具有减少的副作用
公开(公告)号：US20050123627A1
公开(公告)日：2005-06-09
申请号：US10763340
申请日：2004-01-23
申请人： Timothy Hagen , Julian Lo , Avinash Thombre , Scott Herbig , Leah Appel , Marshall Crew , Dwayne Friesen , David Lyon , Scott McCray , James West
发明人： Timothy Hagen , Julian Lo , Avinash Thombre , Scott Herbig , Leah Appel , Marshall Crew , Dwayne Friesen , David Lyon , Scott McCray , James West
IPC分类号： C07H17/00 , A61K9/00 , A61K9/16 , A61K9/20 , A61K31/7052 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/44 , A61P31/04 , A01N59/26 , A61K31/198 , A61K31/7008 , A61K33/10 , A61K33/42
CPC分类号： A61K9/1611 , A61K9/143 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K31/7052
摘要： An oral dosage form comprising azithromycin and an effective amount of an alkalizing agent. Preferably, said oral dosage form comprises an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule. Additionally disclosed is an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. Preferably, the azithromycin is in multiparticulate form wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Also disclosed is a method for reducing gastrointestinal side effects, associated with administering azithromycin to a mammal, comprising contiguously administering azithromycin and an effective amount of alkalizing agent to said mammal wherein the frequency of gastrointestinal side effects is lower than that experienced by administering an equal dose of azithromycin without said alkalizing agent. Further disclosed is a method of treating a bacterial or protozoal infection in a mammal in need thereof comprising contiguously administering to said mammal a single dose of an oral dosage form wherein said oral dosage form comprises azithromycin and an effective amount of an alkalizing agent. Additionally disclosed are azithromycin multiparticulates comprising azithromycin, a surfactant; and a pharmaceutically acceptable carrier.
摘要翻译：包含阿奇霉素和有效量的碱化剂的口服剂型。优选地，所述口服剂型包含有效量的碱化剂和阿奇霉素多颗粒，其中所述多颗粒包括阿奇霉素，单山嵛酸甘油酯，二苯乙酸甘油酯和枸橼酸甘油酯和泊洛沙姆的混合物。通常，口服剂型包括任何合适的口服给药方式，例如用于口服悬浮液的粉末，单位剂量包或小药囊，片剂或胶囊。另外公开了包含阿奇霉素，有效量的碱化剂和载体的口服悬浮液。优选地，阿奇霉素是多颗粒形式，其中所述多颗粒包括阿奇霉素，甘油单山嵛酸甘油酯，二苯甲酸甘油酯和枸橼酸甘油酯和泊洛沙姆的混合物。还公开了一种减少与向哺乳动物施用阿奇霉素相关的胃肠道副作用的方法，包括向所述哺乳动物连续施用阿奇霉素和有效量的碱化剂，其中胃肠道副作用的频率低于施用相等剂量的阿奇霉素不含碱化剂。进一步公开的是一种在有需要的哺乳动物中治疗细菌或原生动物感染的方法，其包括向所述哺乳动物连续施用单剂量的口服剂型，其中所述口服剂型包含阿奇霉素和有效量的碱化剂。另外公开了包含阿奇霉素，表面活性剂的阿奇霉素多颗粒; 和药学上可接受的载体。

54. 发明申请

US20050063099A1 Data transfer device and head assembly therefor 审中-公开
标题翻译：数据传输装置及其头部组件
公开(公告)号：US20050063099A1
公开(公告)日：2005-03-24
申请号：US10832454
申请日：2004-04-27
申请人： James West , David Callaghan
发明人： James West , David Callaghan
IPC分类号： G11B15/62 , G11B33/14 , G11B15/64
CPC分类号： G11B15/62 , G11B33/1446
摘要： A magnetic tape drive includes a head assembly comprising a read and/or write head mounted for movement along at least one guide rail. A rail cleaner cleans at least a portion of the rail. The cleaner moves along the rail with the head assembly.
摘要翻译：磁带驱动器包括头部组件，其包括安装成沿着至少一个导轨移动的读取和/或写入头部。轨道清洁器清洁轨道的至少一部分。清洁剂沿着轨道与头部组件移动。

55. 发明授权

US4167984A Interlocking safety handle for a friction drive apparatus 失效
标题翻译：用于摩擦驱动装置的联锁安全手柄
公开(公告)号：US4167984A
公开(公告)日：1979-09-18
申请号：US850135
申请日：1977-11-10
申请人： Ronald W. Hottes , James West
发明人： Ronald W. Hottes , James West
IPC分类号： B62M6/10 , B62M6/15 , B62M6/35 , B62M13/04
CPC分类号： B62M6/15 , B62M13/04 , B62M6/10 , B62M6/35
摘要： An apparatus for frictionally engaging and driving a rotatable wheel of a lightweight vehicle is disclosed. The apparatus has a pivotable handle which is movable between a first and a second position. In the first position the handle blocks access to a fuel tank while permitting operation of the engine and engagement of a driven friction surface with the rotatable wheel. In the second position of the handle, the engine is inoperable, the fuel tank may be refilled, and the friction surface cannot engage the rotatable wheel. Preferably, the handle provides means for pivoting the engine to and from a position in which the friction surface engages the rotatable wheel and for operationally engaging an electrical switch to control operation of the engine.
摘要翻译：公开了一种用于摩擦接合和驱动轻型车辆的可旋转车轮的装置。该装置具有可在第一和第二位置之间移动的可枢转手柄。在第一位置，手柄阻挡进入燃料箱，同时允许发动机的操作和从动摩擦表面与可旋转轮的啮合。在手柄的第二位置，发动机不可操作，燃料箱可以被重新填充，并且摩擦表面不能接合可旋转轮。优选地，手柄提供用于将发动机枢转到摩擦表面接合可旋转轮的位置并且用于操作地接合电开关以控制发动机的操作的装置。

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