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51. 发明申请

US20080125843A1 Combined parasympathetic stimulation and drug therapy 有权
标题翻译：联合副交感神经刺激和药物治疗
公开(公告)号：US20080125843A1
公开(公告)日：2008-05-29
申请号：US11975240
申请日：2007-10-17
申请人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.
摘要翻译：提供了一种用于治疗受试者的方法，包括将电流施加到从包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉受试者的动脉，受试者的颈动脉窦，受试者的腔静脉和受试者的颈内静脉。该方法还包括配置电流以便治疗从以下列表中选择的受试者的状况：自身免疫疾病，自身免疫性炎性疾病，多发性硬化症，脑炎，脊髓炎，免疫介导的神经病，肌炎，皮肌炎，多发性肌炎，包涵体肌炎，炎性脱髓鞘多发性神经病，吉兰巴利综合征，重症肌无力，神经系统炎症，炎性肠病，克罗恩病，溃疡性结肠炎，SLE（系统性红斑狼疮），类风湿性关节炎，血管炎，结节性多动脉炎，干燥综合征，混合结缔组织病，肾小球性肾炎，甲状腺自身免疫性疾病，败血症，脑膜炎，细菌感染，病毒感染，真菌感染，结节病，肝炎和门静脉高血压。

52. 发明申请

US20080091245A1 Combined parasympathetic stimulation and cardiac pacing 审中-公开
标题翻译：联合副交感神经刺激和心脏起搏
公开(公告)号：US20080091245A1
公开(公告)日：2008-04-17
申请号：US11978831
申请日：2007-10-29
申请人： Omry Ben-Ezra , Ehud Cohen , Tamir Ben-David
发明人： Omry Ben-Ezra , Ehud Cohen , Tamir Ben-David
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： Apparatus for treating a subject suffering from spontaneous atrial fibrillation includes an electrode device, adapted to be coupled to a vagus nerve of the subject, and a control unit, adapted to drive the electrode device to apply an electrical current to the vagus nerve, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.
摘要翻译：用于治疗患有自发性心房颤动的受试者的装置包括适于耦合到受试者的迷走神经的电极装置和适于驱动电极装置向迷走神经施加电流的控制单元，以及配置电流以维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。

53. 发明申请

US20080091241A1 Vagal stimulation for cardioversion of atrial fibrillation 审中-公开
标题翻译：迷走神经刺激心房颤动复律
公开(公告)号：US20080091241A1
公开(公告)日：2008-04-17
申请号：US11977291
申请日：2007-10-23
申请人： Omry Ben-Ezra , Ehud Cohen , Tamir Ben-David
发明人： Omry Ben-Ezra , Ehud Cohen , Tamir Ben-David
IPC分类号： A61N1/365
CPC分类号： A61N1/0556 , A61B5/4035 , A61N1/36114 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： Apparatus (20) for treating a subject (30) suffering from spontaneous atrial fibrillation includes an electrode device (22), adapted to be coupled to a site of the subject (30) selected from the list consisting of: a vagus nerve (24) of the subject (30), an epicardial fat pad of the subject (30), a pulmonary vein of the subject (30), a carotid artery of the subject (30), a carotid sinus of the subject (30), a vena cava vein of the subject (30), and an internal jugular vein of the subject (30), and a control unit (32), adapted to drive the electrode device (22) to apply an electrical current to the site, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.
摘要翻译：用于治疗患有自发性心房颤动的受试者（30）的装置（20）包括电极装置（22），其适于耦合到选自以下的列表中的受试者（30）的位置：迷走神经（24）受试者（30）的心外膜脂肪垫，受试者（30）的肺静脉，受试者（30）的颈动脉，受试者（30）的颈动脉窦，体外受试者（30）的静脉和静脉内部的颈内静脉和控制单元（32），其适于驱动电极装置（22）向该部位施加电流，并且配置目前为了维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。

54. 发明申请

US20060206155A1 Parasympathetic pacing therapy during and following a medical procedure, clinical trauma or pathology 有权
标题翻译：副交感神经起搏治疗期间和之后的医疗手术，临床创伤或病理学
公开(公告)号：US20060206155A1
公开(公告)日：2006-09-14
申请号：US11359266
申请日：2006-02-21
申请人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen
发明人： Tamir Ben-David , Omry Ben-Ezra , Ehud Cohen
IPC分类号： A61N1/362 , A61N1/18
CPC分类号： A61N1/0556 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： A treatment method is provided, including identifying a subject as one who is selected to undergo an interventional medical procedure, and, in response to the identifying, reducing a likelihood of a potential adverse effect of the procedure by applying an electrical current to a parasympathetic site of the subject selected from the group consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a jugular vein of the subject, a right ventricle of the subject, a parasympathetic ganglion of the subject, and a parasympathetic nerve of the subject.
摘要翻译：提供了一种治疗方法，包括将受试者识别为被选择进行介入医疗程序的受试者，并且响应于鉴定，通过将电流施加到副交感神经部位来减少手术的潜在不利影响的可能性所述对象选自：受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，受试者的颈动脉，受试者的颈动脉窦，冠状窦受试者，受试者的静脉静脉，受试者的颈静脉，受试者的右心室，受试者的副交感神经节和受试者的副交感神经。

55. 发明授权

US08718791B2 Electrode cuffs 有权
标题翻译：电极袖口
公开(公告)号：US08718791B2
公开(公告)日：2014-05-06
申请号：US12947608
申请日：2010-11-16
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/36114
摘要： Apparatus is provided for application to a nerve of a subject, including an electrode cuff, which includes a housing, which is configured to be placed at least partially around the nerve so as to define an inner surface of the housing that faces the nerve. A plurality of insulating elements are coupled to the inner surface of the housing at respective insulating element longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define one or more respective cavities at respective cavity longitudinal positions along the housing. One or more electrodes are fixed to the housing in fewer than all of the cavities, such that at least one of the cavities is an empty cavity that does not have an electrode positioned therein. Other embodiments are also described.
摘要翻译：提供了用于施用于受试者神经的装置，包括电极箍，其包括壳体，其被构造成至少部分地围绕神经放置，以限定外壳面向神经的内表面。多个绝缘元件在沿着壳体的相应绝缘元件纵向位置处联接到壳体的内表面，使得壳体的内表面和成对的绝缘元件在相应的腔纵向位置处限定一个或多个相应的腔住房。一个或多个电极在少于所有的空腔中固定到壳体，使得至少一个空腔是不具有位于其中的电极的空腔。还描述了其它实施例。

56. 发明授权

US08565896B2 Electrode cuff with recesses 有权
标题翻译：带凹槽的电极袖口
公开(公告)号：US08565896B2
公开(公告)日：2013-10-22
申请号：US12952058
申请日：2010-11-22
申请人： Tamir Ben-David , Ehud Cohen , Noam Gavish , Shai Ayal
发明人： Tamir Ben-David , Ehud Cohen , Noam Gavish , Shai Ayal
IPC分类号： A61N1/05
CPC分类号： A61N1/0556
摘要： An electrode assembly includes one or more electrode contact surfaces, and a cuff, to which the contact surfaces are fixed, and which comprises an electrically insulating material, is configured to assume open and closed positions, and, when in the closed position, is shaped so as to define a plurality of planar cross sections perpendicular to a longitudinal axis of the cuff, distributed continuously along an entire length of the cuff along the longitudinal axis, such that the perpendicular cross sections define respective inner closed curves that together define an inner surface that defines and completely surrounds a volume that extends along the entire length of the cuff. The inner closed curves of at least two of the perpendicular cross sections would cross, and not merely intersect, one another if superimposed while preserving orientation and position of the perpendicular cross sections with respect to the cuff. Other embodiments are also described.
摘要翻译：一种电极组件包括一个或多个电极接触表面，以及一个接触表面被固定在其上并且包括电绝缘材料的箍带构造成呈现开和关的位置，并且当处于关闭位置时，以便限定垂直于袖带的纵向轴线的多个平面横截面，其沿着所述袖带的整个长度沿着所述纵向轴线连续分布，使得所述垂直横截面限定相应的内部闭合曲线，所述内部闭合曲线一起限定内部表面其限定并完全围绕沿袖带的整个长度延伸的体积。至少两个垂直横截面的内部闭合曲线将彼此交叉而不是彼此相交，如果在保持相对于袖带的垂直横截面的取向和位置的情况下叠加。还描述了其它实施例。

57. 发明授权

US08386056B2 Parasympathetic stimulation for treating atrial arrhythmia and heart failure 有权
标题翻译：副交感神经刺激治疗心房心律失常和心力衰竭
公开(公告)号：US08386056B2
公开(公告)日：2013-02-26
申请号：US11070842
申请日：2005-02-24
申请人： Tamir Ben David , Shai Ayal , Ehud Cohen
发明人： Tamir Ben David , Shai Ayal , Ehud Cohen
IPC分类号： A61N1/00
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.
摘要翻译：提供了包括适于联接到受试者的迷走神经的电极装置和控制单元的装置，所述控制单元适于驱动所述电极装置向所述迷走神经施加降低所述受试者心率变异性的电流。还提供了一种方法，包括向受试者的迷走神经施加减少受试者心率变异性的电流。

58. 发明申请

US20100010603A1 Electrode cuffs 审中-公开
标题翻译：电极袖口
公开(公告)号：US20100010603A1
公开(公告)日：2010-01-14
申请号：US12217930
申请日：2008-07-09
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/36114
摘要： Apparatus is provided for application to a nerve of a subject, including a housing, which is configured to be placed at least partially around the nerve so as to define an inner surface of the housing that faces the nerve. A plurality of insulating elements are coupled to the inner surface of the housing at respective insulating element longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define one or more respective cavities at respective cavity longitudinal positions along the housing. One or more electrodes are fixed to the housing in fewer than all of the cavities. Other embodiments are also described.
摘要翻译：提供了将装置应用于受试者的神经，包括外壳，其构造成至少部分地围绕神经放置，以限定外壳面向神经的内表面。多个绝缘元件在沿着壳体的相应绝缘元件纵向位置处联接到壳体的内表面，使得壳体的内表面和成对的绝缘元件在相应的腔纵向位置处限定一个或多个相应的腔住房。一个或多个电极在少于所有的空腔中固定到壳体。还描述了其它实施例。

59. 发明申请

US20110098796A1 ELECTRODE CUFFS 有权
标题翻译：电极铜
公开(公告)号：US20110098796A1
公开(公告)日：2011-04-28
申请号：US12947608
申请日：2010-11-16
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/36114
摘要： Apparatus is provided for application to a nerve of a subject, including an electrode cuff, which includes a housing, which is configured to be placed at least partially around the nerve so as to define an inner surface of the housing that faces the nerve. A plurality of insulating elements are coupled to the inner surface of the housing at respective insulating element longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define one or more respective cavities at respective cavity longitudinal positions along the housing. One or more electrodes are fixed to the housing in fewer than all of the cavities, such that at least one of the cavities is an empty cavity that does not have an electrode positioned therein. Other embodiments are also described.
摘要翻译：提供了用于施用于受试者神经的装置，包括电极箍，其包括壳体，其被构造成至少部分地围绕神经放置，以限定外壳面向神经的内表面。多个绝缘元件在沿着壳体的相应绝缘元件纵向位置处联接到壳体的内表面，使得壳体的内表面和成对的绝缘元件在相应的腔纵向位置处限定一个或多个相应的腔住房。一个或多个电极在少于所有的空腔中固定到壳体，使得至少一个空腔是不具有位于其中的电极的空腔。还描述了其它实施例。

60. 发明申请

US20120130463A1 ELECTRODE CUFF WITH RECESSES 有权
标题翻译：电极插座
公开(公告)号：US20120130463A1
公开(公告)日：2012-05-24
申请号：US12952058
申请日：2010-11-22
申请人： Tamir Ben-David , Ehud Cohen , Noam Gavish , Shai Ayal
发明人： Tamir Ben-David , Ehud Cohen , Noam Gavish , Shai Ayal
IPC分类号： A61N1/05
CPC分类号： A61N1/0556
摘要： An electrode assembly includes one or more electrode contact surfaces, and a cuff, to which the contact surfaces are fixed, and which comprises an electrically insulating material, is configured to assume open and closed positions, and, when in the closed position, is shaped so as to define a plurality of planar cross sections perpendicular to a longitudinal axis of the cuff, distributed continuously along an entire length of the cuff along the longitudinal axis, such that the perpendicular cross sections define respective inner closed curves that together define an inner surface that defines and completely surrounds a volume that extends along the entire length of the cuff. The inner closed curves of at least two of the perpendicular cross sections would cross, and not merely intersect, one another if superimposed while preserving orientation and position of the perpendicular cross sections with respect to the cuff. Other embodiments are also described.
摘要翻译：一种电极组件包括一个或多个电极接触表面，以及一个接触表面被固定在其上并且包括电绝缘材料的箍带构造成呈现开和关的位置，并且当处于关闭位置时，以便限定垂直于袖带的纵向轴线的多个平面横截面，其沿着所述袖带的整个长度沿着所述纵向轴线连续分布，使得所述垂直横截面限定相应的内部闭合曲线，所述内部闭合曲线一起限定内部表面其限定并完全围绕沿袖带的整个长度延伸的体积。至少两个垂直横截面的内部闭合曲线将彼此交叉而不是彼此相交，如果在保持相对于袖带的垂直横截面的取向和位置的情况下叠加。还描述了其它实施例。

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