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51. 发明申请

US20130210858A1 SULFAMOYL BENZOIC ACID HETEROBICYCLIC DERIVATIVES AS TRPM8 ANTAGONISTS 有权
标题翻译：作为TRPM8拮抗剂的磺酰胆碱酸异构体衍生物
公开(公告)号：US20130210858A1
公开(公告)日：2013-08-15
申请号：US13820598
申请日：2011-10-03
申请人： Kiyoshi Kawamura , Yuji Shishido , Masashi Ohmi
发明人： Kiyoshi Kawamura , Yuji Shishido , Masashi Ohmi
IPC分类号： C07D471/04 , C07D401/12 , C07D405/14 , A61K31/4709 , A61K31/443 , A61K31/4439 , A61K31/444 , C07D405/12 , A61K45/06
CPC分类号： C07D471/04 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D209/08 , C07D215/12 , C07D231/56 , C07D249/18 , C07D307/79 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14
摘要： The present invention relates to sulfamoyl benzoic acid heterobicyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
摘要翻译：本发明涉及式（I）的氨磺酰基苯甲酸异双环衍生物或其药学上可接受的盐或其前药，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途， TRPM8受体。

52. 发明申请

US20110275628A1 NOVEL PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING 5-HT2B RECEPTOR ANTAGONIST ACTIVITY 有权
标题翻译：具有5-HT2B受体拮抗剂活性的新型吡唑-3-羧酰胺衍生物
公开(公告)号：US20110275628A1
公开(公告)日：2011-11-10
申请号：US13129916
申请日：2009-11-24
申请人： Tatsuya Yamagishi , Kiyoshi Kawamura , Tadashi Inoue , Yuji Shishido , Hiroaki Ito
发明人： Tatsuya Yamagishi , Kiyoshi Kawamura , Tadashi Inoue , Yuji Shishido , Hiroaki Ito
IPC分类号： A61K31/5377 , C07D413/14 , C07D471/04 , A61P1/00 , A61P25/24 , A61P19/02 , A61P25/28 , A61P31/14 , A61P31/12 , A61P25/00 , C07D413/12 , A61P17/02
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/553 , C07D231/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as a selective antagonist of a 5-HT2B receptor. The compound and salt are useful for treatment or prevention of various diseases and conditions associated with a 5-HT2B receptor.
摘要翻译：公开了通式（I）表示的化合物或其药学上可接受的盐，其可用作5-HT 2B受体的选择性拮抗剂。该化合物和盐可用于治疗或预防与5-HT 2B受体相关的各种疾病和病症。

53. 发明申请

US20080166636A1 Polymer, Crosslinked Polymer, Composition for Solid Polymer Electrolyte, Solid Polymer Electrolyte, and Adhesive Composition 有权
公开(公告)号：US20080166636A1
公开(公告)日：2008-07-10
申请号：US11795783
申请日：2006-01-18
申请人： Takeshi Niitani , Masato Amaike , Mikiya Shimada , Kiyoshi Kawamura
发明人： Takeshi Niitani , Masato Amaike , Mikiya Shimada , Kiyoshi Kawamura
IPC分类号： H01M6/16 , C08L31/02 , C09J167/06
CPC分类号： C08F293/005 , C08F290/06 , C08F293/00 , C08F297/02 , C08F297/026 , C08G18/6229 , C08L25/04 , C08L27/16 , C08L29/02 , C08L53/00 , C08L71/02 , C08L75/04 , C08L2205/05 , C08L2666/02 , C09J153/00 , H01M10/052 , H01M10/0565 , H01M2300/0082 , C08L2666/04
摘要： A polymer including a block chain A which is formed from a random copolymer containing a repeating unit (I) represented by the formula (I) wherein R1 to R3 each independently represents hydrogen or C1-10 hydrocarbon and R1 and R3 may bond to form a ring; R4a and R4b each independently represents hydrogen or methyl; R5 represents hydrogen, hydrocarbon, acyl, or silyl; and m represents any integer of 1 to 100 and when m is 2 or more and each R4a may be the same or different from one another and each R4b may be the same or different from one another; and a repeating unit (II) represented by the formula (II) wherein R6 and R8 each independently represents hydrogen or C1-10 hydrocarbon and R6 and R8 may bond to form a ring; R7 represents hydrogen, C1-10 hydrocarbon, hydroxyl, hydrocarbonoxy, carboxyl, acid anhydride, amino, ester, or an organic group having at least one functional group selected from the group consisting of hydroxyl, carboxyl, epoxy, acid anhydride, and amino; and R9 represents an organic group having at least one functional group selected from the group consisting of hydroxyl, carboxyl, epoxy, acid anhydride, and amino; and a block chain B having a repeating unit (III) represented by the formula (III) wherein R10 to R12 each independently represents hydrogen or C1-10 hydrocarbon and R13 represents aryl or heteroaryl; and wherein an arrangement order thereof is B, A, B.

54. 发明申请

US20060194842A1 Oxyindole derivatives 失效
标题翻译：氧吲哚衍生物
公开(公告)号：US20060194842A1
公开(公告)日：2006-08-31
申请号：US11360095
申请日：2006-02-22
申请人： Chikara Uchida , Hiroki Sone , Kiyoshi Kawamura
发明人： Chikara Uchida , Hiroki Sone , Kiyoshi Kawamura
IPC分类号： A61K31/454 , C07D417/14 , C07D413/14 , C07D403/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, R1, R2, R3, R4 and R5 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonistic activity such as, but not limited to, as gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageal disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes or apnea syndrome.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：A，R 1，R 2，R 3， SUP，R 4和R 5各自如本文所述或其药学上可接受的盐，以及含有这些化合物的组合物和这些化合物在治疗病症中的用途由5-HT 4激动剂活性介导，例如但不限于胃食管反流疾病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃食管疾病，恶心，中枢神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心血管疾病，心力衰竭，心律失常，糖尿病或呼吸暂停综合征。

55. 发明授权

US06951876B2 Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents 失效
标题翻译：磺酰基杂芳基吡唑化合物作为抗炎/止痛剂
公开(公告)号：US06951876B2
公开(公告)日：2005-10-04
申请号：US10334329
申请日：2002-12-31
申请人： Kazuo Ando , Kiyoshi Kawamura
发明人： Kazuo Ando , Kiyoshi Kawamura
IPC分类号： A61K31/443 , A61K31/4439 , A61P1/00 , A61P1/04 , A61P7/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/06 , A61P17/02 , A61P19/02 , A61P19/06 , A61P19/08 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07D405/14 , C07D413/14 , C07D417/14 , C07D401/04
CPC分类号： C07D405/14 , C07D413/14 , C07D417/14
摘要： This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is NH2; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.
摘要翻译：本发明涉及下式化合物或其药学上可接受的盐，其中A和R 1各自为任选取代的5至6元杂芳基，其中杂芳基任选地与碳环稠合环或5至6-杂芳基; R 2是NH 2; R 3和R 4各自为氢，卤素，（C 1 -C 4 -C 4）烷基，任选被卤素等; 和X 1至X 4各自为氢，卤素，羟基，（C 1 -C 4 -C 4）烷基任选被卤素等取代。这些化合物具有COX-2抑制活性，因此可用于治疗或预防炎症或其他COX-2相关疾病。

56. 发明授权

US06649636B1 Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents 失效
标题翻译：杂芳基苯基吡唑化合物作为抗炎/止痛剂
公开(公告)号：US06649636B1
公开(公告)日：2003-11-18
申请号：US09723608
申请日：2000-11-28
申请人： Kazuo Ando , Martha L. Minich , Jin Li , Subas M. Sakya , Kristin M. Lundy , Hengmiao Cheng , Brian S. Bronk , Kiyoshi Kawamura , Tomoki Kato
发明人： Kazuo Ando , Martha L. Minich , Jin Li , Subas M. Sakya , Kristin M. Lundy , Hengmiao Cheng , Brian S. Bronk , Kiyoshi Kawamura , Tomoki Kato
IPC分类号： C07D40114
CPC分类号： C07D405/14 , C07D413/14 , C07D417/14
摘要： This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is (C1-C4)alkyl optionally substituted with halo, amino or an alkyl amino; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐，其中A和R 1各自为任选取代的5至6元杂芳基，其中杂芳基任选地稠合于碳环或5至6个杂芳基 R 2是任选被卤素，氨基或烷基氨基取代的（C 1 -C 4）烷基; R 3和R 4各自为氢，卤素，任选被卤素取代的（C 1 -C 4）烷基等; X 1至X 4各自为氢，卤素，羟基，任选被卤素取代的（C 1 -C 4）烷基等。这些化合物具有COX-2抑制活性，因此可用于治疗或预防炎症或其他COX-2相关疾病。

57. 发明授权

US06380472B1 ELECTRIC TUTOR FOR DIRECTLY INDICATING MANIPULATORS TO BE ACTUATED, MUSICAL INSTRUMENT WITH BUILT-IN ELECTRIC TUTOR, METHOD FOR GUIDING FINGERING AND INFORMATION STORAGE MEDIUM FOR STORING PROGRAM REPRESENTATIVE OF THE METHOD 有权
标题翻译：用于直接指示要被启动的操纵器的电子指示器，具有内置电动引导器的音乐仪器，用于引导指向的方法和用于存储该方法的程序代码的信息存储介质
公开(公告)号：US06380472B1
公开(公告)日：2002-04-30
申请号：US09471665
申请日：1999-12-24
申请人： Nobuo Sugiyama , Haruki Uehara , Kiyoshi Kawamura
发明人： Nobuo Sugiyama , Haruki Uehara , Kiyoshi Kawamura
IPC分类号： G09B1508
CPC分类号： G10G1/02 , G09B15/08
摘要： A keyboard musical instrument that is equipped with an electric tutor for guiding a trainee in practicing manipulation of black and white piano keys, whereby the electric tutor reads pieces of musical data information representative of the black and white keys to be depressed and a timing to depress each of the black or white keys for guiding the trainee in the fingering. More specifically, while the trainee is practicing a piece of music, the electric tutor automatically sinks the designated black or white keys as an advanced notice to the trainee so that the trainee can prepare to depress the keys at the appropriate timing, and whereby the electric tutor sinks the same keys again for an inductive action at the time when such keys are to be appropriately depressed.
摘要翻译：一种键盘乐器，其配备有电导师，用于引导受训者练习黑白钢琴键，由此电导师读取表示要按压的黑白键的音乐数据信息，并按下按钮每个黑色或白色键用于指导学员在指法中。更具体地说，当受训者正在练习一段音乐时，电导师自动地将指定的黑色或白色键作为高级通知下达给受训者，使得受训者可以准备在适当的时机按下键，从而电辅导老师再次吸收相同的键，以便在这样的键被适当地按下时进行感应动作。

58. 发明授权

US06011214A Keyboard instruments having hammer stopper outwardly extending from hammer shank and method of remodeling piano into the keyboard instrument 失效
标题翻译：具有从锤柄向外延伸的锤塞的键盘乐器和将钢琴重新配置到键盘乐器中的方法
公开(公告)号：US06011214A
公开(公告)日：2000-01-04
申请号：US222477
申请日：1998-12-29
申请人： Kiyoshi Kawamura
发明人： Kiyoshi Kawamura
IPC分类号： G10C3/16 , G10C5/00 , G10H1/34 , G10C3/00 , G10C3/18
CPC分类号： G10C3/161 , G10C5/005 , G10H1/346
摘要： A stopper, a driver unit, key and pedal sensors, a sound processing unit and a sound system are installed in an acoustic piano so as to remodel the acoustic piano into a keyboard musical instrument performable with either acoustic or electronic sounds.
摘要翻译：声学钢琴中安装有一个塞子，一个驱动单元，钥匙和踏板传感器，一个声音处理单元和一个声音系统，以便将声学钢琴改造成可以用声音或电子声音执行的键盘乐器。

59. 发明授权

US5587410A Aqueous resin composition 失效
标题翻译：水性树脂组合物
公开(公告)号：US5587410A
公开(公告)日：1996-12-24
申请号：US417615
申请日：1995-04-05
申请人： Kenta Kanaida , Kiyoshi Kawamura
发明人： Kenta Kanaida , Kiyoshi Kawamura
IPC分类号： C08L23/00 , C08L23/26 , C08L23/28 , C08L33/06 , C08L39/00 , C08L39/04 , C08L51/06 , C08L63/08
CPC分类号： C08L23/28 , C08L23/26 , C08L33/062 , C08L51/06 , Y10T428/31913
摘要： An aqueous resin composition includes a polymer and an aqueous medium, wherein the polymer at least partially includes a polyolefin chloride resin and has a carboxyl group and an oxazoline group.
摘要翻译：水性树脂组合物包括聚合物和水性介质，其中所述聚合物至少部分地包含聚烯烃氯树脂并具有羧基和恶唑啉基。

60. 发明授权

US5565635A Automatic playing apparatus with pedal actuators supported by bracket independent of case of acoustic piano 失效
标题翻译：自动播放设备，带有踏板执行器，支架独立于钢琴的外壳
公开(公告)号：US5565635A
公开(公告)日：1996-10-15
申请号：US317754
申请日：1994-10-04
申请人： Yasutoshi Kaneko , Kiyoshi Kawamura
发明人： Yasutoshi Kaneko , Kiyoshi Kawamura
IPC分类号： G10F1/02 , G10F3/00 , G10C3/20 , G10C3/26 , G10F5/02
CPC分类号： G10F3/00
摘要： An automatic playing apparatus is provided for an acoustic piano for reproducing a music without fingering of a player on a keyboard, and has a pedal actuator unit directly supported by a floor so that a reaction of the pedal is never exerted to the piano case, thereby preventing the key bed from deformation due to the reaction.
摘要翻译：提供了一种用于钢琴的自动演奏装置，用于在不用键盘上的玩家的指法的情况下再现音乐，并且具有由地板直接支撑的踏板致动器单元，使得踏板的反作用力不会施加到钢琴盒防止钥匙床因反应而变形。

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