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51. 发明授权

US09592324B2 Tissue separating device with reinforced support for anchoring mechanisms 有权
标题翻译：组织分离装置，具有用于锚固机构的加强支撑
公开(公告)号：US09592324B2
公开(公告)日：2017-03-14
申请号：US11980155
申请日：2007-10-30
申请人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
发明人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
IPC分类号： A61L31/14 , A61L31/08
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

52. 发明授权

US09492596B2 Barrier layer with underlying medical device and one or more reinforcing support structures 有权
标题翻译：具有底层医疗装置和一个或多个加强支撑结构的阻隔层
公开(公告)号：US09492596B2
公开(公告)日：2016-11-15
申请号：US11701799
申请日：2007-02-02
申请人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
发明人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
IPC分类号： A61F2/02 , A61L31/14 , A61L31/16
CPC分类号： A61L31/145 , A61F2/0063 , A61F2/82 , A61F2002/0086 , A61F2002/009 , A61L31/16 , A61L2300/41 , A61L2300/606
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

53. 发明申请

US20120213839A1 HYDROPHOBIC CROSS-LINKED GELS FOR BIOABSORBABLE DRUG CARRIER COATINGS 有权
标题翻译：用于生物可溶性药物载体涂层的疏水性交联凝胶
公开(公告)号：US20120213839A1
公开(公告)日：2012-08-23
申请号：US13404487
申请日：2012-02-24
申请人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
发明人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
IPC分类号： A61K9/00 , A61K47/14 , A61P9/00 , A61P7/02 , A61P35/00 , A61K47/12 , A61P29/00
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
摘要翻译：描述了用于医疗装置的涂层，制备涂层的方法及其使用方法。

54. 发明授权

US07740793B2 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US07740793B2
公开(公告)日：2010-06-22
申请号：US11068680
申请日：2005-02-28
申请人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译：一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸，径向膨胀力。该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。

55. 发明授权

US5980799A Methods of making controlled porosity expanded polytetrafluoroethylene products and fabrication 失效
标题翻译：制造控制孔隙率膨胀聚四氟乙烯产品和制造方法
公开(公告)号：US5980799A
公开(公告)日：1999-11-09
申请号：US98195
申请日：1998-06-16
申请人： Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/06 , A61L27/16 , A61L27/56 , B29C47/00 , B29C55/00 , B29C69/00 , B29D23/00 , B29K27/12 , B29K105/04 , D02J1/06 , B29C55/22
CPC分类号： B29D23/001 , A61F2/06 , A61L27/16 , A61L27/56 , B01D67/0027 , B01D69/02 , B01D69/12 , B01D71/36 , B29C47/0004 , B29C47/0021 , B29C55/005 , B01D2325/02 , B29C47/0023 , B29C47/0026 , B29C47/0042 , B29C47/0057 , B29C47/062 , B29C47/065 , B29K2027/18 , B29K2105/04 , B29L2023/005 , B29L2023/007 , Y10T428/139 , Y10T428/1397 , Y10T428/24273 , Y10T428/249986 , Y10T428/24999 , Y10T428/249992 , Y10T428/31544
摘要： A method of forming porous articles with a varying pore distribution by extrusion from a billet with a varying lubricant distribution. A single-polymer polytetrafluoroethylene is extruded and then stretched and sintered to provide a differential porous PTFE structure composed of fibers and nodes connected to one another by these fibers. The microfibrous structure has a portion within the cross-section that possesses a different pore size, accompanied by a different node and fiber geometry, than adjacent areas within that cross section. In a vascular graft, the pores taper inwardly, providing a fluid-tight lumen wall structure that prevents leakage, yet promotes cellular ingrowth and natural tissue regeneration. A node structure of radially-oriented plates provides flexibility, suture strength, and enhanced protection against collapse.
摘要翻译：通过从具有变化的润滑剂分布的坯料挤出形成具有不同孔分布的多孔制品的方法。挤出单聚合物聚四氟乙烯，然后进行拉伸和烧结，以提供由纤维和由这些纤维相互连接的节点组成的差异多孔PTFE结构。微纤维结构在横截面内具有与该截面内的相邻区域不同的孔径的部分，伴随不同的节点和纤维几何形状。在血管移植物中，孔向内逐渐变细，提供流体密封的腔壁结构，其防止泄漏，但促进细胞向内生长和天然组织再生。径向定向板的节点结构提供柔性，缝合强度和增强的防止塌陷的保护。

56. 发明授权

US5824050A Prosthesis with in-wall modulation 失效
公开(公告)号：US5824050A
公开(公告)日：1998-10-20
申请号：US760115
申请日：1996-12-03
申请人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
发明人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/04
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： The wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure transmission, or locally alters fluid-born-distribution of biological material through the wall and allows more natural gradients for tissue regeneration and growth in the outer region of the wall.

57. 发明申请

US20100034867A1 DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开
标题翻译：用于医疗设备的药物输送涂料和治疗血管损伤的方法
公开(公告)号：US20100034867A1
公开(公告)日：2010-02-11
申请号：US11919363
申请日：2006-04-28
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Theodore Karwoski , Trevor Carlton
IPC分类号： A61L27/54 , A61K31/436 , A61K38/13 , A61K47/12 , A61P9/00 , A61L29/16
CPC分类号： A61K31/436 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/434 , A61L2300/45
摘要： The present inventions provide various embodiments of medical devices coated with a therapeutic coating comprising a mTOR targeting compound and a calcineurin inhibitor, and methods of applying said coatings. In various aspects, the therapeutic coating comprises a bio-absorbable carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
摘要翻译：本发明提供涂覆有包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗性涂层的医疗器械的各种实施方案，以及施用所述涂层的方法。在各个方面，治疗性包衣包含至少部分由细胞吸收抑制剂和细胞摄取增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分。在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。

58. 发明申请

US20080109017A1 Barrier layer with underlying medical device and one or more reinforcing support structures 有权
标题翻译：具有底层医疗装置和一个或多个加强支撑结构的阻隔层
公开(公告)号：US20080109017A1
公开(公告)日：2008-05-08
申请号：US11701799
申请日：2007-02-02
申请人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
发明人： Steve A. Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Richard Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/145 , A61F2/0063 , A61F2/82 , A61F2002/0086 , A61F2002/009 , A61L31/16 , A61L2300/41 , A61L2300/606
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内用于短期或长期应用，并且可包括治疗剂的受控释放。

59. 发明授权

US06395208B1 Method of making an expandable fluoropolymer device 有权
标题翻译：制造可膨胀氟聚合物装置的方法
公开(公告)号：US06395208B1
公开(公告)日：2002-05-28
申请号：US09410329
申请日：1999-10-01
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： B29C4904
CPC分类号： B29C55/24 , A61L29/041 , A61M25/10 , B29C47/00 , B29C47/0023 , B29C47/0026 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable device having a body constructed of a generally inelastic, expanded fluoropolymer material. The body is deployable upon application of a radial expansion force from a reduced diameter, collapsed configuration to an expanded configuration having a pre-defined and fixed increased diameter. The body has a singular, unitary construction of generally homogenous material that is characterized by a seamless construction of expanded fluoropolymer material, such as expanded polytetrafluoroethylene (ePTFE), and is preferably constructed through an extrusion and expansion process. The body is further characterized by a microstructure of nodes interconnected by fibrils in which substantially all the nodes of the body are oriented generally perpendicularly to the longitudinal axis of the body. The monolithic construction of the body and the orientation of the nodes, perpendicular to the longitudinal axis of the body, yields a radially expandable device that predictably and dependably expands to a predefined, fixed maximum diameter that is generally independent of the expansion force used to radially expand the device.
摘要翻译：一种制造径向可膨胀装置的方法，该装置具有由通常无弹性的膨胀的含氟聚合物材料构成的主体。当径向膨胀力从减小的直径，收缩构型施加到具有预定义和固定的增大直径的膨胀构型时，主体可展开。本体具有通常均匀材料的单一，单一结构，其特征在于扩展的氟聚合物材料如膨胀聚四氟乙烯（ePTFE）的无缝构造，并且优选通过挤出和膨胀方法构造。身体的特征还在于通过原纤维相互连接的节点的微结构，其中主体的基本上所有的节点大致垂直于身体的纵向轴线定向。身体的整体结构和垂直于身体的纵向轴线的节点的取向产生可预测和可靠地扩展到预定的，固定的最大直径的径向可扩张装置，其通常与用于径向的膨胀力无关展开设备。

60. 发明授权

US5925074A Vascular endoprosthesis and method 失效
公开(公告)号：US5925074A
公开(公告)日：1999-07-20
申请号：US759861
申请日：1996-12-03
申请人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/82 , A61L31/04 , A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61L31/048 , A61F2/90 , A61F2/958
摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.

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