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51. 发明申请

US20100241117A1 Assessment of Electrode Coupling for Tissue Ablation 有权
标题翻译：电极耦合用于组织消融的评估
公开(公告)号：US20100241117A1
公开(公告)日：2010-09-23
申请号：US12095701
申请日：2006-12-06
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

52. 发明申请

US20100228247A1 Assessment of electrode coupling of tissue ablation 有权
标题翻译：评估组织消融的电极耦合
公开(公告)号：US20100228247A1
公开(公告)日：2010-09-09
申请号：US12095688
申请日：2006-12-06
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

53. 发明申请

US20090158852A1 Contact Sensing Flexible Conductive Polymer Electrode 有权
标题翻译：接触感应柔性导电聚合物电极
公开(公告)号：US20090158852A1
公开(公告)日：2009-06-25
申请号：US11963321
申请日：2007-12-21
申请人： Saurav Paul , Chou Thao , Troy T. Tegg
发明人： Saurav Paul , Chou Thao , Troy T. Tegg
IPC分类号： G01L9/00 , H01S4/00
CPC分类号： G01L1/16 , A61B5/042 , A61B5/6885 , G01L5/0038 , Y10T29/49002
摘要： A contact sensing catheter system includes a catheter shaft having a distal end; a flexible conductive polymer electrode located at the distal end of the shaft; and an electromechanical contact sensor positioned at least partially within the electrode. The sensor outputs an electrical signal in response to a mechanical force acting thereon. The sensor may be a piezoelectric sensor, a strain gauge, a fiber optic sensor, or another suitable electromechanical contact sensor. The electrical signal output by the sensor typically varies in response to variations in the mechanical force acting on the sensor. An output device may receive the signal output by the contact sensor and present to a user of the system an indicator of contact between the electrode and a tissue by assessing, for example, the amplitude or periodicity of the signal.
摘要翻译：接触感测导管系统包括具有远端的导管轴; 位于所述轴的远端的柔性导电聚合物电极; 以及至少部分地位于电极内的机电接触传感器。传感器响应于作用在其上的机械力而输出电信号。传感器可以是压电传感器，应变计，光纤传感器或另一适合的机电接触传感器。由传感器输出的电信号通常响应于作用在传感器上的机械力的变化而变化。输出装置可以接收由接触传感器输出的信号，并通过评估例如信号的幅度或周期性向系统的用户呈现电极和组织之间的接触的指示。

54. 发明申请

US20080281319A1 Assessment of Electrode Coupling For Tissue Ablation 有权
标题翻译：电极耦合用于组织消融的评估
公开(公告)号：US20080281319A1
公开(公告)日：2008-11-13
申请号：US12096071
申请日：2006-12-06
申请人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
发明人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.
摘要翻译：公开了电极导管和用于评估电极组织接触和耦合的方法。示例性电极导管包括适于施加电能的电极。测量电路适于在电极接近目标组织时测量电极和地面之间的阻抗。处理器至少部分地基于由测量电路测量的阻抗的电抗来确定目标组织的接触和耦合条件。在另一示例性实施例中，电极导管至少部分地基于阻抗的相位角确定接触和耦合条件。

55. 发明申请

US20080161889A1 Pressure-sensitive conductive composite electrode and method for ablation 有权
标题翻译：压敏导电复合电极及其消融方法
公开(公告)号：US20080161889A1
公开(公告)日：2008-07-03
申请号：US11647316
申请日：2006-12-29
申请人： Saurav Paul , Kedar Ravindra Belhe , Chou Thao , Hong Cao
发明人： Saurav Paul , Kedar Ravindra Belhe , Chou Thao , Hong Cao
IPC分类号： A61N7/00
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00791 , A61B2018/1437 , A61B2090/064 , A61B2090/065 , A61B2218/002
摘要： The present invention is directed to ablation devices and methods utilizing pressure sensitive conductive composites, such as quantum tunneling composites, or other contact-sensitive, conductive polymers. The materials provide for electrodes and methods capable of differentiating between a soft and a hard push. The present invention thus provides an electrode for delivering selective electrical energy for ablation that may be varied based upon the pressure exerted on the surface area of the targeted tissue.
摘要翻译：本发明涉及使用压敏导电复合材料如量子隧道复合材料或其它接触敏感的导电聚合物的消融装置和方法。这些材料提供了能够区分软推和硬推的电极和方法。因此，本发明提供了一种用于输送用于消融的选择性电能的电极，其可以基于施加在目标组织的表面积上的压力而变化。

56. 发明授权

US07276064B2 Side-port sheath for catheter placement and translation 失效
标题翻译：用于导管放置和翻译的侧端口护套
公开(公告)号：US07276064B2
公开(公告)日：2007-10-02
申请号：US10856145
申请日：2004-05-27
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , John Avi Roop , Chou Thao
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , John Avi Roop , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/042 , A61B2018/143 , A61B2018/1475 , A61B2018/1497
摘要： Side-port sheaths for catheter placement and translation are disclosed. The sheaths include a side-port opening through which a gliding catheter may be deployed during diagnosis or treatment of tissue. The side-port sheath may include a suspension ribbon used to deploy, or that aids in the deployment of, the embedded gliding catheter. The suspension ribbon may be slideably or fixably engaged with an outer surface of the sheath of the gliding catheter.
摘要翻译：公开了用于导管放置和平移的侧端口护套。护套包括侧口开口，在组织的诊断或处理期间可以通过滑动导管展开滑动导管。侧端口护套可以包括用于部署或有助于部署嵌入式滑翔导管的悬挂带。悬挂带可以与滑动导管的护套的外表面可滑动地或可固定地接合。

57. 发明授权

US10085798B2 Ablation electrode with tactile sensor 有权
公开(公告)号：US10085798B2
公开(公告)日：2018-10-02
申请号：US11647279
申请日：2006-12-29
申请人： Hong Cao , Chou Thao , Saurav Paul
发明人： Hong Cao , Chou Thao , Saurav Paul
IPC分类号： A61B18/14 , A61B90/00
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. The assembly includes a catheter shaft and a pressure sensitive conductive composite member whose electrical resistance varies with pressure applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive conductive composite member. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive conductive composites.

58. 发明授权

US09254163B2 Assessment of electrode coupling for tissue ablation 有权
公开(公告)号：US09254163B2
公开(公告)日：2016-02-09
申请号：US13593676
申请日：2012-08-24
申请人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
发明人： Saurav Paul , Hong Cao , Kedar Ravindra Belhe , Chou Thao
IPC分类号： A61B18/12 , A61B5/053 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1206 , A61B5/0538 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00732 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/128
摘要： An electrode catheter and a method for assessing electrode-tissue contact and coupling are disclosed. An exemplary electrode catheter comprises an electrode adapted to apply electrical energy. A measurement circuit is adapted to measure impedance between the electrode and ground as the electrode approaches a target tissue. A processor determines a contact and coupling condition for the target tissue based at least in part on reactance of the impedance measured by the measurement circuit. In another exemplary embodiment, the electrode catheter determines the contact and coupling condition based at least in part on a phase angle of the impedance.

59. 发明授权

US08728077B2 Handle set for ablation catheter with indicators of catheter and tissue parameters 有权
标题翻译：用于消融导管的手柄，其具有导管和组织参数指示
公开(公告)号：US08728077B2
公开(公告)日：2014-05-20
申请号：US12096069
申请日：2006-12-06
申请人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao , James A. Hassett
发明人： Saurav Paul , Kedar Ravindra Belhe , Hong Cao , Chou Thao , James A. Hassett
IPC分类号： A61B18/18 , A61B5/05
CPC分类号： A61B18/1206 , A61B18/1492 , A61B34/20 , A61B2018/00303 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00702 , A61B2018/0075 , A61B2018/00755 , A61B2018/00869 , A61B2018/00875 , A61B2090/064 , A61B2090/065
摘要： An electrode coupling output system provides indication to the physician, via electrode guidance instrumentation, concerning the electrical coupling of an electrode, such as an ablative or mapping electrode, with a patient. The output can be provided to the physician via an output device incorporated into the handle set of the electrode catheter. For example, a visual, audio or mechanical output can be provided via the handle set. Additionally or alternatively, the output can be provided to the physician via a navigation system. The indication may be provided by changing the color or other display characteristics of the electrode on the navigation system display or by way of providing a waveform indicating the electrode coupling. In this manner, electrode coupling information is provided to a physician in a manner that minimizes physician distraction.
摘要翻译：电极耦合输出系统通过电极引导仪器向医师提供关于电极（例如烧蚀或映射电极）与患者的电耦合的指示。输出可以通过结合到电极导管的手柄组中的输出装置提供给医师。例如，可以通过手柄组提供视觉，音频或机械输出。另外或替代地，输出可以经由导航系统提供给医师。可以通过改变导航系统显示器上的电极的颜色或其他显示特性或通过提供指示电极耦合的波形来提供指示。以这种方式，电极耦合信息以最小化医师分心的方式提供给医师。

60. 发明授权

US08226648B2 Pressure-sensitive flexible polymer bipolar electrode 有权
标题翻译：压敏柔性聚合物双极电极
公开(公告)号：US08226648B2
公开(公告)日：2012-07-24
申请号：US11968044
申请日：2007-12-31
申请人： Saurav Paul , Harry Puryear , Chou Thao
发明人： Saurav Paul , Harry Puryear , Chou Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1206 , A61B2018/00023 , A61B2018/00577 , A61B2018/00875
摘要： The present invention is directed to bipolar ablation systems. A bipolar electrode system for ablation therapy is disclosed, including a pressure-sensitive conducting composite layer and a pair of electrodes in electrical conductive contact or communication with the pressure-sensitive conducting composite layer. Energy (e.g., ablation energy) is delivered via the pressure-sensitive conductive composition when sufficient pressure is applied to transform the pressure-sensitive conductive composite to an electrical conductor. An electrically insulative flexible layer, which may include a passageway for a fill material is also disclosed. In some embodiments, the systems can also be used for targeted delivery of compounds, such as drugs, using a bipolar electrode.
摘要翻译：本发明涉及双相消融系统。公开了一种用于消融治疗的双极电极系统，包括压敏导电复合层和一对导电接触或与压敏导电复合层连通的电极。当施加足够的压力以将压敏导电复合材料转变成电导体时，能量（例如，消融能量）经由压敏导电组合物递送。还公开了可以包括用于填充材料的通道的电绝缘柔性层。在一些实施方案中，所述系统也可用于使用双极电极靶向递送化合物，例如药物。

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