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51. 发明申请

US20050245447A1 Modified chimeric polypeptides with improved pharmacokinetic properties and methods of making and using thereof 有权
标题翻译：具有改善的药代动力学性质的修饰的嵌合多肽及其制备和使用方法
公开(公告)号：US20050245447A1
公开(公告)日：2005-11-03
申请号：US11016503
申请日：2004-12-17
申请人： Nicholas Papadopoulos , Samuel Davis , George Yancopoulos
发明人： Nicholas Papadopoulos , Samuel Davis , George Yancopoulos
IPC分类号： A61K38/00 , C07K14/71 , A61K38/17
CPC分类号： C07K14/71 , A61K38/00 , C07K16/22 , C07K19/00 , C07K2319/00 , C07K2319/30
摘要： Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.
摘要翻译：公开了具有改善的药代动力学的修饰的嵌合多肽。具体地，公开了已经以改善其药代动力学特征的方式修饰的修饰的嵌合Flt1受体多肽。还公开了制备和使用修饰的多肽的方法，包括但不限于使用修饰的多肽来降低或抑制哺乳动物的血浆渗透和/或血管通透性。

52. 发明申请

US20130045492A1 Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain 审中-公开
标题翻译：使用普通轻链制备全人类双特异性抗体的方法
公开(公告)号：US20130045492A1
公开(公告)日：2013-02-21
申请号：US13488628
申请日：2012-06-05
申请人： Robert Babb , John McWhirter , Lynn MacDonald , Sean Stevens , Samuel Davis , David R. Buckler , Karolina A. Hosiawa , Andrew J. Murphy
发明人： Robert Babb , John McWhirter , Lynn MacDonald , Sean Stevens , Samuel Davis , David R. Buckler , Karolina A. Hosiawa , Andrew J. Murphy
IPC分类号： C12P21/00 , G01N21/64 , G01N33/566
CPC分类号： C07K16/468 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N15/8509 , C12N2800/204
摘要： A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.
摘要翻译：提供遗传修饰的小鼠，其中小鼠表达免疫球蛋白轻链总谱，其特征在于有限数量的轻链可变结构域。提供的小鼠在其种系中仅来自有限谱系的一个或几个免疫球蛋白轻链可变结构域。提供了使用如本文所述的小鼠制备具有通用轻链的双特异性抗体的方法，包括人轻链可变区。提供了适合用于多特异性结合蛋白（例如双特异性抗体）和宿主细胞的人可变区的方法。提供了能够结合第一和第二抗原的双特异性抗体，其中第一和第二抗原是单个蛋白质的分离表位或两种不同蛋白质上的分离表位。

53. 发明申请

US20120021409A1 Common Light Chain Mouse 审中-公开
公开(公告)号：US20120021409A1
公开(公告)日：2012-01-26
申请号：US13093156
申请日：2011-04-25
申请人： John McWhirter , Lynn MacDonald , Sean Stevens , Samuel Davis , David R. Buckler , Karolina A. Hosiawa , Andrew J. Murphy
发明人： John McWhirter , Lynn MacDonald , Sean Stevens , Samuel Davis , David R. Buckler , Karolina A. Hosiawa , Andrew J. Murphy
IPC分类号： C12Q1/68 , G01N33/566 , A01K67/027
摘要： A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making light chain variable regions in mice, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, are provided.

54. 发明申请

US20070056197A1 Kinetic display assembly 失效
标题翻译：动力显示组件
公开(公告)号：US20070056197A1
公开(公告)日：2007-03-15
申请号：US11223983
申请日：2005-09-13
申请人： Samuel Davis
发明人： Samuel Davis
IPC分类号： G09F19/14
CPC分类号： G09F19/14 , G09F1/06
摘要： A display assembly is provided comprising; (a) an image insert, the image insert being bendable from a planar configuration to a non-planar display configuration, wherein the image insert comprises a plurality of first surfaces for displaying a first image, and a plurality of second surfaces for displaying a second image; and (b) a display frame for supporting the image insert in the non-planar display configuration. The display frame comprises an abutment structure for abutting the plurality of first surfaces and the plurality of second surfaces to secure the plurality of first surfaces at a non-zero angle relative to the plurality of second surfaces and to resist unbending of the image insert. Optionally, the display assembly may be part of a book.
摘要翻译：提供一种显示组件，包括：（a）图像插入件，所述图像插入件可从平面配置弯曲成非平面显示配置，其中所述图像插入件包括用于显示第一图像的多个第一表面和用于显示第二图像的多个第二表面图片; 和（b）用于在非平面显示配置中支持图像插入物的显示框架。显示框架包括用于邻接多个第一表面和多个第二表面的邻接结构，以使多个第一表面相对于多个第二表面以非零角度固定，并抵抗图像插入物的不弯曲。可选地，显示组件可以是书的一部分。

55. 发明申请

US20060260778A1 Method for adding boron to metal alloys 审中-公开
标题翻译：硼添加到金属合金中的方法
公开(公告)号：US20060260778A1
公开(公告)日：2006-11-23
申请号：US11132621
申请日：2005-05-19
申请人： Samuel Davis , Neil Baker , John Riskalla , Richard Carrano
发明人： Samuel Davis , Neil Baker , John Riskalla , Richard Carrano
IPC分类号： B22D27/00
CPC分类号： B22D27/20 , B22D11/001 , B22D21/00 , B22F2998/00 , B22F9/08
摘要： A method to grain refine and deoxidize a precious metal alloy or a master alloy includes the steps of (a) forming a precursor melt consisting essentially of constituents of the precious metal alloy or master alloy and inevitable impurities; (b) dispersing a compound selected from the group consisting of boron containing metal hydrides, boron containing metal fluorides and mixtures thereof throughout the precursor melt; and (c) solidifying the boron containing precious melt alloy or master alloy. One suitable compound is solid sodium borohydride (sodium tetrahydroborate). To minimize evaporation of the boron on contact with the precursor alloy melt, the sodium borohydride may be wrapped in a metal foil formed from constituents of the precious metal alloy or master alloy. The cast precious metal alloy or master alloy has been found to have a reduced number of hard spots and reduced silicon contamination when compared to conventional casting methods.
摘要翻译：一种对贵金属合金或母合金进行晶粒细化和脱氧的方法包括以下步骤：（a）形成基本上由贵金属合金或母合金的成分组成的前体熔体和不可避免的杂质; （b）将选自含硼金属氢化物，含硼金属氟化物及其混合物的化合物的化合物分散在整个前体熔体中; 和（c）固化含硼珍贵熔体合金或母合金。一种合适的化合物是固体硼氢化钠（四氢硼酸钠）。为了最小化与前体合金熔体接触时硼的蒸发，硼氢化钠可以包裹在由贵金属合金或母合金的成分形成的金属箔中。与传统的铸造方法相比，已经发现铸造的贵金属合金或母合金具有减少的硬斑数量和减少的硅污染。

56. 发明申请

US20050003543A1 Methods of modifying genes in eukaryotic cells 有权
标题翻译：在真核细胞中修饰基因的方法
公开(公告)号：US20050003543A1
公开(公告)日：2005-01-06
申请号：US10865424
申请日：2004-06-10
申请人： Aris Economides , David Valenzuela , Samuel Davis , George Yancopoulos
发明人： Aris Economides , David Valenzuela , Samuel Davis , George Yancopoulos
IPC分类号： A01K67/027 , C12N5/08 , C12N15/90 , C12N5/06 , C12N15/85
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A61D19/04 , C12N15/907 , C12N2800/30 , C12N2830/42 , C12N2840/44
摘要： Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombination such that a mature mRNA transcript produced from a genomic region of the genome comprising the genomic exon does not contain the modification are provided. The methods provide for a rapid method for introducing mutations and/or modifications of any type into a mammalian cell genome.
摘要翻译：通过将内含子通过同源重组插入到基因组外显子中而在基因组外显子中产生突变的方法。此外，提供了通过将内含子通过同源重组插入到基因组外显子中而将修饰引入基因组外显子的方法，从而提供了从包含基因组外显子的基因组的基因组区域产生的成熟mRNA转录物不含修饰。所述方法提供了用于将任何类型的突变和/或修饰引入哺乳动物细胞基因组的快速方法。

57. 发明申请

US20050106099A1 Expressed ligand-vascular intercellular signaling molecule 审中-公开
标题翻译：表达配体 - 血管细胞间信号分子
公开(公告)号：US20050106099A1
公开(公告)日：2005-05-19
申请号：US10928911
申请日：2004-08-27
申请人： Samuel Davis , George Yancopoulos
发明人： Samuel Davis , George Yancopoulos
IPC分类号： G01N33/53 , A61K38/00 , A61K38/18 , A61K45/00 , A61K48/00 , A61K51/00 , A61P7/00 , A61P7/02 , A61P9/00 , A61P17/02 , A61P27/00 , A61P29/00 , A61P35/00 , C07K14/515 , C07K14/71 , C07K16/22 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12N15/63 , C12N15/85 , C12P21/02 , C12P21/08 , A61K39/395 , C07K16/46
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A01K2267/03 , A01K2267/0331 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , C07K14/515 , C07K14/71 , C07K2319/00 , C07K2319/02
摘要： The present invention provides for a modified TIE-2 ligand 2 which has been altered by addition, deletion or substitution of one or more amino acids, or by way of tagging, with for example, the Fc portion of human IgG-1, but which retains its ability to bind the TIE-2 receptor.
摘要翻译：本发明提供了修饰的TIE-2配体2，其通过一个或多个氨基酸的添加，缺失或取代而被改变，或者通过例如使用例如人IgG-1的Fc部分进行标记而改变，但是哪些保留其结合TIE-2受体的能力。

58. 发明申请

US20050035322A1 Universal quick-disconnect 审中-公开
标题翻译：通用快速断开
公开(公告)号：US20050035322A1
公开(公告)日：2005-02-17
申请号：US10661419
申请日：2003-09-12
申请人： Samuel Davis , James Johnson , Kevin Bergenthun , Timothy Frasier
发明人： Samuel Davis , James Johnson , Kevin Bergenthun , Timothy Frasier
IPC分类号： B67D1/08 , B67D7/02 , F16L29/04 , F16L37/32 , F16L37/413 , F16L37/44 , F16L29/00
CPC分类号： B67D7/0294 , B67D1/0835 , F16L29/04 , F16L37/32 , F16L37/413 , F16L37/44 , Y10T137/5109 , Y10T137/87957
摘要： A single-service package coupling and valve includes a fitment having a spout and a sliding tubular valve member mounted therein for receiving a cooperating dispensing connector of a liquid distributing and dispensing system, and an external adapter ring designed to cooperate with the mounting mechanisms of a plurality of conventional commercially available dispensing connectors. An internal adapter sleeve is mounted with in the sliding tubular valve member to provide a tight seal with any of the conventional dispensing connectors. The external adapter ring is provided with a pair of radially extending flanges adapted to accept and position different dispensing connectors. At least one of the radially extending flanges is provided with at lest two wings to engage a threaded mounting collar of a service line connector.
摘要翻译：单一服务包装联接器和阀包括具有出口的安装件和安装在其中的滑动管状阀构件，用于接收液体分配和分配系统的配合分配连接器，以及设计成与安装机构配合的外部适配器环多个常规的可商购的分配连接器。内部紧固套筒安装在滑动管状阀构件中，以提供与任何常规分配连接器的紧密密封。外部适配器环设置有一对径向延伸的凸缘，其适于接纳和定位不同的分配连接器。径向延伸的凸缘中的至少一个设置有至少两个翼部以接合服务线连接器的螺纹安装环。

59. 发明授权

US08586713B2 Readily isolated bispecific antibodies with native immunoglobulin format 有权
标题翻译：用本地免疫球蛋白形式轻松分离双特异性抗体
公开(公告)号：US08586713B2
公开(公告)日：2013-11-19
申请号：US12823838
申请日：2010-06-25
申请人： Samuel Davis , Eric Smith , Douglas MacDonald , Kara Louise Olson
发明人： Samuel Davis , Eric Smith , Douglas MacDonald , Kara Louise Olson
IPC分类号： C07K16/00
CPC分类号： C07K1/22 , A61K2039/505 , C07K16/247 , C07K16/248 , C07K16/2809 , C07K16/2866 , C07K16/2887 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/56 , C07K2317/76
摘要： A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.
摘要翻译：提供提供易于分离的双特异性抗体形式，包括在CH3结构域中差异修饰的免疫球蛋白重链可变结构域，其中所述差异修饰是相对于CH3修饰的非免疫原性或基本上非免疫原性的，以及至少一种基于其对蛋白A的亲和力，所述修饰导致针对亲和试剂例如蛋白A的双特异性抗体的差异亲和力，并且双特异性抗体可从破坏的细胞，培养基或抗体混合物中分离。

60. 发明授权

US07356953B2 Kinetic display assembly 失效
标题翻译：动力显示组件
公开(公告)号：US07356953B2
公开(公告)日：2008-04-15
申请号：US11223983
申请日：2005-09-13
申请人： Samuel Davis
发明人： Samuel Davis
IPC分类号： G09F19/14 , G09F19/00 , B65D27/00 , A45C1/00
CPC分类号： G09F19/14 , G09F1/06
摘要： A display assembly is provided comprising; (a) an image insert, the image insert being bendable from a planar configuration to a non-planar display configuration, wherein the image insert comprises a plurality of first surfaces for displaying a first image, and a plurality of second surfaces for displaying a second image; and (b) a display frame for supporting the image insert in the non-planar display configuration. The display frame comprises an abutment structure for abutting the plurality of first surfaces and the plurality of second surfaces to secure the plurality of first surfaces at a non-zero angle relative to the plurality of second surfaces and to resist unbending of the image insert. Optionally, the display assembly may be part of a book.
摘要翻译：提供一种显示组件，包括：（a）图像插入件，所述图像插入件可从平面配置弯曲成非平面显示配置，其中所述图像插入件包括用于显示第一图像的多个第一表面和用于显示第二图像的多个第二表面图片; 和（b）用于在非平面显示配置中支持图像插入物的显示框架。显示框架包括用于邻接多个第一表面和多个第二表面的邻接结构，以使多个第一表面相对于多个第二表面以非零角度固定，并抵抗图像插入物的不弯曲。可选地，显示组件可以是书的一部分。

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