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    • 59. 发明授权
    • Ocular hypotensive agents
    • 眼低血压药
    • US06420422B1
    • 2002-07-16
    • US08476583
    • 1995-06-07
    • Ryuzo UenoRyuji UenoTomio Oda
    • Ryuzo UenoRyuji UenoTomio Oda
    • A61K31455
    • A61K31/557C07C405/00
    • The present invention relates to an ocular hypotensive composition and a composition for treatment of glaucoma which comprising an amount of 20-substituted-PGs or 20-substituted 15-keto-PGs effective as an ocular hypotensive agent; these compounds exhibit no or little side effect such as transient ocular hypertensive response, hyperemia of conjunctiva or of iris, dacryops, lema, closed eye and the like. The present invention relates to ocular hypotensive agents which contains 13,14-dihydro-15-keto-prostagrandins, which shows no transient ocular hypertensive response that PGs usually show.
    • 本发明涉及一种眼部降血压药物组合物和治疗青光眼的组合物,其含有作为眼部降压药有效的20-取代的PG或20-取代的15-酮基-PG的量; 这些化合物没有或没有副作用,例如暂时性高眼压反应,结膜充血或虹膜,泪囊虫,莱马,闭眼等。本发明涉及含有13,14-二氢-15- 酮前列腺素,其不显示PG通常显示的暂时性高眼压反应。