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51. 发明申请

US20090076046A1 Compounds modulating c-fms and/or c-kit activity and uses therefor 有权
标题翻译：调节c-fms和/或c-kit活性的化合物及其用途
公开(公告)号：US20090076046A1
公开(公告)日：2009-03-19
申请号：US11986667
申请日：2007-11-21
申请人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
发明人： Jiazhong Zhang , Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Guoxian Wu , Hongyao Zhu , Marika Nespi , Chao Zhang
IPC分类号： A61K31/506 , A61P35/00 , C07D471/04 , A61K31/454 , C07D239/02
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms活性的化合物。本文还提供了可用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物及其使用方法。

52. 发明授权

US07491831B2 PPAR active compounds 有权
标题翻译： PPAR活性化合物
公开(公告)号：US07491831B2
公开(公告)日：2009-02-17
申请号：US11679777
申请日：2007-02-27
申请人： Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
发明人： Dean R. Artis , Prabha N. Ibrahim , Jack Lin , Chao Zhang
IPC分类号： A61K31/40 , A61K31/41 , A61K31/405
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译：描述了对PPARs有活性的化合物，包括泛活性化合物。还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。

53. 发明申请

US20080255201A1 PPAR ACTIVE COMPOUNDS 有权
公开(公告)号：US20080255201A1
公开(公告)日：2008-10-16
申请号：US12043069
申请日：2008-03-05
申请人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号： A61K31/454 , A61K31/404 , C07D209/04 , A61P3/04 , C07D401/02
CPC分类号： C07D401/12 , C07D209/18 , C07D403/12
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.

54. 发明申请

US20080234349A1 PPAR active compounds 审中-公开
公开(公告)号：US20080234349A1
公开(公告)日：2008-09-25
申请号：US11517010
申请日：2006-09-06
申请人： Jack Lin , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean R. Artis , Prabha N. Ibrahim , Byunghun Lee
发明人： Jack Lin , Shenghua Shi , Chao Zhang , Rebecca Zuckerman , Dean R. Artis , Prabha N. Ibrahim , Byunghun Lee
IPC分类号： A61K31/4155 , C07D409/12 , A61K31/4025 , A61P25/00 , A61P3/04 , C07D409/14
CPC分类号： C07D409/12 , C07D209/08 , C07D409/14
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.

55. 发明申请

US20080045581A1 PPAR ACTIVE COMPOUNDS 有权
标题翻译： PPAR活性化合物
公开(公告)号：US20080045581A1
公开(公告)日：2008-02-21
申请号：US11679792
申请日：2007-02-27
申请人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean Artis , Clarence Hurt , Prabha Ibrahim , Heike Krupka , Jack Lin , Michael Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K31/404 , A61P3/00 , A61P35/00 , A61P9/00 , C07D209/18 , C07D409/12
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译：描述了对PPARs有活性的化合物，包括泛活性化合物。还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。

56. 发明申请

US20070155818A1 PPAR ACTIVE COMPOUNDS 有权
公开(公告)号：US20070155818A1
公开(公告)日：2007-07-05
申请号：US11679738
申请日：2007-02-27
申请人： Dean Artis , Prabha Ibrahim , Jack Lin , Chao Zhang
发明人： Dean Artis , Prabha Ibrahim , Jack Lin , Chao Zhang
IPC分类号： A61K31/404 , C07D209/18
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

57. 发明申请

US20070049615A1 Compounds and methods for development of Ret modulators 有权
标题翻译： Ret调制剂的开发化合物和方法
公开(公告)号：US20070049615A1
公开(公告)日：2007-03-01
申请号：US11016350
申请日：2004-12-17
申请人： Prabha Ibrahim , Dean Artis , Ryan Bremer , Gaston Habets , Clarence Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Artis , Ryan Bremer , Gaston Habets , Clarence Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译：描述了在Ret上活性的化合物，以及使用这些化合物的方法。还描述了使用X射线晶体学测定的Ret替代物的晶体结构。使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。

58. 发明申请

US20060100218A1 PDE4B inhibitors 有权
标题翻译： PDE4B抑制剂
公开(公告)号：US20060100218A1
公开(公告)日：2006-05-11
申请号：US11219635
申请日：2005-09-02
申请人： Prabha Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean Artis , Byunghun Lee , Rebecca Zuckerman
发明人： Prabha Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean Artis , Byunghun Lee , Rebecca Zuckerman
IPC分类号： A61K31/506 , A61K31/4745 , A61K31/4709 , A61K31/4439 , A61K31/423 , A61K31/405 , A61K31/416 , G06F19/00 , C07D471/02 , C07D403/02 , C07D405/02 , C07D413/02
CPC分类号： C07D471/04 , C07D209/12 , C07D401/12 , C07D405/04 , G06F19/16 , G06F19/706
摘要： Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
摘要翻译：描述了在PDE4上有活性的化合物。还描述了使用X射线晶体学测定的PDE4B的晶体结构，使用PDE4B晶体和结构信息来鉴定分子支架，用于开发结合和调节PDE4B的配体，以及基于已知配体鉴定改进的配体。

59. 发明申请

US20060047850A1 Multi-chassis, multi-path storage solutions in storage area networks 审中-公开
标题翻译：存储区域网络中的多机箱多路存储解决方案
公开(公告)号：US20060047850A1
公开(公告)日：2006-03-02
申请号：US10931504
申请日：2004-08-31
申请人： Harinder Singh Bhasin , Ambrish Verma , Shreyas Gandhi , Chao Zhang
发明人： Harinder Singh Bhasin , Ambrish Verma , Shreyas Gandhi , Chao Zhang
IPC分类号： G06F17/30
CPC分类号： H04L67/1097 , H04L69/40
摘要： Systems and methods in accordance with various disclosed embodiments are provided for multi-chassis, multi-pathing solutions in storage area networks. A physical target connected to a first storage switch can be virtualized as a member of a virtual logical unit at a second storage switch to which the physical target is not connected. An inter-chassis link can be provided between the storage switches. If the first storage switch becomes inaccessible, the physical target can be accessed via the second storage switch. A virtual logical unit can also be provisioned at the first switch with a member corresponding to the same physical target. The virtual logical units provisioned at each storage switch can be assigned the same identifier to create a clustered virtual logical unit apparent to host devices. Multiple paths to the same logical unit are thus provided to host devices via either switch.
摘要翻译：根据各种公开的实施例的系统和方法被提供用于存储区域网络中的多机箱，多路径解决方案。连接到第一存储交换机的物理目标可以在物理目标未连接到的第二存储交换机上被虚拟化为虚拟逻辑单元的成员。可以在存储交换机之间提供机架间链路。如果第一存储交换机变得不可访问，则可以经由第二存储交换机访问物理目标。虚拟逻辑单元也可以在第一交换机处配置与对应于相同物理目标的成员。在每个存储交换机处提供的虚拟逻辑单元可以被分配相同的标识符以创建对于主机设备而言显着的集群虚拟逻辑单元。因此，通过任一交换机将多个到相同逻辑单元的路径提供给主机设备。

60. 发明申请

US20060041006A1 PDE4B inhibitors and uses therefor 有权
公开(公告)号：US20060041006A1
公开(公告)日：2006-02-23
申请号：US11123893
申请日：2005-05-06
申请人： Prabha Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean Artis , Rebecca Zuckerman , Chao Zhang
发明人： Prabha Ibrahim , Hanna Cho , Bruce England , Sam Gillette , Dean Artis , Rebecca Zuckerman , Chao Zhang
IPC分类号： A61K31/4025 , A61K31/401 , A61K31/381 , A61K31/34 , C07D409/02 , C07D403/02
CPC分类号： C07C311/48 , C07D215/36 , C07D215/40 , C07D231/12 , C07D239/18 , C07D239/46 , C07D275/04 , C07D277/42 , C07D277/62 , C07D333/36 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.

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