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51. 发明授权

US08425858B2 Detection apparatus and associated method 有权
标题翻译：检测装置及相关方法
公开(公告)号：US08425858B2
公开(公告)日：2013-04-23
申请号：US11480068
申请日：2006-06-30
申请人： Steven Francis LeBoeuf , Peter Micah Sandvik , Radislav Alexandrovich Potyrailo
发明人： Steven Francis LeBoeuf , Peter Micah Sandvik , Radislav Alexandrovich Potyrailo
IPC分类号： G01N31/22
CPC分类号： G01N33/54366 , G01N21/6428 , G01N21/645 , G01N33/54373 , G01N2021/7786
摘要： An apparatus includes an article and a detector. The article includes a substrate, a faceted structure disposed on the substrate, and a sensor layer disposed on the faceted structure. The faceted structure is disposed on the substrate first surface and itself has a surface. The faceted structure surface has peripheral edge defining a diameter of the faceted structure surface. The sensor layer is disposed on the faceted structure surface. The sensor layer can react or can interact with a target species when the target species is sufficiently proximate to the sensor layer. The sensor layer responds to the reaction or to the interaction in a detectable manner. The detector detects a response to the reaction, or to the interaction, of the target species with the sensor layer.
摘要翻译：一种装置包括物品和检测器。该物品包括基底，设置在基底上的刻面结构以及设置在刻面结构上的传感器层。小面结构设置在基板第一表面上并且本身具有表面。小面结构表面具有限定小平面结构表面直径的周缘。传感器层设置在刻面结构表面上。当目标物种足够靠近传感器层时，传感器层可以与目标物种反应或相互作用。传感器层以可检测的方式响应于反应或相互作用。检测器检测到目标物种与传感器层的反应或相互作用的响应。

52. 发明申请

US20120235690A1 METHODS FOR ANALYTE DETECTION 有权
标题翻译：分析检测方法
公开(公告)号：US20120235690A1
公开(公告)日：2012-09-20
申请号：US13484674
申请日：2012-05-31
申请人： Radislav Alexandrovich Potyrailo , Matthew Damian Pietrzykowski , Yongjae Lee
发明人： Radislav Alexandrovich Potyrailo , Matthew Damian Pietrzykowski , Yongjae Lee
IPC分类号： G01R27/28
CPC分类号： G01N27/028 , G01N27/026
摘要： A method is provided for selectively detecting the presence and concentration of at least four analytes in a mixture. In certain embodiments, the method comprises contacting a single sensor with the mixture of analytes, wherein the sensor comprises at least one resonant sensor circuit comprising a sensing material that comprises at least two material properties that change in the presence of four or more analytes in their mixtures, and generating a multivariate sensor response pattern. The methods disclosed herein further optionally comprise performing analyte classification and analyte quantitation. Methods for selectively detecting the concentration of at least one analyte in a mixture further comprising at least one interference are also described in the instant application.
摘要翻译：提供了一种用于选择性地检测混合物中至少四种分析物的存在和浓度的方法。在某些实施方案中，所述方法包括使单个传感器与分析物的混合物接触，其中所述传感器包括至少一个共振传感器电路，所述至少一个谐振传感器电路包括感测材料，所述传感材料包含至少两种材料性质，所述材料性质在它们混合物，并产生多变量传感器响应模式。本文公开的方法进一步任选地包括进行分析物分类和分析物定量。在本申请中还描述了选择性地检测混合物中至少一种分析物的浓度进一步包含至少一种干扰的方法。

53. 发明申请

US20120161787A1 TEMPERATURE-INDEPENDENT CHEMICAL AND BIOLOGICAL SENSORS 有权
标题翻译：温度独立的化学和生物传感器
公开(公告)号：US20120161787A1
公开(公告)日：2012-06-28
申请号：US12977599
申请日：2010-12-23
申请人： Radislav Alexandrovich Potyrailo , Cheryl Margaret Surman
发明人： Radislav Alexandrovich Potyrailo , Cheryl Margaret Surman
IPC分类号： G01N27/02 , G01R27/28 , G01R3/00 , G01R35/00
CPC分类号： G01N27/02 , G01N27/025 , G01N33/48792 , Y10T29/49007
摘要： Methods and sensors for selective fluid sensing are provided. A sensor includes a resonant inductor-capacitor-resistor (LCR) circuit and a sensing material disposed over a sensing region. The sensing region comprises at least a portion of the LCR circuit. Temperature-dependent response coefficients of inductance L, capacitance C, and resistance R properties of the LCR circuit and the sensing material are at least approximately 5 percent different from one another. The difference in the temperature-dependent response coefficients of the properties of the LCR circuit and the sensing material enables the sensor to selectively detect analyte fluids from an analyzed fluid mixture substantially independent of temperature.
摘要翻译：提供了选择性流体感测的方法和传感器。传感器包括谐振电感器 - 电容器电阻（LCR）电路和设置在感测区域上的感测材料。感测区域包括LCR电路的至少一部分。 LCR电路和传感材料的电感L，电容C和电阻R性质的温度依赖性响应系数至少大约相差5％。 LCR电路和感测材料的性质的温度依赖性响应系数的差异使得传感器能够基本上独立于温度从分析的流体混合物中选择性地检测分析物流体。

54. 发明申请

US20120114089A1 Apparatus for Detecting Contaminants in a Liquid and a System for Use Thereof 有权
标题翻译：用于检测液体中污染物的装置及其使用系统
公开(公告)号：US20120114089A1
公开(公告)日：2012-05-10
申请号：US11560476
申请日：2006-11-16
申请人： Radislav Alexandrovich Potyrailo , David James Monk , Ryo Tamaki
发明人： Radislav Alexandrovich Potyrailo , David James Monk , Ryo Tamaki
IPC分类号： G21C17/00 , G01N27/00
CPC分类号： G21C17/022 , G01N27/126 , G01N33/1893 , G21Y2002/202 , G21Y2002/302 , G21Y2004/30
摘要： Disclosed herein are apparatus and methods for detecting and quantifying contaminants in aqueous solutions. In one embodiment, an apparatus for the detection of contaminants within a liquid comprises a sensor and a controller. The sensor comprises a film and a transducer configured such that, during use, a first surface of the transducer is in fluid communication with a liquid, and the film is disposed between the first surface and the liquid. The film can be a polymeric material capable of hindering the transport of a non-desired species therethrough. The controller is in operational communication to the transducer, and is configured to determine the concentration of contaminants within the liquid.
摘要翻译：本文公开了用于检测和定量水溶液中的污染物的装置和方法。在一个实施例中，用于检测液体内的污染物的装置包括传感器和控制器。传感器包括膜和换能器，其被配置为使得在使用期间，换能器的第一表面与液体流体连通，并且膜设置在第一表面和液体之间。该膜可以是能够妨碍非期望物质通过其传输的聚合物材料。控制器与传感器进行操作通信，并被配置为确定液体内污染物的浓度。

55. 发明申请

US20110101996A1 METHOD AND SYSTEM FOR PERFORMANCE ENHANCEMENT OF RESONANT SENSORS 有权
标题翻译：谐振传感器性能提高的方法与系统
公开(公告)号：US20110101996A1
公开(公告)日：2011-05-05
申请号：US12609131
申请日：2009-10-30
申请人： Radislav Alexandrovich Potyrailo
发明人： Radislav Alexandrovich Potyrailo
IPC分类号： G01N27/02 , G01N27/00
CPC分类号： G01D21/00
摘要： The present invention related to methods and systems for simultaneously sensing two or more environmental parameters of a sample. Included is an inductor-capacitor-resistor (LCR) resonator sensor and a pick up coil in operative association with the LCR resonator sensor wherein viscoelastic changes in the sensing film cause displacement of the antenna relative to the pick up coil.
摘要翻译：本发明涉及用于同时检测样品的两个或多个环境参数的方法和系统。包括电感器 - 电容电阻（LCR）谐振器传感器和与LCR谐振器传感器有效关联的拾取线圈，其中感测膜中的粘弹性变化导致天线相对于拾取线圈的位移。

56. 发明申请

US20080116908A1 Methods for Detecting Contaminants in a Liquid 失效
标题翻译：检测液体中污染物的方法
公开(公告)号：US20080116908A1
公开(公告)日：2008-05-22
申请号：US11560485
申请日：2006-11-16
申请人： Radislav Alexandrovich Potyrailo , David James Monk , Ryo Tamaki
发明人： Radislav Alexandrovich Potyrailo , David James Monk , Ryo Tamaki
IPC分类号： G01N27/06 , G01R27/02
CPC分类号： G21C17/022 , G01N27/126 , G01N33/1893 , G21Y2002/204 , G21Y2002/303 , G21Y2004/30 , G21Y2004/40
摘要： In one embodiment, a method for detecting contaminants in a liquid comprises: contacting a sensor with a liquid, generating electrical information based upon a concentration of the contaminant in the liquid, transmitting the electrical information to a controller, and determining the concentration of a contaminant in the liquid. The sensor can comprise a film, a purge chamber, and a transducer, which are configured such that a first surface of the film is in fluid communication with the liquid and the purge chamber is in fluid communication with a second surface of the film that is opposite the first surface, and wherein the transducer is in fluid communication with the purge chamber.
摘要翻译：在一个实施例中，一种用于检测液体中的污染物的方法包括：使传感器与液体接触，基于液体中污染物的浓度产生电信息，将电信息传输到控制器，并确定污染物的浓度在液体中。传感器可以包括膜，净化室和换能器，其被构造成使得膜的第一表面与液体流体连通，并且净化室与膜的第二表面流体连通与第一表面相对，并且其中换能器与净化室流体连通。

57. 发明授权

US06763322B2 Method for enhancement in screening throughput 失效
标题翻译：提高筛选产量的方法
公开(公告)号：US06763322B2
公开(公告)日：2004-07-13
申请号：US10040420
申请日：2002-01-09
申请人： Radislav Alexandrovich Potyrailo , Ronald Eugene Shaffer
发明人： Radislav Alexandrovich Potyrailo , Ronald Eugene Shaffer
IPC分类号： G06F1500
CPC分类号： G01N21/65 , G01J3/28 , G01J3/44
摘要： The present invention provides methods and an apparatus for the rapid analysis of data from imaging, spectroscopic, scanning probe, or sensor methods. By application of mathematical transform analysis such as wavelet transform algorithms to one or multi-order data sets obtained from individual samples or sample arrays, the analytical features of the data are preserved while undesired noise is removed, thereby reducing the integration time by more than 10-fold in subsequent measurements. The reduction in integration time enables the high-throughput measurement of combinatorial libraries and rapid dynamic processes, while still providing a signal-to-noise level suitable for a reliable measurement.
摘要翻译：本发明提供了用于从成像，光谱，扫描探针或传感器方法快速分析数据的方法和装置。通过将诸如小波变换算法的数学变换分析应用于从单个样本或样本阵列获得的一个或多个数据集，数据的分析特征将被保留，同时消除不必要的噪声，从而将积分时间减少10倍以上在随后的测量中。集成时间的减少使得组合库的高吞吐量测量和快速动态过程同时仍然提供适合于可靠测量的信噪比。

58. 发明授权

US06558624B1 Method and analytical system for rapid screening of combinatorial libraries 失效
标题翻译：组合库快速筛选方法与分析系统
公开(公告)号：US06558624B1
公开(公告)日：2003-05-06
申请号：US09626261
申请日：2000-07-25
申请人： John Patrick Lemmon , Radislav Alexandrovich Potyrailo
发明人： John Patrick Lemmon , Radislav Alexandrovich Potyrailo
IPC分类号： G01N3096
CPC分类号： G01N21/253 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00511 , B01J2219/00527 , B01J2219/00585 , B01J2219/00587 , B01J2219/00605 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , C40B60/14 , G01N21/64 , G01N21/65 , Y10T436/24
摘要： Rapid, sensitive detection of analytes in small-scale samples is achieved with an analytical method in which samples are adsorbed on a sorbent material and probed spectroscopically. The method is suitable for monitoring the progress of reactions in combinatorial screening experiments.
摘要翻译：通过分析方法实现对小样品中分析物的快速，灵敏检测，其中将样品吸附在吸附剂材料上并用光谱法进行探测。该方法适用于监测组合筛选实验中反应进程。

59. 发明授权

US06541264B1 Aromatic polycarbonate characterization 失效
标题翻译：芳香聚碳酸酯表征
公开(公告)号：US06541264B1
公开(公告)日：2003-04-01
申请号：US09692548
申请日：2000-10-19
申请人： Radislav Alexandrovich Potyrailo , John Patrick Lemmon , Terry Kay Leib
发明人： Radislav Alexandrovich Potyrailo , John Patrick Lemmon , Terry Kay Leib
IPC分类号： G01N3344
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6421
摘要： In a rapid and non-invasive method for characterizing aromatic polycarbonates, fluorescence intensities are determined at least two wavelength ranges and used to calculate a compositional or physical property of the sample. The method is suitable for determining the relative amounts of linear and branched polycarbonates, and it is fast enough to monitor the progress of polymerization reactions.
摘要翻译：在用于表征芳族聚碳酸酯的快速和非侵入性方法中，荧光强度被确定为至少两个波长范围，并用于计算样品的组成或物理性质。该方法适用于确定直链和支链聚碳酸酯的相对量，并且足够快以监测聚合反应的进展。

60. 发明授权

US06538725B2 Method for determination of structural defects of coatings 有权
公开(公告)号：US06538725B2
公开(公告)日：2003-03-25
申请号：US09765757
申请日：2001-01-22
申请人： Radislav Alexandrovich Potyrailo , Daniel Robert Olson , Michael Jarlath Brennan , James Norman Cawse , Bret Ja Chisholm
发明人： Radislav Alexandrovich Potyrailo , Daniel Robert Olson , Michael Jarlath Brennan , James Norman Cawse , Bret Ja Chisholm
IPC分类号： G01B1116
CPC分类号： G01N21/6452 , C09K11/06 , G01N21/25 , G01N21/31 , G01N21/8422 , G01N21/88 , G01N2021/6417 , G01N2021/646
摘要： The present invention provides a method for quantifying structural defects of a coating composition on a given substrate, where certain structural defect-inducing tests are performed. In this method, a coating formulation is doped with a colorimetric or luminescent material. Concentration of the material depends on the quantum efficiency, excitation and emission wavelengths, and employed detection techniques, and can range from about 1 fM to about 1 mM. Before, during and/or after such tests, the coating is illuminated with a wavelength of radiation at which the reflected or transmitted color or emitted luminescence of the material in the coating is detectable with an optical detector or by visual inspection. In this fashion, the percentage of failure of the coating can be quantified as well as the level of interdiffusion of coating into substrate or substrate into coating. The method of the invention is thus particularly well-suited for the combinatorial analysis of an array of coating samples. Additionally, when the structural defect-inducing material test is being performed, the removed coating material can be analyzed in like fashion.

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