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    • 56. 发明授权
    • Method for the catalytic production of substituted bipyridyl derivatives
    • 催化生产取代联吡啶衍生物的方法
    • US06500956B1
    • 2002-12-31
    • US09674063
    • 2000-11-30
    • Holger GeisslerPeter Gross
    • Holger GeisslerPeter Gross
    • C07D40102
    • C07B37/04C07D213/22C07D213/64C07D213/803
    • The invention relates to a process for the preparation of bipyridyls by converting at least one pyridine of the formula (III) in which S′, S″, S′″, S″″ and S′″″, independently of one another, are identical or different and are hydrogen, (C1-C18)-alkyl, alkoxy-(C1-C18), acyloxy-(C1-C18), aryloxy-(C1-C18), perfluoroacyloxy-(C1-C8), NO2, (C1-C18)-aryl, (C1-C18)-heteroaryl, halogen, hydroxyl, nitro, nitroso, CN, COOH, CHO, PO3H2, SO3H, SO2R, SOR, NH2, NH-alkyl-(C1-C18), N-alkyl2-(C1-C18), protected amine, CF3, NHCO-alkyl-(C1-C4), N-alkyl-(C1-C4)-CO-alkyl-(C1-C4), COO-alkyl-(C1-C18), CONH2, CO-alkyl-(C1-C18), NHCOH, NHCOO-alkyl-(C1-C4), CO-(C1-C18)-aryl, COO-(C1-C18)-aryl, CHCH-CO2-alkyl-(C1-C18), CHCHCO2H, PO-phenyl2, PO-alkyl2-(C1-C4), (COO−)n(cation)n+, (PO32−)n(cation)2n+, (SO3−)n(cation)n+ and/or (O−)n(cation)n+, where optionally S′, S″, S′″, S″″ and/or S′″″ among one another together form one or more aliphatic and/or aromatic rings and/or in which optionally S′, S″, S′″, S″″and/or S′″″forms a bridge to at least one further pyridine of the formula (III) and/or in which optionally the radicals S′, S″, S′″, S″″, and/or S′″″ have the meanings given above and are substituted by at least one radical which has the meaning given above for S′, S″, S′″, S″″ and/or S′″″ in water in the presence of an alcohol, a base, a palladium catalyst and optionally one or more further solvents at a temperature of 0-200° C.
    • 本发明涉及通过将至少一种式(III)的吡啶独立地转化成其中S',S“,S”',S“”和“”“的吡啶来制备联吡啶的方法。 (C 1 -C 18),酰氧基 - (C 1 -C 18),芳氧基 - (C 1 -C 18),全氟酰氧基 - (C 1 -C 8)烷基, ),NO2,(C1-C18) - 芳基,(C1-C18) - 杂芳基,卤素,羟基,硝基,亚硝基,CN,COOH,CHO,PO3H2,SO3H,SO2R,SOR,NH2,NH-烷基 - (C1 (C1-C4)-CO-烷基 - (C1-C4),CO-烷基 - (C1-C4)-CO-烷基 - (C1-C4) (C 1 -C 18) - 烷基 - (C 1 -C 18),CONH 2,CO-烷基 - (C 1 -C 18),NHCOH,NHCOO-烷基 - (C 1 -C 4) 芳基,CHCH-CO 2 - 烷基 - (C 1 -C 18),CHCHCO 2 H,PO-苯基2,PO-烷基2-(C 1 -C 4),(COO-)n(阳离子)n +,(PO32-) ,(SO 3 - )n(阳离子)n +和/或(O-)n(阳离子)n +,其中任选地有S',S“,S”',S“'和/或S” “彼此在一起形成一个或多个脂族和/或芳香环和/或其中任选的S',S”,S“',S” '和/或S''''与至少一种式(III)的另外的吡啶形成桥,和/或其中任选的基团S',S“,S”',S“ '和/或S'''具有上述含义,并被至少一个具有上述意义的基团代替S',S“,S”,S“”和/ 在醇,碱,钯催化剂和任选的一种或多种其它溶剂的存在下,在0-200℃的温度下,在水中加入S“或”S“