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51. 发明授权

US08415128B2 Mitigation of photodamage in analytical reactions 有权
标题翻译：减轻分析反应中的光损伤
公开(公告)号：US08415128B2
公开(公告)日：2013-04-09
申请号：US13191256
申请日：2011-07-26
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC分类号： C12N9/10
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
摘要翻译：用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法这小于光损伤阈值期。

52. 发明申请

US20130057069A1 MAXIMUM POWER POINT TRACKER 有权
标题翻译：最大功率点追踪器
公开(公告)号：US20130057069A1
公开(公告)日：2013-03-07
申请号：US13566735
申请日：2012-08-03
申请人： Scott Alan Meredith-Jones , Stephen Turner , Michael Cade
发明人： Scott Alan Meredith-Jones , Stephen Turner , Michael Cade
IPC分类号： G05F1/46 , H02M7/44 , H02J1/00
CPC分类号： G05F1/67 , H02J3/385 , Y02E10/58 , Y10T307/50
摘要： A method is provided for determining a value for an electrical output of a converter of renewable energy. The method comprises obtaining a signal representing the electrical output of the converter wherein that electrical output has an initial value. The method further comprises applying a pulse signal to the signal representing the electrical output, wherein the pulse signal comprises a positive portion and a negative portion. The method further comprises obtaining a measurement of electrical power produced by the converter during application of the pulse signal, removing the pulse signal and then obtaining a measurement of electrical power produced by the converter in the absence of the pulse signal. An error value is determined from the obtained electrical power measurements and that error value is applied to the initial value to obtain a target value for the electrical output of the converter.
摘要翻译：提供了一种用于确定可再生能源的转换器的电输出的值的方法。该方法包括获得表示转换器的电输出的信号，其中该电输出具有初始值。该方法还包括对表示电输出的信号施加脉冲信号，其中脉冲信号包括正部分和负部分。该方法还包括获得在施加脉冲信号期间由转换器产生的电功率的测量值，去除脉冲信号，然后在不存在脉冲信号的情况下获得由转换器产生的功率的测量值。从获得的电功率测量值确定误差值，并将误差值应用于初始值以获得转换器的电输出的目标值。

53. 发明申请

US20120115736A1 NUCLEIC ACID SEQUENCE ANALYSIS 有权
标题翻译：核酸序列分析
公开(公告)号：US20120115736A1
公开(公告)日：2012-05-10
申请号：US13271889
申请日：2011-10-12
申请人： Keith Bjornson , Arek Bibillo , Fred Christians , Kevin Travers , Robin Emig , Stephen Turner
发明人： Keith Bjornson , Arek Bibillo , Fred Christians , Kevin Travers , Robin Emig , Stephen Turner
IPC分类号： C12Q1/68 , C40B20/00
CPC分类号： C12Q1/6869 , C07K14/00 , C12Q1/6874 , C12Q2531/125 , C12Q2521/101
摘要： Provided are methods for sequencing a nucleic acid with a sequencing enzyme, e.g., a polymerase or exonuclease. The sequencing enzyme can optionally be exchanged with a second sequencing enzyme, which continues the sequencing of the nucleic acid. In certain embodiments, a template is fixed to a surface through a template localizing moiety. The template localizing moiety can optionally anneal with the nucleic acid and/or associate with the sequencing enzyme. Also provided are compositions comprising a nucleic acid and a first sequencing enzyme, which can sequence the nucleic acid and optionally exchange with a second sequencing enzyme present in the composition. Compositions in which a template localizing moiety is immobilized on a surface are provided. Also provided are methods for using data from analytical reactions wherein two different enzymes are employed, e.g., at a same or different reaction regions.
摘要翻译：提供了用测序酶（例如聚合酶或外切核酸酶）对核酸进行测序的方法。测序酶可以任选地与第二个测序酶交换，其继续测序核酸。在某些实施方案中，通过模板定位部分将模板固定在表面上。模板定位部分可任选地与核酸退火和/或与测序酶缔合。还提供了包含核酸和第一测序酶的组合物，其可以对核酸进行序列化并且任选与组合物中存在的第二测序酶交换。提供其中将模板定位部分固定在表面上的组合物。还提供了使用来自分析反应的数据的方法，其中使用两种不同的酶，例如在相同或不同的反应区域。

54. 发明申请

US20120003699A1 SEPARTION OF TAGGED FRAGMENTS 审中-公开
标题翻译：标记片段的分离
公开(公告)号：US20120003699A1
公开(公告)日：2012-01-05
申请号：US13171766
申请日：2011-06-29
申请人： Cheryl Heiner , Stephen Turner , Kevin Travers
发明人： Cheryl Heiner , Stephen Turner , Kevin Travers
IPC分类号： C12P19/34 , C07K14/00 , C12S3/02 , C07K1/14 , C07H21/00 , C07H1/06
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q2563/179 , C12Q2563/155 , C12Q2525/307
摘要： Methods of separating tagged nucleic acid fragments from populations of fragments are provided. The fragments are produced from a population of tagged nucleic acids. In some cases, the population of tagged nucleic acids comprises a population of clonal nucleic acids.
摘要翻译：提供了从片段群体分离标记的核酸片段的方法。片段由标记核酸群体产生。在一些情况下，标记核酸的群体包括克隆核酸群体。

55. 发明授权

US08071346B2 System for the mitigation of photodamage in analytical reactions 有权
标题翻译：分析反应中减轻光损伤的系统
公开(公告)号：US08071346B2
公开(公告)日：2011-12-06
申请号：US11981626
申请日：2007-10-31
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC分类号： C12N9/96
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
摘要翻译：用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法这小于光损伤阈值期。

56. 发明授权

US07993895B2 Mitigation of photodamage in analytical reactions 有权
标题翻译：减轻分析反应中的光损伤
公开(公告)号：US07993895B2
公开(公告)日：2011-08-09
申请号：US11566153
申请日：2006-12-01
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC分类号： C12N9/10
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
摘要翻译：用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法这小于光损伤阈值期。

57. 发明申请

US20110111401A1 METHOD FOR SEQUENCING NUCLEIC ACID MOLECULES 审中-公开
标题翻译：用于测序核酸分子的方法
公开(公告)号：US20110111401A1
公开(公告)日：2011-05-12
申请号：US12841819
申请日：2010-07-22
申请人： Jonas KORLACH , Watt W. Webb , Michael Levene , Stephen Turner , Harold G. Craighead , Mathieu Foquet
发明人： Jonas KORLACH , Watt W. Webb , Michael Levene , Stephen Turner , Harold G. Craighead , Mathieu Foquet
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6869 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/537 , C12Q2537/149 , C12Q2561/113 , C12Q2521/543 , C12Q2565/518 , C12Q2561/12
摘要： The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme on the template nucleic acid molecule to be sequenced is followed in real time. The sequence is deduced by identifying which base is being incorporated into the growing complementary strand of the target nucleic acid by the catalytic activity of the nucleic acid polymerizing enzyme at each step in the sequence of base additions. A polymerase on the target nucleic acid molecule complex is provided in a position suitable to move along the target nucleic acid molecule and extend the oligonucleotide primer at an active site. A plurality of labelled types of nucleotide analogs are provided proximate to the active site, with each distinguishable type of nucleotide analog being complementary to a different nucleotide in the target nucleic acid sequence. The growing nucleic acid strand is extended by using the polymerase to add a nucleotide analog to the nucleic acid strand at the active site, where the nucleotide analog being added is complementary to the nucleotide of the target nucleic acid at the active site. The nucleotide analog added to the oligonucleotide primer as a result of the polymerizing step is identified. The steps of providing labelled nucleotide analogs, polymerizing the growing nucleic acid strand, and identifying the added nucleotide analog are repeated so that the nucleic acid strand is further extended and the sequence of the target nucleic acid is determined.
摘要翻译：本发明涉及对具有多个碱基的靶核酸分子进行测序的方法。在其原理中，聚合反应中碱添加的时间顺序是在核酸分子上测量的，即核酸聚合酶在待测序的模板核酸分子上的活性被实时跟踪。通过在碱添加序列的每个步骤中通过核酸聚合酶的催化活性鉴定哪个碱基被掺入靶核酸的生长互补链中来推断该序列。在靶核酸分子复合物上提供聚合酶，其适于沿着靶核酸分子移动并在活性位点延伸寡核苷酸引物。多个标记类型的核苷酸类似物在活性位点附近提供，每种可区分类型的核苷酸类似物与靶核酸序列中的不同核苷酸互补。生长的核酸链通过使用聚合酶延伸到活性位点处的核酸链的核苷酸类似物，其中加入的核苷酸类似物与活性位点上的靶核酸的核苷酸互补。鉴定作为聚合步骤的结果添加到寡核苷酸引物中的核苷酸类似物。重复提供标记的核苷酸类似物，聚合生长的核酸链和鉴定添加的核苷酸类似物的步骤，使得核酸链进一步延长并确定靶核酸的序列。

58. 发明授权

US07906284B2 Arrays of optical confinements and uses thereof 有权
标题翻译：光学限制阵列及其用途
公开(公告)号：US07906284B2
公开(公告)日：2011-03-15
申请号：US11925607
申请日：2007-10-26
申请人： Stephen Turner , Jonas Korlach
发明人： Stephen Turner , Jonas Korlach
IPC分类号： C12Q1/68
CPC分类号： G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
摘要： The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
摘要翻译：本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。本发明中体现的装置和方法对于高通量和低成本的单分子分析特别有用。

59. 发明申请

US20100221716A1 Classification of Nucleic Acid Templates 有权
标题翻译：核酸模板分类
公开(公告)号：US20100221716A1
公开(公告)日：2010-09-02
申请号：US12635618
申请日：2009-12-10
申请人： Benjamin Flusberg , Stephen Turner , Jessica Lee , Lei Jia , Jonas Korlach , Jon Sorenson , Dale Webster , John Lyle , Kevin Travers , Jeremiah Hanes
发明人： Benjamin Flusberg , Stephen Turner , Jessica Lee , Lei Jia , Jonas Korlach , Jon Sorenson , Dale Webster , John Lyle , Kevin Travers , Jeremiah Hanes
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6837 , C12Q1/6858 , C12Q2561/113 , C12Q2537/164 , C12Q2527/113 , C12Q2521/101 , C12Q2525/307 , C12Q2525/117
摘要： Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
摘要翻译：提供了方法，组合物和系统用于表征修饰的核酸。在某些优选实施方案中，提供单分子测序方法用于鉴定核酸序列内的修饰的核苷酸。通过本文提供的方法可检测的修饰物包括化学修饰的碱基，酶修饰的碱基，脱碱基位点，非天然碱基，二级结构和与模板核酸结合的试剂。

60. 发明申请

US20100143466A1 MODIFIED RELEASE IBUPROFEN DOSAGE FORM 有权
标题翻译：改良释放IBUPROFEN剂型
公开(公告)号：US20100143466A1
公开(公告)日：2010-06-10
申请号：US12706429
申请日：2010-02-16
申请人： Michael Hite , Cathy Federici , Alan Brunelle , Stephen Turner
发明人： Michael Hite , Cathy Federici , Alan Brunelle , Stephen Turner
IPC分类号： A61K9/20 , A61K31/192
CPC分类号： A61K9/2054 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/2059 , A61K31/192 , A61K47/02 , A61K47/183 , A61K47/38
摘要： The present invention is a solid dosage form for oral administration of ibuprofen comprising a modified release formulation of ibuprofen which provides an immediate burst effect and thereafter a sustained release of sufficient ibuprofen to maintain blood levels at least 6.4 μg/ml over an extended period of at least 8 hours following administering of a single dose.
摘要翻译：本发明是用于口服施用布洛芬的固体剂型，其包含布洛芬的改良释放制剂，其提供立即的爆发作用，然后持续释放足够的布洛芬以在长时间内维持血液水平至少为6.4μg/ ml 在给予单次剂量后至少8小时。

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