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51. 发明申请

US20080258322A1 USE OF SURFACTANTS IN EXTRACTION PROCEDURES FOR SILICONE HYDROGEL OPHTHALMIC LENSES 有权
标题翻译：表面活性剂在硅胶水性眼镜提取程序中的应用
公开(公告)号：US20080258322A1
公开(公告)日：2008-10-23
申请号：US11737059
申请日：2007-04-18
申请人： Jay Scott Daulton , Charlie Chen , Tim Warren
发明人： Jay Scott Daulton , Charlie Chen , Tim Warren
IPC分类号： B29D11/00
CPC分类号： B29D11/00067 , B29C33/60 , B29C37/0067 , B29D11/0025 , Y10S425/808
摘要： Methods of producing silicone hydrogel ophthalmic lenses include contacting one or more delensed silicone hydrogel ophthalmic lens with a liquid composition that contains alcohol, water, and a surfactant. The methods can be steps of an extraction/hydration procedure used in the production of silicone hydrogel contact lenses. In some examples, contacting silicone hydrogel ophthalmic lens products with a liquid composition that contains alcohol, water, and a surfactant can significantly reduce or prevent surface distortion of the ophthalmic lens resulting from the extraction procedure. Some methods include subsequently contacting the silicone hydrogel ophthalmic lens with a liquid composition consisting essentially of water and a surfactant.
摘要翻译：生产硅酮水凝胶眼科镜片的方法包括将一种或多种疏水性硅氧水凝胶眼用透镜与含有醇，水和表面活性剂的液体组合物接触。该方法可以是用于生产硅酮水凝胶隐形眼镜的提取/水合程序的步骤。在一些实例中，将硅酮水凝胶眼用透镜产品与含有醇，水和表面活性剂的液体组合物接触可显着降低或防止由提取程序引起的眼科镜片的表面变形。一些方法包括随后使硅氧水凝胶眼用透镜与基本上由水和表面活性剂组成的液体组合物接触。

52. 发明申请

US20070191443A1 Methods and materials for assessing prostate cancer therapies and compounds 有权
标题翻译：用于评估前列腺癌疗法和化合物的方法和材料
公开(公告)号：US20070191443A1
公开(公告)日：2007-08-16
申请号：US10590445
申请日：2005-02-23
申请人： Michael Jung , Samedy Ouk , Charles Sawyers , Charlie Chen , Derek Welsbie
发明人： Michael Jung , Samedy Ouk , Charles Sawyers , Charlie Chen , Derek Welsbie
IPC分类号： A61K31/4166 , C07D233/84
CPC分类号： A61K31/426
摘要： A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.
摘要翻译：雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。本发明提供用于检查新的治疗方式的基于细胞的测定法，并提供新的抗雄激素化合物的设计。

53. 发明申请

US20120194779A1 Materials For Use In Ophthalmic Applications And Methods 有权
标题翻译：用于眼科应用和方法的材料
公开(公告)号：US20120194779A1
公开(公告)日：2012-08-02
申请号：US13395134
申请日：2010-09-21
申请人： Yun Zhang , Charlie Chen , Peter Zhu , Ying Ye , Hongjin Qiu
发明人： Yun Zhang , Charlie Chen , Peter Zhu , Ying Ye , Hongjin Qiu
IPC分类号： G02C7/04 , B05D5/06
CPC分类号： C08J7/16
摘要： A lens body comprising at least one form of boronic acid, boronic ester or boronic anhydride is provided. The lens body is contacted with a solution comprising at least one form of TRIS. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.
摘要翻译：提供了包含至少一种形式的硼酸，硼酸酯或硼酸酐的透镜体。透镜体与包含至少一种形式的TRIS的溶液接触。还提供了包括隐形眼镜的隐形眼镜包，以及制造和使用隐形眼镜的方法。

54. 发明申请

US20080090888A2 METHODS AND MATERIALS FOR ASSESSING PROSTATE CANCER THERAPIES AND COMPOUNDS 有权
标题翻译：用于评估前列腺癌治疗和化合物的方法和材料
公开(公告)号：US20080090888A2
公开(公告)日：2008-04-17
申请号：US10590445
申请日：2006-08-24
申请人： Michael Jung , Samedy Ouk , Charles Sawyers , Charlie Chen , Derek Welsbie
发明人： Michael Jung , Samedy Ouk , Charles Sawyers , Charlie Chen , Derek Welsbie
IPC分类号： A61K31/4166 , C07D233/84
CPC分类号： A61K31/426
摘要： A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.
摘要翻译：雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。本发明提供用于检查新的治疗方式的基于细胞的测定法，并提供新的抗雄激素化合物的设计。

55. 发明申请

US20070166717A1 Methods and materials for assessing prostate cancer therapies 有权
标题翻译：用于评估前列腺癌疗法的方法和材料
公开(公告)号：US20070166717A1
公开(公告)日：2007-07-19
申请号：US10583280
申请日：2004-12-16
申请人： Charles Sawyer , Charlie Chen , Derek Welsbie
发明人： Charles Sawyer , Charlie Chen , Derek Welsbie
IPC分类号： C12Q1/68 , A61K48/00
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N2333/723 , G01N2500/04
摘要： Using microarray-based profiling of isogenic prostate cancer xenograft models, we found that a modest (2-5 fold) increase in androgen receptor (AR) mRNA was the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides insight toward the design of novel antiandrogens.
摘要翻译：使用基于芯片的同基因前列腺癌异种移植模型，我们发现雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。本发明提供用于检查新治疗方式的基于细胞的测定法，并提供对新型抗雄激素的设计的洞察。

56. 发明授权

US07225563B2 Shoe with adjustable fitting 失效
标题翻译：鞋可调配件
公开(公告)号：US07225563B2
公开(公告)日：2007-06-05
申请号：US10916259
申请日：2004-08-10
申请人： Eddie Chen , Charlie Chen , Paul Yang
发明人： Eddie Chen , Charlie Chen , Paul Yang
IPC分类号： A43B23/28
CPC分类号： A43B3/26 , A43B7/20 , A43B23/28 , A43C11/14
摘要： A shoe includes an upper having a heel portion that has a rear wall adapted to extend around the heel of a foot. At least one adjustment pad is attached loosely to the rear wall within the heel portion. The adjustment pad includes an intermediate part, first and second ends on two opposite sides of the intermediate part, a first surface confronting the rear wall, and a second surface opposite to the first surface. A strap passage unit is provided on the rear wall. A strap is attached to the adjustment pad, and passes movably through the strap passage unit. When the strap is pulled to move through the strap passage unit, the strap is tensed, and the adjustment pad is moved inward so as to abut against the foot in the shoe.
摘要翻译：鞋包括具有足跟部分的鞋面，后跟部分具有适于围绕足部脚跟延伸的后壁。至少一个调节垫松散地附接到后跟部分中的后壁。调整垫包括中间部分，中间部分的两个相对侧上的第一和第二端，与后壁相对的第一表面和与第一表面相对的第二表面。在后壁上设置带通道单元。带子附接到调节垫，并且可移动地穿过带通道单元。当带被拉动以移动通过带通道单元时，带被张紧，并且调节垫向内移动以抵靠鞋中的脚。

57. 发明申请

US20060032090A1 Shoe with adjustable fitting 失效
标题翻译：鞋可调配件
公开(公告)号：US20060032090A1
公开(公告)日：2006-02-16
申请号：US10916259
申请日：2004-08-10
申请人： Eddie Chen , Charlie Chen , Paul Yang
发明人： Eddie Chen , Charlie Chen , Paul Yang
IPC分类号： A43C11/00 , A43B23/28 , A43B7/20
CPC分类号： A43B3/26 , A43B7/20 , A43B23/28 , A43C11/14
摘要： A shoe includes an upper having a heel portion that has a rear wall adapted to extend around the heel of a foot. At least one adjustment pad is attached loosely to the rear wall within the heel portion. The adjustment pad includes an intermediate part, first and second ends on two opposite sides of the intermediate part, a first surface confronting the rear wall, and a second surface opposite to the first surface. A strap passage unit is provided on the rear wall. A strap is attached to the adjustment pad, and passes movably through the strap passage unit. When the strap is pulled to move through the strap passage unit, the strap is tensed, and the adjustment pad is moved inward so as to abut against the foot in the shoe.
摘要翻译：鞋包括具有足跟部分的鞋面，后跟部分具有适于围绕足部脚跟延伸的后壁。至少一个调节垫松散地附接到后跟部分中的后壁。调整垫包括中间部分，中间部分的两个相对侧上的第一和第二端，与后壁相对的第一表面和与第一表面相对的第二表面。在后壁上设置带通道单元。带子附接到调节垫，并且可移动地穿过带通道单元。当带被拉动以移动通过带通道单元时，带被张紧，并且调节垫向内移动以抵靠鞋中的脚。

58. 发明申请

US20050037812A1 Island type mobile communication arrangement 有权
标题翻译：岛式移动通信安排
公开(公告)号：US20050037812A1
公开(公告)日：2005-02-17
申请号：US10714626
申请日：2003-11-18
申请人： Ching-Hsiang Hsu , Charlie Chen , Hsiao-Wei Hsu , Kan-Lin Lee
发明人： Ching-Hsiang Hsu , Charlie Chen , Hsiao-Wei Hsu , Kan-Lin Lee
IPC分类号： H04L12/28 , H04W4/04 , H04W4/20 , H04W8/06 , H04W16/00 , H04W16/20 , H04W64/00 , H04W84/02 , H04W84/10 , H04Q7/20
CPC分类号： H04W16/00 , H04W4/04 , H04W4/20 , H04W8/06 , H04W64/00 , H04W84/02 , H04W84/10
摘要： An island type mobile communication arrangement is disclosed. A plurality of BTSs connected to BSCs are reassigned as island BTSs and connected to an island BSC, the island BSC is connected to an island MSC. When entering or leaving the scope of the island MSC, a cellular phone performs a location updating procedure, and thus the island type mobile communication arrangement can provide a special service to all cellular phones in a particular local area by reading MSISDNs in an island VLR corresponding to the island MSC.
摘要翻译：公开了一种岛式移动通信装置。连接到BSC的多个BTS被重新分配为岛BTS并连接到岛BSC，岛BSC连接到岛MSC。当进入或离开岛MSC的范围时，蜂窝电话执行位置更新过程，因此岛式移动通信装置可以通过读取对应的岛屿VLR中的MSISDN来向特定局部区域中的所有蜂窝电话提供特殊服务到海岛MSC。

59. 发明授权

US4992903A Structure of computer main frame 失效
标题翻译：计算机主机架构
公开(公告)号：US4992903A
公开(公告)日：1991-02-12
申请号：US458275
申请日：1989-12-28
申请人： Charlie Chen
发明人： Charlie Chen
IPC分类号： G06F1/18
CPC分类号： G06F1/184 , G06F1/187
摘要： A computer main frame includes a bottom block connected with an upper cover through tongue-and-groove joint, for positioning therein of floppy disc and hard disc. The upper cover includes an inner wall surface specially designed to conform to the geometry of the floppy disc and hard disc being received. The floppy and hard disc which are received in the main frame have holes thereon for insertion therein of stub tenons upstanding from the bottom block, such that the positioning of the floppy and hard disc can be secured without the use of any fastening means.
摘要翻译：计算机主框架包括通过榫槽接头与上盖连接的底部块，用于在其中定位软盘和硬盘。上盖包括专门设计成符合被接收的软盘和硬盘的几何形状的内壁表面。容纳在主框架中的软盘和硬盘在其上具有孔，用于插入其中从底部块直立的短杆孔，从而可以在不使用任何紧固装置的情况下固定软盘和硬盘的定位。

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