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51. 发明申请

US20120302456A1 VERTICAL FLOW-THROUGH DEVICES FOR MULTIPLEXED ELISA DRIVEN BY WICKING 审中-公开
标题翻译：垂直流动装置，用于通过点火驱动的多重ELISA
公开(公告)号：US20120302456A1
公开(公告)日：2012-11-29
申请号：US13303797
申请日：2011-11-23
申请人： George M. Whitesides , Max Narovlyansky , Ozge A. Halatci , Charles R. Mace
发明人： George M. Whitesides , Max Narovlyansky , Ozge A. Halatci , Charles R. Mace
IPC分类号： C12M1/40 , G01N21/78 , C40B30/04 , C40B40/10 , G01N33/53
CPC分类号： G01N33/54306 , G01N33/54366 , Y02A50/58
摘要： The invention provides kits, methods and devices for detection of analytes in a biological sample. Capillary action is employed to carry out single or multiplexed immunoassays in a vertical flow-through format.
摘要翻译：本发明提供用于检测生物样品中分析物的试剂盒，方法和装置。毛细管作用用于以垂直流通形式进行单次或多路复用的免疫测定。

52. 发明申请

US20120272642A1 SELF-REGULATING PRESSURE SOURCE 有权
标题翻译：自调压源
公开(公告)号：US20120272642A1
公开(公告)日：2012-11-01
申请号：US13420886
申请日：2012-03-15
申请人： Cagdas Denizel Onal , Daniela Rus , Xin Chen , George M. Whitesides
发明人： Cagdas Denizel Onal , Daniela Rus , Xin Chen , George M. Whitesides
IPC分类号： F15B13/16 , B01J19/00
CPC分类号： G05D16/0636 , F15B21/06
摘要： Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.
摘要翻译：自调压源。压力源包括封闭化学单元推进剂的室。可移动的凸台连接到密封空气室的可变形膜，可移动的凸台和空气室设置在室内。催化剂设置在膜周围，以便被凸起覆盖在缩回位置，使得单组分推进剂被催化剂分解以产生气体。在室内气体压力将增加，导致空气室中的空气压缩，从而将凸台拉到缩回位置以覆盖催化剂，从而调节室内的压力。自调节压力源特别适用于流体弹性致动器。

53. 发明授权

US07771647B2 Electric microcontact printing method and apparatus 有权
标题翻译：电微接触印刷方法和装置
公开(公告)号：US07771647B2
公开(公告)日：2010-08-10
申请号：US10316997
申请日：2002-12-11
申请人： Heiko O. Jacobs , George M. Whitesides
发明人： Heiko O. Jacobs , George M. Whitesides
IPC分类号： H05B6/54 , G11C11/23 , B41J2/385
CPC分类号： G03G5/02 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F7/0002
摘要： A method and apparatus for providing electric microcontact printing is provided. A stamp is brought into contact with the surface of a substrate to provide high resolution features. Aspects of the invention may be used for data storage, microcontact printing, and for other applications requiring high resolution pattern transfer.
摘要翻译：提供了一种用于提供电微接触印刷的方法和装置。使印模与基板的表面接触以提供高分辨率特征。本发明的各方面可用于数据存储，微接触印刷以及需要高分辨率图案转印的其它应用。

54. 发明授权

US07741130B2 Fluidic arrays and method of using 有权
标题翻译：流体阵列和使用方法
公开(公告)号：US07741130B2
公开(公告)日：2010-06-22
申请号：US10783983
申请日：2004-02-20
申请人： Jessamine Lee, Jr. , Rustem F. Ismagilov , Xingyu Jiang , Paul J. A. Kenis , Rosaria Ferrigno , George M. Whitesides
发明人： Jessamine Lee, Jr. , Rustem F. Ismagilov , Xingyu Jiang , Paul J. A. Kenis , Rosaria Ferrigno , George M. Whitesides
IPC分类号： G01N11/00 , G01N33/53
CPC分类号： B01D61/08 , B01D61/18 , B01D63/08 , B01D63/081 , B01D63/082 , B01F5/0619 , B01F5/0644 , B01F13/0059 , B01F13/0093 , B01F15/0404 , B01F2005/0621 , B01F2005/0636 , B01F2215/0431 , B01J19/0046 , B01J19/0093 , B01J2219/00783 , B01J2219/00844 , B01J2219/0086 , B01J2219/00907 , B01J2219/0095 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502753 , B01L3/502776 , B01L2300/0681 , B01L2300/0874 , B01L2300/0887 , B01L2400/0418 , B01L2400/0472 , B01L2400/0487 , B01L2400/086 , B82Y30/00 , Y10S436/809 , Y10T436/2575
摘要： The present invention relates to fluidic systems and, in particular, fluidic arrays and methods for using them to promote interaction of materials. In one embodiment, the present invention is directed to a microfluidic system. The microfluidic system includes a first fluid path and a second fluid path segregated from the first fluid path by a first convection controller at a first contact region, wherein at least one of the first fluid path and the second fluid path has a cross-sectional dimension of less than about 1 millimeter. In another aspect, the present invention is directed to a method of promoting interaction. In another aspect, the invention relates to a device and method for performing titrations.
摘要翻译：本发明涉及流体系统，特别是涉及使用它们来促进材料相互作用的流体阵列和方法。在一个实施方案中，本发明涉及微流体系统。微流体系统包括在第一接触区域处由第一对流控制器与第一流体路径分离的第一流体路径和第二流体路径，其中第一流体路径和第二流体路径中的至少一个具有横截面尺寸小于约1毫米。另一方面，本发明涉及促进相互作用的方法。在另一方面，本发明涉及一种用于进行滴定的装置和方法。

55. 发明申请

US20100116343A1 VALVES AND RESERVOIRS FOR MICROFLUIDIC SYSTEMS 有权
标题翻译：微流体系统的阀门和储存器
公开(公告)号：US20100116343A1
公开(公告)日：2010-05-13
申请号：US11883260
申请日：2006-01-31
申请人： Douglas B. Weibel , Andrew Lee , Scott Potenta , Adam Siegel , Maarten Kruithof , George M. Whitesides
发明人： Douglas B. Weibel , Andrew Lee , Scott Potenta , Adam Siegel , Maarten Kruithof , George M. Whitesides
IPC分类号： G05D7/00 , F16K3/24 , F16K31/02 , F16K31/50
CPC分类号： F15B1/04 , B01L3/502738 , B01L3/502746 , B01L2200/0636 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , F15B2201/21 , F15B2201/305 , F15B2201/4053 , F16K99/0001 , F16K99/0026 , F16K99/0034 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , Y10T137/0318 , Y10T137/0396 , Y10T137/2213 , Y10T137/4824 , Y10T137/6161
摘要： A microfluidic valve assembly includes a structure defining a microfluidic fluid path and an actuator that can be moved between different positions controlling flow through the channel. In one embodiment, the actuator can be threaded into at least a portion of the structure, and can be moved rotationally between a first position, causing relatively greater constriction of a microfluidic fluid path, and a second position causing relatively lesser constriction of the fluid path. Actuating the actuator, e.g., by rotation, can deform material between the valve and the fluid path, thereby constricting at least a portion of the underlying fluid path and regulating the flow of a fluid in the fluid path. In another aspect, the invention provides a reservoir into which fluid can be placed and from which fluid can be introduced into a microfluidic system. In one embodiment, the reservoir is expandable and thereby able to store fluid under pressure for delivery to a microfluidic system.
摘要翻译：微流体阀组件包括限定微流体流体路径的结构和可以在控制流过通道的不同位置之间移动的致动器。在一个实施例中，致动器可以被螺纹连接到结构的至少一部分中，并且可以在第一位置和第二位置之间旋转地移动，第一位置引起微流体流体路径的相对较大的收缩，并且引起相对较小的流体路径收缩的第二位置。例如通过旋转来致动致动器可以在阀和流体路径之间变形材料，从而收缩下面的流体路径的至少一部分并且调节流体路径中的流体的流动。在另一方面，本发明提供了一种储存器，流体可以放置在该储存器中，并且可以从该储存器将流体引入到微流体系统中。在一个实施例中，储存器是可膨胀的并且因此能够在压力下存储流体以递送到微流体系统。

56. 发明授权

US07659053B2 Methods of alteration of surface affinities using non-chemical force-creating fields 有权
标题翻译：使用非化学力创造领域改变表面亲和力的方法
公开(公告)号：US07659053B2
公开(公告)日：2010-02-09
申请号：US11181371
申请日：2005-07-14
申请人： Xingyu Jiang , Rosaria Ferrigno , George M. Whitesides
发明人： Xingyu Jiang , Rosaria Ferrigno , George M. Whitesides
IPC分类号： C12Q1/00 , G01N33/53
CPC分类号： B82Y30/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3225 , B01J20/3227 , B01J20/3248 , B01J20/3251 , B01J20/3274 , B01J20/3285 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B05D3/14 , B05D3/207 , G01N33/54353 , G01N2610/00 , Y10S436/823 , Y10T436/118339
摘要： The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.
摘要翻译：本发明提供了一系列用于改变表面性质（例如，细胞毒性和/或亲水性）的方法，组合物和制品，通过将至少一部分表面暴露于非化学，产生场和/或力，例如电场。场/力可以通过任何合适的技术来产生。例如，可以通过在表面上施加电压，通过电感应等来产生该场。在某些实施例中，表面包括附着于其上的分子，当暴露于非化学，力产生场和/或从而改变表面的至少一部分的化学成分。在一组实施方案中，连接到表面的分子可以包括在表面上形成自组装单层的分子。在一些实施方案中，附着于表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），通过该分子可以使分子附着于表面。在某些情况下，分子可以在一个或多个亲水基团例如未改性的乙二醇部分的非附着端封端。在一些情况下，附着于表面的分子可以包括可结合各种实体的一个或多个部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，该技术用于使新的测定方法用于确定有效增加或减少细胞形状变化和/或表面活力的药物和/或治疗的细胞运动性和/或扩散和筛选试验。

57. 发明申请

US20090240040A1 PURIFICATION OF A BIVALENTLY ACTIVE ANTIBODY USING A NON-CHROMATOGRAPHIC METHOD 有权
标题翻译：使用非色谱方法纯化双活性抗体
公开(公告)号：US20090240040A1
公开(公告)日：2009-09-24
申请号：US12303089
申请日：2007-06-01
申请人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
发明人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
IPC分类号： C07K1/00
CPC分类号： C07K16/065 , C07K16/468 , C07K2317/31 , C07K2317/54 , Y10S436/822
摘要： The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immunoglobulin aggregates by addition of multivalent hapten to a salt solution of soluble antibodies or antibody fragments, wherein the multivalent hapten possesses a linker between the two haptens effective to prevent the binding of both haptens of the ligand to the same antibody or antibody fragment.
摘要翻译：本发明公开了一种纯化二价抗体或抗体片段的方法，所述二价抗体或抗体片段在使用非色谱法的抗体或抗体片段来源的两个Fab位点都是活性的，其包括通过将多价半抗原加入到可溶性抗体或抗体片段的盐溶液，其中多价半抗原具有两个半抗原之间的接头，其有效地防止配体的半抗原与相同的抗体或抗体片段的结合。

58. 发明申请

US20090236310A1 Adjustable solubility in sacrificial layers for microfabrication 有权
标题翻译：用于微细加工的牺牲层中可调节的溶解度
公开(公告)号：US20090236310A1
公开(公告)日：2009-09-24
申请号：US11918269
申请日：2006-04-14
申请人： Vincent Linder , Byron Gates , Declan Ryan , Babak Amirparviz , George M. Whitesides
发明人： Vincent Linder , Byron Gates , Declan Ryan , Babak Amirparviz , George M. Whitesides
IPC分类号： B44C1/22
CPC分类号： B81C1/00246 , B81C2201/0108 , B81C2203/0735 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： The present invention provides fabrication methods using sacrificial materials comprising polymers. In some embodiments, the polymer may be treated to alter its solubility with respect to at least one solvent (e.g., aqueous solution) used in the fabrication process. The preparation of the sacrificial materials is rapid and simple, and dissolution of the sacrificial material can be carried out in mild environments. Sacrificial materials of the present invention may be useful for surface micromachining, bulk micromachining, and other microfabrication processes in which a sacrificial layer is employed for producing a selected and corresponding physical structure.
摘要翻译：本发明提供了使用包含聚合物的牺牲材料的制造方法。在一些实施方案中，可以处理聚合物以改变其相对于在制造过程中使用的至少一种溶剂（例如水溶液）的溶解度。牺牲材料的制备是快速和简单的，牺牲材料的溶解可以在温和的环境中进行。本发明的牺牲材料可用于表面微加工，体微加工和其它微加工工艺，其中牺牲层用于产生选定的和相应的物理结构。

59. 发明申请

US20090097808A1 Fluid waveguide and uses thereof 审中-公开
标题翻译：流体波导及其用途
公开(公告)号：US20090097808A1
公开(公告)日：2009-04-16
申请号：US11658339
申请日：2005-08-01
申请人： Daniel B. Wolfe , Kateri E. Paul , Dmitri V. Vezenov , Brian T. Mayers , Richard S. Conroy , Piotr Garstecki , Michael A. Fischbach , Valentine I. Vullev , Kam Yan Tang , Mara G. Prentiss , George M. Whitesides
发明人： Daniel B. Wolfe , Kateri E. Paul , Dmitri V. Vezenov , Brian T. Mayers , Richard S. Conroy , Piotr Garstecki , Michael A. Fischbach , Valentine I. Vullev , Kam Yan Tang , Mara G. Prentiss , George M. Whitesides
IPC分类号： G02B6/032
CPC分类号： G02B6/032 , G02B6/10 , G02B6/122
摘要： The invention relates to methods and apparatuses for guiding and emitting electromagnetic radiation from a fluid waveguide. Various methods for changing optical properties (e.g., refractive index, absorption, and fluorescence) and/or physical properties (e.g., magnetic susceptibility, electrical conductivity, and temperature) of either the waveguide core or the cladding, or both, are provided herein. In one embodiment, electromagnetic radiation is guided and/or emitted at multiple distinct wavelengths, including emission in the form of an essentially continuous band, in some cases covering at least 150 nanometers. In another embodiment, methods for splitting a waveguide core and/or the joining of at least two waveguide cores in a waveguide are provided. In yet another embodiment, the invention includes the use of thermal gradients to generate a waveguide and/or to change the properties of waveguides. Embodiments of the waveguides may be used for optical detection or spectroscopic analysis.
摘要翻译：本发明涉及用于引导和发射来自流体波导的电磁辐射的方法和装置。本文提供用于改变波导芯或包层或两者的光学性质（例如，折射率，吸收和荧光）和/或物理性质（例如磁化率，导电性和温度）的各种方法。在一个实施例中，电磁辐射是以多个不同的波长被引导和/或发射的，包括基本连续带形式的发射，在某些情况下覆盖至少150纳米。在另一个实施例中，提供了用于在波导中分离波导芯和/或至少两个波导芯的接合的方法。在另一个实施例中，本发明包括使用热梯度来产生波导和/或改变波导的性质。波导的实施例可以用于光学检测或光谱分析。

60. 发明授权

US07459151B2 Phosphate-binding polymers for oral administration 有权
标题翻译：用于口服给药的磷酸盐结合聚合物
公开(公告)号：US07459151B2
公开(公告)日：2008-12-02
申请号：US11295159
申请日：2005-12-06
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , George M. Whitesides
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , George M. Whitesides
IPC分类号： A61K31/74 , A61K31/785
CPC分类号： A61K31/662 , A61K31/785 , A61K31/795
摘要： Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
摘要翻译：提供磷酸盐结合聚合物用于从胃肠道除去磷酸盐。口服聚合物，可用于治疗高磷血症。

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