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51. 发明授权

US08608972B2 Method for patterning a surface 失效
标题翻译：图案化方法
公开(公告)号：US08608972B2
公开(公告)日：2013-12-17
申请号：US12483128
申请日：2009-06-11
申请人： Brian T. Mayers , Jeffrey Carbeck , Wajeeh Saadi , George M. Whitesides , Ralf Kügler , Monika Kursawe , Johannes Canisius
发明人： Brian T. Mayers , Jeffrey Carbeck , Wajeeh Saadi , George M. Whitesides , Ralf Kügler , Monika Kursawe , Johannes Canisius
IPC分类号： C03C25/68
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y20/00 , B82Y40/00
摘要： The present invention is directed to methods for patterning surfaces using contact printing and pastes, and products formed therefrom.
摘要翻译：本发明涉及使用接触印刷和糊剂以及由其形成的产品来图案化表面的方法。

52. 发明申请

US20130313483A1 MULTIPHASE SYSTEMS AND USES THEREOF 有权
标题翻译：多相系统及其用途
公开(公告)号：US20130313483A1
公开(公告)日：2013-11-28
申请号：US13817976
申请日：2011-08-22
申请人： Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
发明人： Charles R. Mace , Ozge Akbulut Halatci , Ashok A. Kumar , Nathan D. Shapiro , George M. Whitesides
IPC分类号： G01N33/18
CPC分类号： G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要： A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities.
摘要翻译：多相系统包括包含至少两相的相分离溶液，每相具有选自聚合物，表面活性剂及其组合的相组分，其中至少一相包含聚合物，其中相一起表示密度梯度。公开了新型的两相，三相，四相，五相或六相系统。使用所公开的多相聚合物体系，可以基于它们不同的密度或亲和力来分离颗粒或感兴趣的其它分析物。

53. 发明申请

US20130182328A1 Structured Smudge-Resistant Anti-Reflective Coatings and Methods of Making and Using the Same 审中-公开
标题翻译：耐结垢的抗反射涂层及其制造和使用方法
公开(公告)号：US20130182328A1
公开(公告)日：2013-07-18
申请号：US13515145
申请日：2010-12-10
申请人： Matthew Stewart , Joseph M. McLellan , Graciela B. Blanchet , Brian T. Mayers , Adam Winkleman , Sandip Agarwal , George M. Whitesides
发明人： Matthew Stewart , Joseph M. McLellan , Graciela B. Blanchet , Brian T. Mayers , Adam Winkleman , Sandip Agarwal , George M. Whitesides
IPC分类号： G02B1/11
CPC分类号： G02B1/11 , B82Y20/00 , G02B1/118 , G02B1/18 , G02B27/0006 , Y10S977/902 , Y10T428/24355 , Y10T428/24479 , Y10T428/24612
摘要： The present invention is directed to articles comprising smudge-resistant anti-reflective surfaces, and products and devices comprising the articles.
摘要翻译：本发明涉及包含抗污垢抗反射表面的制品，以及包括制品的产品和装置。

54. 发明授权

US08486833B2 Fabrication of conductive pathways, microcircuits and microstructures in microfluidic networks 有权
标题翻译：微流控网络中导电通路，微电路和微结构的制作
公开(公告)号：US08486833B2
公开(公告)日：2013-07-16
申请号：US11920483
申请日：2006-05-18
申请人： Derek A. Bruzewicz , Mila Boncheva-Bettex , George M. Whitesides , Adam Siegel , Douglas B. Weibel , Sergey S. Shevkoplyas , Andres Martinez
发明人： Derek A. Bruzewicz , Mila Boncheva-Bettex , George M. Whitesides , Adam Siegel , Douglas B. Weibel , Sergey S. Shevkoplyas , Andres Martinez
IPC分类号： H01L21/44 , H01L21/4763
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as “microsolidic” devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，所形成的装置包括通过固化存在于一个或多个微流体通道中的液体金属形成的导电通路（以下称为“微溶体”装置）。在某些这样的器件中，其中可以在微流体结构中的区域之间形成和/或重组电连接; 在一些情况下，形成的器件/电路可以是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与其相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，所形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

55. 发明授权

US08389272B2 Fluid delivery system and method 有权
公开(公告)号：US08389272B2
公开(公告)日：2013-03-05
申请号：US13226154
申请日：2011-09-06
申请人： Vincent Linder , Samuel K. Sia , George M. Whitesides
发明人： Vincent Linder , Samuel K. Sia , George M. Whitesides
IPC分类号： C12M1/34
CPC分类号： G01N33/5304 , B01L3/0293 , B01L3/5027 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B82Y30/00 , G01N33/543 , G01N35/08 , G01N35/1002 , G01N35/1065 , Y10T137/0318
摘要： A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.

56. 发明授权

US08206992B2 Cotton thread as a low-cost multi-assay diagnostic platform 有权
标题翻译：棉线作为低成本多分析诊断平台
公开(公告)号：US08206992B2
公开(公告)日：2012-06-26
申请号：US12934702
申请日：2009-03-27
申请人： Meital Reches , Michael D. Dickey , Manish J. Butte , George M. Whitesides
发明人： Meital Reches , Michael D. Dickey , Manish J. Butte , George M. Whitesides
IPC分类号： G01N21/77
CPC分类号： B01L3/5023 , B01L3/5088 , B01L2200/0605 , B01L2200/10 , B01L2300/0825 , B01L2300/0845 , B01L2300/087 , B01L2300/12 , B01L2300/161 , B01L2400/0406 , G01N33/54386
摘要： Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread. A method of detecting the presence or absence of an analyte in a fluid sample includes applying the sample to an inlet zone of a diagnostic system that includes a hydrophilic loading thread with an inlet zone at a proximal end; an intermediate zone; and a testing zone at a distal end; wherein the testing zone does not directly contact the inlet zone.
摘要翻译：描述了作为廉价，低容量，便携式诊断系统的平台的亲水丝线及其制造方法。诊断系统包括在近端具有入口区域的亲水加载螺纹; 远端的测试区; 以及位于入口区域和测试区域之间的中间区域，其中测试区域不直接接触入口区域。在另一方面，诊断系统包括（i）亲水加载线，其包括在近端处的入口区域和在远端处的中间区域; 和（ii）接触加载螺纹的中间区域的一个或多个附加亲水丝线。检测流体样品中分析物的存在或不存在的方法包括将样品施加到诊断系统的入口区域，诊断系统的入口区域包括具有近端的入口区域的亲水加载螺纹; 中间区和远端的测试区; 其中所述测试区域不直接接触所述入口区域。

57. 发明申请

US20110277930A1 OPTICAL MODULATOR/DETECTOR BASED ON RECONFIGURABLE DIFFRACTION GRATING 审中-公开
标题翻译：基于可重构衍射光栅的光学调制器/探测器
公开(公告)号：US20110277930A1
公开(公告)日：2011-11-17
申请号：US13031149
申请日：2011-02-18
申请人： Olivier J.A. Schueller , David C. Duffy , John A. Rogers , Scott T. Brittain , George M. Whitesides
发明人： Olivier J.A. Schueller , David C. Duffy , John A. Rogers , Scott T. Brittain , George M. Whitesides
IPC分类号： B32B37/02 , B32B37/14 , B32B37/12
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L2200/0689 , B01L2300/0654 , B01L2300/0861 , B01L2300/123 , B01L2400/0418 , G01N21/45 , G01N21/4788 , Y10T428/24562 , Y10T428/2457 , Y10T428/24744 , Y10T428/31663
摘要： A system is provided for positioning separate portions of a sample in elongate, parallel channels of a sample chamber and for irradiating a sample in the chamber to create a diffraction pattern where the sample and chamber differ in refractive index. The system also can measure absorption of electromagnetic radiation by a sample in the chamber, and can measure the absorption simultaneously with measurement of diffraction by the sample.
摘要翻译：提供了一种用于将样品的分离部分定位在样品室的细长平行通道中并用于在室中照射样品以产生样品和室的折射率不同的衍射图案的系统。该系统还可以测量室内样品对电磁辐射的吸收，并可以通过样品的衍射测量同时测量吸收。

58. 发明申请

US20110111517A1 PAPER-BASED MICROFLUIDIC SYSTEMS 有权
标题翻译：基于纸张的微流体系统
公开(公告)号：US20110111517A1
公开(公告)日：2011-05-12
申请号：US12934857
申请日：2009-03-27
申请人： Adam C. Siegel , Scott T. Phillips , Michael D. Dickey , Dorota Rozkiewicz , Benjamin Wiley , George M. Whitesides , Andres W. Martinez
发明人： Adam C. Siegel , Scott T. Phillips , Michael D. Dickey , Dorota Rozkiewicz , Benjamin Wiley , George M. Whitesides , Andres W. Martinez
IPC分类号： G01N21/00 , C12M1/34 , G01N21/75
CPC分类号： B01L3/502707 , B01L2200/027 , B01L2200/0642 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/025 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2300/0819 , B01L2300/087 , B01L2300/12 , B01L2300/126 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , Y10T436/25 , Y10T436/2575
摘要： Paper-based microfluidic systems and methods of making the same are described.
摘要翻译：描述了基于纸的微流体系统及其制备方法。

59. 发明申请

US20110105360A1 PAPER-BASED CELLULAR ARRAYS 有权
标题翻译：基于纸张的细胞阵列
公开(公告)号：US20110105360A1
公开(公告)日：2011-05-05
申请号：US12934192
申请日：2009-03-27
申请人： Ratmir Derda , Anna Laromaine Sague , George M. Whitesides
发明人： Ratmir Derda , Anna Laromaine Sague , George M. Whitesides
IPC分类号： C40B30/06 , C40B40/02 , C40B50/14 , B05D5/00 , C40B60/14
CPC分类号： G01N33/548 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00619 , B01J2219/00641 , B01J2219/00644 , B01J2219/00743 , B01L3/5085 , B01L2300/0819 , B01L2300/0829 , B01L2300/126 , B01L2300/161 , G01N33/502
摘要： Three-dimensional cellular arrays, methods of making three-dimensional cellular arrays, and methods of identifying agents using the arrays are disclosed.
摘要翻译：公开了三维细胞阵列，制备三维细胞阵列的方法以及使用阵列识别药剂的方法。

60. 发明授权

US07736890B2 Assay device and method 有权
标题翻译：测定装置和方法
公开(公告)号：US07736890B2
公开(公告)日：2010-06-15
申请号：US10584819
申请日：2004-12-29
申请人： Samuel K. Sia , Vincent Linder , Babak Amir-Parviz , Adam Siegel , George M. Whitesides
发明人： Samuel K. Sia , Vincent Linder , Babak Amir-Parviz , Adam Siegel , George M. Whitesides
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/56988 , B01L3/502707 , B01L2300/0822 , B01L2300/168 , G01N21/05 , G01N21/59 , G01N33/5302 , G01N33/543 , G01N33/585 , G01N2021/0346 , Y10T436/11 , Y10T436/117497 , Y10T436/118339
摘要： An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion (140) of a surface (130) of a microfluidic chamber (120,122,124); passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.
摘要翻译：描述了测定方法，其包括以下步骤：将待检测分析物（例如，抗体或抗原）的结合配偶体（例如，抗原或抗体）固定在表面（130）的部分（140）上微流体室（120,122,124）; 将流体样品通过表面并允许分析物结合到结合配偶体; 允许金属胶体，例如金共轭抗体与结合的分析物缔合; 在表面上流动金属溶液，例如银溶液，以形成不透明的金属层; 并且例如通过目视检查或通过在将金属溶液流过表面之后测量金属溶液中的层的透光率，层的导电性或电阻或金属浓度来检测所述金属层的存在。

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