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51. 发明申请

US20050244479A1 Sustained release intraocular implants and methods for preventing retinal dysfunction 有权
标题翻译：持续释放眼内植入物和预防视网膜功能障碍的方法
公开(公告)号：US20050244479A1
公开(公告)日：2005-11-03
申请号：US10837143
申请日：2004-04-30
申请人： Glenn Huang , James Burke , Patrick Hughes , Kai-Ming Zhang , Ton Lin , Larry Wheeler , Rosy Donn
发明人： Glenn Huang , James Burke , Patrick Hughes , Kai-Ming Zhang , Ton Lin , Larry Wheeler , Rosy Donn
IPC分类号： A61F2/02 , A61K9/00 , A61K9/14 , A61K31/498
CPC分类号： A61K31/498 , A61K9/0051 , A61K47/34
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以防止发生一种或多种眼部病症，或者减少眼部疾病如眼睛神经感觉障碍等的一种或多种症状。

52. 发明申请

US20050244478A1 Anti-excititoxic sustained release intraocular implants and related methods 审中-公开
标题翻译：抗兴奋性持续释放眼内植入物及相关方法
公开(公告)号：US20050244478A1
公开(公告)日：2005-11-03
申请号：US10837142
申请日：2004-04-30
申请人： Patrick Hughes , James Burke , Rhett Schiffman
发明人： Patrick Hughes , James Burke , Rhett Schiffman
IPC分类号： A61K9/00 , A61K31/13 , A61F2/02
CPC分类号： A61K9/0051
摘要： Biocompatible intraocular implants include an anti-excitotoxic agent and a biodegradable polymer that is effective to facilitate release of the anti-excitotoxic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.
摘要翻译：生物相容性眼内植入物包括抗兴奋性毒性剂和可生物降解的聚合物，其有效促进抗兴奋性毒性剂长时间释放到眼睛中。植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。

53. 发明申请

US20050142165A1 Implant device with a retinoid for improved biocompatibility 失效
标题翻译：具有类视黄醇的植入装置，用于改善生物相容性
公开(公告)号：US20050142165A1
公开(公告)日：2005-06-30
申请号：US11066773
申请日：2005-02-25
申请人： Orest Olejnik , Patrick Hughes , John Kent
发明人： Orest Olejnik , Patrick Hughes , John Kent
IPC分类号： A61K9/00 , A61K9/22 , A61K31/07 , A61K31/192 , A61K31/455 , A61L27/18 , A61L27/54 , A61K31/203
CPC分类号： A61L27/18 , A61K9/0051 , A61K31/07 , A61K31/192 , A61K31/455 , A61L27/54 , A61L2300/428 , A61L2300/442 , A61L2300/604 , Y10S514/953 , C08L67/04
摘要： An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device. may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated with a retinoid for increasing the biocompatibility thereof.
摘要翻译：提供了一种植入装置，其包含用于改善组织中装置的生物相容性的类视黄醇。装置。可以在组织中系统地或局部释放治疗剂的目的进行生物蚀刻，或者它可以是永久性植入物，其包括用类视黄醇处理以增加其生物相容性的表面。

54. 发明授权

US4918603A Computerized statistical football game 失效
标题翻译：电脑统计足球比赛
公开(公告)号：US4918603A
公开(公告)日：1990-04-17
申请号：US226724
申请日：1988-08-01
申请人： Patrick Hughes , Michael Hughes , David Yager
发明人： Patrick Hughes , Michael Hughes , David Yager
IPC分类号： G06F19/00
CPC分类号： G09B19/00
摘要： A method and apparatus for playing football. The football game is played on a computer system and is based upon actual football performances by a database of football players. The computer football game is played by a league of individuals, each of whom can individually, or in groups, own a franchise. Franchises select their players from an initial draft. The starting players are then selected by individual franchise owners. Wins and losses for the computer football games occur by calculating a total of each individual player's points who make up a team. The calculation of points is done automatically either manually or using actual weekly performance by individual NFL players as the basis for determining points.
摘要翻译：一种踢足球的方法和装置。足球比赛是在计算机系统上进行的，并且基于足球运动员的数据库的实际足球表演。电脑足球比赛是由一个个人联盟组成的，每个人都可以单独或分组拥有一个特许经营权。特许经营从初稿中选出他们的球员。然后由个人特许经营者选择起始选手。计算机足球比赛的胜利和损失是通过计算组成一个团队的每个单个球员的积分的总和。点的计算可以手动进行，也可以使用单个NFL玩家的实际每周表现作为确定点的依据。

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