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51. 发明申请

US20060140988A1 Visco-supplement composition and methods 审中-公开
标题翻译：粘贴补充剂组成和方法
公开(公告)号：US20060140988A1
公开(公告)日：2006-06-29
申请号：US11305939
申请日：2005-12-19
申请人： Guohua Chen , Edwin Chan , Joel Rosenblatt
发明人： Guohua Chen , Edwin Chan , Joel Rosenblatt
IPC分类号： A61K31/728 , A61K9/00 , A61K9/14
CPC分类号： A61K9/0019 , A61K9/107 , A61K47/26 , A61K47/34
摘要： The present invention relates to methods and depot emulsion compositions for delivery of visco-supplements.
摘要翻译：本发明涉及用于递送粘补补品的方法和贮存剂乳液组合物。

52. 发明申请

US20050107772A1 Osmotically driven active agent delivery device providing an ascending release profile 有权
标题翻译：渗透驱动的活性剂递送装置提供上升释放特征
公开(公告)号：US20050107772A1
公开(公告)日：2005-05-19
申请号：US10953895
申请日：2004-09-29
申请人： Guohua Chen , Rupal Ayer , Scott Lautenbach
发明人： Guohua Chen , Rupal Ayer , Scott Lautenbach
IPC分类号： A61K9/00 , A61K9/22 , A61M5/145
CPC分类号： A61K9/0024 , A61K9/0004 , A61M5/145 , A61M2005/14513
摘要： In one aspect, the present invention is directed to an osmotic pump that automatically provides an ascending release rate of active agent as the osmotic pump functions in an environment of operation and may be designed for implantation within a desired animal or human subject. An osmotic pump according to the present invention includes a reservoir, a rate controlling membrane, an expandable osmotic composition, an active agent formulation and an exit orifice. Once administered to an environment of operation, water passes through the rate controlling membrane and into the osmotic composition, which causes the osmotic composition to expand and expel the active agent formulation through the exit orifice at a rate that is directly proportional to the rate at which water passes through the rate controlling membrane. An osmotic pump according to the present invention permits the flow of water through the rate controlling membrane to increase automatically without the need for manipulation of the osmotic pump after administration. As the flow of water through the rate controlling membrane increases, the rate at which active agent is delivered from the osmotic pump will also increase proportionally.
摘要翻译：一方面，本发明涉及一种渗透泵，其随着渗透泵在操作环境中的功能而自动提供活性剂的上升释放速率，并且可被设计用于植入期望的动物或人类受试者内。根据本发明的渗透泵包括储存器，速率控制膜，可膨胀渗透组合物，活性剂制剂和出口孔。一旦施用于操作环境，水通过速率控制膜并进入渗透组合物，其导致渗透组合物通过出口孔膨胀并排出活性剂制剂，速率与其速率成正比水通过速率控制膜。根据本发明的渗透泵允许通过速率控制膜的水流自动增加，而不需要在给药后操纵渗透泵。随着通过速率控制膜的水流量增加，活性剂从渗透泵输送的速率也将成比例地增加。

53. 发明申请

US20050106214A1 Excipients in drug delivery vehicles 审中-公开
公开(公告)号：US20050106214A1
公开(公告)日：2005-05-19
申请号：US10985122
申请日：2004-11-10
申请人： Guohua Chen
发明人： Guohua Chen
IPC分类号： A61K9/14 , A61K38/27 , A61K47/30
CPC分类号： A61K9/0024 , A61K47/34
摘要： Injectable depot gel compositions and kits that provide an excipient for modulating a release rate and stabilizing beneficial agents are provided. Methods of administering and preparing such systems are also provided. The gel compositions comprise biodegradable, bioerodible polymers and water-immiscible solvents in amounts effective to plasticize the polymers and form gels with the polymers. Suitable excipients include pH modifiers, reducing agents, and antioxidants.

54. 发明授权

US09234068B2 Method for preparing aqueous polyacrylate modified polyurethane dispersions 有权
公开(公告)号：US09234068B2
公开(公告)日：2016-01-12
申请号：US12285372
申请日：2008-10-02
申请人： Caideng Yuan , Guohua Chen , Xixiang Zhang , Zongjin Li , Zhimeng Liu
发明人： Caideng Yuan , Guohua Chen , Xixiang Zhang , Zongjin Li , Zhimeng Liu
IPC分类号： C08G18/08 , C08G18/62 , C08G18/12 , C08G18/66 , C08G18/67 , C08G18/75 , C08G18/76 , C09D175/04
CPC分类号： C08G18/6254 , C08G18/0823 , C08G18/12 , C08G18/6692 , C08G18/675 , C08G18/755 , C08G18/7621 , C08G2270/00 , C09D175/04 , C08G18/3228 , C08G18/62
摘要： A novel method for the preparation of an aqueous polyacrylate modified polyurethane dispersion is disclosed. The preparation method includes three main steps: a) preparation of polyacrylate polymer or copolymer emulsion; b) preparation of polyurethane prepolymer with carboxylic groups and neutralization treatment to the carboxylic groups; and c) dispersion and chain-extension of polyurethane prepolymer by adding the polyacrylate emulsion into the polyurethane prepolymer under vigorous agitation, or other mechanical operation. The aqueous polyacrylate modified polyurethane dispersion has self-crosslinkability when an unsaturated acetoacetoxy compound is used for the preparation of the polyacrylate emulsion.

55. 发明授权

US08460694B2 Solvent/polymer solutions as suspension vehicles 有权
公开(公告)号：US08460694B2
公开(公告)日：2013-06-11
申请号：US13647228
申请日：2012-10-08
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61F2/00 , A61K9/22 , A61K9/14 , A61K45/00 , A61K38/00
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

56. 发明授权

US08440226B2 Solvent/polymer solutions as suspension vehicles 有权
公开(公告)号：US08440226B2
公开(公告)日：2013-05-14
申请号：US13526375
申请日：2012-06-18
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61K9/14 , A61K45/00 , A61K38/00
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

57. 发明申请

US20130035670A1 SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES 有权
公开(公告)号：US20130035670A1
公开(公告)日：2013-02-07
申请号：US13647228
申请日：2012-10-08
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
IPC分类号： A61M5/168 , B23P11/00
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

58. 发明申请

US20130034210A1 SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES 有权
标题翻译：溶剂/聚合物溶液作为悬浮液
公开(公告)号：US20130034210A1
公开(公告)日：2013-02-07
申请号：US13647873
申请日：2012-10-09
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
IPC分类号： G01N23/04
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
摘要翻译：能够悬浮活性剂的非水性单相载体。非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯，不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。

59. 发明授权

US08252303B2 Injectable depot compositions and uses thereof 失效
标题翻译：可注射贮库组合物及其用途
公开(公告)号：US08252303B2
公开(公告)日：2012-08-28
申请号：US10295814
申请日：2002-11-14
申请人： Guohua Chen , Paul R. Houston , Lothar Walter Kleiner , John J. Spaltro
发明人： Guohua Chen , Paul R. Houston , Lothar Walter Kleiner , John J. Spaltro
IPC分类号： A61F2/00 , A61K47/30
CPC分类号： A61K38/1858 , A61K9/0002 , A61K9/0024 , A61K9/1617 , A61K31/445 , A61K38/27 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/34
摘要： Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
摘要翻译：提供了可注射的储库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中的混溶性小于或等于7wt。％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。组合物基本上改善了剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

60. 发明申请

US20120122782A1 COMPLEXATION OF METAL IONS WITH POLYPEPTIDES 审中-公开
标题翻译：金属离子与多糖的复合
公开(公告)号：US20120122782A1
公开(公告)日：2012-05-17
申请号：US13301739
申请日：2011-11-21
申请人： Catherine M. Rohloff , Guohua Chen , Zhongli Ding , Stephen Andrew Berry , Latha Pisharody Narayanan , Michael Desjardin
发明人： Catherine M. Rohloff , Guohua Chen , Zhongli Ding , Stephen Andrew Berry , Latha Pisharody Narayanan , Michael Desjardin
IPC分类号： A61K38/27 , A61P5/06 , A61K38/02
CPC分类号： A61K47/32 , A61K9/0019 , A61K9/1617 , A61K9/1623 , A61K9/1688 , A61K38/27 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/44
摘要： Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide.
摘要翻译：提供了制备和方法，用于提高暴露于存在于非水悬浮载体中的多肽的水性介质时的稳定性。在本发明的特定方面，提供了包含悬浮在非水生物相容性悬浮载体中的金属离子和多肽的复合物的制剂。当将水性介质引入这种制剂用于稳定多肽时，单个多肽分子的聚集被降低。

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