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51. 发明授权

US07579599B2 Parameter adjustment for medical device 有权
标题翻译：医疗器械参数调整
公开(公告)号：US07579599B2
公开(公告)日：2009-08-25
申请号：US11941562
申请日：2007-11-16
申请人： Nan Zhang , Volker Matschl , Niraj K. Doshi , Matthias J. Schmand
发明人： Nan Zhang , Volker Matschl , Niraj K. Doshi , Matthias J. Schmand
IPC分类号： G01T1/164
CPC分类号： A61B6/037 , A61B6/56
摘要： A medical device with a high voltage connection line for carrying a high DC supply voltage has a control unit generating said high DC supply voltage which is fed through a first AC block unit to said high voltage connection line and generating a digital control signal fed through a first AC coupling unit to said high voltage connection line, and a remotely located unit a second AC block unit coupled to said high voltage connection line for receiving said high DC supply voltage and a second AC coupling unit coupled to said high voltage connection line for receiving said digital control signal.
摘要翻译：具有用于承载高直流电源电压的高压连接线的医疗装置具有产生所述高直流电源电压的控制单元，所述高直流电源电压通过第一AC块单元馈送到所述高压连接线，并产生通过第一AC耦合单元连接到所述高压连接线，以及远程定位单元，耦合到所述高压连接线的第二AC块单元，用于接收所述高DC电源电压;以及第二AC耦合单元，耦合到所述高压连接线，用于接收所述数字控制信号。

52. 发明申请

US20090108206A1 MR-Compatible Blood Sampling System For PET Imaging Applications in Combined PET/MR Imaging System 有权
标题翻译： MR兼容血液采样系统用于PET / MR成像系统的PET成像应用
公开(公告)号：US20090108206A1
公开(公告)日：2009-04-30
申请号：US12260966
申请日：2008-10-29
申请人： Johannes Breuer , Ronald Grazioso , James Corbeil , Nan Zhang , Matthias J. Schmand
发明人： Johannes Breuer , Ronald Grazioso , James Corbeil , Nan Zhang , Matthias J. Schmand
IPC分类号： G01T1/164 , G01V3/00
CPC分类号： G01R33/28 , A61B5/150992 , G01R33/481 , G01T1/1603
摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.
摘要翻译：用于PET成像应用的自动采血系统，其可以在MR扫描器的视野（FOV）中或非常接近的范围内操作，例如在组合的MR / PET成像系统中。辐射检测器使用APD（雪崩光电二极管）从正电子 - 电子湮灭光子被吸收的晶体中收集闪烁光。必要的伽马屏蔽由合适的屏蔽材料制成，优选钨聚合物复合材料。由于APD相当小并且磁性不敏感，所以它们可以在无扰动的MR设备的强磁场中操作。

53. 发明申请

US20080255157A1 6-Aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents 失效
标题翻译： 6-芳基-7-卤代 - 咪唑并[1,2-a]嘧啶作为抗癌剂
公开(公告)号：US20080255157A1
公开(公告)日：2008-10-16
申请号：US11903100
申请日：2007-09-19
申请人： Nan Zhang , Semiramis Ayral-Kaloustian
发明人： Nan Zhang , Semiramis Ayral-Kaloustian
IPC分类号： A61K31/519 , A61P35/04
CPC分类号： C07D487/04
摘要： This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及某些6-芳基-7-卤代咪唑并[1,2-a]嘧啶或其药学上可接受的盐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于通过促进微管聚合治疗哺乳动物的癌症。本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，并进一步提供了治疗或预防表达多重耐药性（MDR）或耐多药耐药性的癌性肿瘤的方法在有需要的哺乳动物中，所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。

54. 发明申请

US20080086239A1 METHOD FOR VOLTAGE INSTABILITY LOAD SHEDDING USING LOCAL MEASUREMENTS 有权
标题翻译：使用本地测量的电压不稳定性负载分析方法
公开(公告)号：US20080086239A1
公开(公告)日：2008-04-10
申请号：US11539758
申请日：2006-10-09
申请人： Pei Zhang , Liang Min , Nan Zhang
发明人： Pei Zhang , Liang Min , Nan Zhang
IPC分类号： G05F3/02
CPC分类号： H02J3/14 , H02J3/24 , Y02B70/3225 , Y04S20/222
摘要： A method of voltage instability load shedding, that includes the steps of measuring current and voltage waveforms of an electrical system at a local bus estimating the Thevenin equivalent admittance based on Kalman Filter techniques, then a voltage stability margin index is calculated using the voltage magnitude. The determined Thevenin admittance and the load at the local system bus and the calculated voltage stability margin index is compared with a predetermined threshold value to determine whether to initiate a load shedding action.
摘要翻译：一种电压不稳定性负载脱落的方法，其中包括测量基于卡尔曼滤波技术估算戴维南等效导纳的局部总线上电气系统的电流和电压波形的步骤，然后使用电压幅值计算电压稳定裕度指数。将确定的戴维宁导纳和本地系统总线的负载以及计算的电压稳定性裕度指数与预定阈值进行比较，以确定是否启动负载脱落动作。

55. 发明申请

US20080070913A1 Thieno [ 3,2-b] pyridine-6-carbonitriles and thieno [2,3-b] pyridine-5-carbonitriles as protein kinase inhibitors 审中-公开
标题翻译：噻吩并[3,2-b]吡啶-6-羰腈和噻吩并[2,3-b]吡啶-5-腈作为蛋白激酶抑制剂
公开(公告)号：US20080070913A1
公开(公告)日：2008-03-20
申请号：US11903754
申请日：2007-09-24
申请人： Diane Boschelli , Nan Zhang , Ana Barrios Sosa , Haris Durutlic , Biqi Wu
发明人： Diane Boschelli , Nan Zhang , Ana Barrios Sosa , Haris Durutlic , Biqi Wu
IPC分类号： A61K31/44 , A61K31/497 , A61K31/535 , A61P43/00 , C07D401/00 , C07D413/00 , C07D471/02
CPC分类号： C07D495/04 , A61K31/44 , A61K31/497 , A61K31/535
摘要： This invention provides compounds of Formula (1a)-(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z′, Z′″, Z″ and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
摘要翻译：本发明提供式（1a） - （1f），II的化合物，其中：X，m，n，q，R 1，R 2，R 3 R 4，R 5，R 5，R 6，R 7，R 8，在本说明书中定义，R 9，Y，Q，Z，Z'，Z“'，Z”和J“可以用于治疗癌症，中风，心肌梗塞，神经性疼痛，骨质疏松症，多囊肾病，自身免疫性疾病，类风湿性关节炎和移植排斥反应以及用于制备所述化合物的方法。

56. 发明申请

US20060063784A1 Method of using substituted pyrazolo [1,5-a] pyrimidines 审中-公开
标题翻译：使用取代的吡唑并[1,5-a]嘧啶的方法
公开(公告)号：US20060063784A1
公开(公告)日：2006-03-23
申请号：US11221846
申请日：2005-09-09
申请人： Yanong Wang , Ariamala Gopalsamy , Erick Honores , Lee Jennings , Steven Johnson , Dennis Powell , Fuk-Wah Sum , Hwei-Ru Tsou , Biqi Wu , Nan Zhang
发明人： Yanong Wang , Ariamala Gopalsamy , Erick Honores , Lee Jennings , Steven Johnson , Dennis Powell , Fuk-Wah Sum , Hwei-Ru Tsou , Biqi Wu , Nan Zhang
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as anti-proliferative agents in mammals, including humans.
摘要翻译：本发明涉及使用某些吡唑并[1,5-a]嘧啶化合物及其治疗上可接受的盐的新方法。本发明还涉及在哺乳动物（包括人）中使用这些化合物作为抗增殖剂的新方法。

57. 发明申请

US20050065167A1 6-Aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents 失效
标题翻译： 6-芳基-7-卤代 - 咪唑并[1,2-a]嘧啶作为抗癌剂
公开(公告)号：US20050065167A1
公开(公告)日：2005-03-24
申请号：US10950542
申请日：2004-09-24
申请人： Nan Zhang , Semiramis Ayral-Kaloustian
发明人： Nan Zhang , Semiramis Ayral-Kaloustian
IPC分类号： A61K31/519 , A61P35/00 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04
摘要： This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及某些6-芳基-7-卤代咪唑并[1,2-a]嘧啶或其药学上可接受的盐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于通过促进微管聚合治疗哺乳动物的癌症。本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，并进一步提供了治疗或预防表达多重耐药性（MDR）或耐多药耐药性的癌性肿瘤的方法在有需要的哺乳动物中，所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。

58. 发明授权

US06689772B1 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors 失效
标题翻译： 3-氰基喹啉，3-氰基-1,6-萘啶和3-氰基-1,7-萘啶作为蛋白激酶抑制剂
公开(公告)号：US06689772B1
公开(公告)日：2004-02-10
申请号：US10318213
申请日：2002-12-12
申请人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
发明人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
IPC分类号： A61K3133
CPC分类号： C07D401/04 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14
摘要： This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
摘要翻译：本发明提供式（I）化合物，其具有其中T，Z，X，A，R 1，R 2a，R 2b，R 2c，R 3，R 4，和n在本文中定义，或其药学上可接受的盐，其可用作抗肿瘤剂并用于治疗骨质疏松症和多囊肾病。

59. 发明授权

US06526197B2 MEMS optical balanced path switch 失效
标题翻译： MEMS光学平衡路径开关
公开(公告)号：US06526197B2
公开(公告)日：2003-02-25
申请号：US09829212
申请日：2001-04-09
申请人： Nan Zhang
发明人： Nan Zhang
IPC分类号： G02B626
CPC分类号： G02B6/3518
摘要： An optical switch formed on a substrate with receiving channels defined by alignment grooves formed in the substrate that are offset from alignment grooves that form the inputting channels. The offset receiving channels reduce the output power differentiation from an optical switch in which there is no offset.
摘要翻译：一种形成在基板上的光学开关，其具有由形成在基板中的对准槽限定的接收通道，该对准槽与形成输入通道的对准槽偏移。偏移接收通道减少与没有偏移的光开关的输出功率微分。

60. 发明授权

US06469361B2 Semiconductor wafer 失效
标题翻译：半导体晶圆
公开(公告)号：US06469361B2
公开(公告)日：2002-10-22
申请号：US09946390
申请日：2001-09-04
申请人： Nan Zhang
发明人： Nan Zhang
IPC分类号： H01L2900
CPC分类号： H01L21/32139 , G03F7/095 , G03F7/16 , H01L21/0274 , H01L21/31144
摘要： Techniques for etching a wafer layer using multiple layers of the same photoresistant material and structures formed using such techniques are provided. In a method, first, multiple layers of the same photoresist material are formed over the wafer layer to form a composite photoresist layer. The composite photoresist layer is patterned and developed to form a patterned photoresist layer. Exposed portions of the wafer layer are then removed using the pattern photoresist layer. Each of the multiple layers of photoresist may, for example, be formed to a maximum rated thickness for the photoresist material. Structures formed using this process may have relatively small dimensions (e.g., widths of 5 microns or less or a spacing or pitch of 5 microns or less). In addition, structures may also have sidewalls which are relatively long, smooth, and/or vertical.
摘要翻译：提供了使用相同光致抗蚀剂材料的多层蚀刻晶片层的技术和使用这些技术形成的结构。在一种方法中，首先在晶片层上形成多层相同的光致抗蚀剂材料以形成复合光致抗蚀剂层。将复合光致抗蚀剂层图案化并显影以形成图案化的光致抗蚀剂层。然后使用图案光致抗蚀剂层去除晶片层的暴露部分。例如，可以将多层光致抗蚀剂中的每一层形成为光致抗蚀剂材料的最大额定厚度。使用该方法形成的结构可以具有相对小的尺寸（例如，5微米或更小的宽度或5微米或更小的间距或间距）。此外，结构还可以具有相对长，平滑和/或垂直的侧壁。

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