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51. 发明申请

US20160264106A1 Vehicle Integrated Jack Device 审中-公开
标题翻译：车载集成插孔设备
公开(公告)号：US20160264106A1
公开(公告)日：2016-09-15
申请号：US14656310
申请日：2015-03-12
申请人： Alain Pierre
发明人： Alain Pierre
IPC分类号： B60S9/04
CPC分类号： B60S9/12
摘要： A vehicle integrated jack device provides independent extension of separate jack arms controlled from an interior of a vehicle. The assembly includes a vehicle having a frame and a plurality of wheels coupled to the frame. Each of a plurality of jack arms is coupled to and extendable from the frame of the vehicle. Each of the jack arms is positioned proximate an associated one of the wheels. A control unit is positioned in an interior of the vehicle. Each of the jack arms is operationally coupled to the control unit such that each jack arm is independently extendable by operation of the control unit.
摘要翻译：车辆集成千斤顶装置提供从车辆内部控制的单独的千斤顶臂的独立延伸。组件包括具有框架和耦合到框架的多个轮子的车辆。多个千斤顶臂中的每一个联接到车辆的框架并且可从车辆的框架延伸。每个千斤顶臂都位于相关的一个轮子附近。控制单元位于车辆的内部。每个千斤顶臂可操作地耦合到控制单元，使得每个千斤顶臂可以通过控制单元的操作独立地延伸。

52. 发明授权

US06686348B2 Metalloprotease inhibitors 失效
标题翻译：金属蛋白酶抑制剂
公开(公告)号：US06686348B2
公开(公告)日：2004-02-03
申请号：US10036689
申请日：2001-12-21
申请人： Guillaume De Nanteuil , Alain Benoist , Philippe Pastoureau , Massimo Sabatini , John Hickman , Alain Pierre , Gordon Tucker
发明人： Guillaume De Nanteuil , Alain Benoist , Philippe Pastoureau , Massimo Sabatini , John Hickman , Alain Pierre , Gordon Tucker
IPC分类号： A61K3133
CPC分类号： C07D417/14 , C07D405/14 , C07D491/04
摘要： A compound of formula (I): wherein: R1 represents hydrogen, halogen, alkyl or alkoxy, X represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents any one of the groups described in the description, their isomers and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as metalloprotease inhibitor.
摘要翻译：式（I）的化合物：其中：R1表示氢，卤素，烷基或烷氧基，X表示氧，硫或NR，其中R表示氢或烷基，A表示说明书中所述的任何一种基团，其异构体和加成其与药学上可接受的酸或碱的盐和含有它们的药物可用作金属蛋白酶抑制剂。

53. 发明授权

US4626088A Ocular parameter measuring device with digitally controlled virtual graticules 失效
标题翻译：具有数字控制的虚拟刻度的眼睛参数测量装置
公开(公告)号：US4626088A
公开(公告)日：1986-12-02
申请号：US683389
申请日：1984-12-19
申请人： Christian Joncour , Alain Pierre , Patrice Renan , Jean-Louis Roumegoux , Francoise Richard, deceased , by Jacques M. G. Richard, heir , Alexandra A. C. Richard, heir , Anne-Lise P. M. Richard, heir
发明人： Christian Joncour , Alain Pierre , Patrice Renan , Jean-Louis Roumegoux , Francoise Richard, deceased , by Jacques M. G. Richard, heir , Alexandra A. C. Richard, heir , Anne-Lise P. M. Richard, heir
IPC分类号： A61B3/11 , G02C13/00 , A61B3/10
CPC分类号： A61B3/111 , G02C13/005
摘要： A device for measuring a subject's ocular parameters, in particular the interpupillary distance, comprises a front plate against which the face of the subject is placed, comprising two windows substantially corresponding to the lenses of a pair of eyeglasses. A lens is movable along its optical axis, which is perpendicular to the front plate, from an origin position near the front plate. A viewing eyepiece is disposed at the focus of the lens when in the origin position. A semi-reflecting mirror disposed at 45.degree. renders the eyepiece and a point source coincident, as far as the subject is concerned. Parallel to the semi-reflecting mirror, another mirror reflects an image of a cathode ray tube screen to the eyepiece through another lens. Adjustable calibrated voltage sources are used to produce coincidence of the reflections of the source on the corneas of the eyes of the subject and the luminous traces on the screen of the cathode ray tube, as seen by an operator looking through the eyepiece. These traces constitute graticules, and the voltages which generate them constitute basic measurements of the ocular parameters. The appropriate calculations are implemented by a microprocessor.
摘要翻译：用于测量被摄体的眼睛参数，特别是瞳孔间距离的装置包括被放置对象的脸部的前板，包括基本对应于一对眼镜的镜片的两个窗口。透镜可以沿着与其前端板垂直的光轴从前板附近的原点位置移动。当在原点位置时，观察目镜设置在透镜的焦点处。设置在45度的半反射镜使目镜和点光源重合，就目标而言。与半反射镜平行，另一个镜子通过另一透镜将阴极射线管屏幕的图像反射到目镜。使用可调校准电压源来产生源于受试者眼睛和阴极射线管屏幕上的发光迹线的源的反射的一致性，如通过目镜观察的操作者所见。这些迹线构成刻度，产生它们的电压构成了眼睛参数的基本测量。适当的计算由微处理器实现。

54. 发明授权

US4612736A Method and apparatus for bevelling or grooving ophthalmic lenses 失效
标题翻译：用于斜面或开槽眼镜片的方法和装置
公开(公告)号：US4612736A
公开(公告)日：1986-09-23
申请号：US661314
申请日：1984-10-16
申请人： Christian Massard , Alain Pierre , Jean-Louis Roumegoux
发明人： Christian Massard , Alain Pierre , Jean-Louis Roumegoux
IPC分类号： B24B9/14 , G02C13/00
CPC分类号： B24B9/14
摘要： The peripheral edge of an ophthalmic lens is maintained in contact with a bevelling or grooving wheel while being rotated about an axis of the lens parallel to the axis of the bevelling wheel whereby a bevel or groove is formed in said peripheral edge. The ophthalmic lens is capable of relative axial displacement relative to said bevelling wheel. By way of a force or displacement sensor, the relative axial position of the ophthalmic lens with respect to the bevelling wheel can be made subject to the axial component of reaction forces generated between the lens and the bevelling wheel in their mutual contact zone.
摘要翻译：眼镜片的周边边缘保持与斜边或切槽轮相接触，同时围绕透镜的轴线平行于斜边轮的轴线旋转，从而在所述周缘形成有斜面或凹槽。眼镜片相对于所述倾斜轮具有相对的轴向位移。通过力或位移传感器，眼镜片相对于倾斜轮的相对轴向位置可以在透镜和倾斜轮之间在其相互接触区域中产生的反作用力的轴向分量。

55. 发明申请

US20100168150A1 Camptothecin Analogue Compounds, a Process for Their Preparation and Pharmaceutical Compositions Containing Them. 审中-公开
标题翻译：喜树碱类似物，其制备方法和含有他们的药物组合物。
公开(公告)号：US20100168150A1
公开(公告)日：2010-07-01
申请号：US11990104
申请日：2006-08-04
申请人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , John Hickman , Stephane Leonce
发明人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre , John Hickman , Stephane Leonce
IPC分类号： A61K31/475 , C07D471/14 , A61P35/00
CPC分类号： C07D471/14
摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R5, R80, R90, R81, R91, Alk, Alk′, X, X′ and G are as defined in the description. Medicinal products containing the same which are useful in the treatment of cancer diseases.
摘要翻译：式（I）化合物：其中：R1，R2，R3，R4，R5，R80，R90，R81，R91，Alk，Alk'，X，X'和G如说明书中所定义。含有该药物的药物可用于治疗癌症疾病。

56. 发明授权

US06638962B2 Cycloheptene compounds 失效
标题翻译：环庚烯化合物
公开(公告)号：US06638962B2
公开(公告)日：2003-10-28
申请号：US10050666
申请日：2002-01-16
申请人： Patrick Casara , Thierry Le Diguarher , Gilbert Dorey , John Hickman , Alain Pierre , Gordon Tucker , Nicolas Guilbaud
发明人： Patrick Casara , Thierry Le Diguarher , Gilbert Dorey , John Hickman , Alain Pierre , Gordon Tucker , Nicolas Guilbaud
IPC分类号： A61K314174
CPC分类号： C07D233/64 , A61K31/4164 , C07D213/38 , C07D401/06
摘要： Compound of formula (I): wherein: X represents a bond or alkylene, CO, S(O)n, —S(O)n—A1—, —CO—A1—, —A—S(O)n—A′1— or —A1—CO—A′1—, Y represents aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted, R1, R2, R3 and R4 each independently of the others represent hydrogen or aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each unsubstituted or substituted, or R1, R2, R3 and R4, taken in pairs, together form a bond, or form a fused benzene ring or a fused aromatic or partially unsaturated heterocycle, T represents —CH(R5)—, —N(R5)— or —N(R5)CO—, V represents hydrogen or unsubstituted or substituted aryl or heteroaryl, A2 represents [C(R6)(R′6)]p, R7 and R8 are as defined in the description, their isomers and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as farnesyl transferase inhibitors.
摘要翻译：式（I）的化合物：其中：X表示键或亚烷基，CO，S（O）n，-S（O）n -A1，-CO-A1-，-AS（O）n-A'1 - 或-A1-CO-A'1-，Y表示芳基，杂芳基，环烷基或杂环烷基，每个未取代或取代的，R 1，R 2，R 3和R 4各自独立地表示氢或芳基，杂芳基，环烷基或杂环烷基，每个未取代或取代的或R 1，R 2，R 3和R 4成对取代，一起形成键，或形成稠合苯环或稠合芳族或部分不饱和杂环，T表示-CH（R 5） - ， - N（ R5） - 或-N（R5）CO-，V表示氢或未取代或取代的芳基或杂芳基，A2表示[C（R6）（R'6）] p，R7和R8如说明书中所定义，并且其与药学上可接受的酸或碱的加成盐和含有它们的药物可用作法呢基转移酶抑制剂。

57. 发明授权

US5389644A 1,4-dihydropyridine compounds 失效
标题翻译： 1,4-二氢吡啶化合物
公开(公告)号：US5389644A
公开(公告)日：1995-02-14
申请号：US13297
申请日：1993-02-04
申请人： Jean-Louis Peglion , Ghanem Aasssi , Alain Pierre , Laurence Kraus-Berthier , Nicolas Guilbaud , Jean-Paul Vilaine
发明人： Jean-Louis Peglion , Ghanem Aasssi , Alain Pierre , Laurence Kraus-Berthier , Nicolas Guilbaud , Jean-Paul Vilaine
IPC分类号： A61K31/455 , A61K31/4427 , A61K31/4433 , A61P35/00 , A61P43/00 , C07D211/90 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/44
CPC分类号： C07D211/90 , C07D401/12 , C07D409/12 , C07D413/10 , C07D417/12
摘要： The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to increase the sensitivity of tumor cells to antitumor agents.A compound disclosed is d-2-{[2-(2-(N-p-nitrobenzylamino)ethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine.
摘要翻译：化合物是它们的右旋形式的2,4-二取代的3-乙氧基羰基5-甲氧基羰基-6-甲基1,4-二氢吡啶，可用于增强细胞毒性剂的活性并增加肿瘤细胞对抗肿瘤剂的敏感性。所公开的化合物是d-2 - {[2-（2-（N-硝基苄基氨基）乙氧基）乙氧基]甲基} -4-（2,3-二氯苯基）-3-乙氧基羰基-5-甲氧基羰基-6-甲基-1 ，4-二氢吡啶。

58. 发明授权

US5100881A N-(23-vincristinoyl) and N-(5'-noranhydro-23-vinblastinoyl) compounds of 1-aminomethylphosphonic acid useful for the treatment of neoplastic diseases 失效
标题翻译：用于治疗神经疾病的1-氨基乙基磷酸的N-（23-VINCRISTINOYL）和N-（5'-去甲基-23-VINBLASTINOYL）化合物
公开(公告)号：US5100881A
公开(公告)日：1992-03-31
申请号：US561065
申请日：1990-08-01
申请人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre
发明人： Gilbert Lavielle , Patrick Hautefaye , Alain Pierre
IPC分类号： A61K31/675 , A61P35/00 , C07F9/32 , C07F9/6558 , C07F9/6561
CPC分类号： C07F9/6561
摘要： The invention relates to the compounds of general formula I: ##STR1## in which: R.sub.1 represents a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkenyl radical containing from 2 to 6 carbon atoms, an arylalkyl radical having 7 to 10 carbon atoms and which can bear a halogen atom as a substituent on the aromatic ring, a hydroxyl radical or an alkyl or alkoxy radical each containing from 1 to 5 carbon atoms, a 2-indolylmethyl radical, a 4-imidazolylmethyl radical or an alkoxycarbonylmethyl radical containing from 3 to 11 carbon atoms,R.sub.2 and R.sub.3, which may be identical or different, each represents a linear or branched alkyl radical containing from 1 to 6 carbon atoms,n is equal to 1 or 2,R.sub.4 represents a hydrogen atom, a formyl radical or a methyl radical, with the proviso, however, that R.sub.4 is never the methyl radical when n is equal to 2, andeither R.sub.5 and R.sub.6 together form a double bond, or R.sub.5 represents a hydrogen atom and R.sub.6 a hydroxyl radical,in the form of a mixture of diastereoisomers or of pure isomers, their N.sub.b,-oxides and their addition salts with a pharmaceutically acceptable inorganic or organic acid.These compounds are antitumor agents.
摘要翻译：本发明涉及通式I的化合物：其中：R 1表示氢原子，含有1至6个碳原子的直链或支链烷基，含有直链或支链烯基的基团 2至6个碳原子，具有7至10个碳原子的芳基烷基，其可以带有卤素原子作为芳族环上的取代基，羟基或每个含有1至5个碳原子的烷基或烷氧基， 2-吲哚基甲基，4-咪唑基甲基或含有3至11个碳原子的烷氧基羰基甲基，可以相同或不同的R 2和R 3各自表示含有1至6个碳原子的直链或支链烷基，n 等于1或2，R4表示氢原子，甲酰基或甲基，但条件是，当n等于2时，R 4不是甲基，R 5和R 6一起形成双键，或R 5表示氢原子和R6是非对映异构体或纯异构体的混合物形式的羟基，它们的Nb， - 氧化物及其与药学上可接受的无机酸或有机酸的加成盐。这些化合物是抗肿瘤剂。

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