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51. 发明申请

US20110178133A1 CALCIUM RECEPTOR MODULATING AGENTS 有权
标题翻译：钙受体调节剂
公开(公告)号：US20110178133A1
公开(公告)日：2011-07-21
申请号：US12738279
申请日：2008-10-15
申请人： Thomas S. Coulter , Christopher H. Fotsch , Chiara Ghiron , Paul E. Harrington , Michael G. Kelly , Philip Miller , Gilbert M. Rishton , David J. St.Jean, JR. , David J. Semin
发明人： Thomas S. Coulter , Christopher H. Fotsch , Chiara Ghiron , Paul E. Harrington , Michael G. Kelly , Philip Miller , Gilbert M. Rishton , David J. St.Jean, JR. , David J. Semin
IPC分类号： A61K31/4439 , C07D233/64 , C07D207/335 , C07D207/48 , C07D277/28 , C07D231/16 , C07D231/12 , C07D261/08 , C07D271/06 , C07D401/04 , A61K31/417 , A61K31/40 , A61K31/426 , A61K31/415 , A61K31/42 , A61K31/4245 , A61P3/14 , A61P5/18 , A61P9/00 , A61P1/00 , A61P3/00
CPC分类号： C07D233/64 , C07D207/335 , C07D207/48 , C07D231/12 , C07D231/16 , C07D231/22 , C07D261/08 , C07D271/06 , C07D277/28 , C07D401/04
摘要： The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula I.
摘要翻译：本发明一般涉及新型的拟钙化合物和包含它们的药物组合物。本发明还涉及使用式I表示的化合物治疗与钙感受受体的功能相关的疾病或病症的方法。

52. 发明申请

US20100298285A1 Biclycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof 审中-公开
标题翻译：二辛基芳基化合物作为P2x7调节剂及其用途
公开(公告)号：US20100298285A1
公开(公告)日：2010-11-25
申请号：US12225275
申请日：2007-03-16
申请人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
发明人： Michael G. Kelly , John Kincaid , Yunfeng Fang , Jianhua He , Yeyu Cao , Carl Kaub , Sumithra Gowlugari , Zhan Wang
IPC分类号： A61K31/397 , C07D217/18 , C07D217/04 , C07D413/12 , A61K31/47 , A61K31/538 , A61P29/00 , A61P25/16 , A61P37/00 , A61P25/18 , A61P25/00 , A61P25/06 , A61P9/10 , A61P13/00 , A61P19/02 , A61P3/04 , A61P17/06 , A61P3/00 , A61P35/00
CPC分类号： C07D409/06 , C07D217/04 , C07D217/06 , C07D217/08 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

53. 发明申请

US20090264424A1 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
标题翻译： VANILLOID受体配体及其在治疗中的应用
公开(公告)号：US20090264424A1
公开(公告)日：2009-10-22
申请号：US12492376
申请日：2009-06-26
申请人： Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
发明人： Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号： A61K31/536 , C07D265/36 , A61P29/00
CPC分类号： C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

54. 发明授权

US07579347B2 Vanilloid receptor ligands and their use in treatments 失效
标题翻译：香草素受体配体及其在治疗中的应用
公开(公告)号：US07579347B2
公开(公告)日：2009-08-25
申请号：US11100077
申请日：2005-04-05
申请人： Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
发明人： Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , A61K31/4427 , A61K31/4523 , A61K31/47 , A61K31/497 , A61K31/5377 , A61P29/00 , A61P25/04
CPC分类号： C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，咳嗽痛，交感神经痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒症，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

55. 发明申请

US20090170838A1 Bicycloheteroaryl compounds as P2X7 modulators and uses thereof 审中-公开
标题翻译：双环杂芳基化合物作为P2X7调节剂及其用途
公开(公告)号：US20090170838A1
公开(公告)日：2009-07-02
申请号：US12218620
申请日：2008-07-16
申请人： Michael G. Kelly , John Kincaid
发明人： Michael G. Kelly , John Kincaid
IPC分类号： A61K31/47 , C07D217/24 , C07D401/06 , C07D413/06 , C07D417/06 , A61K31/497 , A61K31/5377 , A61K31/541 , A61P25/00 , A61P35/00 , A61P3/00 , A61P9/00
CPC分类号： C07D217/24 , C07D401/06 , C07D405/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D487/04
摘要： Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的双杂环芳基化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

56. 发明申请

US20080300243A1 Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same 审中-公开
标题翻译：酰胺衍生物作为离子通道配体和药物组合物及其使用方法
公开(公告)号：US20080300243A1
公开(公告)日：2008-12-04
申请号：US11885300
申请日：2006-02-24
申请人： Michael G. Kelly , John Kincaid , Matthew Duncton , Kiran Sahasrabudhe , Satyanarayana Janagani , Ravindra B. Upasani , Guoxian Wu , YunFeng Fang , Zhi-Liang Wei , Carl Kaub , Jianhua He
发明人： Michael G. Kelly , John Kincaid , Matthew Duncton , Kiran Sahasrabudhe , Satyanarayana Janagani , Ravindra B. Upasani , Guoxian Wu , YunFeng Fang , Zhi-Liang Wei , Carl Kaub , Jianhua He
IPC分类号： A61K31/5365 , C07C211/44 , A61K31/136 , C07D215/38 , A61K31/4706 , A61K31/416 , C07D471/04 , C07D277/62 , A61K31/357 , C07D209/82 , C07D405/02 , C07D401/14 , C07D333/72 , A61K31/381 , A61K31/498 , C07D241/36 , C07D237/30 , A61K31/502 , A61P19/02 , A61P25/28 , A61K31/403 , A61K31/4439 , A61K31/443 , C07D319/14 , A61K31/428 , A61K31/437 , A61K31/404 , C07D209/04 , C07D231/56 , C07D498/04
CPC分类号： C07D319/18 , C07C233/65 , C07C233/66 , C07C233/75 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07D209/08 , C07D209/88 , C07D215/38 , C07D217/02 , C07D231/56 , C07D265/36 , C07D267/14 , C07D277/64 , C07D317/66 , C07D333/54 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D498/04
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛，炎症，创伤性损伤等。

57. 发明申请

US20080275037A1 2-Cyanophenyl fused heterocyclic compounds, and compositions and uses thereof 有权
标题翻译： 2-氰基苯基稠合杂环化合物及其组合物和用途
公开(公告)号：US20080275037A1
公开(公告)日：2008-11-06
申请号：US12080253
申请日：2008-03-31
申请人： Zhi-Liang Wei , Donogh John Roger O'Mahony , Matthew Duncton , John Kincaid , Michael G. Kelly , Zhan Wang
发明人： Zhi-Liang Wei , Donogh John Roger O'Mahony , Matthew Duncton , John Kincaid , Michael G. Kelly , Zhan Wang
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61P25/00 , A61P25/28 , A61P25/18 , A61P29/00 , A61P11/00 , A61P1/00 , A61P19/02 , A61P17/06 , A61P19/00 , A61P3/00 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
摘要翻译：根据式1提供稠合的杂环化合物：其中R 1，R 2，R 3和M如本文所定义。提供的化合物及其药物组合物可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，认知障碍，焦虑，抑郁等。

58. 发明申请

US20080200524A1 Amide compounds as ion channel ligands and uses thereof 审中-公开
公开(公告)号：US20080200524A1
公开(公告)日：2008-08-21
申请号：US11982351
申请日：2007-11-01
申请人： Michael G. Kelly , Satyanarayana Janagani , Guoxian Wu , John Kincaid
发明人： Michael G. Kelly , Satyanarayana Janagani , Guoxian Wu , John Kincaid
IPC分类号： A61K31/4418 , A61P13/00 , A61P25/00 , A61P29/00 , A61P19/02
CPC分类号： C07D405/12 , C04B35/632 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/75 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

59. 发明授权

US5005823A Corner alignment system 失效
标题翻译：角对齐系统
公开(公告)号：US5005823A
公开(公告)日：1991-04-09
申请号：US376391
申请日：1989-07-06
申请人： Donald C. Fyler , Edward A. Van Duyne , Michael G. Kelly
发明人： Donald C. Fyler , Edward A. Van Duyne , Michael G. Kelly
IPC分类号： A41H43/02 , B65H7/02
CPC分类号： A41H43/02 , B65H7/02 , B65H2511/20 , B65H2511/514 , B65H2513/50 , B65H2557/52 , Y10S294/907
摘要： A system for locating a corner of an angularly oriented workpiece on a worksurface includes a gripper and associated two axis transport assembly, and a set of sensors on the gripper for detecting reflected radiation from the workpiece and surrounding work. A controller translates the gripper in the directions of two orthogonal axes until the sensors each overlie an edge of the corner-to-be detected. In the preferred form, the transport assembly includes a pneumatic position control system for each axis. Each pneumatic position control system includes an air cylinder and associated piston, a position valve assembly and a controller, and may further include a velocity valve assembly. The controller may control the position valve assembly to be in a first state during a selected time interval, thereby establishing axial motion of the piston in a first direction during that interval. Alternatively, the controller may control the position valve assembly to be in a second state during a selected time interval, thereby establishing axial motion of the piston in a second direction during that interval. The controller may also establish substantially no motion of the piston during a selected interval by alternately controlling the position valve assembly to be in its first state and its second state during the time interval. The velocity valve assembly controls the pneumatic impedance in the coupling path to the cylinder in order to selectively establish desired velocity for piston motion.
摘要翻译：用于定位工件表面上的角度定向的工件的角的系统包括夹具和相关联的双轴传送组件以及夹持器上的一组传感器，用于检测来自工件的反射辐射和周围的工作。控制器将夹具沿两个正交轴线的方向平移，直到传感器各自覆盖待检测角的边缘。在优选形式中，运输组件包括用于每个轴的气动位置控制系统。每个气动位置控制系统包括气缸和相关联的活塞，位置阀组件和控制器，并且还可以包括速度阀组件。控制器可以在选定的时间间隔期间控制位置阀组件处于第一状态，从而在该间隔期间沿第一方向建立活塞的轴向运动。或者，控制器可以在选定的时间间隔期间将位置阀组件控制在第二状态，从而在该间隔期间在第二方向上建立活塞的轴向运动。控制器还可以通过在时间间隔期间交替地控制位置阀组件处于其第一状态和其第二状态来在所选择的间隔期间基本上不建立活塞的运动。速度阀组件控制到气缸的联接路径中的气动阻抗，以便选择性地建立用于活塞运动的期望速度。

60. 发明授权

US4395566A Solvent-free esterification of carboxyaromatics 失效
标题翻译：无溶剂的羧基芳族化合物的酯化
公开(公告)号：US4395566A
公开(公告)日：1983-07-26
申请号：US355812
申请日：1982-03-08
申请人： James H. Covill , Michael G. Kelly , Thomas F. Leahy
发明人： James H. Covill , Michael G. Kelly , Thomas F. Leahy
IPC分类号： C07C67/08
CPC分类号： C07C67/08
摘要： An improved process for exterifying carboxyaromatics is disclosed wherein an anhydride of a carboxyaromatic, such as pyromellitic dianhydride, is reacted with a fluorinated alcohol and an epoxide to give a mixed ester capable of imparting oil and/or water repellency to textiles. The improvement comprises utilizing the epoxide as the reaction medium to reduce reaction times and waste water treatment requirements.
摘要翻译：公开了一种改进的羧基芳族化合物的方法，其中羧基芳族化合物如1,2,4,5-苯四酸二酐与氟化醇和过氧化物反应，得到能够赋予纺织品油和/或拒水性的混合酯。改进之处在于利用过氧化物作为反应介质，以减少反应时间和废水处理要求。

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