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    • 52. 发明授权
    • In situ venous valve device and method of formation
    • 原位静脉瓣装置及其形成方法
    • US06902576B2
    • 2005-06-07
    • US10376047
    • 2003-02-26
    • William J. DraslerJoseph M. Thielen
    • William J. DraslerJoseph M. Thielen
    • A61F2/24A61F2/06
    • A61F2/2475A61F2/2412
    • A venous valve device provides antegrade blood flow in venous vessels of the body having dysfunctional valves; it is formed in situ from autologous vein conduit not having a valve present locally. An overlap region is formed by attaching two opposing walls of the vein together in a generally axial direction forming two tubular regions. One region provides antegrade blood flow and the other region provides a sinus cavity that is filled during the initiation of retrograde blood flow. A valve cusp is formed by attaching vessel wall together forming a commissure that extends between the two overlap regions. A single valve cusp moves toward the sinus cavity to allow antegrade blood flow and moves away from the sinus cavity to block retrograde blood flow. The venous valve can also be formed from biological tissue from an autologous, heterologous, or other tissue source and implanted interpositionally at the site of valvular incompetancy.
    • 静脉瓣装置在身体的静脉血管中提供顺行血流,具有功能不全的瓣膜; 它是从没有局部存在阀的自体静脉导管就地形成的。 通过将静脉的两个相对的壁沿大致轴向连接形成两个管状区域而形成重叠区域。 一个区域提供顺行血流,另一个区域提供在逆行血流开始期间填充的窦腔。 通过将容器壁连接在一起而形成阀尖,形成在两个重叠区域之间延伸的连合部。 单个阀尖朝向窦腔移动以允许顺行血液流动并远离窦腔移动以阻止逆行血流。 静脉瓣也可以由来自自体,异源或其他组织源的生物组织形成,并且插入位置在瓣膜无能力部位。
    • 54. 发明授权
    • Distal protection and delivery system and method
    • 远端保护和输送系统及方法
    • US07261727B2
    • 2007-08-28
    • US10458996
    • 2003-06-11
    • Joseph M. Thielen
    • Joseph M. Thielen
    • A61M29/00
    • A61F2/013A61F2002/015A61F2002/018A61F2002/30329A61F2220/0025A61F2230/0006A61F2230/0008A61F2230/008
    • A distal protection and delivery system is used to collect and remove embolic debris in the blood vessel. The system includes a guidewire, a filter assembly, and a distal introducer. The distal introducer can be positioned on a distal end of an introducer catheter or an angioplasty catheter or other interventional catheter. The guidewire has a small ferrule or locking mechanism fixed to it that does not affect the flexibility, torqueability, or trackability in comparison to standard guidewires. The introducer containing the filter assembly is advanced over the guidewire to a site distal to the lesion. Upon retraction of the guidewire proximally, the ferrule latches with an ejector latch of the filter assembly. Either advancement of the guidewire distally or retraction of the distal introducer proximally allows the filter assembly to be ejected from the distal introducer and into the blood vessel.
    • 远端保护和输送系统用于收集和清除血管中的栓塞性碎屑。 该系统包括导丝,过滤器组件和远端导引器。 远端引导器可以定位在导引导管或血管成形术导管或其他介入导管的远端上。 导丝具有固定到其上的小套圈或锁定机构,其与标准导线相比不影响柔性,可扭转性或可跟踪性。 包含过滤器组件的导引器在导丝上前进到病变远侧的部位。 当导丝线向近端缩回时,套圈用过滤器组件的推出器闩锁闩锁。 导线的前进或远端引导器向远端的缩回允许过滤器组件从远端导引器喷射并进入血管。
    • 55. 发明授权
    • Distal protection and delivery system and method
    • 远端保护和输送系统及方法
    • US06616680B1
    • 2003-09-09
    • US09703887
    • 2000-11-01
    • Joseph M. Thielen
    • Joseph M. Thielen
    • A61M2900
    • A61F2/013A61F2002/015A61F2002/018A61F2002/30329A61F2220/0025A61F2230/0006A61F2230/0008A61F2230/008
    • A distal protection and delivery system is used to collect and remove embolic debris in the blood vessel. The system includes a guidewire, a filter assembly, and a distal introducer. The distal introducer can be positioned on a distal end of an introducer catheter or an angioplasty catheter or other interventional catheter. The guidewire has a small ferrule or locking mechanism fixed to it that does not affect the flexibility, torqueability, or trackability in comparison to standard guidewires. The introducer containing the filter assembly is advanced over the guidewire to a site distal to the lesion. Upon retraction of the guidewire proximally, the ferrule latches with an ejector latch of the filter assembly. Either advancement of the guidewire distally or retraction of the distal introducer proximally allows the filter assembly to be ejected from the distal introducer and into the blood vessel.
    • 远端保护和输送系统用于收集和清除血管中的栓塞性碎屑。 该系统包括导丝,过滤器组件和远端导引器。 远端引导器可以定位在导引导管或血管成形术导管或其他介入导管的远端上。 导丝具有固定到其上的小套圈或锁定机构,其与标准导丝线相比不会影响柔性,可扭转性或可跟踪性。 包含过滤器组件的导引器在导丝上前进到病变远侧的部位。 当导丝线向近端缩回时,套圈用过滤器组件的推出器闩锁闩锁。 远端引导导线的前进或远端引导器向近端的缩回允许过滤器组件从远端导引器喷射并进入血管。