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51. 发明授权

US08577458B1 Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring 有权
标题翻译：用于提供电刺激颈部迷走神经用于治疗慢性心脏功能障碍的无植入式器械的无植入装置
公开(公告)号：US08577458B1
公开(公告)日：2013-11-05
申请号：US13314126
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/05
CPC分类号： A61N1/3702 , A61N1/36114 , A61N1/36139 , A61N1/36175
摘要： An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. Finally, the neurostimulator includes an integrated leadless heart rate sensor configured to sense heart rate and to record the sensed heart rate as data into a memory.
摘要翻译：提供了一种用于提供用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激用于无引导心率监测的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射，方向动作电位。最后，神经刺激器包括被配置为感测心率并将感测的心率作为数据记录到存储器中的集成的无引线心率传感器。

52. 发明申请

US20130184773A1 Vagus Nerve Neurostimulator With Multiple Patient-Selectable Modes For Treating Chronic Cardiac Dysfunction 有权
标题翻译：迷走神经神经刺激器具有多种患者可选择的治疗慢性心脏功能障碍的模式
公开(公告)号：US20130184773A1
公开(公告)日：2013-07-18
申请号：US13352244
申请日：2012-01-17
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/3727
摘要： A vagus nerve neurostimulator system with multiple patient-selectable modes for treating chronic cardiac dysfunction is provided. An implantable neurostimulator includes a pulse generator coupled to a therapy lead terminated by a pair of helical electrodes positioned over a cervical vagus nerve. The pulse generator is configured to deliver through the helical electrodes continuously-cycling, intermittent and periodic electrical stimulation that is parametrically defined to bi-directionally propagate through nerve fibers in the cervical vagus nerve. The implantable neurostimulator includes a magnetic switch configured to switch the pulse generator between a plurality of operating modes that are each separately selectable in response to a unique and remotely-applied magnetic signal. An external controller includes patient-actuatable controls configured to enable selection of one of the operating modes of the pulse generator. The external controller includes an electromagnetic transmitter configured to output the magnetic signal uniquely associated with the operating mode as selected with the controls.
摘要翻译：提供了一种具有多种患者可选择的用于治疗慢性心脏功能障碍的模式的迷走神经神经刺激器系统。可植入的神经刺激器包括一个脉冲发生器，该脉冲发生器耦合到由位于颈部迷走神经上的一对螺旋电极终止的治疗引线。脉冲发生器被配置为通过螺旋电极连续循环，间歇和周期性电刺激传递，其被参数限定以通过颈部迷走神经中的神经纤维双向传播。可植入神经刺激器包括磁开关，其被配置为在多个操作模式之间切换脉冲发生器，所述多个操作模式可以响应于独特的和远程施加的磁信号而分别可选择。外部控制器包括被配置为能够选择脉冲发生器的一个操作模式的患者致动控制。外部控制器包括电磁发射机，其被配置为输出与通过控制选择的操作模式唯一相关联的磁信号。

53. 发明申请

US20130158622A1 Implantable Device For Facilitating Control Of Electrical Stimulation Of Cervical Vagus Nerves For Treatment Of Chronic Cardiac Dysfunction 有权
标题翻译：用于促进控制电刺激颈椎迷走神经治疗慢性心脏功能障碍的植入装置
公开(公告)号：US20130158622A1
公开(公告)日：2013-06-20
申请号：US13314130
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/37217 , A61N1/36114
摘要： An implantable device for facilitating control of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. Finally, the neurostimulator includes a programmable switch configured to alter the triggering of the bi-directional action potentials in response to a magnetic signal received from outside the housing.
摘要翻译：提供了一种用于促进控制用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射，方向动作电位。最后，神经刺激器包括可编程开关，其被配置为响应于从壳体外部接收的磁信号来改变双向动作电位的触发。

54. 发明申请

US20080183264A1 ELECTRODE CONFIGURATIONS FOR TRANSVASCULAR NERVE STIMULATION 审中-公开
标题翻译：用于透视神经刺激的电极配置
公开(公告)号：US20080183264A1
公开(公告)日：2008-07-31
申请号：US11668957
申请日：2007-01-30
申请人： Mark J. Bly , David J. Smith , Imad Libbus
发明人： Mark J. Bly , David J. Smith , Imad Libbus
IPC分类号： A61N1/05
CPC分类号： A61N1/057
摘要： An intravascular lead adapted to be deployed to a stimulation site within a vessel adjacent a nerve to be stimulated includes at least a first electrode adapted to deliver an electrical pulse across a vessel wall. The first electrode includes an electrically active surface having one or more surface features adapted to focus current. The first electrode is disposed on the distal portion that the electrically active surface can be directed towards the nerve to be stimulated.
摘要翻译：适于部署到邻近被刺激的神经的血管内的刺激部位的血管内线包括至少第一电极，其适于将电脉冲传送穿过血管壁。第一电极包括具有适于聚焦电流的一个或多个表面特征的电活性表面。第一电极设置在远端部分上，电活性表面可以被引导到被刺激的神经。

55. 发明申请

US20120046709A1 METHOD AND APPARATUS FOR CONTROLLING NEURAL STIMULATION DURING DISORDERED BREATHING 有权
标题翻译：用于控制异常呼吸期间神经刺激的方法和装置
公开(公告)号：US20120046709A1
公开(公告)日：2012-02-23
申请号：US13285457
申请日：2011-10-31
申请人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
发明人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

56. 发明授权

US08457734B2 System and method for neural stimulation 有权
公开(公告)号：US08457734B2
公开(公告)日：2013-06-04
申请号：US11468135
申请日：2006-08-29
申请人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
发明人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

57. 发明授权

US08554323B2 Method and apparatus for neural stimulation with respiratory feedback 有权
标题翻译：呼吸反馈神经刺激的方法和装置
公开(公告)号：US08554323B2
公开(公告)日：2013-10-08
申请号：US13363198
申请日：2012-01-31
申请人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
发明人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/365
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

58. 发明申请

US20100114226A1 SYSTEM TO PROVIDE MYOCARDIAL AND NEURAL STIMULATION 有权
标题翻译：系统提供心肌和神经刺激
公开(公告)号：US20100114226A1
公开(公告)日：2010-05-06
申请号：US12686704
申请日：2010-01-13
申请人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
发明人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/36114 , A61N1/36057 , A61N1/36117 , A61N1/36128 , A61N1/3621 , A61N1/3627
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种方面提供可植入装置。在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到电极。刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适用于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。

59. 发明授权

US07660628B2 System to provide myocardial and neural stimulation 有权
标题翻译：系统提供心肌和神经刺激
公开(公告)号：US07660628B2
公开(公告)日：2010-02-09
申请号：US11087935
申请日：2005-03-23
申请人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
发明人： Imad Libbus , Qingsheng Zhu , Scott Vanderlinde , Andrew P. Kramer , Ankur Garg , Kristofer J. James
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36057 , A61N1/36117 , A61N1/36128 , A61N1/3621 , A61N1/3627
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种方面提供可植入装置。在各种实施例中，该装置包括至少一个端口，其中每个端口适于将引线与电极连接到该装置。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道传递到电极。刺激电路适于通过刺激通道递送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适用于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。

60. 发明授权

US08050765B2 Method and apparatus for controlling neural stimulation during disordered breathing 有权
标题翻译：在无序呼吸期间控制神经刺激的方法和装置
公开(公告)号：US08050765B2
公开(公告)日：2011-11-01
申请号：US11468603
申请日：2006-08-30
申请人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
发明人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
IPC分类号： A61N1/08
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

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