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51. 发明申请

US20060206150A1 Methods and apparatus for treating acute myocardial infarction 审中-公开
标题翻译：治疗急性心肌梗死的方法和装置
公开(公告)号：US20060206150A1
公开(公告)日：2006-09-14
申请号：US11368971
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Howard Levin , Mark Gelfand
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating acute myocardial infarction, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于通过脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗急性心肌梗塞的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，凋亡的坏死和/或诱导，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

52. 发明申请

US20060265015A1 Methods and apparatus for monopolar renal neuromodulation 有权
标题翻译：单极肾神经调节的方法和装置
公开(公告)号：US20060265015A1
公开(公告)日：2006-11-23
申请号：US11403329
申请日：2006-04-13
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Howard Levin , Mark Gelfand , US Zadno
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Howard Levin , Mark Gelfand , US Zadno
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/0551 , A61N1/32 , A61N1/327
摘要： Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.
摘要翻译：提供了用于单极神经调节的方法和装置，例如通过脉冲电场。这种单极神经调节可能会导致不可逆的电穿孔或电融合，坏死和/或诱导凋亡，基因表达的改变，动作电位减弱或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，单极神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种单极神经调节是双侧进行的。

53. 发明申请

US20070213740A1 Obesity treatment tools and methods 有权
公开(公告)号：US20070213740A1
公开(公告)日：2007-09-13
申请号：US11801474
申请日：2007-05-10
申请人： Mark Deem , Douglas Sutton , Hanson Gifford , Benard Andreas , Ronald French
发明人： Mark Deem , Douglas Sutton , Hanson Gifford , Benard Andreas , Ronald French
IPC分类号： A61B17/122
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods

54. 发明申请

US20070118158A1 Obesity treatment tools and methods 有权
标题翻译：肥胖治疗工具和方法
公开(公告)号：US20070118158A1
公开(公告)日：2007-05-24
申请号：US11654709
申请日：2007-01-18
申请人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
发明人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
IPC分类号： A61B17/08
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.
摘要翻译：本文描述了各种肥胖治疗工具和方法，以及用于其它胃相关疾病例如GERD的治疗。治疗包括减小胃袋的尺寸以限制热量摄入以及提供较早的饱腹感。这可以通过在胃内部直接从胃内部产生较小的胃袋来完成。较小的袋可以通过使用单独的锚定装置，旋转探针或体积减小装置来制造。还可以进行幽门成形术以使幽门括约肌无能力。另外可以使用无创伤的磁性吻合装置进行胃旁路手术，使得糖和脂肪在绕过胃时直接通过肠。这些程序中的许多可以以各种组合进行。治疗可能会通过阻止摄入高热量食物而产生强制行为改变。

55. 发明申请

US20060174870A1 Methods and devices for use in performing pulmonary procedures 有权
公开(公告)号：US20060174870A1
公开(公告)日：2006-08-10
申请号：US11395396
申请日：2006-03-30
申请人： Mark Deem , Hanson Gifford , Ronald French , Douglas Sutton
发明人： Mark Deem , Hanson Gifford , Ronald French , Douglas Sutton
IPC分类号： A61M16/00 , A62B9/06
CPC分类号： F16K15/147 , A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/04 , A61F2/24 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , Y10S128/912
摘要： Systems, methods and devices for performing pulmonary procedures, and in particular treating lung disease. A flow control element includes a valve that prevents airflow in the inhalation direction but permits airflow in the exhalation direction. The flow control element is guided to and positioned at the site by a bronchoscope that is introduced into the patient's trachea and used to view the lungs during delivery of the flow control element. The valve may include one, two or more valve elements, and it may be collapsible for easier delivery. A source of vacuum or suction may be used to increase the amount of fluid withdrawn from the lung tissue. A device for measuring hollow structures, such as bronchioles, and a device for removing a previously-placed flow control element are disclosed as well.

56. 发明申请

US20070213748A1 Obesity treatment tools and methods 有权
公开(公告)号：US20070213748A1
公开(公告)日：2007-09-13
申请号：US11801450
申请日：2007-05-10
申请人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
发明人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
IPC分类号： A61B17/00
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods

57. 发明申请

US20070118159A1 Obesity treatment tools and methods 有权
公开(公告)号：US20070118159A1
公开(公告)日：2007-05-24
申请号：US11654783
申请日：2007-01-18
申请人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
发明人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.

58. 发明申请

US20050051163A1 Methods and devices for use in performing pulmonary procedures 审中-公开
公开(公告)号：US20050051163A1
公开(公告)日：2005-03-10
申请号：US10703919
申请日：2003-11-06
申请人： Mark Deem , Bernard Andreas , Sunmi Chew , Antony Fields , Ronald French , Hanson Gifford , Ronald Hundermark , Alan Rapacki , Douglas Sutton , Peter Wilson
发明人： Mark Deem , Bernard Andreas , Sunmi Chew , Antony Fields , Ronald French , Hanson Gifford , Ronald Hundermark , Alan Rapacki , Douglas Sutton , Peter Wilson
IPC分类号： A61B17/22 , A61B19/00 , A61F2/04 , A61F2/24 , A61M23/00 , A62B7/00 , A61M15/00
CPC分类号： A61F2/24 , A61B17/12104 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0067 , A61F2230/0091 , F16K15/147
摘要： An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.

59. 发明申请

US20070282349A1 Obesity treatment tools and methods 有权
公开(公告)号：US20070282349A1
公开(公告)日：2007-12-06
申请号：US11801449
申请日：2007-05-10
申请人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
发明人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
IPC分类号： A61B17/00
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods

60. 发明申请

US20070129760A1 Methods and apparatus for intravasculary-induced neuromodulation or denervation 有权
标题翻译：用于血管内诱导的神经调节或去神经支配的方法和装置
公开(公告)号：US20070129760A1
公开(公告)日：2007-06-07
申请号：US11599649
申请日：2006-11-14
申请人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Erik Thai , Benjamin Clark , Nicolas Zadno
发明人： Denise Demarais , Hanson Gifford , Mark Deem , Douglas Sutton , Erik Thai , Benjamin Clark , Nicolas Zadno
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61B18/1492 , A61B2018/00214 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00613 , A61B2018/143 , A61B2018/1432 , A61N1/0529 , A61N1/0539 , A61N1/0551 , A61N1/36007 , A61N1/36017 , A61N1/36021 , A61N1/36025 , A61N1/36114 , A61N7/022 , A61N2007/003
摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation or denervation. Neuromodulation may be achieved via direct and/or via indirect application of energy or neuromodulatory agents to target neural matter, or to vascular structures that support the target neural matter. In some embodiments, parameters of the target neural matter, of non-target tissue, or of the apparatus may be monitored via one or more sensors for controlling the neuromodulation or denervation. Such monitoring data optionally may be utilized for feedback control of the neuromodulation or denervation.
摘要翻译：提供了血管内诱导的神经调节或去神经支配的方法和装置。神经调节可以通过直接和/或通过将能量或神经调节剂间接施用于靶神经物质或支持靶神经物质的血管结构来实现。在一些实施例中，可以通过用于控制神经调节或去神经支配的一个或多个传感器监测目标神经物质，非目标组织或装置的参数。这种监测数据可选地用于神经调节或去神经支配的反馈控制。

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