专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明授权

US5981275A Transgene expression system for increased persistence 失效
标题翻译：转基因表达系统增加持久性
公开(公告)号：US5981275A
公开(公告)日：1999-11-09
申请号：US839552
申请日：1997-04-14
申请人： Donna Armentano , John Marshall , Nelson S. Yew , Seng H. Cheng , Richard J. Gregory
发明人： Donna Armentano , John Marshall , Nelson S. Yew , Seng H. Cheng , Richard J. Gregory
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P11/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/861 , C12N15/00
CPC分类号： C12N15/86 , C07K14/4712 , A61K48/00 , C12N2710/10343 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/60 , C12N2830/85
摘要： The invention is directed to a transgene expression system comprising a transcription unit which contains a transgene operably linked to expression control sequences, preferably the CMV promoter, and which is delivered simultaneously with all or part of the adenovirus E4 genomic region to a cell in order to facilitate persistent expression of the transgene. The components of the transgene expression system can be delivered by vectors including plasmids and/or viruses and may be complexed with cationic amphiphiles to facilitate entry into a cell. The invention is also directed to methods for the production of the transgene expression system. The invention is further directed to compositions that contain the transgene expression system and to methods for the use of such compositions to deliver transgenes encoding biologically active proteins to cells.
摘要翻译：本发明涉及包含转录单元的转基因表达系统，该转录单元含有可操作地连接到表达调控序列，优选CMV启动子的转基因，并且其与全部或部分腺病毒E4基因组区域同时递送至细胞，以便促进转基因的持续表达。转基因表达系统的组分可以通过包括质粒和/或病毒的载体递送，并且可以与阳离子两亲物复合以便于进入细胞。本发明还涉及生产转基因表达系统的方法。本发明还涉及含有转基因表达系统的组合物以及使用这种组合物将编码生物活性蛋白质的转基因递送至细胞的方法。

52. 发明授权

US5939401A Cationic amphiphile compositions for intracellular delivery of therapeutic molecules 失效
标题翻译：用于细胞内递送治疗分子的阳离子两亲物组合物
公开(公告)号：US5939401A
公开(公告)日：1999-08-17
申请号：US680354
申请日：1996-07-15
申请人： John Marshall , David J. Harris , Edward R. Lee , Craig S. Siegel , Simon J. Eastman , Chau-Dung Chang , Ronald K. Scheule , Seng H. Cheng
发明人： John Marshall , David J. Harris , Edward R. Lee , Craig S. Siegel , Simon J. Eastman , Chau-Dung Chang , Ronald K. Scheule , Seng H. Cheng
IPC分类号： A61K47/48 , A61K9/127 , A61K31/70 , A61K47/28 , A61K48/00 , C07J41/00 , C07J43/00 , C12N15/87 , C12N15/88 , A61K38/00 , C07J9/00
CPC分类号： A61K9/1272 , A61K47/48038 , A61K47/48046 , A61K47/48123 , C07J41/0005 , C07J41/0055 , C07J41/0061 , C07J43/003 , C12N15/88 , A61K48/00
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. By this invention, such cationic amphiphile is used in a state in which it is capable of accepting additional protons, i.e., it is not fully protonated. For purposes of this invention, cationic amphiphiles may be considered to encompass four general categories: (A) T-shaped/steroid-based amphiphiles; (B) T-shaped/non steroid-based amphiphiles; (C) non T-shaped/steroid based amphiphiles and (D) non T-shaped/non steroid-based amphiphiles.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。通过本发明，这种阳离子两亲物以其能够接受另外的质子即不完全质子化的状态使用。为了本发明的目的，阳离子两亲物可以被认为包括四个一般类别：（A）T型/类固醇基两亲物; （B）T型/非类固醇基两亲物; （C）非T型/类固醇基两亲物和（D）非T型/非类固醇基两亲物。

53. 发明授权

US5650096A Cationic amphiphiles for intracellular delivery of therapeutic molecules 失效
标题翻译：阳离子两亲物用于细胞内递送治疗分子
公开(公告)号：US5650096A
公开(公告)日：1997-07-22
申请号：US352479
申请日：1994-12-09
申请人： David J. Harris , Edward R. Lee , Craig S. Siegel , Seng H. Cheng , Simon J. Eastman , John Marshall
发明人： David J. Harris , Edward R. Lee , Craig S. Siegel , Seng H. Cheng , Simon J. Eastman , John Marshall
IPC分类号： A61K9/127 , A61K48/00 , C07J41/00 , C07J43/00 , B01F17/16
CPC分类号： C07J43/003 , A61K47/48038 , A61K47/48046 , A61K47/48123 , A61K48/00 , A61K9/1272 , C07J41/0005 , C07J41/0055 , C07J41/0061 , Y10S514/975
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active molecules into cells. Typically, the amphiphiles contain lipophilic groups derived from steroids or from mono or dialkylamines, and two cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles, with or without colipids, and therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, polypeptides and low molecular weight organic compounds. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性分子进入细胞。通常，两亲物含有衍生自类固醇或单或二烷基胺的亲脂基团，以及两种阳离子基团，其在生理pH下可质子化，衍生自胺，烷基胺或多烷基胺。还提供了通常通过使一种或多种阳离子两亲物的分散体与或不与咔啉和治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA，多肽和低分子量有机化合物。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。

54. 发明授权

US4638639A Gas refrigeration method and apparatus 失效
标题翻译：气体制冷方法及装置
公开(公告)号：US4638639A
公开(公告)日：1987-01-27
申请号：US758001
申请日：1985-07-23
申请人： John Marshall , John D. Oakey
发明人： John Marshall , John D. Oakey
IPC分类号： F25J1/00 , F25B9/10 , F25J1/02
CPC分类号： F25J1/004 , F25J1/0015 , F25J1/0022 , F25J1/0037 , F25J1/0045 , F25J1/0072 , F25J1/0208 , F25J2270/06 , F25J2270/90 , F25J2290/10
摘要： A method of liquefying a permanent gas stream, includes the steps of reducing the temperature of the permanent gas stream at elevated pressure to below its critical pressure and performing at least two working fluid cycles to provide at least part of the refrigeration necessary to reduce the temperature of the permanent gas to below its critical temperature. Each working fluid cycle comprises work-expanding the cooled working fluid in countercurrent heat exchange with the permanent gas stream and with the working fluid being cooled, refrigeration thereby being provided for the permanent gas stream. In at least one working fluid cycle, work-expanded working fluid is brought into countercurrent heat exchange relationship with the permanent gas stream at a temperature below the critical temperature of the permanent gas and in the or each such cycle on completion of the work expansion the working fluid is at a pressure of at least 10 atmospheres.
摘要翻译：一种液化永久性气体流的方法包括以下步骤：将永久气体流在升高的压力下降低至其临界压力以下，并执行至少两个工作流体循环以提供必要的至少一部分制冷以降低温度的永久气体低于其临界温度。每个工作流体循环包括使冷却的工作流体与永久气流逆流热交换并且工作流体被冷却的工作膨胀，由此为永久气流提供制冷。在至少一个工作流体循环中，工作膨胀的工作流体在低于永久气体的临界温度的温度下与永久性气体流形成逆流热交换关系，并且在工作膨胀完成时或每个这样的循环中工作流体处于至少10个大气压的压力。

55. 发明授权

US4021300A Improved nuclear fuel assembly grid spacer 失效
标题翻译：改进的核燃料组件网格间隔
公开(公告)号：US4021300A
公开(公告)日：1977-05-03
申请号：US580498
申请日：1975-05-23
申请人： John Marshall , Samuel Kaplan
发明人： John Marshall , Samuel Kaplan
IPC分类号： G21C3/352 , G21C3/30
CPC分类号： G21C3/352 , Y02E30/40
摘要： An improved fuel assembly grid spacer and method of retaining the basic fuel rod support elements in position within the fuel assembly containment channel. The improvement involves attachment of the grids to the hexagonal channel and of forming the basic fuel rod support element into a grid structure, which provides a design which is insensitive to potential channel distortion (ballooning) at high fluence levels. In addition the improved method eliminates problems associated with component fabrication and assembly.
摘要翻译：一种改进的燃料组件栅格间隔件和将基本燃料棒支撑元件保持在燃料组件容纳通道内的适当位置的方法。改进之处在于将格栅连接到六边形通道并将基本的燃料棒支撑元件形成为格栅结构，其提供对在高注量水平下的潜在通道变形（膨胀）不敏感的设计。此外，改进的方法消除了与部件制造和组装相关的问题。

56. 发明公开

US20240207467A1 Sanitizing Radiation Apparatus 审中-公开
公开(公告)号：US20240207467A1
公开(公告)日：2024-06-27
申请号：US18087591
申请日：2022-12-22
申请人： John Marshall
发明人： John Marshall
IPC分类号： A61L2/10 , A61L2/24
CPC分类号： A61L2/10 , A61L2/24
摘要： A surface-contaminated sanitizing apparatus is configured to emit energy, particularly user-safe 222 nanometer UV light, for sanitizing a surface, such as, a door handle, a bank of elevator floor selectors, and other potentially unsanitary surfaces that human beings touch repeatedly. This apparatus may be configured to operate automatically in response to detection of a user's finger or hand contacting/touching/nearing such a surface, and to sanitize the surface after any such contact.

57. 发明授权

US09373102B2 System and method using a simplified XML format for real-time content publication 有权
标题翻译：系统和方法使用简化的XML格式进行实时内容发布
公开(公告)号：US09373102B2
公开(公告)日：2016-06-21
申请号：US13195654
申请日：2011-08-01
申请人： Sameer Merchant , Gerald Bueshel , Jules Michael McLeod , John Marshall
发明人： Sameer Merchant , Gerald Bueshel , Jules Michael McLeod , John Marshall
IPC分类号： G06Q10/10 , H04L12/58 , H04L12/18
CPC分类号： H04L51/066 , G06Q10/107 , H04L12/1868 , H04L12/1877 , H04L12/1895 , H04L51/30 , H04L67/02
摘要： A system and method for delivering content in real-time using advanced messaging technology that reduces the risk of content being lost or dropped in transmission. The system and method utilize a custom, simplified XML format to deliver real-time textual, numeric, and metadata content directly to subscribers. The XML tag set specifies all of the information needed to package, process, and distribute real-time content messages and includes an advanced tagging structure that allows granular content customization. Messages are built on the fly using multi-channel data processing techniques. The XML delivery system and method offers an array of real-time market-specific page-based “Alert” services and aggregated newswires with accompanying real-time numeric data feeds. These feeds contain proprietary assessments and other price data across a broad spectrum of global and regional commodity markets, including oil, petrochemicals, metals, electric power, natural gas, coal, and risk.
摘要翻译：一种使用先进消息传递技术实时传送内容的系统和方法，可降低内容在传输中丢失或丢失的风险。该系统和方法利用自定义的简化XML格式直接向用户提供实时文本，数字和元数据内容。 XML标签集指定了包装，处理和分发实时内容消息所需的所有信息，并包括允许细粒度内容自定义的高级标记结构。使用多通道数据处理技术即时构建消息。 XML传递系统和方法提供了一系列实时的基于市场的基于页面的“警报”服务和聚合新闻线以及附带的实时数字数据。这些饲料包含广泛的全球和区域商品市场的专有评估和其他价格数据，包括石油，石化，金属，电力，天然气，煤炭和风险。

58. 发明授权

US09061796B2 Multi-function condiment container 有权
标题翻译：多功能调味品容器
公开(公告)号：US09061796B2
公开(公告)日：2015-06-23
申请号：US12766164
申请日：2010-04-23
申请人： Craig S. Caldwell , John Marshall , William F. Rasile
发明人： Craig S. Caldwell , John Marshall , William F. Rasile
IPC分类号： B29D22/00 , B65D21/02 , B65D75/32 , B65D85/72
CPC分类号： B65D21/0202 , B65D75/326 , B65D85/72 , B65D2221/00 , B65D2313/00
摘要： A container for condiments includes a container portion having generally planar bottom, a generally parallel flange, a discharge spout, and a sidewall extending between the bottom and the flange. A generally planar cover portion is secured to the flange by an adhesive such that there exists a non-bonded region between the cover and the flange. At least one section of the flange in the non-bonded region is bent downwardly away from the cover portion to form therebetween a finger-access gap. The sidewall includes a front portion disposed below the spout and extending downwardly with respect thereto. The sidewall front portion is configured to prevent the spout from becoming displaced upwardly in response to the sidewall front portion being contacted by the rear portion of another container in a package of the containers.
摘要翻译：用于调味品的容器包括具有大致平坦的底部的容器部分，大致平行的凸缘，排出口以及在底部和凸缘之间延伸的侧壁。大致平坦的盖部分通过粘合剂固定到凸缘上，使得在盖和凸缘之间存在非接合区域。非接合区域中的凸缘的至少一个部分从盖部分向下弯曲，从而在其间形成手指进入间隙。侧壁包括设置在喷嘴下方并相对于喷嘴向下延伸的前部。侧壁前部构造成防止喷口响应于侧壁前部与容器的包装中的另一容器的后部接触而向上移位。

59. 发明授权

US08562595B2 Retinal regeneration 有权
标题翻译：视网膜再生
公开(公告)号：US08562595B2
公开(公告)日：2013-10-22
申请号：US12446677
申请日：2007-10-25
申请人： Malcolm Plunkett , Aly Hussain , John Marshall
发明人： Malcolm Plunkett , Aly Hussain , John Marshall
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61F9/00821 , A61F2009/00863
摘要： A method of retinal regeneration which improves retinal function by reversal of the degradation of the transport properties of Bruch's membrane. The method involves irradiation through the cornea of the eye to the retinal pigmented epithelium by a laser pulse or sequence of laser pulses having a pulse duration in the range of 10 ps to 20 μs and at a wavelength in the range of about 500 nm to 900 nm. The method applies a radiant exposure which results in the damaging or altering of the retinal pigmented epithelium cells in such a manner as to trigger cellular responses which improve the hydraulic conductivity of Bruch's membrane without causing irreversible damage to adjacent retinal structures and layers.
摘要翻译：视网膜再生的方法通过逆转Bruch膜转运性能的降低来改善视网膜功能。该方法包括通过激光脉冲或脉冲序列的脉冲持续时间在10ps至20微米的范围内并且在约500nm至900nm的波长范围内通过眼睛的角膜照射到视网膜色素上皮 nm。该方法应用辐射暴露，其导致视网膜色素上皮细胞的损伤或改变，以触发细胞反应，其改善Bruch膜的水力传导性，而不会对相邻的视网膜结构和层造成不可逆的损伤。

60. 发明授权

US08453147B2 Techniques for reducing thread overhead for systems with multiple multi-threaded processors 有权
标题翻译：用于减少具有多个多线程处理器的系统的线程开销的技术
公开(公告)号：US08453147B2
公开(公告)日：2013-05-28
申请号：US11446609
申请日：2006-06-05
申请人： Robert Jeter , John Marshall , William Lee , Trevor Garner
发明人： Robert Jeter , John Marshall , William Lee , Trevor Garner
IPC分类号： G06F9/46
CPC分类号： G06F9/5027
摘要： Techniques for processing requests from a processing thread for a shared resource shared among threads on one or more processors include receiving a bundle of requests from a portion of a thread that is executed during a single wake interval on a particular processor. The bundle includes multiple commands for one or more shared resources. The bundle is processed at the shared resource(s) to produce a bundle result. The bundle result is sent to the particular processor. The thread undergoes no more than one wake interval to sleep interval cycle while the bundle commands are processed at the shared resource(s). These techniques allow a lock for shared resource(s) to be obtained, used and released all while the particular thread is sleeping, so that locks are held for shorter times than in conventional approaches. Using these techniques, line rate packet processing is more readily achieved in routers with multiple multi-threaded processors.
摘要翻译：用于处理来自处理线程的用于在一个或多个处理器上的线程之间共享的共享资源的请求的技术包括从在特定处理器上的单个唤醒间隔期间执行的线程的一部分接收一束请求。捆绑包包含一个或多个共享资源的多个命令。在共享资源处理捆绑包以产生捆绑结果。捆绑结果发送到特定的处理器。线程经历不超过一个唤醒间隔到休眠间隔周期，而束命令在共享资源处被处理。这些技术允许在特定线程正在休眠期间获得，使用和释放共享资源的锁定，使得锁比一般方法保持更短的时间。使用这些技术，在具有多个多线程处理器的路由器中更容易实现线路速率分组处理。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式