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51. 发明授权

US4867992A Natural coffee flavor by fermentation 失效
标题翻译：天然咖啡味发酵
公开(公告)号：US4867992A
公开(公告)日：1989-09-19
申请号：US168829
申请日：1988-03-16
申请人： Barbara Boniello , Ernest Gum Jr. , Richard Scarpellino , Barbara Doonan , John Patterson , Geoffrey Bertkau
发明人： Barbara Boniello , Ernest Gum Jr. , Richard Scarpellino , Barbara Doonan , John Patterson , Geoffrey Bertkau
IPC分类号： A23F5/46 , A23L27/24
CPC分类号： A23F5/465 , A23L27/24 , A23L27/25 , A23Y2220/17
摘要： A buttery and/or winey flavor of which diacetyl and acetoin are the major flavor constituents is produced by the fermentation of a coffee substrate. The process involves forming a nutrient media containing water and soluble coffee solids as the nutrient component, the soluble solids concentration being at least 0.5%. A microorganism which is either a strain of lactic acid producing bacteria or yeast capable of producing diacetyl is added the nutrient media and the combination is mixed and simultaneously placed into an environment of a pH of from 4.0 to 7.0, a temperature of from 16.degree. to 37.degree. C., for a period of time effective to produce diacetyl and aeration conditions wherein the nutrient media contains sufficient oxygen to allow for diacetyl production. The aforementioned process will produce diacetyl and acetoin. The diacetyl which is produced is recovered and or concentrated and added to a coffee product.
摘要翻译：通过咖啡基质的发酵产生其中主要的风味成分是二乙酰基和乙酰丁胺的黄油和/或葡萄酒。该方法包括形成含有水和可溶性咖啡固体的营养培养基作为营养成分，可溶性固体浓度至少为0.5％。作为产生乳酸的细菌的菌体或能够产生二乙酰基的酵母的微生物加入营养培养基，并将该组合物混合并同时置于pH 4.0至7.0的环境中，温度为16℃至在一段时间内有效地产生二乙酰基和通气条件，其中营养培养基含有足够的氧气以允许二乙酰基生产。上述方法将产生二乙酰和乙偶姻。将生产的二乙酰基回收和/或浓缩并加入到咖啡产品中。

52. 发明申请

US20220109377A1 CAPACITIVE COUPLER FOR HIGH VOLTAGE STEP-DOWN 有权
公开(公告)号：US20220109377A1
公开(公告)日：2022-04-07
申请号：US17487655
申请日：2021-09-28
申请人： Tyler D. Smith , John Patterson , Clinton W. Ewell
发明人： Tyler D. Smith , John Patterson , Clinton W. Ewell
IPC分类号： H02M7/04 , H02M7/219
摘要： Systems and methods for a capacitive coupler for high-voltage step-down include an actively-controlled current-steering circuit connected in series with a current-limiting capacitor in order to transform a higher and potentially variable AC voltage to a lower regulated DC voltage. The actively-controlled current-steering circuit includes a switching element which, during operation, is predominantly either fully open or fully closed, and comparatively spends only a small fraction of operating time in a transition-state between the open and closed positions.

53. 外观设计

USD580296S1 Decorative sculpture of two nuts 有权
标题翻译：两个坚果的装饰雕塑
公开(公告)号：USD580296S1
公开(公告)日：2008-11-11
申请号：US29225290
申请日：2005-03-15
申请人： John Patterson
设计人： John Patterson

54. 发明申请

US20070232654A1 Novel Compounds and Compositions as Cathepsin Inhibitors 审中-公开
标题翻译：新型化合物和组合物作为组织蛋白酶抑制剂
公开(公告)号：US20070232654A1
公开(公告)日：2007-10-04
申请号：US11758894
申请日：2007-06-06
申请人： John Patterson , Sheila Zipfel
发明人： John Patterson , Sheila Zipfel
IPC分类号： A61K31/44 , A61K31/16 , C07C213/00 , C07D263/52 , C07C233/00 , A61K31/423
CPC分类号： C07D213/40 , C07C255/24 , C07C2601/14 , C07D209/08 , C07D213/64 , C07D213/75 , C07D215/06 , C07D215/12 , C07D217/02 , C07D217/06 , C07D235/14 , C07D263/32 , C07D263/56 , C07D295/185 , C07D307/16 , C07D333/20
摘要： The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译：本发明涉及新的选择性组织蛋白酶S抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。

55. 发明申请

US20070015755A1 NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS 审中-公开
标题翻译：新型化合物和组合物作为蛋白酶抑制剂
公开(公告)号：US20070015755A1
公开(公告)日：2007-01-18
申请号：US11533582
申请日：2006-09-20
申请人： Clifford Bryant , Barry Bunin , Erica Kraynack , John Patterson
发明人： Clifford Bryant , Barry Bunin , Erica Kraynack , John Patterson
IPC分类号： A61K31/5375 , A61K31/277 , C07D265/30 , C07C255/60
CPC分类号： C07D213/70 , C07B2200/07 , C07C255/24 , C07C255/29 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/09 , C07C317/50 , C07C323/60 , C07C323/62 , C07C2601/14 , C07D207/16 , C07D209/06 , C07D209/26 , C07D209/52 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/26 , C07D239/28 , C07D277/30 , C07D277/42 , C07D277/56 , C07D295/155 , C07D295/215 , C07D307/68 , C07D333/20 , C07D333/38 , C07D417/04 , C07D417/12
摘要： The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译：本发明涉及新型N-氰甲基酰胺，它们是半胱氨酸蛋白酶抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。

56. 发明申请

US20060212517A1 Method, system, and program product for maintaining synchronization among replicated applications using externality forwarding 审中-公开
标题翻译：方法，系统和程序产品，用于维护使用外部转发的复制应用程序之间的同步
公开(公告)号：US20060212517A1
公开(公告)日：2006-09-21
申请号：US11080148
申请日：2005-03-15
申请人： Steven Rohall , John Patterson
发明人： Steven Rohall , John Patterson
IPC分类号： G06F15/16
CPC分类号： G06F9/52 , G06F9/547
摘要： The present invention provides a method, system, and computer program product for maintaining synchronization among replicated applications. The method comprises: detecting an externality in an application on a moderator and making an external call associated with the externality; and forwarding results of the external call to a replica of the application on a collaborator.
摘要翻译：本发明提供一种用于维持复制应用之间的同步的方法，系统和计算机程序产品。该方法包括：在主持人的应用程序中检测外部性并进行与外部性相关联的外部呼叫; 并将外部呼叫的结果转发给协作者上的应用程序副本。

57. 发明申请

US20060122184A1 Cyanomethyl derivatives as cysteine protease inhibitors 审中-公开
标题翻译：氰甲基衍生物作为半胱氨酸蛋白酶抑制剂
公开(公告)号：US20060122184A1
公开(公告)日：2006-06-08
申请号：US10536889
申请日：2003-11-26
申请人： Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
发明人： Michael Graupe , Agnes Lau , John Link , Yang Liu , Craig Mossman , John Patterson , Sheila Zipfel
IPC分类号： A61K31/53 , A61K31/50 , A61K31/4965 , A61K31/421 , A61K31/381 , A61K31/277 , A61K31/415
CPC分类号： C07C255/25 , A61K38/00 , C07D211/66 , C07D213/82 , C07D277/30 , C07D333/40 , C07K5/06139
摘要： The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsin B, K, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译：本发明涉及作为半胱氨酸蛋白酶，特别是组织蛋白酶B，K，F和S的抑制剂的氰甲基衍生物，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的药物组合物及其制备方法。

58. 发明申请

US20050182829A1 System for selecting a connectivity mechanism 有权
标题翻译：用于选择连接机制的系统
公开(公告)号：US20050182829A1
公开(公告)日：2005-08-18
申请号：US10508123
申请日：2003-03-24
申请人： John King , Peter Hovell , John Patterson
发明人： John King , Peter Hovell , John Patterson
IPC分类号： H04L29/06 , H04L29/12 , G06F15/177
CPC分类号： H04L29/1233 , H04L29/06 , H04L29/12377 , H04L29/12443 , H04L61/25 , H04L61/2517 , H04L61/2542 , H04L69/16 , H04L69/167
摘要： An address resolver system that assists a node in an IPv6 network to select an address for connectivity with a node in an IPv4 network when both DSTM and NAT-PT transition mechanisms are available. Native connectivity can be achieved by preferring an encapsulation or tunnelling mechanism such as DSTM where possible over a translation mechanism such as NAT-PT. A range of encapsulation and translation mechanisms are envisaged. The resolver determines capabilities of the node and of the application that requires the address in order to make the selection
摘要翻译：当DSTM和NAT-PT转换机制都可用时，协助IPv6网络中的节点选择与IPv4网络中的节点连接的地址的地址解析器系统。本地连接可以通过在诸如NAT-PT之类的转换机制的情况下，优先考虑诸如DSTM之类的封装或隧道机制来实现。设想了一系列封装和翻译机制。解析器确定要进行选择的节点和应用程序的能力

59. 发明申请

US20050149858A1 System and method for managing documents with expression of dates and/or times 审中-公开
标题翻译：用日期和/或时间表达来管理文件的系统和方法
公开(公告)号：US20050149858A1
公开(公告)日：2005-07-07
申请号：US10745484
申请日：2003-12-29
申请人： Mia Stern , Daniel Gruen , John Patterson , Bernard Kerr
发明人： Mia Stern , Daniel Gruen , John Patterson , Bernard Kerr
IPC分类号： G06F17/00 , G06F17/27 , G06Q10/00
CPC分类号： G06F17/278 , G06Q10/107 , G06Q10/109
摘要： An apparatus and method identifies, handles, and/or searches for email messages that include references to dates and/or times, regardless of the syntax or context in which the dates and/or times are expressed in the document. Each incoming document is searched for date-time expressions which may be converted into a canonically formatted date and stored for subsequent comparison to other date-time expressions. In some embodiments of the invention, a mechanism is provided for creating a calendar event from the date-time expression in the document. In some embodiments of the invention, a calendar icon indicates whether a document includes a date-time expression. In some embodiments of the invention, documents that include a date-time expression corresponding to a particular date may be retrieved.
摘要翻译：一种装置和方法来识别，处理和/或搜索包括对日期和/或时间的引用的电子邮件消息，而不管日期和/或时间在文档中表达的语法或上下文。搜索每个传入文档的日期时间表达式，可以将其转换为规范格式化的日期并存储，以便后续与其他日期时间表达式进行比较。在本发明的一些实施例中，提供了用于从文档中的日期时间表达式创建日历事件的机制。在本发明的一些实施例中，日历图标指示文档是否包括日期时间表达。在本发明的一些实施例中，可以检索包括对应于特定日期的日期时间表达的文档。

60. 外观设计

USD414194S Polygonal indexable cutting insert 失效
公开(公告)号：USD414194S
公开(公告)日：1999-09-21
申请号：US94225
申请日：1998-09-24
申请人： John Patterson , Tony Lowe , Brendan Brockett , Thomas Bernadic
设计人： John Patterson , Tony Lowe , Brendan Brockett , Thomas Bernadic

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