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51. 发明授权

US08431132B2 Recombinant human EPO-FC fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo 有权
标题翻译：重组人EPO-FC融合蛋白具有延长的半衰期和体内增强的红细胞生成活性
公开(公告)号：US08431132B2
公开(公告)日：2013-04-30
申请号：US12555743
申请日：2009-09-08
申请人： Haitao Wang , Du Yong , Rui Zhang , Jing Xu , Longbin Liu
发明人： Haitao Wang , Du Yong , Rui Zhang , Jing Xu , Longbin Liu
IPC分类号： A61K39/00 , C07K1/00 , C07K16/00
CPC分类号： C07K14/505 , A61K9/0019 , A61K38/00 , A61K47/6811 , C07K2317/53 , C07K2319/30
摘要： A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.
摘要翻译：描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

52. 发明申请

US20130052462A1 NETWORKED POLYMERIC NANOFIBERS, PROCESS FOR PRODUCING SAME, GAS ADSORBENT, AND GAS SEPARATION MATERIAL 审中-公开
标题翻译：联网聚合纳米纤维，其生产方法，气体吸附剂和气体分离材料
公开(公告)号：US20130052462A1
公开(公告)日：2013-02-28
申请号：US13635735
申请日：2011-02-14
申请人： Izumi Ichinose , Xinsheng Peng , Sadaki Samitsu , Rui Zhang
发明人： Izumi Ichinose , Xinsheng Peng , Sadaki Samitsu , Rui Zhang
IPC分类号： B01J20/26 , C08G64/42 , C08G75/20 , C08G75/23 , C08F120/44 , C08G73/10 , C08F114/06 , D01F6/00 , C08F112/08 , C08G65/48 , B82Y30/00
CPC分类号： D01D5/00 , B01D53/02 , B01D2253/202 , B01D2257/504 , B01D2257/7025 , B01J20/262 , B01J20/28007 , B01J20/28023 , B01J20/28057 , B01J20/3085 , B82Y30/00 , B82Y40/00 , D01F6/22 , Y02C10/08 , Y02C20/20 , Y02P70/621 , Y10T428/2975
摘要： The invention provides networked polymeric nanofibers having a structure in which amorphous polymeric fibers are branched at multiple sites and having a diameter of from 1 nanometer to 100 nanometers.A solution of a polymer such as polystyrene in a good solvent thereof is rapidly frozen to form a nanoscale phase-separation structure of the polymer and the frozen solvent. The networked polymeric nanofibers can then be obtained upon removing the frozen solvent.
摘要翻译：本发明提供了具有这样的结构的网状聚合物纳米纤维，其中无定形聚合物纤维在多个位点处分支并具有1纳米至100纳米的直径。将聚合物如聚苯乙烯在其良溶剂中的溶液迅速冷冻以形成聚合物和冷冻溶剂的纳米尺度相分离结构。然后可以在除去冷冻溶剂后获得网状聚合物纳米纤维。

53. 发明申请

US20120302641A1 BIPHENYL DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS 有权
标题翻译：二苯乙烯衍生物作为GLUCAGON受体拮抗剂有用
公开(公告)号：US20120302641A1
公开(公告)日：2012-11-29
申请号：US13478568
申请日：2012-05-23
申请人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
发明人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
IPC分类号： A61K31/197 , A61P13/12 , A61P3/04 , C07C237/36 , A61P3/10
CPC分类号： C07C237/36
摘要： The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及联苯衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体，包括例如代谢性疾病如II型糖尿病和肥胖症而改善的病症和病症中的用途。

54. 发明申请

US20120302610A1 PICOLINAMIDO-PROPANOIC ACID DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS 有权
标题翻译：作为GLUCAGON受体拮抗剂有用的PICOLINAMIDO-丙二酸衍生物
公开(公告)号：US20120302610A1
公开(公告)日：2012-11-29
申请号：US13478534
申请日：2012-05-23
申请人： Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
发明人： Devraj Chakravarty , Kevin Kreutter , Mark Powell , Brian Shook , Fengbin Song , Guozhang Xu , Shyh-Ming Yang , Rui Zhang , Bao-Ping Zhao
IPC分类号： A61K31/4418 , A61P13/12 , A61P3/04 , C07D213/81 , A61P3/10
CPC分类号： C07D213/81
摘要： The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及吡啶甲酰 - 丙酸衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体而改善的病症和病症的用途，包括例如代谢性疾病如II型糖尿病和肥胖。

55. 发明申请

US20120282644A1 MULTIPLE-ELECTRODE AND METAL-COATED PROBES 有权
标题翻译：多电极和金属涂层探针
公开(公告)号：US20120282644A1
公开(公告)日：2012-11-08
申请号：US13263234
申请日：2010-04-23
申请人： Haim H. Bau , Michael G. Schrlau , Rui Zhang
发明人： Haim H. Bau , Michael G. Schrlau , Rui Zhang
IPC分类号： C12M1/34 , B44C1/22 , G01N27/26 , B05D5/12
CPC分类号： G01N33/48728
摘要： Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the probes' performance. The probes may also be used to inject a fluid or other agent into the subject and simultaneously monitor changes in the subject's electrical characteristics in response to the injection. Related methods of fabricating and of using the inventive probes are also provided.
摘要翻译：提供了具有多个电极的探针，其探针具有纳米范围的直径并且可以插入细胞或其他受试者中，以便监测受试者的电特性。探针还可以包括至少一个探针元件上的导电涂层以改善探针的性能。探针还可以用于将流体或其它试剂注射到受试者中并且同时监测受试者响应于注射的电特征的变化。还提供了制造和使用本发明的探针的相关方法。

56. 发明授权

US08270495B2 Reduced bandwidth off-loading of entropy coding/decoding 有权
标题翻译：降低熵编码/解码带宽的卸载
公开(公告)号：US08270495B2
公开(公告)日：2012-09-18
申请号：US12370699
申请日：2009-02-13
申请人： Jim Chen Chou , Rui Zhang
发明人： Jim Chen Chou , Rui Zhang
IPC分类号： H04N7/26
CPC分类号： H04N19/40 , H04N19/42 , H04N19/46 , H04N19/61
摘要： Techniques are provided herein to produce encoded video bitstreams and to similarly decode encoded video bitstreams according to a coding standard not supported by an on-chip encoder/decoder. For purposes of encoding, a video sequence is received at a first device. A first bitstream is generated at the first device by encoding the video sequence according to a first coding standard and information associated with the video sequence is generated at the first device according to a second coding standard. The first bitstream and the information are then transmitted to a second device. At the second device the first bitstream is decoded to produce a second bitstream. The second bitstream and the information are combined by removing syntax elements associated with the first coding standard from the second bitstream and adding the information to produce a third bitstream according to the second coding standard. Similar techniques are provided for decoding an encoded bitstream to recover a video sequence.
摘要翻译：本文提供了技术来产生编码视频比特流，并且根据不由片上编码器/解码器支持的编码标准类似地解码经编码的视频比特流。为了编码的目的，在第一设备处接收视频序列。通过根据第一编码标准编码视频序列，在第一设备处产生第一比特流，并且根据第二编码标准在第一设备处生成与视频序列相关联的信息。然后将第一比特流和信息发送到第二设备。在第二设备处，第一比特流被解码以产生第二比特流。通过从第二比特流中除去与第一编码标准相关联的语法元素，并根据第二编码标准添加信息以产生第三比特流，来组合第二比特流和信息。提供了用于解码编码比特流以恢复视频序列的类似技术。

57. 发明授权

US08258177B2 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs 有权
标题翻译： 4 - （（苯氧基烷基）硫代） - 苯氧基乙酸和类似物
公开(公告)号：US08258177B2
公开(公告)日：2012-09-04
申请号：US13207809
申请日：2011-08-11
申请人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
IPC分类号： A61K31/192 , A61K31/36 , A61K31/357 , A61P9/00 , A61P3/04
CPC分类号： C07C59/70 , C07C323/20 , C07C323/60 , C07C323/62 , C07C2601/02 , C07D213/64 , C07D303/08 , C07D303/18 , C07D317/22 , C07D319/12
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译：本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPARδ调节剂治疗或抑制例如血脂异常进展的方法。

58. 发明授权

US08249281B2 Condenser microphone 有权
标题翻译：冷凝器麦克风
公开(公告)号：US08249281B2
公开(公告)日：2012-08-21
申请号：US12651455
申请日：2010-01-01
申请人： Rui Zhang
发明人： Rui Zhang
IPC分类号： H04R25/00
CPC分类号： H04R19/005
摘要： A condenser microphone is disclosed. The condenser microphone includes a substrate having a cavity, a backplate connected to the substrate, a diaphragm facing to the backplate, and an anchor supporting the diaphragm. A first gap is formed between the diaphragm and the backplate. A groove is arranged on the anchor and the diaphragm partially covers the groove. The diaphragm and the groove forms a second gap communicating with the first gap.
摘要翻译：公开了一种电容麦克风。电容麦克风包括具有空腔的基板，连接到基板的背板，面向背板的隔膜和支撑隔膜的锚固件。在隔膜和背板之间形成第一间隙。在锚上布置有凹槽，并且隔膜部分地覆盖凹槽。隔膜和凹槽形成与第一间隙连通的第二间隙。

59. 发明授权

US08242173B2 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs 有权
标题翻译： 4 - （（苯氧基烷基）硫代） - 苯氧基乙酸和类似物
公开(公告)号：US08242173B2
公开(公告)日：2012-08-14
申请号：US12873383
申请日：2010-09-01
申请人： Alan DeAngelis , Keith T Demarest , Gee-Hong Kuo , Patricia Pelton , Aihua Wang , Rui Zhang
发明人： Alan DeAngelis , Keith T Demarest , Gee-Hong Kuo , Patricia Pelton , Aihua Wang , Rui Zhang
IPC分类号： A61K31/275 , A61K31/192 , C07C59/135 , C07C255/41 , A61P3/10 , A61P1/00 , A61P3/06 , A61P3/04 , A61P9/10 , A61P9/00 , A61P13/12
CPC分类号： C07C323/60 , C07C59/68 , C07C323/20
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译：本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。

60. 发明授权

US08106095B2 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs 有权
公开(公告)号：US08106095B2
公开(公告)日：2012-01-31
申请号：US12623824
申请日：2009-11-23
申请人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan R. DeAngelis
IPC分类号： A61K31/192 , A61P3/10 , A61P9/10 , A61P3/04 , A61P9/00
CPC分类号： A61K31/277 , A61K31/192 , C07C59/68 , C07C59/70 , C07C317/22 , C07C323/20 , C07C323/60 , C07C323/62 , C07D333/16 , C07D333/28
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

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