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51. 发明授权

US08032224B2 Sensitivity analysis for selecting therapy parameter sets 有权
标题翻译：灵敏度分析选择治疗参数集
公开(公告)号：US08032224B2
公开(公告)日：2011-10-04
申请号：US11691413
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61N1/34 , A61N1/36
CPC分类号： A61M5/14276 , A61B3/113 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/0488 , A61B5/11 , A61B5/1459 , A61B5/4815 , A61B5/4824 , A61B5/4839 , A61B8/06 , A61B8/12 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/08 , A61N1/36071 , A61N1/36135 , A61N1/36146 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/37241 , G06F19/00
摘要： Techniques for controlling delivery of a therapy to a patient by a medical device, such as an implantable medical device (IMD), involve a sensitivity analysis of a performance metric. The performance metric may relate to efficacy or side effects of the therapy. For example, the performance metric may comprise a sleep quality metric, an activity level metric, a movement disorder metric for patients with Parkinson's disease, epilepsy, or the like. The sensitivity analysis identifies values of therapy parameters that defines a substantially maximum or minimum value of the performance metric. The identified therapy parameters are a baseline therapy parameter set, and a medical device may control delivery of the therapy based on the baseline therapy parameter set.
摘要翻译：用于通过医疗装置（例如可植入医疗装置（IMD））控制对患者的治疗递送的技术涉及对性能度量的灵敏度分析。性能指标可能与治疗的功效或副作用有关。例如，性能度量可以包括睡眠质量度量，活动水平度量，帕金森病患者的运动障碍度量，癫痫等。灵敏度分析确定定义性能度量的基本上最大或最小值的治疗参数的值。所确定的治疗参数是基线治疗参数组，并且医疗装置可以基于基线治疗参数集来控制治疗的递送。

52. 发明授权

US08725244B2 Determination of sleep quality for neurological disorders 有权
标题翻译：确定神经系统疾病的睡眠质量
公开(公告)号：US08725244B2
公开(公告)日：2014-05-13
申请号：US11591286
申请日：2006-10-31
申请人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61N1/36135 , A61B3/113 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0816 , A61B5/1116 , A61B5/1118 , A61B5/145 , A61B5/4815 , A61B5/4818 , A61B5/6814 , A61B5/6823 , A61B5/6825 , A61B5/686 , A61B2562/0219 , A61M5/14276 , A61M5/1723 , A61N1/36025 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/37247
摘要： A device determines values for one or more metrics that indicate the quality of a patient's sleep based on sensed physiological parameter values. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. The sleep quality metric values may be used, for example, to evaluate the effectiveness of a therapy delivered to the patient by a medical device. In some embodiments, determined sleep quality metric values are automatically associated with the therapy parameter sets according to which the medical device delivered the therapy when the physiological parameter values were sensed, and used to evaluate the effectiveness of the various therapy parameter sets. The medical device may deliver the therapy to treat a non-respiratory neurological disorder, such as epilepsy, a movement disorder, or a psychological disorder. The therapy may be, for example, deep brain stimulation (DBS) therapy.
摘要翻译：设备基于感测到的生理参数值来确定指示患者睡眠质量的一个或多个度量的值。睡眠效率，睡眠延迟和在更深的睡眠状态中花费的时间是可以确定值的示例性睡眠质量度量。例如，可以使用睡眠质量度量值来评估由医疗装置递送给患者的治疗的有效性。在一些实施例中，确定的睡眠质量量度值与治疗参数组自动相关联，当感测到生理参数值时医疗设备根据该参数设置递送治疗，并且用于评估各种治疗参数组的有效性。医疗装置可以递送治疗以治疗非呼吸神经障碍，例如癫痫，运动障碍或心理障碍。治疗可以是例如深部脑刺激（DBS）治疗。

53. 发明授权

US08332038B2 Detecting sleep to evaluate therapy 有权
标题翻译：检测睡眠以评估治疗
公开(公告)号：US08332038B2
公开(公告)日：2012-12-11
申请号：US13249862
申请日：2011-09-30
申请人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61N1/08
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/0476 , A61B5/4809 , A61B5/4815 , A61B5/4818 , A61M5/14276 , A61M2005/1726 , A61M2210/0693 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36067 , A61N1/36082 , A61N1/36135 , A61N1/36585 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep. In addition, an electroencephalogram signal may be used to identify sleep states of the patient.
摘要翻译：系统包括一个或多个传感器和处理器。每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。处理器监视生理参数，并根据参数确定患者是否睡着了。在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。此外，可以使用脑波信号来识别患者的睡眠状态。

54. 发明授权

US07881798B2 Controlling therapy based on sleep quality 有权
标题翻译：基于睡眠质量控制治疗
公开(公告)号：US07881798B2
公开(公告)日：2011-02-01
申请号：US11691430
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61N1/18
CPC分类号： A61N1/36082
摘要： A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.
摘要翻译：诸如可植入医疗装置（IMD）的医疗设备确定指示患者睡眠质量的一个或多个指标的值，并且基于睡眠质量量度值控制治疗的递送。例如，医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较，并且基于比较来调整治疗。在一些实施例中，医疗装置基于比较来调整治疗的强度，例如当比较表明患者的睡眠质量差时，增加治疗强度。在一些实施例中，医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值，自动选择可用于递送治疗的多个治疗参数集中的一个。

55. 发明授权

US08308661B2 Collecting activity and sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集活动和睡眠质量信息
公开(公告)号：US08308661B2
公开(公告)日：2012-11-13
申请号：US11691425
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61B5/103 , A61B5/117 , A61B5/04
CPC分类号： A61B5/4815 , A61B5/1116 , A61B5/1118 , A61B5/6814 , A61B5/6823 , A61B5/6825 , A61B5/686 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/37247 , G06F19/00 , G06F19/3456 , G06F19/3481 , G06Q50/22 , G16H40/63
摘要： A device, such as an implantable medical device (IMD), programming device, or other computing device determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by a medical device.
摘要翻译：诸如可植入医疗设备（IMD），编程设备或其他计算设备的设备确定患者何时尝试睡眠。当设备确定患者正在尝试睡眠时，设备基于患者的至少一个生理参数来确定指示患者睡眠质量的一个或多个度量的值。当设备确定患者没有尝试睡眠时，设备周期性地确定患者的活动水平。活动度量值可以基于所确定的活动水平来确定。临床医生可以使用由编程设备呈现的睡眠质量信息和患者活动信息，以例如评估由医疗设备递送给患者的治疗的有效性。

56. 发明申请

US20120022340A1 DETECTING SLEEP TO EVALUATE THERAPY 有权
标题翻译：检测睡眠以评估治疗
公开(公告)号：US20120022340A1
公开(公告)日：2012-01-26
申请号：US13249862
申请日：2011-09-30
申请人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61B5/0476 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/0476 , A61B5/4809 , A61B5/4815 , A61B5/4818 , A61M5/14276 , A61M2005/1726 , A61M2210/0693 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36067 , A61N1/36082 , A61N1/36135 , A61N1/36585 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep. In addition, an electroencephalogram signal may be used to identify sleep states of the patient.
摘要翻译：系统包括一个或多个传感器和处理器。每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。处理器监视生理参数，并根据参数确定患者是否睡着了。在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。此外，可以使用脑波信号来识别患者的睡眠状态。

57. 发明授权

US08326431B2 Implantable medical device for the concurrent treatment of a plurality of neurological disorders and method therefore 有权
标题翻译：因此，用于同时治疗多种神经障碍的植入式医疗装置和方法
公开(公告)号：US08326431B2
公开(公告)日：2012-12-04
申请号：US11414153
申请日：2006-04-28
申请人： Jonathan Werder , Leslie A. LeMire , Nina M. Graves , David C. Ullestad
发明人： Jonathan Werder , Leslie A. LeMire , Nina M. Graves , David C. Ullestad
IPC分类号： A61N1/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/0693 , A61N1/0529 , A61N1/0534 , A61N1/36082 , G06F19/00
摘要： Implantable medical device adapted to be implanted in a patient having a plurality of neurological disorders. First and second therapy modules are adapted to provide first and second outputs to the patient for the treatment of first and second of the plurality of disorders, respectively. Also, a method for the treatment of a plurality of neurological disorders in a patient. A first output is provided to the patient for the treatment of a first one of the plurality of neurological disorders and a second output is provided to the patient for the treatment of a second one of the plurality of neurological disorders.
摘要翻译：植入式医疗装置适于植入患有多种神经障碍的患者中。第一和第二治疗模块适于向患者提供第一和第二输出以分别治疗多种疾病中的第一和第二种。另外，一种治疗患者多种神经障碍的方法。向患者提供第一输出用于治疗多种神经障碍中的第一种，并且向患者提供第二输出用于治疗多种神经障碍中的第二种神经障碍。

58. 发明授权

US08594798B2 Multi-modal operation of a medical device system 有权
标题翻译：医疗器械系统的多模式操作
公开(公告)号：US08594798B2
公开(公告)日：2013-11-26
申请号：US10687289
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Mark T. Rise , Scott F. Schaffner , Nina M. Graves
发明人： Ivan Osorio , Mark G. Frei , Mark T. Rise , Scott F. Schaffner , Nina M. Graves
IPC分类号： A61N1/08
CPC分类号： A61N1/36025 , A61N1/08 , A61N1/36082
摘要： Apparatuses and methods support multi-modal operation of a medical device system for a nervous system disorder. The medical device system comprises an implanted component and an external component and supports a first feature and a second feature that are associated with the treatment therapy. The medical device system supports both features when the implanted component and the external component are coupled. If the external component is decoupled, the implanted component continues to support the first feature. Moreover, the embodiment may support a plurality of features during a treatment interval. Another aspect of the invention allows for modularly expanding a medical device system in order to add a feature that enhances existing functionality or that provides additional functionality. In an embodiment, a module that is associated with an external component of the medical device system supports the added feature.
摘要翻译：装置和方法支持用于神经系统障碍的医疗装置系统的多模式操作。医疗装置系统包括植入部件和外部部件，并且支撑与治疗疗法相关联的第一特征和第二特征。当植入部件和外部部件联接时，医疗装置系统支持两个特征。如果外部组件解耦，则植入组件继续支持第一个特征。此外，该实施例可以在治疗间隔期间支持多个特征。本发明的另一方面允许模块化地扩展医疗设备系统，以便添加增强现有功能或提供附加功能的特征。在一个实施例中，与医疗设备系统的外部部件相关联的模块支持附加的特征。

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