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51. 发明授权

US06781752B2 Optical arrangement for the illumination of specimens for confocal scanning microscopes 有权
标题翻译：用于共焦扫描显微镜照明的光学布置
公开(公告)号：US06781752B2
公开(公告)日：2004-08-24
申请号：US10730803
申请日：2003-12-09
申请人： Johann Engelhardt , Juergen Hoffmann
发明人： Johann Engelhardt , Juergen Hoffmann
IPC分类号： G02B2106
CPC分类号： G02B21/0072 , G02B21/0032
摘要： A confocal scanning microscope has an illuminating beam path and at least one light source. The light of the light source is coupled into a fiber in which laser transitions can be induced. At least laser light induced in the fiber serves for specimen illumination after passing through an excitation pinhole.
摘要翻译：共焦扫描显微镜具有照明光束路径和至少一个光源。光源的光耦合到可以诱导激光转换的光纤中。至少在光纤中感应的激光用于通过激发针孔后的样本照明。

52. 发明授权

US06738190B2 Method for examining a specimen 有权
标题翻译：检查样本的方法
公开(公告)号：US06738190B2
公开(公告)日：2004-05-18
申请号：US09947334
申请日：2001-09-05
申请人： Johann Engelhardt , Juergen Hoffmann , Werner Knebel
发明人： Johann Engelhardt , Juergen Hoffmann , Werner Knebel
IPC分类号： G02B2100
CPC分类号： G02B21/0076 , G02B21/0024 , G02B21/0032 , G02B21/008
摘要： A method for examining a specimen (11) by means of a confocal scanning microscope having at least one light source (1), preferably a laser, to generate an illuminating light beam (4) for the specimen (11), and a beam deflection device (9) to guide the illuminating light beam (4) over the specimen (11) comprises the following method steps: Firstly a preview image is acquired. Then at least one region of interest in the preview image is marked. This is followed by allocation of individual illuminating light beam wavelengths and/or illuminating light beam power levels to the region or regions. Illumination of the region or regions of the specimen (11) in accordance with the allocation is then accomplished. Lastly, the reflected and/or fluorescent light proceeding from the specimen (11) is detected.
摘要翻译：一种通过具有至少一个光源（1）（优选为激光）的共焦扫描显微镜检查样本（11）以产生用于样本（11）的照明光束（4）的方法，以及光束偏转将照明光束（4）引导到试样（11）上方的装置（9）包括以下方法步骤：首先获取预览图像。然后，标记预览图像中的至少一个感兴趣区域。随后将各个照明光束波长和/或照射光束功率电平分配给该区域。然后根据分配对样品（11）的区域或区域进行照明。最后，检测从样品（11）进行的反射和/或荧光。

53. 发明授权

US06677579B2 Method and apparatus for phase correction of position and detection signals in scanning microscopy, and scanning microscope 有权
标题翻译：扫描显微镜下位置和检测信号相位校正的方法和装置，以及扫描显微镜
公开(公告)号：US06677579B2
公开(公告)日：2004-01-13
申请号：US09920311
申请日：2001-08-03
申请人： Johann Engelhardt
发明人： Johann Engelhardt
IPC分类号： H01J314
CPC分类号： G02B21/008 , G02B21/0072 , G02B21/0084
摘要： A method and an apparatus for phase correction of position and detection signals in scanning microscopy. The method includes generation of a position signal from the position of a beam deflection device (7) and generation, from the light (17) proceeding from the specimen (15), of a detection signal pertinent to the position signal. The position signal and detection signal are then transferred to a processing unit (23). In the processing unit (23), a correction value is determined. The correction value is transferred to a computer (34) to compensate for time differences between the position signal and detection signal.
摘要翻译：一种用于扫描显微镜中位置和检测信号的相位校正的方法和装置。该方法包括从光束偏转装置（7）的位置产生位置信号，并从与样本（15）进行的光（17）产生与位置信号相关的检测信号。然后，位置信号和检测信号被传送到处理单元（23）。在处理单元（23）中，确定校正值。校正值被传送到计算机（34）以补偿位置信号和检测信号之间的时间差。

54. 发明授权

US06636352B2 Apparatus for objective changing and microscope having an apparatus for objective changing 有权
公开(公告)号：US06636352B2
公开(公告)日：2003-10-21
申请号：US09681918
申请日：2001-06-26
申请人： Johann Engelhardt
发明人： Johann Engelhardt
IPC分类号： G02B2100
CPC分类号： G02B21/0072 , G02B21/248
摘要： The apparatus for objective changing comprises an inventory of at least one objective (5) which defines a longitudinal axis (6). The objective change between an objective storage position (22) and a reference objective position (5a) is made possible by the apparatus, and the reference objective position (5a) lies within an optical beam path that defines an optical axis (3). A retaining element defines the reference objective position (5a), and during the objective change, the objective (5) with its longitudinal axis (6) is movable, in the vicinity of the retaining element (26), substantially coaxially with the optical axis (3). The objective change is accomplished along a guide rail (17).

55. 发明授权

US06567164B2 Entangled-photon microscope and confocal microscope 有权
公开(公告)号：US06567164B2
公开(公告)日：2003-05-20
申请号：US09880825
申请日：2001-06-15
申请人： Holger Birk , Rafael Storz , Johann Engelhardt
发明人： Holger Birk , Rafael Storz , Johann Engelhardt
IPC分类号： G01N2163
CPC分类号： G02B6/02328 , B82Y20/00 , G02B6/02347 , G02B6/02361 , G02B6/02366 , G02B6/02371 , G02B6/1225 , G02B6/2552 , G02B21/002 , G02B21/0032 , G02B21/0056 , G02B21/0064 , G02B21/0076 , G02B21/008 , G02B21/06 , H01S3/005 , H01S3/1625 , H01S3/1636
摘要： The invention discloses an entangled-photon microscope (1) having a light source (3) and an objective (31). The entangled-photon microscope (1) has a microstructured optical element (11), in which entangled photons can be produced, between the light source (3) and the objective (31), the entangled photons propagating in a beam (15) inside and outside the microstructured optical element.

56. 发明授权

US06515802B2 Optical arrangement 有权
标题翻译：光学布置
公开(公告)号：US06515802B2
公开(公告)日：2003-02-04
申请号：US09821286
申请日：2001-03-29
申请人： Johann Engelhardt
发明人： Johann Engelhardt
IPC分类号： G02B2712
CPC分类号： G02B27/126 , G02B21/0064 , G02B21/0068
摘要： An optical arrangement for at least partial spectral selection of light components from a polychromatic light beam (1) is configured, in the interest of multifarious spectral selection capabilities, with means of simple design in such a way that a dispersive medium (2) for spatial spectral spreading of the polychromatic light beam (1) into individual light bundles (3), and an attenuation means (5, 6) for at least partial attenuation of the intensity of one or more light bundles (3), are provided.
摘要翻译：用于从多色光束（1）中的光分量的至少部分光谱选择的光学装置被配置为以多种光谱选择能力为特征，以简单设计的方式，使得用于空间的分散介质（2）提供了多色光束（1）到各个光束（3）中的光谱扩展，以及用于至少部分衰减一个或多个光束（3）的强度的衰减装置（5,6）。

57. 发明授权

US06493135B1 Temperature regulated microscope 有权
标题翻译：温度调节显微镜
公开(公告)号：US06493135B1
公开(公告)日：2002-12-10
申请号：US09622425
申请日：2000-08-16
申请人： Johann Engelhardt
发明人： Johann Engelhardt
IPC分类号： G02B2126
CPC分类号： G02B7/16 , G02B21/248 , G02B21/30
摘要： A microscope with an objective turret (2) carrying an objective (1) and with a specimen holder (4) serving to receive a specimen (3), in order to assure an undesired transport of heat between the specimen (3) and the objective (1), is characterized by the fact that all objectives (1) carried by the objective turret (2) are simultaneously adjusted for temperature by means of the objective turret (2).
摘要翻译：具有携带物镜（1）的目标转台（2）和用于接收样本（3）的样品架（4）的显微镜，以确保在样品（3）和物镜之间不希望的热传递（1）的特征在于，通过客观转塔（2）同时调节物镜（2）承载的所有物镜（1）的温度。

58. 发明授权

US06418153B1 Method for operating a laser light source 有权
标题翻译：操作激光光源的方法
公开(公告)号：US06418153B1
公开(公告)日：2002-07-09
申请号：US09307738
申请日：1999-05-10
申请人： Johann Engelhardt , Thomas Zapf , William Hug
发明人： Johann Engelhardt , Thomas Zapf , William Hug
IPC分类号： H01S3101
CPC分类号： G02B21/0032 , G02B21/0036 , G02B21/0084
摘要： In order to extend the life of the laser light source and to reduce the operating costs, a method for operating a laser light source, in particular for scanning in a confocal scanning laser microscope, the laser light source being supplied with electricity via a power pack, is one wherein the laser light source is operated with the requisite power essentially only during the working beam time, preferably during the data acquisition. When a pulsed laser light source is used, the working beam time, in particular the data acquisition, is essentially synchronized with the emission cycle of the laser light source.
摘要翻译：为了延长激光光源的寿命并降低操作成本，一种用于操作激光光源的方法，特别是用于在共聚焦扫描激光显微镜中进行扫描的方法，激光光源经由电源组件被供电，其中激光光源基本上仅在工作光束时间期间以所需功率运行，优选在数据采集期间。当使用脉冲激光光源时，工作光束时间，特别是数据采集基本上与激光光源的发射周期同步。

59. 发明授权

US5988849A Device and process for controlling the movement of an object 失效
标题翻译：用于控制物体运动的装置和过程
公开(公告)号：US5988849A
公开(公告)日：1999-11-23
申请号：US817699
申请日：1997-05-01
申请人： Johann Engelhardt
发明人： Johann Engelhardt
IPC分类号： B25J9/10 , B25J9/18 , G05B19/18 , G05B19/19 , G05B19/23 , G05B19/404 , G05D3/12 , G05B3/02
CPC分类号： G05B19/231
摘要： In the movement of objects, especially benches or robot arms, on a programmed path, the object must be moved into a new position as fast and as smoothly as possible. To this end, the control device of the invention has a compensating unit 17 employing a movement equation describing the state of the system as a reference value Y. At the same time, deviations are controlled by a regulating unit (19). The regulating unit (19) is thus more dynamic and automatically compensates for changes locally and in time in the system parameters.
摘要翻译： PCT No.PCT / DE95 / 01479 Sec。 371日期1997年5月1日 102（e）日期1997年5月1日PCT提交1995年10月24日PCT公布。公开号WO96 / 16360 PCT 日期1996年5月30日在对象，特别是长凳或机器人手臂的移动中，在编程的路径上，物体必须尽可能快地平滑地移动到新的位置。为此，本发明的控制装置具有采用描述系统状态的运动方程作为参考值Y的补偿单元17.同时，由调节单元（19）控制偏差。因此，调节单元（19）更加动态，并且自动补偿系统参数中的局部和时间上的变化。

60. 发明授权

US08559021B2 Three-dimensionally localizing light emitting molecules of unknown orientation and unknown Z-position 有权
标题翻译：三维定位未知取向和未知Z位的发光分子
公开(公告)号：US08559021B2
公开(公告)日：2013-10-15
申请号：US13441043
申请日：2012-04-06
申请人： Johann Engelhardt , Stefan W. Hell , Jan Keller-Findeisen
发明人： Johann Engelhardt , Stefan W. Hell , Jan Keller-Findeisen
IPC分类号： G01B11/14 , G01J3/30 , G06K9/00
CPC分类号： G02B21/0076 , G01N21/6456 , G01N2021/6463
摘要： To the end of three-dimensionally localizing light emitting marker entities of unknown orientation and unknown position in a sample, the light emitted by each single marker entity is imaged in at least two different ways onto at least one detection plane which corresponds to a focal plane (13) in the sample resulting in at least two images of the marker entity. Virtual x- and y-positions of the marker entity in parallel to the focal plane (13) are separately determined from the emitted light intensity distribution over each image of the marker entity. Further, the z-position of the marker entity normal to the focal plane is determined from the emitted light intensity distributions over the images of the marker entity. The real x- and y-positions of the marker entity in parallel to the focal plane (13) are determined based on its virtual x- and y-positions and on its z-position.
摘要翻译：在三维定位样品中未知取向和未知位置的发光标记实体的三维定位结束时，由每个单个标记实体发射的光以至少两种不同的方式成像到至少一个对应于焦平面的检测平面（13），导致标记实体的至少两个图像。标记实体与焦平面（13）平行的虚拟x和y位置根据标记实体的每个图像上的发射光强度分布分别确定。此外，从标记实体的图像上的发射光强度分布确定垂直于焦平面的标记实体的z位置。标记实体与焦平面（13）平行的真实x和y位置基于其虚拟x和y位置及其z位置来确定。

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