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51. 发明申请

US20110020331A1 N-GLYCOSYLATED ANTIBODY 有权
标题翻译： N-糖苷抗体
公开(公告)号：US20110020331A1
公开(公告)日：2011-01-27
申请号：US12786378
申请日：2010-05-24
申请人： Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译：本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段，其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带双重杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。

52. 发明申请

US20100261214A1 Method for Determining ACE2 Activity 有权
标题翻译：确定ACE2活性的方法
公开(公告)号：US20100261214A1
公开(公告)日：2010-10-14
申请号：US12445906
申请日：2007-10-19
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat
IPC分类号： C12Q1/37
CPC分类号： G01N33/573 , C12Q1/37
摘要： The present invention relates to a method of determining ACE2 activity, comprising the following steps: providing ACE2-binding units immobilized on a solid carrier and specific for a part of ACE2 which is not involved in the catalytic activity of ACE2; contacting the immobilized ACE2-binding units with a sample which potentially includes the ACE2, wherein the ACE2 is bound by the ACE2-binding unit; removing the non-binding portions of the sample from the ACE2 bound to the ACE2-binding units; adding a substrate of the ACE2 which is reacted by the ACE2 activity, with the reaction providing a signal; and measuring the change in the signal during a specific period of time, wherein the change can be correlated with the ACE2 activity.
摘要翻译：本发明涉及一种测定ACE2活性的方法，包括以下步骤：提供固定在固体载体上且对ACE2的不参与ACE2催化活性的一部分ACE2特异的ACE2结合单元; 使固定化的ACE2结合单元与潜在地包含ACE2的样品接触，其中ACE2被ACE2结合单元结合; 从与ACE2结合单元结合的ACE2中除去样品的非结合部分; 加入由ACE2活性反应的ACE2底物，反应提供信号; 并测量特定时间段内信号的变化，其中变化可以与ACE2活性相关。

53. 发明申请

US20100260808A1 Method for Increasing Immunoreactivity 有权
标题翻译：增加免疫反应性的方法
公开(公告)号：US20100260808A1
公开(公告)日：2010-10-14
申请号：US12747326
申请日：2008-12-10
申请人： Gottfried Baier , Hans Loibner , Manfred Schuster , Gunther Lametschwandtner , Dominik Wolf
发明人： Gottfried Baier , Hans Loibner , Manfred Schuster , Gunther Lametschwandtner , Dominik Wolf
IPC分类号： A61K39/00 , C12N5/078 , A61P35/00 , A61P35/02 , A61P31/18
CPC分类号： C12N5/0636 , A61K31/713 , A61K35/17 , A61K2035/122 , A61K2039/5158 , C12N15/1137 , C12N2310/14 , C12Y603/02019
摘要： The invention relates to an in vitro or ex vivo method for increasing the immunoreactivity of cells of the immune system, which were contacted with an antigen, said method comprising the reduction or inhibition of the Cbl-b function of said cells, thereby increasing the immunoreactivity of the cells towards the antigen.
摘要翻译：本发明涉及用于增加与抗原接触的免疫系统的细胞的免疫反应性的体外或离体方法，所述方法包括减少或抑制所述细胞的Cbl-b功能，从而增加免疫反应性的细胞朝向抗原。

54. 发明授权

US07759464B2 N-glycosylated antibody 有权
标题翻译： N-糖基化抗体
公开(公告)号：US07759464B2
公开(公告)日：2010-07-20
申请号：US11571983
申请日：2004-07-14
申请人： Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody, or fragment of the antibody, that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region of the antibody, or fragment of the antibody, carries a bi-sected hybrid type N-glycosylation pattern and that the antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译：本发明涉及识别Lewis Y抗原的来自亲本单克隆抗体的单克隆抗体或抗体片段，其特征在于抗体的Fc区或抗体的片段携带双链抗体，所述杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。

55. 发明授权

US06982120B2 Hardened steel components and process of treating the same 失效
标题翻译：硬化钢组件及其处理方法
公开(公告)号：US06982120B2
公开(公告)日：2006-01-03
申请号：US10489742
申请日：2002-07-20
申请人： Manfred Schuster
发明人： Manfred Schuster
IPC分类号： C21D9/40
CPC分类号： F16D3/223 , C21D1/10 , C21D1/78 , C21D9/0068 , C21D9/40 , C23C8/80 , F16D2300/10 , Y02P10/253 , Y10T428/24975 , Y10T428/26 , Y10T428/265
摘要： The invention relates to components made of steel, more particularly outer joint parts and inner joint parts of constant velocity joints, and to a process of heat treating such components made of steel. The heat treatment operation includes the process stages of nitriding, induction surface layer hardening and tempering, which processes follow one another. As a result of the nitriding operation, the joint parts are provided with a surface layer (15) including nitrides and a diffusion layer (18) positioned thereunderneath. The subsequent induction hardening process causes the diffusion layer (18) to be hardened, so that it comprises good supporting characteristics for supporting the surface layer (15) positioned above same.
摘要翻译：本发明涉及由钢制成的部件，更具体地说是外接头部件和恒速接头的内接头部件以及由钢制成的部件进行热处理的工序。热处理操作包括氮化，感应表面层硬化和回火的工艺阶段，这些过程相互依存。作为渗氮操作的结果，接合部分设置有包括氮化物的表面层（15）和位于其上的扩散层（18）。随后的感应淬火过程使得扩散层（18）硬化，使得它包括用于支撑位于其上方的表面层（15）的良好的支撑特性。

56. 发明授权

US06226349B1 X-ray analysis apparatus with a graded multilayer mirror 有权
标题翻译：具有渐变多层镜的X射线分析装置
公开(公告)号：US06226349B1
公开(公告)日：2001-05-01
申请号：US09356346
申请日：1999-07-19
申请人： Manfred Schuster , Herbert Goebel , Carsten Michaelsen , Ruediger Bormann
发明人： Manfred Schuster , Herbert Goebel , Carsten Michaelsen , Ruediger Bormann
IPC分类号： G01N23207
CPC分类号： G01N23/201 , G01N23/20 , G21K1/062
摘要： An X-ray analysis apparatus having a curved paraboloid-shaped curved graded multilayer Bragg reflector (5) is characterized in that the layers of the reflector (5) are directly introduced onto a concave curved surface of a paraboloid-shaped hollow substrate and a maximum allowable shape deviation for the concave substrate surface facing the reflector is &Dgr;p={square root over (2px)} &Dgr;&thgr;R, and having a maximum allowable waviness Δ ⁢ ⁢ y Δ ⁢ ⁢ x = 1 2 ⁢ Δθ R and a maximum allowable roughness &Dgr;y=d/2&pgr;, preferentially &Dgr;y≦0.3 nm, wherein the X radiation (7) impinges on the curved surface of the reflector (5) at an angle of incidence 0°
摘要翻译：具有弯曲抛物面形弯曲多层布拉格反射体（5）的X射线分析装置的特征在于，将反射器（5）的各层直接导入抛物面形中空基板的凹曲面上，面向反射器的凹面基板表面的允许形状偏差为DELTAp = {平方根超过（2px）} DELTAthetaR，并且具有最大允许波纹度和最大允许粗糙度DELTAy = d / 2pi，优选为DELTAy <= 0.3nm，其中X 辐射（7）以入射角0°<= 5°撞击反射器（5）的弯曲表面，随着反射器层朝向抛物面开口的周期厚度d在x方向上增加，偏差DELTAd / DELTAx小于d /（2x）。以这种方式，在可靠性和寿命方面，分析装置的传输被显着地提高，同时降低了制造难度和费用。

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