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51. 发明授权

US06574497B1 MRI medical device markers utilizing fluorine-19 有权
标题翻译：使用氟-19的MRI医疗器械标记
公开(公告)号：US06574497B1
公开(公告)日：2003-06-03
申请号：US09746843
申请日：2000-12-22
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： A61M2500
CPC分类号： G01R33/285 , A61B90/39 , A61B2090/3954 , A61F2/01 , A61F2/07 , A61F2/91 , A61F2002/075 , A61L29/18 , A61L31/18 , A61M25/0127
摘要： Medical devices that incorporate compounds containing fluorine-19 materials for use as contrast agents and passive markers in interventional magnetic resonance angiography. The device may be a guidewire, guiding catheter, angioplasty catheter, stent, embolic protection device, endovascular graft, endotracheal tube, Foley catheter, Hickman catheter, Broviac catheter, cerebrospinal fluid shunt, biliary stent, stylet, biopsy needle, electrode, percutaneous or endoluminal transducer or other desired interventional medical device. The fluorine-19 material may be configured from an elastomer, a fluid, a fluorosilicone, or a perfluorocarbon grease or oil. Such materials may be incorporated into marker bands and/or stripes, or may be deposited into or dispersed within the walls or lumens of the medical device to be visualized. Use of fluorine-19 containing markers and contrast agents provide a novel method of performing angioplasty and deploying stents, grafts, embolic protection and other such devices using interventional magnetic resonance angiography.
摘要翻译：包含氟-19材料的化合物的医疗装置用作介入性磁共振血管造影剂中的造影剂和被动标记物。该装置可以是导丝，引导导管，血管成形术导管，支架，栓塞保护装置，血管内移植物，气管内导管，Foley导管，Hickman导管，Broviac导管，脑脊液分流，胆管支架，探针，活检针，电极，经皮或腔内换能器或其他所需的介入医疗装置。氟-19材料可以由弹性体，流体，氟硅氧烷或全氟化碳润滑脂或油构成。这样的材料可以并入到标记带和/或条纹中，或者可以沉积到或分散在待显现的医疗装置的壁或腔内。使用含氟-19的标记物和造影剂提供了使用介入磁共振血管造影术进行血管成形术和部署支架，移植物，栓塞保护和其它这样的装置的新方法。

52. 发明授权

US08349350B2 Coatings for drug delivery devices 失效
公开(公告)号：US08349350B2
公开(公告)日：2013-01-08
申请号：US12511921
申请日：2009-07-29
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61L27/16 , A61L27/30 , A61L27/54 , A61L31/16 , C09D129/04 , C09D129/06 , C08L29/02
摘要： A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.

53. 发明授权

US08343206B2 Drug-eluting stent and delivery system with tapered stent in shoulder region 有权
标题翻译：药物洗脱支架和带锥形支架的递送系统在肩部区域
公开(公告)号：US08343206B2
公开(公告)日：2013-01-01
申请号：US13285627
申请日：2011-10-31
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2002/9583 , A61F2220/005 , A61F2220/0058 , A61F2230/0013 , A61F2250/0067 , Y10T29/49826
摘要： A drug-eluting stent delivery system has a balloon disposed about at least a portion of a catheter, the balloon having a first end and a second end and a working length therebetween, the first end and the second end each including a tapered portion, each tapered portion being attached to the catheter, the balloon being inflatable from a collapsed configuration to an inflated configuration. A drug-eluting stent has a first end and a second end, the first end and the second end each including a tapered portion, wherein the drug-eluting stent is disposed over the balloon such that at least a portion of the first end and the second end of the balloon are covered by the tapered drug-eluting stent.
摘要翻译：药物洗脱支架递送系统具有围绕导管的至少一部分设置的球囊，所述球囊具有第一端和第二端以及其间的工作长度，第一端和第二端各自包括锥形部分，每个包括锥形部分锥形部分附接到导管，气囊可从折叠构型充气到膨胀构型。药物洗脱支架具有第一端和第二端，第一端和第二端各自包括锥形部分，其中药物洗脱支架设置在气囊上方，使得第一端和第二端的至少一部分气囊的第二端由锥形药物洗脱支架覆盖。

54. 发明申请

US20110283501A1 CRIMPING APPARATUS 有权
标题翻译：冲击装置
公开(公告)号：US20110283501A1
公开(公告)日：2011-11-24
申请号：US13197611
申请日：2011-08-03
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： B23Q1/00 , B05C11/02
CPC分类号： A61F2/958 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/9522 , A61F2240/001 , A61L31/022 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2420/06 , B05C11/00 , B21D39/048 , Y10T29/49863 , Y10T29/49865 , Y10T29/49925 , Y10T29/49927 , Y10T29/53996
摘要： An apparatus is disclosed including a workspace for receiving a stent and a delivery device for the stent; a source for exposing the stent in the workspace to a plasticizing agent, vapor, or moisture, wherein the stent can be reduced in diameter in the workspace while under exposure of the plasticizing agent, vapor or moisture; and a device for reducing the diameter of the stent in the workspace to position the stent on or within the deliver device.
摘要翻译：公开了一种包括用于接收支架的工作空间和用于支架的输送装置的装置; 用于将工作空间中的支架暴露于塑化剂，蒸汽或水分的源，其中在塑化剂，蒸气或水分暴露的同时，支架可以在工作空间中直径减小; 以及用于在工作空间中减小支架的直径以将支架定位在输送装置上或内部的装置。

55. 发明授权

US08057526B2 Drug-eluting stent and delivery system with tapered stent in shoulder region 有权
标题翻译：药物洗脱支架和带锥形支架的递送系统在肩部区域
公开(公告)号：US08057526B2
公开(公告)日：2011-11-15
申请号：US11646781
申请日：2006-12-28
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2002/9583 , A61F2220/005 , A61F2220/0058 , A61F2230/0013 , A61F2250/0067 , Y10T29/49826
摘要： A drug-eluting stent delivery system for the treatment of edge restenosis in a blood vessel. The drug-eluting stent delivery system has a balloon disposed about at least a portion of a catheter, the balloon having a first end and a second end and a working length therebetween, the first end and the second end each including a tapered portion, each tapered portion being attached to the catheter, the balloon being inflatable from a collapsed configuration to an inflated configuration. A drug-eluting stent contacts a wall of the blood vessel to maintain the patency of the vessel. The drug-eluting stent has a first end and a second end, the first end and the second end each including a tapered portion, wherein the drug-eluting stent is disposed over the balloon such that at least a portion of the first end and the second end of the balloon are covered by the tapered drug-eluting stent. A method for making the same is also disclosed herein.
摘要翻译：用于治疗血管中边缘再狭窄的药物洗脱支架递送系统。药物洗脱支架递送系统具有围绕导管的至少一部分设置的球囊，所述球囊具有第一端和第二端以及其间的工作长度，第一端和第二端各自包括锥形部分，每个锥形部分附接到导管，气囊可从折叠构型充气到膨胀构型。药物洗脱支架接触血管的壁以维持血管的通畅。药物洗脱支架具有第一端和第二端，第一端和第二端各自包括锥形部分，其中药物洗脱支架设置在气囊上方，使得第一端和第二端的至少一部分气囊的第二端由锥形药物洗脱支架覆盖。本文还公开了制备该方法的方法。

56. 发明授权

US08015684B2 Crimping apparatus 有权
标题翻译：压接装置
公开(公告)号：US08015684B2
公开(公告)日：2011-09-13
申请号：US12692536
申请日：2010-01-22
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： B23P11/00 , B23P25/00
CPC分类号： A61F2/958 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/9522 , A61F2240/001 , A61L31/022 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2420/06 , B05C11/00 , B21D39/048 , Y10T29/49863 , Y10T29/49865 , Y10T29/49925 , Y10T29/49927 , Y10T29/53996
摘要： An apparatus is disclosed including a workspace for receiving a stent and a delivery device for the stent; a source for exposing the stent in the workspace to a plasticizing agent, vapor, or moisture, wherein the stent can be reduced in diameter in the workspace while under exposure of the plasticizing agent, vapor or moisture; and a device for reducing the diameter of the stent in the workspace to position the stent on or within the deliver device.
摘要翻译：公开了一种包括用于接收支架的工作空间和用于支架的输送装置的装置; 用于将工作空间中的支架暴露于塑化剂，蒸汽或水分的源，其中在塑化剂，蒸气或水分暴露的同时，支架可以在工作空间中直径减小; 以及用于在工作空间中减小支架的直径以将支架定位在输送装置上或内部的装置。

57. 发明申请

US20100192353A1 Method of Producing Stent-Balloon Assembly 有权
标题翻译：生产支气管装配方法
公开(公告)号：US20100192353A1
公开(公告)日：2010-08-05
申请号：US12692537
申请日：2010-01-22
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： B23P11/00
CPC分类号： A61F2/958 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/9522 , A61F2240/001 , A61L31/022 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2420/06 , B05C11/00 , B21D39/048 , Y10T29/49863 , Y10T29/49865 , Y10T29/49925 , Y10T29/49927 , Y10T29/53996
摘要： A method of producing a stent-balloon assembly is disclosed which includes providing a stent having a polymeric component; exposing the stent to a relative humidity of 20% to 100%; and crimping the stent on a balloon of a catheter assembly. The polymeric component could be at least part of the material from which the stent is made or could be a constituent of a coating for the stent, such as a drug delivery coating. In lieu of or in addition to the application of humidity, a plasticizing agent can be applied to the polymeric component. A crimping device is also disclosed which allows the stent to be exposed to humidity during the crimping process.
摘要翻译：公开了一种制造支架 - 球囊组件的方法，其包括提供具有聚合物组分的支架; 将支架暴露于20％至100％的相对湿度; 并将支架卷曲在导管组件的气球上。聚合物组分可以是制造支架的材料的至少一部分，或者可以是用于支架的涂层的成分，例如药物递送涂层。除了施加湿度之外，还可以将增塑剂施加到聚合物组分上。还公开了压接装置，其允许支架在压接过程期间暴露于湿度。

58. 发明授权

US07753926B1 Method and apparatus for treating vulnerable plaque 有权
标题翻译：治疗易损斑块的方法和装置
公开(公告)号：US07753926B1
公开(公告)日：2010-07-13
申请号：US10459171
申请日：2003-06-10
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： A61M29/00 , A61B17/22
CPC分类号： A61B17/320725 , A61B17/22032 , A61B2017/22081 , A61M25/10 , A61M29/02 , A61M2025/1097
摘要： Embodiments include, a medical device having a balloon portion with a first end, a second end, and a variable balloon mass to inflate the balloon portion non-uniformly from the first end to the second end. In one embodiment, the balloon portion inflates in a controlled manner to rupture a vulnerable plaque near the second end.
摘要翻译：实施例包括具有第一端的球囊部分，第二端和可变球囊的医疗装置，以使球囊部分从第一端部至第二端部不均匀地膨胀。在一个实施例中，球囊部分以受控的方式膨胀以破坏靠近第二端的易损斑块。

59. 发明申请

US20100122446A1 Crimping Apparatus 有权
标题翻译：压接装置
公开(公告)号：US20100122446A1
公开(公告)日：2010-05-20
申请号：US12692536
申请日：2010-01-22
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： B23P19/04
CPC分类号： A61F2/958 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/9522 , A61F2240/001 , A61L31/022 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2420/06 , B05C11/00 , B21D39/048 , Y10T29/49863 , Y10T29/49865 , Y10T29/49925 , Y10T29/49927 , Y10T29/53996
摘要： An apparatus is disclosed including a workspace for receiving a stent and a delivery device for the stent; a source for exposing the stent in the workspace to a plasticizing agent, vapor, or moisture, wherein the stent can be reduced in diameter in the workspace while under exposure of the plasticizing agent, vapor or moisture; and a device for reducing the diameter of the stent in the workspace to position the stent on or within the deliver device.
摘要翻译：公开了一种包括用于接收支架的工作空间和用于支架的输送装置的装置; 用于将工作空间中的支架暴露于塑化剂，蒸汽或水分的源，其中在塑化剂，蒸气或水分暴露的同时，支架可以在工作空间中直径减小; 以及用于在工作空间中减小支架的直径以将支架定位在输送装置上或内部的装置。

60. 发明申请

US20100115755A1 Method of Inserting Self-Expandable Stent in a Sheath 有权
标题翻译：在护套中插入自扩张支架的方法
公开(公告)号：US20100115755A1
公开(公告)日：2010-05-13
申请号：US12692531
申请日：2010-01-22
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： B23P11/02
CPC分类号： A61F2/958 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/9522 , A61F2240/001 , A61L31/022 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2420/06 , B05C11/00 , B21D39/048 , Y10T29/49863 , Y10T29/49865 , Y10T29/49925 , Y10T29/49927 , Y10T29/53996
摘要： A method is disclosed comprising providing a self-expandable stent having a polymeric component. The stent is exposed to a relative humidity of 20% to 100% (RH) or a plasticizing agent is applied to the polymeric component. The diameter of the stent is reduced. The stent having a reduced diameter is inserted in a constraining sheath such that the sheath constrains the stent in a reduced diameter, such that removal of the stent from the sheath causes the stent to self-expand to a greater diameter.
摘要翻译：公开了一种提供具有聚合物组分的自扩张支架的方法。将支架暴露于20％至100％（RH）的相对湿度，或将增塑剂施加到聚合物组分上。支架的直径减小。具有减小的直径的支架被插入约束护套中，使得护套以缩小的直径限制支架，使得支架从护套中移除会导致支架自膨胀至更大的直径。

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