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51. 发明申请

US20140088487A1 METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE WITH LIGHT 审中-公开
标题翻译：用于用光激活褐色扁桃体组织的方法和装置
公开(公告)号：US20140088487A1
公开(公告)日：2014-03-27
申请号：US13977536
申请日：2011-12-21
申请人： Jason L. Harris , Lee M. Kaplan , David N. Plescia , Taylor W. Aronhalt , James W. Voegele , Nicholas Stylopoulos
发明人： Jason L. Harris , Lee M. Kaplan , David N. Plescia , Taylor W. Aronhalt , James W. Voegele , Nicholas Stylopoulos
IPC分类号： A61N5/06
CPC分类号： A61N5/0613 , A61M5/14276 , A61M2230/06 , A61M2230/201 , A61N5/062
摘要： Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.
摘要翻译：提供了用于用光激活棕色脂肪组织（BAT）的方法和装置。通常，方法和装置可以激活BAT以增加产热，例如增加患者的热产生，其随着时间推移可导致体重减轻和/或改善的代谢功能。在一个实施方案中，提供了一种医疗装置，其通过使用光来刺激BAT来激发BAT，和/或直接刺激棕色脂肪细胞，从而增加BAT中的产热，并通过能量消耗引起体重减轻和/或改善的代谢功能来激活BAT 。光可以配置成直接或间接刺激神经和/或棕色脂肪细胞。光可以被配置为通过激活施用于患者的光可激活介质并配置为响应于光以引起棕色脂肪组织的激活来间接刺激神经和/或棕色脂肪细胞。

52. 依法登记的发明

USH2037H1 Electrosurgical hemostatic device including an anvil 失效
公开(公告)号：USH2037H1
公开(公告)日：2002-07-02
申请号：US08856210
申请日：1997-05-14
申请人： David C. Yates , James W. Voegele , Jesse Kuhns , Anil Nalagatla , Warren P. Williamson, IV , Darrel M. Powell
发明人： David C. Yates , James W. Voegele , Jesse Kuhns , Anil Nalagatla , Warren P. Williamson, IV , Darrel M. Powell
IPC分类号： A61B1818
摘要： An electrosurgical instrument is provided for cauterization and/or welding of tissue of varying impedance, thickness and vascularity especially in the performance of endoscopic procedures. The instrument compresses the tissue between one pole of a bipolar energy source located on one interfacing surface, and a second interfacing surface applying pressure in a predetermined range wherein one of the interfacing surfaces is positioned on an anvil with a specified preload and spring rate. A second pole is located one of the two interfacing surfaces. In a preferred embodiment, the second pole is located on the same interfacing surface as the first pole and an insulator electrically isolates the two poles. A preferred application of the invention is in a cutting instrument wherein a hemostatic line is formed along a cut line using RF energy.

53. 依法登记的发明

USH1904H Electrosurgical hemostatic method and device 失效
标题翻译：电外科止血方法及装置
公开(公告)号：USH1904H
公开(公告)日：2000-10-03
申请号：US856520
申请日：1997-05-14
申请人： David C. Yates , James W. Voegele , Jesse Kuhns , Anil Nalagatla , Warren P. Williamson, IV
发明人： David C. Yates , James W. Voegele , Jesse Kuhns , Anil Nalagatla , Warren P. Williamson, IV
IPC分类号： A61B17/072 , A61B17/115 , A61B17/32 , A61B18/12 , A61B18/14 , A61B19/00 , A61B18/18
CPC分类号： A61B17/07207 , A61B17/32 , A61B18/1206 , A61B18/1402 , A61B18/1447 , A61B2018/00875 , A61B2090/032
摘要： An electrosurgical instrument is provided for cauterization and/or welding of tissue of varying impedance, thickness and vascularity especially in the performance of endoscopic procedures. The instrument compresses the tissue between one pole of a bipolar energy source located on one interfacing surface, and a second interfacing surface applying pressure in a predetermined range. A second pole is located one of the two interfacing surfaces. In a preferred embodiment, the second pole is located on the same interfacing surface as the first pole and an insulator electrically isolates the two poles. A preferred application of the invention is in a cutting instrument wherein a hemostatic line is formed along a cut line using RF energy.
摘要翻译：提供了一种电外科手术器械，用于烧灼和/或焊接不同阻抗，厚度和血管的组织，特别是在内窥镜手术的执行过程中。该仪器压缩位于一个界面表面上的双极能量源的一极之间的组织和在预定范围内施加压力的第二接口表面。第二个极点位于两个接口表面之一。在优选实施例中，第二极位于与第一极相同的接口表面上，绝缘体电隔离两极。本发明的优选应用在切割仪器中，其中使用RF能量沿着切割线形成止血线。

54. 发明授权

US5810811A Electrosurgical hemostatic device 失效
标题翻译：电外科止血装置
公开(公告)号：US5810811A
公开(公告)日：1998-09-22
申请号：US835127
申请日：1997-04-04
申请人： David C. Yates , James W. Voegele , Jesse Kuhns , Anil Nalagatla , Warren P. Williamson IV , Steven H. Mersch , Martin Madden , Richard P. Nuchols
发明人： David C. Yates , James W. Voegele , Jesse Kuhns , Anil Nalagatla , Warren P. Williamson IV , Steven H. Mersch , Martin Madden , Richard P. Nuchols
IPC分类号： A61B18/16 , A61B17/072 , A61B17/115 , A61B17/32 , A61B18/14 , A61B19/00 , A61B17/36
CPC分类号： A61B18/1447 , A61B17/07207 , A61B17/115 , A61B17/1155 , A61B17/32 , A61B18/1206 , A61B2018/00404 , A61B2018/00601 , A61B2018/00642 , A61B2018/00666 , A61B2018/00672 , A61B2018/00678 , A61B2018/00684 , A61B2018/00702 , A61B2018/00708 , A61B2018/00875 , A61B2018/1273 , A61B2018/1861 , A61B2090/032
摘要： An improved electro surgical instrument is provided for cauterization and/or welding of tissue of varying impedances, thicknesses and vascularity especially in the performance of endoscopic procedures. The instrument compresses the tissue between one pole of a bipolar energy source located on one interfacing surface, and a second interfacing surface. A second pole is located on one of the two interfacing surfaces. In a preferred embodiment, the second pole is located on the same interfacing surface as the first pole and an insulator electrically isolates the two poles. A preferred application of the invention is in a cutting instrument wherein a hemostatic line is formed along a cut line using RF energy.
摘要翻译：提供了一种改进的电手术器械，用于对变化的阻抗，厚度和血管的组织进行烧灼和/或焊接，特别是在内窥镜手术的执行中。该仪器压缩位于一个界面表面上的双极能量源的一个极点与第二接口表面之间的组织。第二个极位于两个接口表面中的一个上。在优选实施例中，第二极位于与第一极相同的接口表面上，绝缘体电隔离两极。本发明的优选应用在切割仪器中，其中使用RF能量沿着切割线形成止血线。

55. 发明授权

US07946453B2 Surgical band fluid media dispenser 有权
标题翻译：手术带液体介质分配器
公开(公告)号：US07946453B2
公开(公告)日：2011-05-24
申请号：US11558107
申请日：2006-11-09
申请人： James W. Voegele , John V. Hunt
发明人： James W. Voegele , John V. Hunt
IPC分类号： B67D7/78 , A61B17/00 , A61M5/00
CPC分类号： A61M35/003 , A61B17/00491 , A61B2017/00407
摘要： A multiple use fluid dispenser dispenses a flowable material in a precise pattern and quantity with leaking and clogging between dispensing avoided by employing a trigger fired syringe plunger to expel a fixed volume through a band. Between strokes, an advancement knob rotates the band over a distal dispensing tip to a nondispensing location that wipes excess flowable material and seals a dispensing orifice in a fluid conduit. The advancement knob further may rotate the band to a dispensing position wherein a combination of one or more dispensing holes produce a desired pattern and rate of flow with material over the dispensing hole(s) serving to initiate the flowable material, to control placement, serve as a detachable bandage or buttress material, etc.
摘要翻译：多用途流体分配器以精确的图案和数量分配可流动材料，其中分配之间的泄漏和堵塞，通过使用触发器喷射的针筒柱塞来排除通过带的固定体积。在笔划之间，推进旋钮将带远离分配尖端旋转到非分散位置，其擦除多余的可流动材料并将流体导管中的分配孔密封。推进旋钮还可以将带旋转到分配位置，其中一个或多个分配孔的组合产生期望的图案和流速，分配孔用于启动可流动材料，以控制放置，服务作为可拆卸的绷带或支撑材料等

56. 发明授权

US10441808B2 Methods and devices for activating brown adipose tissue with light 有权
公开(公告)号：US10441808B2
公开(公告)日：2019-10-15
申请号：US13977536
申请日：2011-12-21
申请人： Jason L. Harris , Lee M. Kaplan , David N. Plescia , Taylor W. Aronhalt , James W. Voegele , Nicholas Stylopoulos
发明人： Jason L. Harris , Lee M. Kaplan , David N. Plescia , Taylor W. Aronhalt , James W. Voegele , Nicholas Stylopoulos
IPC分类号： A61N5/06 , A61M5/142
摘要： Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.

57. 发明申请

US20140018767A1 METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE WITH TARGETED SUBSTANCE DELIVERY 有权
标题翻译：用于对具有指定物质输送功能的褐色组织进行活化的方法和装置
公开(公告)号：US20140018767A1
公开(公告)日：2014-01-16
申请号：US13977501
申请日：2011-12-21
申请人： Jason L. Harris , Taylor W. Aronhalt , Dwight Henninger , James W. Voegele , Lee M. Kaplan , Nicholas Stylopoulos
发明人： Jason L. Harris , Taylor W. Aronhalt , Dwight Henninger , James W. Voegele , Lee M. Kaplan , Nicholas Stylopoulos
IPC分类号： A61M35/00 , A61M5/14
CPC分类号： A61F5/0003 , A61K9/0014 , A61K9/0019 , A61K9/7023 , A61M5/14 , A61M5/14276 , A61M35/00 , A61M37/00 , A61M2005/1726 , A61M2205/50 , A61M2230/06 , A61M2230/201
摘要： Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.
摘要翻译：提供了用于激活具有靶向物质递送的棕色脂肪组织的方法和装置。通常，方法和装置可以激活BAT以增加产热，例如增加患者的热产生，其随着时间推移可导致体重减轻和/或改善的代谢功能。在一个实施方案中，可以将配置成刺激活动BAT和/或直接刺激棕色脂肪细胞的神经的化学物质递送给患者，由此增加BAT中的产热，并通过能量消耗引起体重减轻和/或改善的代谢功能。化学品可以局部和/或全身地递送到患者以刺激神经和/或棕色脂肪细胞。

58. 发明申请

US20080114315A1 Surgical Band Fluid Media Dispenser 有权
标题翻译：手术带液体介质分配器
公开(公告)号：US20080114315A1
公开(公告)日：2008-05-15
申请号：US11558107
申请日：2006-11-09
申请人： James W. Voegele , John V. Hunt
发明人： James W. Voegele , John V. Hunt
IPC分类号： A61M35/00 , A61B17/03
CPC分类号： A61M35/003 , A61B17/00491 , A61B2017/00407
摘要： A multiple use fluid dispenser dispenses a flowable material in a precise pattern and quantity with leaking and clogging between dispensing avoided by employing a trigger fired syringe plunger to expel a fixed volume through a band. Between strokes, an advancement knob rotates the band over a distal dispensing tip to a nondispensing location that wipes excess flowable material and seals a dispensing orifice in a fluid conduit. The advancement knob further may rotate the band to a dispensing position wherein a combination of one or more dispensing holes produce a desired pattern and rate of flow with material over the dispensing hole(s) serving to initiate the flowable material, to control placement, serve as a detachable bandage or buttress material, etc.
摘要翻译：多用途流体分配器以精确的图案和数量分配可流动材料，其中分配之间的泄漏和堵塞，通过使用触发器喷射的针筒柱塞来排除通过带的固定体积。在笔划之间，推进旋钮将带远离分配尖端旋转到非分散位置，其擦除多余的可流动材料并将流体导管中的分配孔密封。推进旋钮还可以将带旋转到分配位置，其中一个或多个分配孔的组合产生期望的图案和流速，分配孔用于启动可流动材料，以控制放置，服务作为可拆卸的绷带或支撑材料等

59. 发明授权

US09610429B2 Methods and devices for activating brown adipose tissue with targeted substance delivery 有权
公开(公告)号：US09610429B2
公开(公告)日：2017-04-04
申请号：US13977501
申请日：2011-12-21
申请人： Jason L. Harris , Taylor W. Aronhalt , Dwight Henninger , James W. Voegele , Lee M. Kaplan , Nicholas Stylopoulos
发明人： Jason L. Harris , Taylor W. Aronhalt , Dwight Henninger , James W. Voegele , Lee M. Kaplan , Nicholas Stylopoulos
IPC分类号： A61M5/00 , A61K9/70 , A61M35/00 , A61M5/142 , A61M5/14 , A61M5/172
CPC分类号： A61F5/0003 , A61K9/0014 , A61K9/0019 , A61K9/7023 , A61M5/14 , A61M5/14276 , A61M35/00 , A61M37/00 , A61M2005/1726 , A61M2205/50 , A61M2230/06 , A61M2230/201
摘要： Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.

60. 发明授权

US09381219B2 Brown adipocyte modification 有权
标题翻译：棕色脂肪细胞修饰
公开(公告)号：US09381219B2
公开(公告)日：2016-07-05
申请号：US13977543
申请日：2011-12-21
申请人： Lee M. Kaplan , Nicholas Stylopoulos , Jason L. Harris , Dwight Henninger , Taylor W. Aronhalt , James W. Voegele
发明人： Lee M. Kaplan , Nicholas Stylopoulos , Jason L. Harris , Dwight Henninger , Taylor W. Aronhalt , James W. Voegele
IPC分类号： A61K35/12 , C12N15/85 , A61K35/35 , A61K48/00 , C07K14/47
CPC分类号： A61K35/35 , A61K38/177 , A61K48/005 , C07K14/47 , C07K14/705 , C12N5/0653 , C12N7/00 , C12N15/85 , C12N15/86 , C12N2506/1392 , C12N2750/14143 , C12N2799/025 , C12N2830/002
摘要： Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.
摘要翻译：提供了通过增加棕色脂肪组织活化来治疗代谢紊乱的方法和治疗。通常，方法和治疗可以增加棕色脂肪组织的活化以增加能量消耗并引起体重减轻。在一个实施方案中，增加棕色脂肪组织活化的方法包括修饰棕色脂肪细胞以表达激活棕色脂肪细胞的基因，例如解偶联蛋白1.在另一个实施方案中，增加棕色脂肪组织活化的方法包括增加褐色脂肪细胞这可以通过在体内诱导脂肪细胞的增殖或离体扩展脂肪细胞，将脂肪细胞移植到棕色脂肪组织贮库或其他地方并诱导脂肪细胞祖细胞如MSC，脂肪细胞祖细胞，前脂肪细胞和脂肪细胞前体细胞的分化来实现。

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