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51. 发明授权

US07851504B2 Enhanced bimatoprost ophthalmic solution 有权
标题翻译：增强的比马前列素眼科溶液
公开(公告)号：US07851504B2
公开(公告)日：2010-12-14
申请号：US11083261
申请日：2005-03-16
申请人： Chin-Ming Chang , James N. Chang , Rhett M. Schiffman , R. Scott Jordan , Joan-En Chang-Lin
发明人： Chin-Ming Chang , James N. Chang , Rhett M. Schiffman , R. Scott Jordan , Joan-En Chang-Lin
IPC分类号： A61K31/19 , A61K31/215
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein.A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
摘要翻译：本文公开了包含0.005％至0.02％的比马前列素和100ppm至250ppm苯扎氯铵的组合物，其中所述组合物是配制用于眼部给药的水性液体。本文还公开了可用于治疗与其有关的青光眼或高眼压症的方法。

52. 发明申请

US20090149435A1 PROCESS FOR MAKING A PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：制备药物组合物的方法
公开(公告)号：US20090149435A1
公开(公告)日：2009-06-11
申请号：US11952927
申请日：2007-12-07
申请人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
发明人： Zhengjun Wang , Thomas M. McGrath , Toan N. Ha , Sam W. Lam , Bruce A. Firestone , Robert T. Lyons , James N. Chang , John T. Trogden
IPC分类号： A61K31/573
CPC分类号： A61K9/0019
摘要： Process for making a sterile, injectable pharmaceutical composition by combining triamcinolone, a buffer and a high viscosity hyaluronate.
摘要翻译：通过组合曲安奈德，缓冲液和高粘度透明质酸来制备无菌注射药物组合物的方法。

53. 发明申请

US20080269181A1 METHODS FOR TREATING A POSTERIOR SEGMENT OF AN EYE 有权
标题翻译：治疗眼睛前期部分的方法
公开(公告)号：US20080269181A1
公开(公告)日：2008-10-30
申请号：US12172194
申请日：2008-07-11
申请人： Robert T. LYONS , James N. Chang , John T. Trogden , Scott M. Whitcup
发明人： Robert T. LYONS , James N. Chang , John T. Trogden , Scott M. Whitcup
IPC分类号： A61K31/56 , A61P27/02
CPC分类号： A61K31/58 , A61K9/0048 , A61K31/573 , A61K47/36
摘要： Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.
摘要翻译：提供了组合物和使用这种组合物的方法，其可用于注射到人或动物眼睛的后段中。这样的组合物包括以治疗有效量存在的含皮质类固醇成分的颗粒，粘度诱导组分和水性载体组分。组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。在优选的实施方案中，粘度在约140,000cps至约300,000cps的范围内。组合物有利地将颗粒悬浮长时间。

54. 发明申请

US20080207494A1 Cyclosporin Compositions 有权
标题翻译：环孢菌素组合物
公开(公告)号：US20080207494A1
公开(公告)日：2008-08-28
申请号：US11917448
申请日：2006-07-12
申请人： James N. Chang , Orest Olejnik , Bruce A. Firestone
发明人： James N. Chang , Orest Olejnik , Bruce A. Firestone
IPC分类号： A61K38/13 , A61P27/04
CPC分类号： A61K9/0048 , A61K36/00 , A61K38/13 , A61K2300/00
摘要： Cyclosporin A compositions are disclosed herein comprising an oil and a surfactant. These are useful in the treatment of dry eye disease.
摘要翻译：本文公开了包含油和表面活性剂的环孢菌素A组合物。这些可用于治疗干眼症。

55. 发明授权

US07276476B2 Cyclosporin compositions 有权
公开(公告)号：US07276476B2
公开(公告)日：2007-10-02
申请号：US11181187
申请日：2005-07-13
申请人： James N. Chang , Orest Olejnik , Bruce A. Firestone
发明人： James N. Chang , Orest Olejnik , Bruce A. Firestone
IPC分类号： A61K38/12
CPC分类号： A61K36/23 , A61K9/0048 , A61K9/107 , A61K36/482 , A61K36/54 , A61K36/61 , A61K38/13 , A61K47/08 , A61K47/10 , A61K47/26 , A61K47/38 , A61K47/44 , Y10S514/912 , Y10S514/975 , A61K2300/00
摘要： A composition comprising from 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil selected from the group consisting of anise oil, clove oil, cassia oil, cinnamon oil, and combinations thereof, wherein said composition is an ophthalmically acceptable emulsion is disclosed herein.

56. 发明授权

US06635654B1 Ophthalmic compositions containing loratadine 有权
标题翻译：含有氯雷他定的眼用组合物
公开(公告)号：US06635654B1
公开(公告)日：2003-10-21
申请号：US10340355
申请日：2003-01-09
申请人： Chin-Ming Chang , Eldon Q. Farnes , Orest Olejnik , James N. Chang
发明人： Chin-Ming Chang , Eldon Q. Farnes , Orest Olejnik , James N. Chang
IPC分类号： A61K3144
CPC分类号： A61K9/0048 , A61K31/4545
摘要： The present invention is directed to an ophthalmic formulation which comprises a therapeutically effective amount of ethyl 4-(8-chloro-5,6-dihydro-11-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate, known as loratadine, a fatty acid ester, and a surfactant, which has been found to be useful in treating ocular allergies, especially allergic conjunctivitis, and related conditions.
摘要翻译：本发明涉及一种眼用制剂，其包含治疗有效量的4-（8-氯-5,6-二氢-11-苯并[5,6]环庚并[1,2-b]吡啶-11- 已经被发现可用于治疗眼部过敏症，特别是过敏性结膜炎和相关病症的已知的氯雷他定，脂肪酸酯和表面活性剂的亚胺基-1-哌啶羧酸酯。

57. 发明申请

US20120316243A1 ENHANCED BIMATOPROST OPHTHALMIC SOLUTION 有权
公开(公告)号：US20120316243A1
公开(公告)日：2012-12-13
申请号：US13551362
申请日：2012-07-17
申请人： Chin-Ming Chang , James N. Chang , Rhett M. Schiffman , R. Scott Jordan , Joan-En Chang-Lin
发明人： Chin-Ming Chang , James N. Chang , Rhett M. Schiffman , R. Scott Jordan , Joan-En Chang-Lin
IPC分类号： A61K31/16 , A61P27/06 , A61P27/02
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/08 , A61K31/14 , A61K31/164 , A61K31/165 , A61K47/02 , A61K47/183 , A61K47/186 , A61K2300/00
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.

58. 发明申请

US20090149546A1 Enhanced Bimatoprost Ophthalmic Solution 有权
标题翻译：增强的比马前列素眼科溶液
公开(公告)号：US20090149546A1
公开(公告)日：2009-06-11
申请号：US12351383
申请日：2009-01-09
申请人： Chin-Ming Chang , James N. Chang , Rhett M. Schiffman , R Scott Jordan , Joan-En Chang-Lin
发明人： Chin-Ming Chang , James N. Chang , Rhett M. Schiffman , R Scott Jordan , Joan-En Chang-Lin
IPC分类号： A61K31/165
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein.A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
摘要翻译：本文公开了包含0.005％至0.02％的比马前列素和100ppm至250ppm苯扎氯铵的组合物，其中所述组合物是配制用于眼部给药的水性液体。本文还公开了可用于治疗与其有关的青光眼或高眼压症的方法。

59. 发明申请

US20080097335A1 OCULAR IMPLANT DELIVERY ASSEMBLIES 审中-公开
标题翻译： OCULAR IMPLANT交付组件
公开(公告)号：US20080097335A1
公开(公告)日：2008-04-24
申请号：US11552835
申请日：2006-10-25
申请人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson
发明人： John T. Trogden , Robert T. Lyons , James N. Chang , Michael R. Robinson
IPC分类号： A61M5/178
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A removable distal closure element is provided for closing the distal end opening, and a removable proximal closure element is provided for closing the proximal end opening. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件，其包括具有延伸穿过其中的内腔的套管，近端，近端开口，远端，远端开口和延伸穿过套管的内腔。提供可移除的远端闭合元件用于封闭远端开口，并且提供可移除的近端闭合元件用于封闭近端开口。眼内植入物位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒，并且适于将组件耦合到包含推动凝胶的注射器。

60. 发明申请

US20070293873A1 Apparatus and methods for implanting particulate ocular implants 审中-公开
标题翻译：用于植入颗粒物眼植入物的装置和方法
公开(公告)号：US20070293873A1
公开(公告)日：2007-12-20
申请号：US11455392
申请日：2006-06-19
申请人： James N. Chang
发明人： James N. Chang
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051 , A61K9/1641 , A61K9/1647
摘要： Apparatus and methods for implanting ocular implants in eyes are provided which include a cannula having a lumen extending therethrough, the lumen having a length and a diameter and being configured to receive an ocular implant. The ocular implant is made up of a plurality of substantially uniformly sized particles, preferably a plurality of uniformly sized microspheres, arranged in a one-by-one array along the length of the lumen. The apparatus further comprises a mechanism for delivering the implant through the distal end of the lumen and into the eye, preferably without the use of a liquid or gel carrier medium located in the lumen along with the implant.
摘要翻译：提供了用于在眼睛中植入眼部植入物的装置和方法，其包括具有延伸穿过其中的内腔的套管，所述内腔具有长度和直径并且构造成容纳眼睛植入物。眼部植入物由多个基本上均匀的尺寸的颗粒组成，优选多个均匀尺寸的微球，沿着内腔的长度以一个一个的排列排列。该装置还包括用于将植入物输送通过内腔的远端并进入眼睛的机构，优选地不使用与植入物一起位于内腔中的液体或凝胶载体介质。

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