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51. 发明申请

US20100274330A1 DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT 审中-公开
标题翻译：用光处理血管的装置
公开(公告)号：US20100274330A1
公开(公告)日：2010-10-28
申请号：US12831159
申请日：2010-07-06
申请人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei N. Naimushin
发明人： Phillip Burwell , Zihong Guo , Jennifer K. Matson , Steven Ross Daly , David B. Shine , Gary Lichttenegger , Jean M. Bishop , Nick Yeo , Hugh Narciso , James C. Chen , William L. Barnard , Alexei N. Naimushin
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2017/22051 , A61N5/062 , A61N2005/0602 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
摘要翻译：用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。另一种装置是具有两个气囊的导管和在其间延伸的套管。在套管内，导管包括光源和扩张构件。

52. 发明申请

US20090216300A1 METHOD AND APPARATUS FOR LIGHT-ACTIVATED DRUG THERAPY 审中-公开
标题翻译：用于轻活化药物治疗的方法和装置
公开(公告)号：US20090216300A1
公开(公告)日：2009-08-27
申请号：US12161323
申请日：2007-01-18
申请人： Llew Keltner , Jay Winship , Erik Hagstrom , Frank Zheng , James C. Chen , Joseph M. Hobbs
发明人： Llew Keltner , Jay Winship , Erik Hagstrom , Frank Zheng , James C. Chen , Joseph M. Hobbs
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B2017/00084 , A61B2017/00274 , A61B2017/22068 , A61B2018/00285 , A61B2018/00547 , A61B2018/00821 , A61B2018/2261 , A61K41/0071 , A61N5/0601 , A61N5/0603 , A61N2005/0602 , A61N2005/061 , A61N2005/063 , A61N2005/0652 , A61N2005/067
摘要： A prostate treatment system having a light delivery device positionable in a transurethral device for treatment of benign prostatic hyperplasia (BPH). The light delivery device includes light generator, such as light emitting diodes (LED), laser diodes (LDs) or a diffusion quartz fiber tip connected to a light generator or a light emitting polymer which produces light at a selected wavelength or waveband or alternative sources of suitable light energy. The treatment device may further include a temperature monitoring system for monitoring the temperature at the treatment site. A light-activated drug is administered to the treatment site prior to light activation. The light-activated drug therapy induces cell death of the target tissue. The device provides a minimally invasive transurethral method for treatment of BPH or prostate cancer.
摘要翻译：一种前列腺治疗系统，其具有定位在经尿道装置中的光输送装置，用于治疗良性前列腺增生（BPH）。光输送装置包括光发生器，例如发光二极管（LED），激光二极管（LD）或连接到光产生器或发光聚合物的扩散石英光纤尖端，其产生在所选波长或波段或替代光源合适的光能。治疗装置还可以包括用于监测治疗部位的温度的温度监测系统。光活化药物在光活化之前施用于治疗部位。光激活药物疗法诱导靶组织的细胞死亡。该装置提供用于治疗BPH或前列腺癌的微创经尿道方法。

53. 发明授权

US07523207B2 Configuration of fibre channel SAN path 失效
标题翻译：配置光纤通道SAN路径
公开(公告)号：US07523207B2
公开(公告)日：2009-04-21
申请号：US10719179
申请日：2003-11-20
申请人： James C. Chen , Patricia C. Lu , Chung M. Fung , Minh-Ngoc L. Huynh , Christopher M. Sansone , Dung N. Dang , Gail A. Spear , Richard A. Ripberger
发明人： James C. Chen , Patricia C. Lu , Chung M. Fung , Minh-Ngoc L. Huynh , Christopher M. Sansone , Dung N. Dang , Gail A. Spear , Richard A. Ripberger
IPC分类号： G06F15/16 , G06F15/173 , G06F15/177
CPC分类号： H04L67/1097 , H04L29/12801 , H04L61/6004
摘要： Methods, system and computer program product are provided to configure a path between nodes through a fabric in a fibre channel storage area network (SAN). A node name is provided for a target node on the SAN and a port name is provided for each port in the target node. A relationship is established in a data structure between each port name and a slot in which each port is physically located in the target node. Prior to configuring a path between a source node and a port in the target node, the ports which are physically connected and logged in to the fabric are identified by port address. The port names corresponding to the port addresses are then identified. The port names are used to generate interface_ids of the ports corresponding to the physical slots in which the ports are located. A data structure is created to maintain the relationship between interface_ids and port names. To establish a path connection between a port in the source node and a selected port in the target node, the node name of the target node and the interface_id of the selected port are input to the data structure and the port name of the selected port is output. The port name is then used to obtain the address of the selected port and an I/O session path opened between the source and target nodes.
摘要翻译：提供方法，系统和计算机程序产品，以通过光纤通道存储区域网络（SAN）中的结构来配置节点之间的路径。为SAN上的目标节点提供节点名称，并为目标节点中的每个端口提供端口名称。在每个端口名称和每个端口物理上位于目标节点的时隙之间的数据结构中建立关系。在目标节点中的源节点和端口之间配置路径之前，物理连接并登录到结构的端口由端口地址标识。然后识别与端口地址对应的端口名称。端口名称用于生成与端口所在物理槽相对应的端口的接口ID。创建数据结构以维护interface_ids和端口名称之间的关系。要在源节点中的端口和目标节点的选定端口之间建立路径连接，将目标节点的节点名称和所选端口的interface_id输入到数据结构，所选端口的端口名称为输出。然后使用端口名称来获取所选端口的地址以及在源节点和目标节点之间打开的I / O会话路径。

54. 发明申请

US20080205299A1 CONFIGURATION OF FIBRE CHANNEL SAN PATH 失效
标题翻译：光纤通道SAN路径的配置
公开(公告)号：US20080205299A1
公开(公告)日：2008-08-28
申请号：US12117112
申请日：2008-05-08
申请人： James C. Chen , Patricia C. Lu , Chung M. Fung , Minh-Ngoc L. Huynh , Christopher M. Sansone , Dung N. Dang , Gail A. Spear , Richard A. Ripberger
发明人： James C. Chen , Patricia C. Lu , Chung M. Fung , Minh-Ngoc L. Huynh , Christopher M. Sansone , Dung N. Dang , Gail A. Spear , Richard A. Ripberger
IPC分类号： H04L12/28
CPC分类号： H04L67/1097 , H04L29/12801 , H04L61/6004
摘要： System and computer program product are provided to configure a path between nodes through a fabric in a fibre channel storage area network (SAN). A node name is provided for a target node on the SAN and a port name is provided for each port in the target node. A relationship is established in a data structure between each port name and a slot in which each port is physically located in the target node. Prior to configuring a path between a source node and a port in the target node, the ports which are physically connected and logged in to the fabric are identified by port address. The port names corresponding to the port addresses are then identified. The port names are used to generate interface_ids of the ports corresponding to the physical slots in which the ports are located. A data structure is created to maintain the relationship between interface_ids and port names. To establish a path connection between a port in the source node and a selected port in the target node, the node name of the target node and the interface_id of the selected port are input to the data structure and the port name of the selected port is output. The port name is then used to obtain the address of the selected port and an I/O session path opened between the source and target nodes.
摘要翻译：提供系统和计算机程序产品，以通过光纤通道存储区域网络（SAN）中的结构来配置节点之间的路径。为SAN上的目标节点提供节点名称，并为目标节点中的每个端口提供端口名称。在每个端口名称和每个端口物理上位于目标节点的时隙之间的数据结构中建立关系。在目标节点中的源节点和端口之间配置路径之前，物理连接并登录到结构的端口由端口地址标识。然后识别与端口地址对应的端口名称。端口名称用于生成与端口所在物理槽相对应的端口的接口ID。创建数据结构以维护interface_ids和端口名称之间的关系。要在源节点中的端口和目标节点的选定端口之间建立路径连接，将目标节点的节点名称和所选端口的interface_id输入到数据结构，所选端口的端口名称为输出。然后使用端口名称来获取所选端口的地址以及在源节点和目标节点之间打开的I / O会话路径。

55. 发明授权

US07320786B2 Photodynamic therapy treatment for eye disease 失效
标题翻译：光动力治疗眼病
公开(公告)号：US07320786B2
公开(公告)日：2008-01-22
申请号：US11297880
申请日：2005-12-07
申请人： James C. Chen
发明人： James C. Chen
IPC分类号： A61K9/00 , A61K39/395 , A01N43/38
CPC分类号： A61K41/0057 , A61K41/0071 , A61K41/0076 , A61K47/62 , A61K47/6843 , A61K47/6847 , Y10S514/912
摘要： This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate photosensitizing agent. The photosensitizing agent is bound to a composition that mediates site specific delivery to a neovasculature target tissue of a therapeutically effective amount of a photosensitizing agent that is activated by a relatively low fluence rate of light over a prolonged period of time. Diseases treatable under this invention, include: diabetic retinopathy; macular degeneration; and malignant uveal melanomas.
摘要翻译：本发明公开了通过施用靶向光敏剂并随后暴露于足以光敏化剂的特定波长的光来治疗眼睛新生血管疾病的方法，试剂盒和说明书。光敏剂与一种组合物结合，该组合物介导在新的脉管系统靶组织中治疗有效量的光敏剂的部位特异性递送，所述光敏剂在较长的时间内被相对较低的光通量光激活。本发明可治疗的疾病包括：糖尿病性视网膜病变; 黄斑变性; 和恶性葡萄膜黑素瘤。

56. 发明授权

US07197663B2 Concurrent PPRC/FCP and host access to secondary PPRC/FCP device through independent error management 失效
标题翻译：并发PPRC / FCP，并通过独立的错误管理主机访问次级PPRC / FCP设备
公开(公告)号：US07197663B2
公开(公告)日：2007-03-27
申请号：US10719388
申请日：2003-11-20
申请人： Frederick J. Carberry , Rufus J. Twito , James C. Chen , Richard A. Schaeffer , Kaukab Uddin
发明人： Frederick J. Carberry , Rufus J. Twito , James C. Chen , Richard A. Schaeffer , Kaukab Uddin
IPC分类号： G06F11/00
CPC分类号： G06F3/065 , G06F3/0617 , G06F3/067
摘要： A method of error management in a data storage system having a target device, with the target device receiving commands from a first initiator and the target device concurrently receiving commands from a second initiator. The target device is typically a storage device operating as a PPRC secondary. A first initiator is a device which communicates with the target device through small computer systems interface (SCSI) protocol. The first initiator is typically a host computer or server. The second initiator communicates with the target device through peer-to-peer remote copy PPRC initiator mode commands. The second initiator is typically a separate storage device in a peer-to-peer remote copy (PPRC) relationship with the target device. The method consists of managing errors associated with a command sent to the target device from the first initiator independently from the management of errors associated with a command sent to the target device from the second initiator.
摘要翻译：一种具有目标设备的数据存储系统中的错误管理方法，其中目标设备从第一启动器接收命令，并且目标设备同时从第二启动器接收命令。目标设备通常是作为PPRC辅助设备运行的存储设备。第一启动器是通过小型计算机系统接口（SCSI）协议与目标设备通信的设备。第一个启动器通常是主机或服务器。第二个启动器通过对等远程复制PPRC启动器模式命令与目标设备进行通信。第二个启动器通常是与目标设备的对等远程复制（PPRC）关系中的单独的存储设备。该方法包括管理与从第一启动器发送到目标设备的命令相关联的错误，独立于从与第二启动器发送到目标设备的命令相关联的错误的管理。

57. 发明授权

US6112277A Method and means for reducing device contention by random accessing and partial track staging of records according to a first DASD format but device mapped according to a second DASD format 失效
公开(公告)号：US6112277A
公开(公告)日：2000-08-29
申请号：US937423
申请日：1997-09-25
申请人： Thao B. Bui , James C. Chen , Chan Y. Ng
发明人： Thao B. Bui , James C. Chen , Chan Y. Ng
IPC分类号： G06F3/06 , G06F12/08 , G06F12/00
CPC分类号： G06F3/061 , G06F12/0866 , G06F3/0638 , G06F3/0689 , G06F3/065
摘要： A staging method and means for both device read and update write operations in which messages and commands between a storage subsystem and a fixed-block formatted RAID array emulating a variable-length record (CKD) formatted device for both read and write operations are evaluated to ascertain whether the record addressing was random and truly in record mode. If they are in that mode, then partial track staging by the RAID array control from the fixed-block formatted HDDs to a subsystem cache or the like would reduce device contention by reading and staging less than full track.

58. 发明授权

US6080160A Use of shape memory alloy for internally fixing light emitting device at treatment site 失效
标题翻译：形状记忆合金用于在处理部位内部固定发光元件
公开(公告)号：US6080160A
公开(公告)日：2000-06-27
申请号：US760057
申请日：1996-12-04
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61B17/00 , A61B17/34 , A61B19/00 , A61M25/04 , A61N5/06
CPC分类号： A61M25/04 , A61B17/3468 , A61N5/0601 , A61B2017/00867 , A61B2090/306 , A61B90/39
摘要： A method and apparatus for selectively engaging and disengaging an anchor to fix a medical device at a selected site within a patient's body. A shape memory alloy (SMA) such as Nitinol is used to fabricate one or more anchors for the medical device. The shape memory effect exhibited by the SMA is thermally activated. One embodiment of the anchor has a substantially circular shape when at its martensite temperature and reverts to an elliptical shape at its austenite temperature. Another embodiment is a substantially straight strip at its martensite temperature and has an end that curls to engage tissue when at its austenite temperature. Still another embodiment includes a pair of anchors that extend outwardly from each side of an elongate probe at their austenite temperature and retract inwardly against the sides of the probe at their martensite temperature. The change in the shape of the SMA elements tends to anchor the medical device or probe at the treatment site. To change the temperature of the SMA elements, an electrical current is selectively energized to provide heat, or thermal conduction between the SMA and a heat source or a heat sink is employed.
摘要翻译：一种用于选择性地接合和分离锚定器以将医疗装置固定在患者体内的选定部位的方法和装置。使用诸如镍钛诺的形状记忆合金（SMA）来制造用于医疗装置的一个或多个锚固件。 SMA表现出的形状记忆效应被热激活。锚固件的一个实施例在其马氏体温度下具有大致圆形形状并且在其奥氏体温度下回复到椭圆形状。另一个实施方案是其马氏体温度下的基本上直的条带，并且具有在其奥氏体温度时卷曲以接合组织的端部。另一个实施例包括一对锚定件，其在其奥氏体温度下从细长探针的每侧向外延伸并且在其马氏体温度下向内靠近探针的侧部。 SMA元件的形状变化倾向于将医疗器械或探针固定在治疗部位。为了改变SMA元件的温度，选择性地通电电流以提供热量，或者使用SMA与热源或散热器之间的热传导。

59. 发明授权

US5957960A Internal two photon excitation device for delivery of PDT to diffuse abnormal cells 失效
标题翻译：内部双光子激发装置用于传递PDT以扩散异常细胞
公开(公告)号：US5957960A
公开(公告)日：1999-09-28
申请号：US850909
申请日：1997-05-05
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61K41/00 , A61K45/00 , A61N5/06 , A61P43/00
CPC分类号： A61N5/062 , A61K41/008 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A plurality of light sources that emit light having a long wavelength are energized for an extended period of time to increase the likelihood of two photon absorption by cells that have preferentially absorbed a photoreactive agent such as psoralen. The cells are preferably microscopic metastatic cancer cells that are diffusely distributed throughout a treatment site, for example, within an organ. The plurality of light sources are arranged in a spaced-apart array, mounted on a support plate that includes a plurality of conductive traces. A plurality of such arrays are preferably mounted to a flexible sheet that can conform to an outer surface of an organ being treated. Because the light emitted by the light sources is in the infrared or near infrared waveband, it penetrates deeply into the tissue at the treatment site. The duration of the treatment and the number of light sources employed for administering the therapy increases the likelihood of two photon absorption by the metastatic cancer cells, which has been shown to activate the photoreactive agent to destroy cancer cells in a tumor, even though the characteristic light absorption waveband of the photoreactive agent is in the ultraviolet waveband.
摘要翻译：发射长波长的光的多个光源被激励一段较长的时间，以增加优先吸收光活性剂如补骨脂素的细胞的双光子吸收的可能性。细胞优选是扩散分布在整个治疗部位，例如器官内的微观转移癌细胞。多个光源被布置成间隔开的阵列，安装在包括多个导电迹线的支撑板上。多个这样的阵列优选地安装到柔性片材上，该柔性片材可以符合被处理器官的外表面。由于光源发出的光线处于红外线或近红外线波段，所以在治疗部位深入到组织中。用于治疗的持续时间和用于治疗该治疗的光源的数量增加了转移癌细胞的两个光子吸收的可能性，已经显示活化光反应剂以破坏肿瘤中的癌细胞，即使特征光反应剂的光吸收波段处于紫外波段。

60. 发明授权

US5876427A Compact flexible circuit configuration 失效
标题翻译：紧凑型柔性电路配置
公开(公告)号：US5876427A
公开(公告)日：1999-03-02
申请号：US787775
申请日：1997-01-29
申请人： James C. Chen , Brent Wiscombe
发明人： James C. Chen , Brent Wiscombe
IPC分类号： A61N5/06 , H01L25/075 , H05K1/18 , A61N21/00
CPC分类号： A61N5/0601 , A61N5/062 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2224/73265 , H01L25/0756 , H05K1/189
摘要： A flexible probe constructed using a flexible circuit having a small cross-sectional profile. In the various disclosed embodiments of the flexible circuit, a flexible substrate includes a plurality of conductive traces that extend along opposite surfaces of the substrate. Light emitting devices (or other electronic devices) are mounted at spaced-apart intervals along the length of the conductive traces using a conductive adhesive/solder. A conductor couples a terminal on the outwardly facing side of each of the light emitting devices to the conductive trace that is disposed on the opposite side of the substrate. In one embodiment, this conductor comprises a short conductive bar that extends between the terminals of pairs of the light emitting devices that are mounted on opposite sides of the flexible substrate so that the pair of light emitting devices are connected in series. In another embodiment, the flexible substrate includes an outwardly extending arm of the conductive trace that wraps around the edge of the flexible substrate to connect to the light emitting device mounted on the opposite side thereof. In each embodiment, a substantially smaller cross-sectional profile is achieved compared to a previous approach in which the conductive traces providing power to a light emitting device were located on the same side of the flexible substrate and fly wires were used to connect the light emitting devices to the conductive traces.
摘要翻译：使用具有小横截面轮廓的柔性电路构成的柔性探头。在柔性电路的各种公开的实施例中，柔性衬底包括沿衬底的相对表面延伸的多个导电迹线。发光器件（或其他电子器件）使用导电粘合剂/焊料沿着导电迹线的长度以间隔的间隔安装。导体将每个发光器件的面向外侧的端子连接到设置在衬底的相对侧上的导电迹线。在一个实施例中，该导体包括短导电棒，其在安装在柔性基板的相对侧上的成对的发光器件的端子之间延伸，使得该对发光器件串联连接。在另一个实施例中，柔性基板包括导电迹线的向外延伸的臂，其围绕柔性基板的边缘缠绕以连接到安装在其相对侧上的发光器件。在每个实施例中，与先前的方法相比，实现了基本上较小的横截面轮廓，其中向发光器件提供功率的导电迹线位于柔性基板的相同侧上，并且使用飞线将发光器件到导电迹线。

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