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51. 发明授权

US08702965B2 Biosensor methods having enhanced stability and hematocrit performance 有权
标题翻译：具有增强的稳定性和血细胞比容性能的生物传感器方法
公开(公告)号：US08702965B2
公开(公告)日：2014-04-22
申请号：US12951382
申请日：2010-11-22
申请人： Huan-Ping Wu , Christine D. Nelson , Hope Spradlin , Eric Maurer
发明人： Huan-Ping Wu , Christine D. Nelson , Hope Spradlin , Eric Maurer
IPC分类号： G01N27/26 , G01N33/48 , G01R27/08
CPC分类号： G01N27/3274 , C12Q1/004 , C12Q1/006 , G01N27/327 , G01N27/3272 , G01N27/3273 , Y10S435/817
摘要： The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 μg/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at −20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.
摘要翻译：本发明涉及电化学传感器条和确定样品中分析物浓度或提高浓度测定性能的方法。电化学传感器条可以包括至多8μg/ mm2的介体。条带，条带试剂层或方法可以提供在与比较条带相比在50℃下储存4周后，确定具有小于±10％的稳定性偏差中的至少一种的浓度值在-20℃下储存4周，全血样品的血细胞比容偏差小于±10％，包括20至60％血细胞比容，截距至最大20mg / dL。还提供了增加定量分析物测定性能的方法。

52. 发明申请

US20120298507A1 Systems, Methods, and Devices Including Amperometric and Voltammetric Duty Cycles 有权
标题翻译：系统，方法和器件包括电流和伏安值的周期
公开(公告)号：US20120298507A1
公开(公告)日：2012-11-29
申请号：US13552954
申请日：2012-07-19
申请人： Huan-Ping Wu
发明人： Huan-Ping Wu
IPC分类号： G01N27/26
CPC分类号： G01N27/3272 , G01N27/3271 , G01N27/3273 , G01N27/48
摘要： A sensor system including devices and methods for determining the concentration of an analyte in a sample is described. Input signals including amperometric and voltammetric duty cycles of excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed system may reduce analysis errors, thus improving measurement performance, by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The disclosed system also may determine the concentration of more than one ionizable species in the sample by adjusting the potential and/or scan rate in response to output currents obtained from voltammetric scans. The multiple, determined concentrations may be used to determine the concentration of multiple analytes or to correct the concentration determined for an analyte, thus improving the measurement performance of the system.
摘要翻译：描述了包括用于确定样品中分析物的浓度的装置和方法的传感器系统。包括激发和松弛的电流和伏安占空比的输入信号可以提供更短的分析时间和/或提高分析的精度和/或精度。所公开的系统可以通过响应于从伏安扫描获得的输出电流调节电位和/或扫描速率来减少分析误差，从而提高测量性能。所公开的系统还可以通过响应于从伏安扫描获得的输出电流调节电位和/或扫描速率来确定样品中多于一个可离子化物质的浓度。可以使用多个确定的浓度来确定多个分析物的浓度或校正分析物确定的浓度，从而提高系统的测量性能。

53. 发明授权

US08287717B2 Voltammetric systems for assaying biological analytes 有权
标题翻译：用于测定生物分析物的伏安系统
公开(公告)号：US08287717B2
公开(公告)日：2012-10-16
申请号：US11596309
申请日：2005-05-16
申请人： Huan-Ping Wu
发明人： Huan-Ping Wu
IPC分类号： G01N27/26 , G01N27/403
CPC分类号： G01N27/3272 , C12Q1/005 , G01N27/327 , G01N27/3273 , G01N27/48 , G01N27/49
摘要： The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect.
摘要翻译：本发明涉及用于确定样品中分析物浓度的系统，方法和装置。使用线性，循环或非循环伏安扫描和/或半积分，衍生或半导数数据处理可以在确定样品中分析物的浓度时提供更高的准确度。血细胞比容补偿与数据处理相结合可降低全血中葡萄糖分析的血细胞比容效应。另一方面，快速扫描速率可降低血细胞比容效应。

54. 发明申请

US20110265548A1 Underfill Detection System For A Biosensor 有权
标题翻译：生物传感器的底部填充检测系统
公开(公告)号：US20110265548A1
公开(公告)日：2011-11-03
申请号：US13107363
申请日：2011-05-13
申请人： Huan-Ping Wu , Christine D. Nelson
发明人： Huan-Ping Wu , Christine D. Nelson
IPC分类号： G01N27/26 , G01N33/487
CPC分类号： G01N27/4163 , G01N27/327 , G01N27/3274 , G01N35/00029 , G01N35/1016 , G01N2035/00108 , Y10T436/10
摘要： A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.
摘要翻译：生物传感器具有底部填充检测系统，其确定生物流体的样品是否足够大以分析一种或多种分析物。底部填充检测系统向样品施加激励信号，其产生响应于激发信号的输出信号。底部填充检测系统切换激励信号的幅度。当样品不够大以进行准确和/或精确的分析时，激发信号向不同幅度的转变会改变输出信号。底部填充检测系统测量并比较输出信号与一个或多个底部填充阈值，以确定是否存在底部填充条件。

55. 发明授权

US08026104B2 Transient decay amperometry 有权
标题翻译：瞬态衰变电流分析法
公开(公告)号：US08026104B2
公开(公告)日：2011-09-27
申请号：US11875942
申请日：2007-10-21
申请人： Huan-Ping Wu , Steven C. Charlton , Amy H. Chu , Andrew J. Edelbrock , Sung-Kwon Jung , Dijia Huang
发明人： Huan-Ping Wu , Steven C. Charlton , Amy H. Chu , Andrew J. Edelbrock , Sung-Kwon Jung , Dijia Huang
IPC分类号： G01N27/00 , G01N27/413
CPC分类号： C12Q1/54 , A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B5/1495 , C12Q1/004 , G01N27/3271 , G01N27/3272
摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.
摘要翻译：生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

56. 发明授权

US07966859B2 Underfill detection system for a biosensor 有权
标题翻译：用于生物传感器的底部填充检测系统
公开(公告)号：US07966859B2
公开(公告)日：2011-06-28
申请号：US12251709
申请日：2008-10-15
申请人： Huan-Ping Wu , Christine D. Nelson
发明人： Huan-Ping Wu , Christine D. Nelson
IPC分类号： G01N27/26 , G01N27/00 , G01N33/487
CPC分类号： G01N27/4163 , G01N27/327 , G01N27/3274 , G01N35/00029 , G01N35/1016 , G01N2035/00108 , Y10T436/10
摘要： A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.
摘要翻译：生物传感器具有底部填充检测系统，其确定生物流体的样品是否足够大以分析一种或多种分析物。底部填充检测系统向样品施加激励信号，其产生响应于激发信号的输出信号。底部填充检测系统切换激励信号的幅度。当样品不够大以进行准确和/或精确的分析时，激发信号向不同幅度的转变会改变输出信号。底部填充检测系统测量并比较输出信号与一个或多个底部填充阈值，以确定是否存在底部填充条件。

57. 发明申请

US20110115504A1 Biosensor Methods Having Enhanced Stability and Hematocrit Performance 有权
标题翻译：增强稳定性和血细胞比容性能的生物传感器方法
公开(公告)号：US20110115504A1
公开(公告)日：2011-05-19
申请号：US12951382
申请日：2010-11-22
申请人： Huan-Ping Wu , Christine D. Nelson , Hope Spradlin , Eric Maurer
发明人： Huan-Ping Wu , Christine D. Nelson , Hope Spradlin , Eric Maurer
IPC分类号： G01R27/08
CPC分类号： G01N27/3274 , C12Q1/004 , C12Q1/006 , G01N27/327 , G01N27/3272 , G01N27/3273 , Y10S435/817
摘要： The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 μg/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at −20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.
摘要翻译：本发明涉及电化学传感器条和确定样品中分析物浓度或提高浓度测定性能的方法。电化学传感器条可以包括至多8μg/ mm2的介体。条带，条带试剂层或方法可以提供在与比较条带相比在50℃下储存4周后，确定具有小于±10％的稳定性偏差中的至少一种的浓度值在-20℃下储存4周，全血样品的血细胞比容偏差小于±10％，包括20至60％血细胞比容，截距至最大20mg / dL。还提供了增加定量分析物测定性能的方法。

58. 发明申请

US20100267161A1 Multi-Region and Potential Test Sensors, Methods, and Systems 有权
标题翻译：多区域和潜在测试传感器，方法和系统
公开(公告)号：US20100267161A1
公开(公告)日：2010-10-21
申请号：US12728457
申请日：2010-03-22
申请人： Huan-Ping Wu , Weiping Zhong , Joseph E. Perry , Eric Maurer , Sung-Kwon Jung
发明人： Huan-Ping Wu , Weiping Zhong , Joseph E. Perry , Eric Maurer , Sung-Kwon Jung
IPC分类号： G01N27/00
CPC分类号： G01N27/3272 , C12Q1/001 , G01N27/3274
摘要： Biosensor systems including a measurement device and test sensors including at least three independently addressable electrodes, with at least two of the electrodes being substantially chemically isolated are disclosed. One or more working electrodes may be combined with two or more counter electrodes. The two or more counter electrodes may operate at different potentials to provide for multi-analyte electrochemical analysis. Analysis methods are provided to perform multi-analyte electrochemical analysis and test sensors are provided having resistance to chemical mixing between secondary analysis regions.
摘要翻译：公开了包括测量装置和包括至少三个可独立寻址的电极的测试传感器的生物传感器系统，其中至少两个电极基本上是化学隔离的。一个或多个工作电极可以与两个或更多个对电极组合。两个或更多个对电极可以在不同的电位下操作以提供多分析物电化学分析。提供分析方法以进行多分析物电化学分析，并提供具有耐二次分析区域之间的化学混合的测试传感器。

59. 发明申请

US20080105568A1 Voltammetric Systems For Assaying Biological Analytes 有权
标题翻译：用于测定生物分析物的伏安系统
公开(公告)号：US20080105568A1
公开(公告)日：2008-05-08
申请号：US11596309
申请日：2005-05-16
申请人： Huan-Ping Wu
发明人： Huan-Ping Wu
IPC分类号： G01N27/26
CPC分类号： G01N27/3272 , C12Q1/005 , G01N27/327 , G01N27/3273 , G01N27/48 , G01N27/49
摘要： The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect.
摘要翻译：本发明涉及用于确定样品中分析物浓度的系统，方法和装置。使用线性，循环或非循环伏安扫描和/或半积分，衍生或半导数数据处理可以在确定样品中分析物的浓度时提供更高的准确度。血细胞比容补偿与数据处理相结合可降低全血中葡萄糖分析的血细胞比容效应。另一方面，快速扫描速率可降低血细胞比容效应。

60. 发明申请

US20080071199A1 Adjustable limb exerciser 审中-公开
标题翻译：可调肢体锻炼者
公开(公告)号：US20080071199A1
公开(公告)日：2008-03-20
申请号：US11518454
申请日：2006-09-11
申请人： Huan-Ping Wu
发明人： Huan-Ping Wu
IPC分类号： A63B15/02 , A61H1/02 , A63B71/00 , A61H1/00
CPC分类号： A63B22/0694 , A61H1/0214 , A61H2205/06 , A61H2205/10 , A63B21/00178 , A63B21/005 , A63B22/0605
摘要： An adjustable limb exerciser includes a relay securable on the circuit board to electrically connect to the motor, resistors electrically connected to the relay to provide different resistance to hinder the motor from operation and an adjusting knob securable on the casing to direct connection between the relay and the resistors. A heat dissipating plate is mounted adjacent to the resistors to dissipate heat from the resistors.
摘要翻译：可调节肢体锻炼器包括可在电路板上固定的继电器以电连接到电动机的电阻器，电连接到继电器的电阻器，以提供不同的阻力以阻止电动机的操作;以及可在壳体上固定的调节旋钮，以引导继电器和电阻器。散热板安装在电阻附近，以消散电阻的热量。

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