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51. 发明申请

US20090324308A1 OIL LESS FUSING USING NANO/MICRO TEXTURED FUSING SURFACES 有权
标题翻译：使用NANO / MICRO TEXTURED FUSING SURFACES进行油不熔化
公开(公告)号：US20090324308A1
公开(公告)日：2009-12-31
申请号：US12164500
申请日：2008-06-30
申请人： Kock-Yee LAW , Hong Zhao
发明人： Kock-Yee LAW , Hong Zhao
IPC分类号： G03G15/20
CPC分类号： G03G15/2053
摘要： Exemplary embodiments provide a fixing member having a textured surface, and methods for making and using the textured fixing member. The fixing member can include a substrate having one or more functional layers formed thereon. The one or more functional layers can include an outermost or top surface having a surface wettability that is hydrophobic and/or oleophobic; ultrahydrophobic and/or ultraoleophobic; or superhydrophobic and/or superoleophobic by forming textured features. Such fixing member can be used as an oil-less fusing member for high speed, high quality electrophotographic printing to ensure and maintain a good toner release from the fused toner image on an image supporting material(e.g., a paper sheet), and further assist paper stripping. In addition, the textured surface can provide an oil-free, such as wax-free, toner design for the oil-less fixing process.
摘要翻译：示例性实施例提供具有纹理表面的固定构件以及用于制造和使用纹理固定构件的方法。固定构件可以包括其上形成有一个或多个功能层的基板。一个或多个功能层可以包括具有疏水性和/或疏油性的表面润湿性的最外表面或顶表面; 超疏水和/或超疏油; 或超疏水和/或超疏油的形成纹理特征。这种固定构件可用作高速，高质量电子照相印刷的无油定影构件，以确保并保持从图像支撑材料（例如，纸张）上的熔融调色剂图像中良好的调色剂释放，并进一步协助剥纸。此外，纹理表面可以为无油定影工艺提供无油，例如无蜡的调色剂设计。

52. 发明授权

US08933030B2 Treatments for gastrointestinal disorders 有权
标题翻译：胃肠道疾病治疗
公开(公告)号：US08933030B2
公开(公告)日：2015-01-13
申请号：US13579685
申请日：2011-02-17
申请人： Angelika Fretzen , Hong Zhao , Marco Kessler
发明人： Angelika Fretzen , Hong Zhao , Marco Kessler
IPC分类号： A61K38/00 , A61P1/04 , A61K38/12 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K7/08 , A61K38/10 , A61K45/06
CPC分类号： C07K7/08 , A61K38/08 , A61K38/10 , A61K45/06 , C07K7/06
摘要： The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明涉及用于治疗胃肠道疾病和病症的肽，组合物和相关方法，包括但不限于肠易激综合征（IBS），胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩氏病疾病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良，内脏痛，胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻），与便秘相关的病症和病症以及其它病症和病症在本文中用肽描述和激活鸟苷酸环化酶C（GC-C）受体的其它试剂。

53. 发明授权

US08682388B2 Mobile device and method for proximity detection verification 有权
标题翻译：用于接近检测验证的移动设备和方法
公开(公告)号：US08682388B2
公开(公告)日：2014-03-25
申请号：US12983121
申请日：2010-12-31
申请人： Sandeep Vuppu , Chris Grivas , Hong Zhao
发明人： Sandeep Vuppu , Chris Grivas , Hong Zhao
IPC分类号： H04W88/02
CPC分类号： H04W52/027 , G06F1/3231 , G06F3/012 , G06F3/0488 , H04M2250/12 , H04M2250/22 , H04M2250/52 , Y02D10/173 , Y02D70/1224 , Y02D70/1242 , Y02D70/1262 , Y02D70/142 , Y02D70/144 , Y02D70/146 , Y02D70/164
摘要： A mobile device includes a touch screen display and touch screen circuit for receiving touch inputs. A camera configured to acquire one or more images in front of the display. A proximity sensor configured to provide an indication that a user is in close proximity to the touch screen display. A processor being effective to determine, in response to the indication of the proximity sensor, whether the user is in a position to view the display based on the one or more images of the camera. If the proximity sensor provides an indication that the user is in close proximity to the display and the processor determines, based on the one or more images, that the user is in a position to view the display, then at least one of the display and the touch screen circuit are not disabled.
摘要翻译：移动设备包括用于接收触摸输入的触摸屏显示器和触摸屏电路。配置为获取显示器前面的一个或多个图像的相机。接近传感器，被配置为提供用户紧邻触摸屏显示器的指示。处理器有效地响应于接近传感器的指示来确定用户是否处于基于相机的一个或多个图像来观看显示器的位置。如果接近传感器提供用户与显示器非常接近的指示，并且处理器基于一个或多个图像确定用户处于查看显示器的位置，则显示器和显示器中的至少一个触摸屏电路不被禁用。

54. 发明申请

US20140001662A1 METHOD FOR PREPARING STABLE-TYPE VITAMIN A MICROCAPSULES CONTINUOUSLY 有权
标题翻译：连续制备稳定型维生素一微生物的方法
公开(公告)号：US20140001662A1
公开(公告)日：2014-01-02
申请号：US13980126
申请日：2011-03-25
申请人： Hong Yin , Jianfeng Chen , Zhirong Chen , Jiexin Wang , Yong Qi , Hong Zhao , Lifang Shi , Dan Qiu
发明人： Hong Yin , Jianfeng Chen , Zhirong Chen , Jiexin Wang , Yong Qi , Hong Zhao , Lifang Shi , Dan Qiu
IPC分类号： A61J3/07
CPC分类号： A61J3/07 , A61K9/1652 , A61K9/1694 , A61K9/5036 , A61K9/5089 , A61K9/5161 , A61K31/07
摘要： A method for continuously preparing stable-type vitamin A microcapsules is disclosed. The method comprises the following steps: adding vitamin A crystals and an antioxidant into a crystal melter continuously according to a certain ratio under the protection of nitrogen to prepare vitamin A melting oil containing the antioxidant; pumping the above melting oil into a high gravity rotary packed bed emulsifier with a liquid distributor by a pump, and pumping aqueous solution containing gellable modified starch into the above high gravity rotary packed bed emulsifier after deoxidation treatment to obtain vitamin A emulsion at the outlet of the high gravity rotary packed bed emulsifier; and atomizing and spraying the emulsion continuously in a cooled starch bed for granulating, and performing fluidization drying and gelation treatment in a fluidized bed by taking nitrogen as a drying medium to obtain the stable-type vitamin A microcapsules. Above method has the advantage of capability of continuous production, and has good embedding effect due to adopting the gellable modified starch, granulating and gelation treatment, thus the product has good storage stability.
摘要翻译：公开了连续制备稳定型维生素A微胶囊的方法。该方法包括以下步骤：在氮保护下，以一定的比例将维生素A晶体和抗氧化剂连续添加到晶体熔化器中，制备含有抗氧化剂的维生素A熔融油; 通过泵将上述熔融油泵送到具有液体分配器的高重力旋转填充床乳化剂中，并且在脱氧处理之后将含有可凝胶改性淀粉的水溶液泵送到上述高重力旋转填充床乳化剂中以在出口处获得维生素A乳液高重力旋转填充床乳化剂; 并在冷却的淀粉床中连续雾化和喷雾乳液进行造粒，并通过以氮气作为干燥介质在流化床中进行流化干燥和凝胶化处理，得到稳定型维生素A微胶囊。上述方法具有连续生产能力的优点，由于采用可凝胶改性淀粉，造粒和凝胶化处理，具有良好的包埋效果，因此产品具有良好的储存稳定性。

55. 发明授权

US08593070B2 Three-phase LED power supply 有权
标题翻译：三相LED电源
公开(公告)号：US08593070B2
公开(公告)日：2013-11-26
申请号：US13128936
申请日：2010-07-26
申请人： Jian Wang , Hong Zhao
发明人： Jian Wang , Hong Zhao
IPC分类号： H05B37/00 , H02M7/00
CPC分类号： H05B33/0815
摘要： A three phase rectifier rectifies received three phase a.c. power to generate a ripple d.e. voltage. A power distribution bus conveys distribution power comprising the ripple d.c. voltage or an a.c. voltage derived therefrom to a location of an LED based lamp that is distal from the three phase rectifier. Additional circuitry disposed with the LED based lamp drives the LED based lamp using the distribution power.
摘要翻译：三相整流器对接收的三相交流整流器进行整流。产生波纹的能力电压。配电总线传送包括波纹直流的配电功率。电压或电流电压源于距离三相整流器远的LED基灯的位置。配有基于LED的灯的附加电路使用分配功率驱动基于LED的灯。

56. 发明授权

US08560092B2 Apparatus and method for model quality estimation and model adaptation in multivariable process control 有权
标题翻译：多变量过程控制中的模型质量估计和模型适应的装置和方法
公开(公告)号：US08560092B2
公开(公告)日：2013-10-15
申请号：US12786052
申请日：2010-05-24
申请人： Qingsheng Quinn Zheng , Hong Zhao
发明人： Qingsheng Quinn Zheng , Hong Zhao
IPC分类号： G06F19/00
CPC分类号： G05B13/048
摘要： Apparatuses and methods for model quality estimation and model adaptation in multivariable process control are disclosed. A method for updating a multiple input multiple output (MIMO) dynamical model of a process includes perturbing the process, auditing the controller model, identifying poor performing submodels and re-testing the relevant process variables, re-identifying submodels and adapting the model online while the process continues to operate within normal operating parameters. An apparatus comprises an online multivariable controller, a tester, a database to store data corresponding to manipulated variables and controlled variables, and a performance diagnosis module configured to identify problematic submodels and adapt a model used by the controller.
摘要翻译：公开了多变量过程控制中的模型质量估计和模型适应的装置和方法。用于更新过程的多输入多输出（MIMO）动态模型的方法包括扰动过程，审核控制器模型，识别执行不良的子模型并重新测试相关过程变量，重新识别子模型并在线适配模型该过程继续在正常操作参数内运行。一种装置包括在线多变量控制器，测试器，用于存储与操作变量和受控变量相对应的数据的数据库，以及性能诊断模块，被配置为识别有问题的子模型并适应控制器使用的模型。

57. 发明申请

US20130201219A1 Method for Managing Screen Orientation of a Portable Electronic Device 有权
标题翻译：便携式电子设备屏幕方向管理方法
公开(公告)号：US20130201219A1
公开(公告)日：2013-08-08
申请号：US13368853
申请日：2012-02-08
申请人： Hong Zhao , LieJun Tao , Dean E. Thorson
发明人： Hong Zhao , LieJun Tao , Dean E. Thorson
IPC分类号： G09G5/00
CPC分类号： G06F3/0346 , G06F1/1686 , G06F1/1694 , G06F3/012 , G06F3/013 , G06F2200/1614 , G06F2200/1637
摘要： There is described a portable electronic device capable of managing screen orientation. The portable electronic device comprises a display, a motion sensor, an image sensor and a processor. The display provides an image at a first orientation. The motion sensor attempts to detect a rotation of the portable electronic device. The image sensor attempts to detect one or more body features. The processor determines a second orientation of the image at the display based on the rotation detected at the motion sensor and/or the body feature or features detected at the image sensor. The portable electronic device may determine an orientation of the image at the display in response to detecting the rotation at the motion sensor and/or the body feature or features at the image sensor.
摘要翻译：描述了能够管理屏幕取向的便携式电子设备。便携式电子设备包括显示器，运动传感器，图像传感器和处理器。显示器以第一方向提供图像。运动传感器尝试检测便携式电子设备的旋转。图像传感器尝试检测一个或多个身体特征。处理器基于在运动传感器处检测到的旋转和/或在图像传感器处检测到的身体特征或特征来确定图像在显示器处的第二取向。响应于检测到运动传感器处的旋转和/或图像传感器处的身体特征或特征，便携式电子设备可以确定显示器处的图像的取向。

58. 发明授权

US08461343B2 Synthesis of thiohydantoins 有权
公开(公告)号：US08461343B2
公开(公告)日：2013-06-11
申请号：US12450423
申请日：2008-03-27
申请人： Ouathek Ouerfelli , Anna Dilhas , Guangbin Yang , Hong Zhao
发明人： Ouathek Ouerfelli , Anna Dilhas , Guangbin Yang , Hong Zhao
IPC分类号： C07D213/84
CPC分类号： C07D401/04 , C07C209/36 , C07C213/08 , C07C227/18 , C07C231/12 , C07C253/00 , C07C253/30 , C07C2601/04 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/72 , C07D213/74 , C07D213/76 , C07D213/84 , C07C211/52 , C07C217/58 , C07C255/46
摘要： A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

59. 发明授权

US08367065B2 Targeted polymeric prodrugs containing multifunctional linkers 失效
标题翻译：含有多功能接头的靶向聚合物前药
公开(公告)号：US08367065B2
公开(公告)日：2013-02-05
申请号：US12402839
申请日：2009-03-12
申请人： Hong Zhao , Prasanna Reddy , Maria Belen Rubio
发明人： Hong Zhao , Prasanna Reddy , Maria Belen Rubio
IPC分类号： A61K47/48 , A61K31/4015 , A61K31/4025 , A61K31/444 , A61K31/44 , A61K31/7088 , A61K39/395 , C07H21/02 , C07K16/00 , C07K17/02 , C07D207/40 , C07D403/12
CPC分类号： C07K7/08 , A61K47/551 , A61K47/60 , A61K47/64 , C07D207/416 , C07D207/448 , C07D213/71 , C07D487/04 , C07K5/0821 , C07K7/06
摘要： The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.
摘要翻译：本发明提供了含有多功能接头的单链抗体定向聚合前药。还公开了制备聚合物递送系统的方法和使用其的治疗哺乳动物的方法。

60. 发明申请

US20120296090A1 Drug Repositioning Methods For Targeting Breast Tumor Initiating Cells 审中-公开
标题翻译：用于靶向乳腺肿瘤起始细胞的药物重新定位方法
公开(公告)号：US20120296090A1
公开(公告)日：2012-11-22
申请号：US13439626
申请日：2012-04-04
申请人： Stephen TC Wong , Hong Zhao , Guangxu Jin
发明人： Stephen TC Wong , Hong Zhao , Guangxu Jin
IPC分类号： G06F19/00 , C07D305/14 , C07C233/15 , C07D413/12
CPC分类号： G16H50/50 , Y02A90/26
摘要： Disclosed are systems biology-based methods for repositioning known pharmaceutical compounds to new indications, through the identification of network-based signatures. In particular, the invention provides new and useful methods for selecting drugs or combinations of drugs (and preferably previously-approved drugs) for use in new therapeutic indications. Also disclosed are methods for identifying anti-breast tumor initiating cell (TIC)-based therapeutics from within populations of target compounds. In illustrative embodiments, the invention provides methods and computer programs for the repositioning of FDA-approved pharmaceutical compounds to new indications using network-based signature analysis coupled with conventional in vitro and in vivo testing of identified drug candidates. The invention also allows identification of drugs or drug combinations for treating unmet medical needs including, for example, “orphan” diseases.
摘要翻译：公开了基于系统生物学的方法，通过识别基于网络的签名将已知药物化合物重新定位到新的指示。特别地，本发明提供用于选择用于新的治疗适应症的药物或药物组合（并优选先前认可的药物）的新的和有用的方法。还公开了用于从目标化合物群体内鉴定抗乳腺肿瘤起始细胞（TIC）的治疗剂的方法。在说明性实施例中，本发明提供了使用基于网络的签名分析与常规的体外和体内测定鉴定的候选药物来重新定位FDA批准的药物化合物到新的适应症的方法和计算机程序。本发明还允许鉴定用于治疗未满足的医疗需要的药物或药物组合，包括例如孤儿疾病。

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