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51. 发明授权

US4073933A Novel bicycloheptene derivatives 失效
标题翻译：新型双环庚烯衍生物
公开(公告)号：US4073933A
公开(公告)日：1978-02-14
申请号：US697152
申请日：1976-06-17
申请人： Hiromi Shimomura , Akihiko Sugie , Junki Katsube , Hisao Yamamoto
发明人： Hiromi Shimomura , Akihiko Sugie , Junki Katsube , Hisao Yamamoto
IPC分类号： C07C405/00 , C07D309/12 , C07D311/94 , C07C177/00 , C07C61/38 , C07C69/74
CPC分类号： C07C405/0091 , C07C405/00 , C07D309/12 , C07D311/94 , Y10S514/925
摘要： Novel bicycloheptene compounds of the formula: ##STR1## wherein A is C.sub.2 -C.sub.4 alkylene; X and B are each ethylene or vinylene; R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.8 alkoxyalkyl, C.sub.5 -C.sub.7 cycloalkyl, C.sub.5 -C.sub.8 cycloalkylalkyl, aryl, C.sub.7 -C.sub.10 arylalkyl, C.sub.7 -C.sub.10 aryloxyalkyl; R.sub.2 is hydrogen, or C.sub.1 -C.sub.4 alkyl; and Z is carboxyl, C.sub.2 -C.sub.5 alkoxycarbonyl or C.sub.1 -C.sub.5 carbamoyl, and its non-toxic salts, which are useful as antiulcers, gastric secretion inhibitors, central nervous system regulators, and labor inducing agents.
摘要翻译：下式的新型双环庚烯化合物：其中A是C 2 -C 4亚烷基; X和B各自为亚乙烯基或亚乙烯基; R1是氢，C1-C8烷基，C4-C8烷氧基烷基，C5-C7环烷基，C5-C8环烷基烷基，芳基，C7-C10芳基烷基，C7-C10芳氧基烷基; R2是氢或C1-C4烷基; Z为羧基，C 2 -C 5烷氧基羰基或C 1 -C 5氨基甲酰基及其无毒盐，其可用作抗溃疡剂，胃分泌抑制剂，中枢神经系统调节剂和劳动诱导剂。

52. 发明授权

US4065565A Acylhydrazones and anti-psychotic compositions thereof 失效
标题翻译：酰腙及其抗精神病药组合物
公开(公告)号：US4065565A
公开(公告)日：1977-12-27
申请号：US603813
申请日：1975-08-12
申请人： Kikuo Sasajima , Keiichi Ono , Masaru Nakao , Isamu Maruyama , Shigenari Katayama , Shigeho Inaba , Hisao Yamamoto
发明人： Kikuo Sasajima , Keiichi Ono , Masaru Nakao , Isamu Maruyama , Shigenari Katayama , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D295/12 , A61K31/15 , A61K31/445 , A61K31/451 , A61P9/12 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/18 , A61P25/20 , C07D211/00 , C07D211/52 , C07D235/00 , C07D241/00 , C07D241/04
CPC分类号： C07D211/52
摘要： Acylhydrazone compounds having excellent pyschotropic activity which are represented by the formula: ##STR1## wherein Z is selected from the groups having the formulas: ##STR2## wherein n is an integer of from 0 to 2 and R.sup.1 -R.sup.12 are as defined hereinbelow.
摘要翻译：其中Z选自具有下式的基团：其中n为0至2的整数，R 1 -R 12的整数为1，其中Z为选自下列基团的酰基腙化合物：如下文所定义。

53. 发明授权

US4048168A Process for preparing 1-polyhaloalkyl-3,4-dihydro-2-(1H)-quinazolinones 失效
标题翻译： 1-多卤代烷基-3,4-二氢-2-（1H） - 喹唑啉酮的制备方法
公开(公告)号：US4048168A
公开(公告)日：1977-09-13
申请号：US754640
申请日：1976-12-27
申请人： Michihiro Yamamoto , Shigenari Katayama , Masao Koshiba , Hisao Yamamoto
发明人： Michihiro Yamamoto , Shigenari Katayama , Masao Koshiba , Hisao Yamamoto
IPC分类号： A61K31/505 , A61K31/517 , A61P25/04 , A61P29/00 , C07D239/78 , C07D239/82 , C07D409/04 , C07D491/056
CPC分类号： C07D239/78 , C07D239/82
摘要： 3,4-Dihydro-2(1H)-quinazolinone derivatives of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkylthio or lower alkoxy, or, when taken together, R.sub.1 and R.sub.2 may form methylenedioxy; R.sub.3 is polyhalo-lower alkyl; R.sub.4 is phenyl, halophenyl, lower alkoxyphenyl, lower alkylphenyl or thienyl; and X is oxygen or sulfur, which are known to be very useful intermediates for the preparation of anti-inflammatory and analgesic agents, are obtained in a high yield by reacting a compound of the formula, ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and X are as defined above, with a compound of the formula,R.sub.4 --CHOwherein R.sub.4 is as defined above, with heating in the presence of a zinc halide as a catalyst.
摘要翻译： 3,4-二氢-2（1H） - 喹唑啉酮衍生物，其中R 1和R 2各自为氢，低级烷基，低级烷硫基或低级烷氧基，或者当R 1和R 2一起形成亚甲二氧基时; R3是多卤代低级烷基; R4是苯基，卤代苯基，低级烷氧基苯基，低级烷基苯基或噻吩基; 通过使下式化合物，其中R 1，R 2，R 3和R 3与式（I）化合物反应，可以高收率获得已知是用于制备抗炎和止痛剂的非常有用的中间体的X是氧或硫。 X如上所定义，与卤化锌作为催化剂的存在下，加热下式的化合物，其中R 4如上定义。

54. 发明授权

US3974145A Novel N'-acylated phenyl-hydrazine and hydrozone derivatives 失效
标题翻译：新型N {40-酰基苯基 - 肼和水解产物
公开(公告)号：US3974145A
公开(公告)日：1976-08-10
申请号：US439035
申请日：1974-02-04
申请人： Michio Kimura , Shigeho Inaba , Hisao Yamamoto
发明人： Michio Kimura , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D209/60 , C07D209/70 , C07D307/54 , C07D317/66 , C07D317/68 , C07D319/18
CPC分类号： C07D307/54 , C07D209/60 , C07D209/70 , C07D317/66 , C07D317/68 , C07D319/18
摘要： Novel indolylacetic acid derivatives, which have excellent anti-inflammatory, antipyretic and analgesic activities, represented by the formula, ##SPC1##Wherein X.sub.1 and X.sub.2 each is a member selected from the group consisting of oxygen and methylene; A is a member selected from the group consisting of unsubstituted saturated hydrocarbon chain having up to 5 carbon atoms, unsubstituted unsaturated hydrocarbon chain having up to 5 carbon atoms and substituted saturated or substituted ethylenically unsaturated hydrocarbon chain having up to 5 carbon atoms, in which the substituents are selected from the group consisting of halogen or phenyl, the hydrocarbon chain being straight or blanched one; m is 0 or 1; n is 1 or 2; R.sub.1 and R.sub.2 each is a member selected from the group consisting of hydrogen and alkyl having up to 4 carbon atoms; R.sub.3 is a member selected from the group consisting of alkyl having up to 4 carbon atoms, unsubstituted or a lower alkyl-, lower alkoxy-, lower alkylthio-, nitro-, cyano-, methylenedioxy-, ethylenedioxy- or halogen-substituted aryl, each of said alkyl, alkoxy and alkylthio substituents containing up to 4 carbon atoms, or unsubstituted, or halogen-, alkyl- or phenyl-substituted or benzene ring-condensed, saturated or unsaturated mono- or poly-aclicyclic group, or alkyl group substituted by said alicyclic group, or unsubstituted or methyl-, ethyl- or halogen-substituted 5- or 6-membered heterocyclic ring group containing oxygen, sulfur or nitrogen atom; R.sub.4 is a member selected from the group consisting of alkyl having up to 4 carbon atoms or hydrogen, or a group of M (wherein M is a cation).The indolylacetic acid of the formula (I) is prepared by reacting a compound of the formula, ##SPC2##Wherein X.sub.1, X.sub.2 and n are the same as defined above and B is a member selected from the group consisting of ##EQU1## and Z (wherein Z is a nitrogen protecting system comprising at least one readily removable group), with an acid halide represented by the formula,R.sub.3 --(A).sub.m --CO--hal (V)wherein R.sub.3, A and m are the same as defined above and hal is halogen, to obtain N.sup.1 -acylated compound of the formula, ##SPC3##Wherein X.sub.1, X.sub.2, R.sub.3, A, B, m and n are the same as defined above, then reacting the resultant N.sup.1 -acylated compound (II) with an aliphatic acid derivative represented by the formula, ##EQU2## wherein R.sub.1, R.sub.2 and R.sub.4 are the same as defined above.
摘要翻译：新型吲哚乙酸衍生物，其具有优异的抗炎，解热和止痛活性，由式WHEREIN X1和X2各自为选自氧和亚甲基的成员; A是选自具有至多5个碳原子的未取代的饱和烃链，具有至多5个碳原子的未取代的不饱和烃链和具有至多5个碳原子的取代的饱和或取代的烯属不饱和烃链的成员，其中取代基选自卤素或苯基，烃链是直链或漂白的; m为0或1; n为1或2; R1和R2各自是选自氢和具有至多4个碳原子的烷基的成员; R3是选自具有至多4个碳原子的烷基，未取代的或低级烷基，低级烷氧基 - ，低级烷硫基 - ，硝基 - ，氰基 - ，亚甲二氧基 - ，亚乙二氧基或卤素取代的芳基的成员，所述烷基，烷氧基和烷硫基取代基含有至多4个碳原子，或未取代的或卤素，烷基或苯基取代的或苯环稠合的饱和或不饱和的单 - 或多 - 酰基基团或烷基取代的或含有氧，硫或氮原子的未取代或甲基，乙基或卤素取代的5元或6元杂环基; R4是选自具有至多4个碳原子的烷基或氢的成员，或一组M（其中M是阳离子）。

55. 发明授权

US3960873A 1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines 失效
标题翻译： 1-苯基硫丙基-4-羟基-4-苯基哌啶
公开(公告)号：US3960873A
公开(公告)日：1976-06-01
申请号：US481796
申请日：1974-06-21
申请人： Isamu Maruyama , Hisao Yamamoto , Masaru Nakao , Shigeru Sakai , Kikuo Sasajima , Sumio Kitagawa , Shigeho Inaba
发明人： Isamu Maruyama , Hisao Yamamoto , Masaru Nakao , Shigeru Sakai , Kikuo Sasajima , Sumio Kitagawa , Shigeho Inaba
IPC分类号： C07D295/092 , C07D211/52
CPC分类号： C07D295/088
摘要： Novel N-substituted heterocyclic derivatives represented by the formula, ##SPC1##Wherein R.sub.1 is hydrogen atom, lower alkyl, lower alkoxy, nitro, halogen or trifluoromethyl group; R.sub.2 is hydrogen atom or lower alkyl group; X is sulfur atom, sulfinyl or sulfonyl group; Y is ##EQU1## group (wherein R.sub.3 is phenyl or substituted phenyl group; R.sub.4 is hydrogen atom, hydroxy, lower alkyl, lower alkoxy, lower alkanoyl, lower alkanoyloxy, carbamoyl, N-(lower alkyl)-carbamoyl or N,N-di(lower akyl)-carbamoyl group; R.sub.5 is hydrogen atom, morpholino, pyrrolidinyl, piperidinyl, hexamethylenimino, lower alkyl, cyclo(lower alkyl), cyclo(lower alkyl)-(lower alkyl), hydroxy-(lower alkyl), (lower alkoxy)-(lower alkyl), phenyl or substituted phenyl group; k is 0 or 1 and m is 0, 1 or 2); and n is 3 or 4, and pharmaceutically acceptable salts thereof, which have excellent tranquillizing, anti-psychotonic, anti-emotional, anti-convulsive, anti-psychosis, sedative, analgesic or anti-hypertensive activities.
摘要翻译：由式WHEREIN R1表示的新型N-取代的杂环衍生物是氢原子，低级烷基，低级烷氧基，硝基，卤素或三氟甲基; R2是氢原子或低级烷基; X是硫原子，亚磺酰基或磺酰基; Y是|| - （CH2）kN-（CH2）m-R3， - （CH2）kC-（CH2）m-R5或| R4 | -CH = C-（CH2）m-R5基（其中R3是苯基或取代的苯基; R 4是氢原子，羟基，低级烷基，低级烷氧基，低级烷酰基，低级烷酰氧基，氨基甲酰基，N-（低级烷基） - 氨基甲酰基或N，N-二（低级烷基） - 氨基甲酰基; 氢原子，吗啉代，吡咯烷基，哌啶基，六亚甲基亚氨基，低级烷基，环（低级烷基），环（低级烷基） - （低级烷基），羟基 - （低级烷基），（低级烷氧基） - （低级烷基）取代苯基; k为0或1，m为0,1或2）; 和n为3或4，及其药学上可接受的盐，其具有优异的镇静，抗心律失常，抗感觉，抗惊厥，抗精神病，镇静，止痛或抗高血压活性。

56. 发明授权

US3932637A Methods and compositions for improving the feed intake of meat producing animals 失效
标题翻译：用于改善肉类生产动物饲料摄入量的方法和组合物
公开(公告)号：US3932637A
公开(公告)日：1976-01-13
申请号：US490813
申请日：1974-07-22
申请人： Hisao Yamamoto , Shigeho Inaba , Mitsuhiro Akatsu , Clifton A. Baile , Roger G. Parish
发明人： Hisao Yamamoto , Shigeho Inaba , Mitsuhiro Akatsu , Clifton A. Baile , Roger G. Parish
IPC分类号： A23K1/16 , A61K31/55 , A61P3/00 , A61K31/33 , A61K31/44
CPC分类号： A61K31/55 , A23K20/116 , A23K20/137
摘要： Compositions and methods for inducing polyphagia in immature meat producing animals comprise administering orally or by injection an effective but nontoxic subpharmacodynamic quantity of a 1,4-benzodiazepinone active ingredient whose structure is characterized by an 1-alkyl-sulfonylalkyl moiety. Preferred active ingredients are 1-(ethylsulfonylethyl)-5-(o-halophenyl)-7-halo-1,3-dihydro-2H-1,4-benzodiazepin-2-ones.
摘要翻译：在未成熟肉生产动物中诱导多食的组合物和方法包括口服或注射有效但无毒的亚药效动力学量的1,4-苯并二氮杂酮活性成分，其结构由1-烷基 - 磺酰基烷基部分表征。优选的活性成分是1-（乙基磺酰基乙基）-5-（邻卤苯基）-7-卤代-1,3-二氢-2H-1,4-苯并二氮杂-2-酮。

57. 发明申请

US20090191481A1 Method of manufacturing relief printing plate and printing plate precursor for laser engraving 失效
标题翻译：制造凸版印刷版和激光雕版用印版前体的方法
公开(公告)号：US20090191481A1
公开(公告)日：2009-07-30
申请号：US12320226
申请日：2009-01-22
申请人： Hiroshi Tashiro , Atsushi Sugasaki , Hisao Yamamoto
发明人： Hiroshi Tashiro , Atsushi Sugasaki , Hisao Yamamoto
IPC分类号： G03F7/20
CPC分类号： B41C1/05
摘要： The invention provides a method of manufacturing a relief printing plate having at least engraving an area which is in a relief forming layer of a relief printing plate precursor for laser engraving and is to be exposed by scanning exposure using a fiber-coupled semiconductor laser which emits laser beam with a wavelength of 700 nm to 1,300 nm. The relief printing plate precursor has at least a relief forming layer provided over a support, and the relief forming layer contains at least a binder polymer and a photo-thermal conversion agent. The invention further provides a relief printing plate precursor for laser engraving which can be used in the method of manufacturing a relief printing plate.
摘要翻译：本发明提供一种制造凸版印刷版的方法，该凸版印刷板至少雕刻在用于激光雕刻的浮雕印版前体的凸版形成层中的区域，并且通过使用发射的光纤耦合半导体激光器的扫描曝光来曝光波长为700nm至1300nm的激光束。凸版印刷版前体至少具有设置在载体上的浮雕形成层，凸版形成层至少含有粘合剂聚合物和光热转换剂。本发明还提供了可用于制造凸版印刷版的方法中的用于激光雕刻的浮雕印版前体。

58. 发明授权

US06811469B2 Grinding wheel for polishing and polishing method employing it 失效
标题翻译：砂轮用于抛光和抛光方法
公开(公告)号：US06811469B2
公开(公告)日：2004-11-02
申请号：US10128258
申请日：2002-04-24
申请人： Hisao Yamamoto , Fumiaki Saito
发明人： Hisao Yamamoto , Fumiaki Saito
IPC分类号： B24B100
CPC分类号： B24D13/145 , B24B9/00 , B24D13/10
摘要： A grinding wheel for polishing, which comprises a grinding substrate and diamond-containing resin fibers implanted in the substrate in a form of a brush.
摘要翻译：一种用于抛光的砂轮，其包括研磨基板和以刷子的形式注入到基板中的含金刚石的树脂纤维。

59. 发明授权

US5772910A Method of providing lubricity to synthetic yarns to be processed for false twisting with short heater 失效
标题翻译：向短加热器假捻加工的合成纱线提供润滑性的方法
公开(公告)号：US5772910A
公开(公告)日：1998-06-30
申请号：US911422
申请日：1997-08-14
申请人： Hisao Yamamoto , Koji Maejima
发明人： Hisao Yamamoto , Koji Maejima
IPC分类号： D01F11/04 , D02G1/02 , D02J1/22 , D06M13/513 , D06M13/517 , D06M15/53 , D06M15/643 , D06M15/647 , D06M15/657 , D06M101/00 , D06M101/16 , D06M101/30 , D06M101/32 , D06M101/34
CPC分类号： D06M15/657 , D06M13/513 , D06M13/517 , D06M15/53 , D06M15/643 , D06M7/00 , D06M2200/40
摘要： A lubricating agent obtained by mixing a polyether compound and linear polyorganosiloxane of a specified type at a specified ratio is applied at a specified rate to synthetic yarns which are to be subjected to a false twisting process by a short heater so as to overcome problems of fuzz, yarn breakage and dyeing specks.
摘要翻译：以规定的比例将特定类型的聚醚化合物和线性聚有机硅氧烷以规定的比率混合而得到的润滑剂以规定的速率施加到通过短加热器进行假捻处理的合成纱线，以克服绒毛的问题纱线断头和染色斑点。

60. 发明授权

US4871794A Pneumatic tires 失效
标题翻译：气动轮胎
公开(公告)号：US4871794A
公开(公告)日：1989-10-03
申请号：US212990
申请日：1988-06-29
申请人： Michio Itoh , Hisao Yamamoto , Nobuyuki Okamura
发明人： Michio Itoh , Hisao Yamamoto , Nobuyuki Okamura
IPC分类号： B60C1/00 , C08K5/18
CPC分类号： B60C1/0016 , C08K5/18 , Y10S152/905
摘要： A pneumatic tire having improved heat resistance and gripping performance is obtained by using as a tread rubber a rubber composition containing particular amounts of specified p-phenylene diamine derivative and specified carbon black.
摘要翻译：通过使用含有特定量的特定对苯二胺衍生物和规定的炭黑的橡胶组合物作为胎面橡胶，可获得耐热性和抓地性能提高的充气轮胎。

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