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51. 发明授权

US08044079B2 Substituted oxindole derivatives, medicaments containing said derivatives and use thereof 有权
标题翻译：取代的羟吲哚衍生物，含有所述衍生物的药物及其用途
公开(公告)号：US08044079B2
公开(公告)日：2011-10-25
申请号：US12095594
申请日：2006-12-01
申请人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
发明人： Thorsten Oost , Wilfried Lubisch , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Herve Geneste , Astrid Netz
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/4525 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/422 , C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D401/14 , C07D401/12
CPC分类号： C07D413/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/551 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel oxindole derivative of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in Claim 1. The invention further relates to medicaments containing said derivatives, and use thereof for the prevention and/or treatment of vasopressin-dependent diseases.
摘要翻译：本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基R 1，R 2，A，B和Y如权利要求1中所定义。本发明还涉及含有所述衍生物的药物及其用于预防和/或加压素依赖性疾病的治疗。

52. 发明授权

US07951807B2 Substituted oxindol derivatives and medicaments containing the same 有权
标题翻译：取代的羟吲哚衍生物和含有它们的药物
公开(公告)号：US07951807B2
公开(公告)日：2011-05-31
申请号：US11632462
申请日：2005-07-13
申请人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Herve Geneste
发明人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Liliane Unger , Wilfried Hornberger , Herve Geneste
IPC分类号： A61K31/404 , A61K31/454 , C07D209/34 , C07D401/12
CPC分类号： C07D401/12 , C07D209/34
摘要： The present invention relates to novel oxindole derivatives of the general formula (I), wherein the substituents A, B, R1, R2 and R3 are as defined in Claim 1, and medicaments containing the same for the prophylaxis and/or treatment of vasopressin-dependent or oxytocin-dependent diseases.
摘要翻译：本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基A，B，R 1，R 2和R 3如权利要求1所定义，以及含有其的用于预防和/或治疗加压素 - 依赖性或催产素依赖性疾病。

53. 发明申请

US20110105528A1 1-(7-(HEXAHYDROPYRROLO [3, 4-C] PYRROL-2 (1H)-YL) QUINOLIN-4-YL) -3- (PYRAZIN-2-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK-3) 有权
标题翻译： 1-（7-（六氢吡喃并[3,4-C]吡咯-2（1H） - 基）喹啉-4-基）-3-（吡嗪-2-基）脲衍生物和相关化合物作为GLYCOGEN SYNTHASE KINASE 3（ GSK-3）
公开(公告)号：US20110105528A1
公开(公告)日：2011-05-05
申请号：US12988833
申请日：2009-04-24
申请人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Wilfried Hornberger
发明人： Sean Colm Turner , Margaretha Henrica Maria Bakker , Wilfried Hornberger
IPC分类号： A61K31/497 , C07D403/14 , C07D405/14 , A61K31/4709 , A61P25/18 , A61P25/28 , A61P25/16 , A61P19/02
CPC分类号： C07D487/04 , C07D487/08 , C07D491/048
摘要： The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译：本发明涉及可用于抑制糖原合酶激酶3（GSK-3），制备该化合物的方法，含该化合物的组合物和使用该化合物的治疗方法的新型杂环化合物。

54. 发明申请

US20110105454A1 SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES 有权
标题翻译：取代的氧化衍生物及其用于治疗依赖于依赖性依赖性的药物
公开(公告)号：US20110105454A1
公开(公告)日：2011-05-05
申请号：US12810561
申请日：2008-12-23
申请人： Wilfried Braje , Astrid Netz , Thorsten Oost , Wolfgang Wernet , Andrea Hager-Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
发明人： Wilfried Braje , Astrid Netz , Thorsten Oost , Wolfgang Wernet , Andrea Hager-Wernet , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch
IPC分类号： A61K31/397 , C07D401/14 , A61K31/496 , A61P25/00
CPC分类号： C07D401/14 , C07D209/34 , C07D401/04
摘要： The present invention relates to novel substituted oxindole derivatives of the formula (I), pharmaceutical agents containing said derivatives, and the use thereof for the treatment of vasopressin-dependent illnesses.
摘要翻译：本发明涉及式（I）的新型取代羟吲哚衍生物，含有所述衍生物的药物及其用于治疗加压素依赖性疾病的用途。

55. 发明申请

US20110071156A1 HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM 有权
公开(公告)号：US20110071156A1
公开(公告)日：2011-03-24
申请号：US12839612
申请日：2010-07-20
申请人： Thorsten Oost , Wilfried Hornberger , Herve Geneste , Daryl Richard Sauer , Wolfgang Wernet , Andrea Hager-Wernet , Liliane Unger , Wilfried Lubisch
发明人： Thorsten Oost , Wilfried Hornberger , Herve Geneste , Daryl Richard Sauer , Wolfgang Wernet , Andrea Hager-Wernet , Liliane Unger , Wilfried Lubisch
IPC分类号： A61K31/501 , C07D417/14 , A61K31/428 , C07D403/14 , A61K31/513 , C07D401/14 , A61K31/4439 , A61K31/497 , A61K31/4725 , A61K31/4709 , A61K31/4184 , A61K31/405 , A61K31/496 , A61P25/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5, R6, and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivatives can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.

56. 发明申请

US20070185126A1 Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing Them 有权
标题翻译：杂芳基取代的1,3-二氢吲哚-2-酮衍生物和含有它们的药物
公开(公告)号：US20070185126A1
公开(公告)日：2007-08-09
申请号：US10574211
申请日：2004-09-30
申请人： Wilfried Lubisch , Wilfried Hornberger , Thorsten Oost , Daryl Sauer , Liliane Unger , Wolfgang Wernet , Herve Geneste
发明人： Wilfried Lubisch , Wilfried Hornberger , Thorsten Oost , Daryl Sauer , Liliane Unger , Wolfgang Wernet , Herve Geneste
IPC分类号： A61K31/506 , A61K31/404 , C07D401/14 , C07D409/04 , C07D413/14 , C07D417/14 , A61K31/501 , A61K31/4709
CPC分类号： C07D401/14 , C07D401/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5 R6 and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivatives can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.
摘要翻译：本发明涉及式（I）的新的1,3-二氢吲哚-2-酮（羟吲哚）衍生物，其中A，R 3，R 4，R 4，根据权利要求1定义5,6和7和R 7以及含有它们用于治疗疾病的药物。特别地，新型羟基吲哚衍生物可用于控制和/或预防各种加压素依赖性或催产素依赖性疾病。

57. 发明授权

US08877794B2 Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy 有权
标题翻译：苯烷基胺衍生物，含有它们的药物组合物及其在治疗中的用途
公开(公告)号：US08877794B2
公开(公告)日：2014-11-04
申请号：US13206937
申请日：2011-08-10
申请人： Frauke Pohlki , Udo Lange , Wilhelm Amberg , Michael Ochse , Berthold Behl , Charles W. Hutchins , Wilfried Hornberger , Mario Mezler , Sean Turner
发明人： Frauke Pohlki , Udo Lange , Wilhelm Amberg , Michael Ochse , Berthold Behl , Charles W. Hutchins , Wilfried Hornberger , Mario Mezler , Sean Turner
IPC分类号： A61K31/135 , C07C211/27 , C07C311/10 , C07D403/12 , C07D231/18 , C07D207/267 , C07D401/12 , C07C311/05 , C07D205/04 , C07D233/42 , C07C311/04 , C07D295/135 , C07D207/08
CPC分类号： C07C311/06 , C07C311/04 , C07C311/05 , C07C311/10 , C07C2601/02 , C07C2601/04 , C07D205/04 , C07D207/08 , C07D207/267 , C07D231/18 , C07D233/42 , C07D233/84 , C07D295/135 , C07D401/12 , C07D403/12
摘要： The present invention relates to phenalkylamine derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.
摘要翻译：本发明涉及式（I）的苯烷基胺衍生物或其生理上耐受的盐。本发明涉及包含这种苯烷基胺衍生物的药物组合物，以及这种苯烷基胺衍生物用于治疗目的的用途。酚烷基胺衍生物是GlyT1抑制剂。

58. 发明授权

US08486931B2 Substituted oxindole compounds 有权
标题翻译：取代的羟吲哚化合物
公开(公告)号：US08486931B2
公开(公告)日：2013-07-16
申请号：US12529542
申请日：2008-02-29
申请人： Herve Genesle , Thorsten Oost , Charles W. Hutchins , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Astrid Netz , Alfred Hahn
发明人： Herve Genesle , Thorsten Oost , Charles W. Hutchins , Liliane Unger , Wilfried Hornberger , Wilfried Lubisch , Astrid Netz , Wolfgang Wernet
IPC分类号： A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/551
CPC分类号： C07D401/14 , C07D401/04 , C07D401/12 , C07D471/08
摘要： The present invention relates to compounds of the general formula (I) in which A, B, R1, R2 and Het have the meaning given in claim 1; Y is a bivalent group of the formula in which D is C1-C3-alkylene, where D may have a substituent R5; R3 is hydrogen, C1-C8-alkyl or together with R4 is C1-C3-alkylene which may have a radical R5a, or together with R5 is C1-C3-alkylene, and R4 is hydrogen, C1-C8-alkyl or together with R3 is C1-C3-alkylene which may have a radical R5a, or together with R5 is C1-C3-alkylene, where R5 together with R5a, where present, are a bond or C1-C3-alkylene; and where one of the following conditions is satisfied: R3 together with R4 is C1-C3-alkylene which may have a radical R5a; or R3 together with R5 is C1-C3-alkylene; or R4 together with R5 is C1-C3-alkylene where the radical A is different from phenyl when the radical B is phenyl or naphthyl; and medicaments which comprise such compounds and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
摘要翻译：本发明涉及通式（I）的化合物，其中A，B，R1，R2和Het具有权利要求1中给出的含义; Y是下式的二价基团，其中D是C 1 -C 3 - 亚烷基，其中D可以具有取代基R 5; R 3是氢，C 1 -C 8烷基或与R 4一起是可以具有基团R 5a的C 1 -C 3亚烷基，或与R 5一起为C 1 -C 3 - 亚烷基，并且R 4是氢，C 1 -C 8 - 烷基或与 R 3是可以具有基团R 5a的C 1 -C 3亚烷基，或与R 5一起为C 1 -C 3 - 亚烷基，其中R 5与存在的R a a为键或C 1 -C 3 - 亚烷基; 并且其中满足以下条件之一：R 3与R 4一起可以具有基团R 5a的C 1 -C 3 - 亚烷基; 或R 3与R 5一起为C 1 -C 3 - 亚烷基; 或R 4与R 5一起为C 1 -C 3 - 亚烷基，其中基团B为苯基或萘基时，基团A不同于苯基; 以及包含这些化合物的药物及其用于预防和/或治疗加压素依赖性和/或催产素依赖性疾病的用途。

59. 发明授权

US08350055B2 Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them 有权
公开(公告)号：US08350055B2
公开(公告)日：2013-01-08
申请号：US12839612
申请日：2010-07-20
申请人： Thorsten Oost , Wilfried Hornberger , Herve Geneste , Daryl Richard Sauer , Wolfgang Wernet , Andrea Hager-Wernet, legal representative , Liliane Unger , Wilfried Lubisch
发明人： Thorsten Oost , Wilfried Hornberger , Herve Geneste , Daryl Richard Sauer , Wolfgang Wernet , Liliane Unger , Wilfried Lubisch
IPC分类号： C07D411/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5, R6, and R7 are defined according to claim 1, and to medicaments containing them for the treatment of diseases. In particular, the novel oxindole derivatives can be used for the control and/or prophylaxis of various vasopressin-dependent or oxytocin-dependent diseases.

60. 发明授权

US08129389B2 Substituted oxindole derivatives, medicaments containing the latter and use thereof 有权
标题翻译：取代的羟基吲哚衍生物，含有后者的药物及其用途
公开(公告)号：US08129389B2
公开(公告)日：2012-03-06
申请号：US11886729
申请日：2006-03-23
申请人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Hervé Geneste
发明人： Wilfried Lubisch , Thorsten Oost , Wolfgang Wernet , Wilfried Hornberger , Liliane Unger , Hervé Geneste
IPC分类号： A61K31/496 , A61K31/506 , C07D401/12 , C07D403/12 , C07D417/12
CPC分类号： C07D403/12 , C07D401/12 , C07D417/12
摘要： The invention relates to novel oxindole derivatives of general formula (I), in which the substituents A, B, R1, R2 and R3 are defined as cited in claim 1, to medicaments containing said derivatives and to the use of the latter for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
摘要翻译：本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基A，B，R 1，R 2和R 3如权利要求1中所定义，含有所述衍生物的药物及其用于预防的药物和/或加压素依赖性和/或催产素依赖性疾病的治疗。

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