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51. 发明申请

US20080043353A1 APPARATUS AND SYSTEM FOR STEERING AN OPTICAL BEAM 审中-公开
标题翻译：用于转向光束的装置和系统
公开(公告)号：US20080043353A1
公开(公告)日：2008-02-21
申请号：US11770277
申请日：2007-06-28
申请人： Christopher Horvath , Laszlo O. Romoda
发明人： Christopher Horvath , Laszlo O. Romoda
IPC分类号： G02B5/08 , A61B18/20 , A61F9/008
CPC分类号： A61F9/008 , A61B2018/208 , A61F9/00821 , A61F2009/00863 , G02B26/0816
摘要： A system and apparatus for directing a light beam along multiple optical paths are disclosed, one embodiment of the apparatus comprising: a base assembly; a first reflective surface set at a first angle to the optical axis of an incident light beam and operable to direct the light beam along a first optical path; and a second reflective surface set at a second angle, different from the first angle, to the optical axis of the incident light beam and operable to direct the light beam along a second optical path, wherein the first reflective surface and the second reflective surface are operable to move in a linear manner along a common axis, and wherein the base assembly is operable to linearly reposition the first and second reflective surfaces along the common axis so that the incident light beam is incident on one or the other. The apparatus can further comprise a movement means operably coupled to the base assembly to provide motive force to reposition the first and second reflective surfaces.
摘要翻译：公开了一种用于沿着多个光路引导光束的系统和装置，该装置的一个实施例包括：基座组件; 第一反射表面，其设置成与入射光束的光轴成一定角度，并且可操作以沿着第一光路引导光束; 以及第二反射表面，其设置成与入射光束的光轴不同于第一角度的第二角度，并且可操作以沿着第二光学路径引导光束，其中第一反射表面和第二反射表面是可操作地沿着共同的轴线以线性方式移动，并且其中基座组件可操作以沿着公共轴线线性地重新定位第一和第二反射表面，使得入射光束入射在一个或另一个上。该装置还可包括可操作地联接到基座组件以提供动力以重新定位第一和第二反射表面的运动装置。

52. 发明申请

US20070027459A1 Method and system for configuring and data populating a surgical device 审中-公开
标题翻译：用于配置和数据填充外科手术装置的方法和系统
公开(公告)号：US20070027459A1
公开(公告)日：2007-02-01
申请号：US11492616
申请日：2006-07-25
申请人： Christopher Horvath , Steven Charles , Edward Malk
发明人： Christopher Horvath , Steven Charles , Edward Malk
IPC分类号： A61B17/04 , A61M5/178
CPC分类号： A61B90/98 , A61B2018/00988 , G16H40/40
摘要： A system and method for configuring a surgical device are disclosed, one embodiment of the system comprising; an interface operable to receive data; a portable component, comprising an identifier operable to store and transmit a set of data; a memory, the memory storing criteria; and a controller, wherein the controller, the memory and the interface are included in the surgical device, and wherein the controller is operable to configure the surgical device based on the set of data transmitted from the identifier and received at the interface. The identifier can be an RFID tag and the interface can be an RFID interface comprising an RFID reader operable to transmit a radio frequency (RF) instruction to activate the RFID tag of the portable component, and a microcontroller operable to cause the RFID reader to transmit the RF instruction. The portable component can be an identification tag that can be attached to the user. The criteria can be user authorization data that is stored in the memory and the controller is operable to determine whether a user associated with the portable component is authorized to use the surgical device based on whether the set of data transmitted from the identifier and received at the interface satisfies the criteria stored in the memory. The criteria can also be an algorithm that the controller applies to the set of data received from the identifier to determine whether the user is authorized to use the surgical device. The controller can cause the surgical device to be disabled if it is determined that the user is not authorized to use the surgical device (e.g., the surgeon, technician or patient is at the wrong surgical device).
摘要翻译：公开了一种用于配置外科装置的系统和方法，所述系统的一个实施例包括：用于接收数据的接口; 便携式组件，包括可操作以存储和发送一组数据的标识符; 内存，内存存储标准; 以及控制器，其中所述控制器，所述存储器和所述接口被包括在所述手术装置中，并且其中所述控制器可操作以基于从所述标识符发送并在所述界面处接收的所述数据集来配置所述外科装置。标识符可以是RFID标签，并且接口可以是RFID接口，其包括RFID读取器，RFID读取器可操作以传送射频（RF）指令以激活便携式部件的RFID标签;以及微控制器，其可操作以使RFID读取器传送 RF指令。便携式组件可以是可以附接到用户的识别标签。标准可以是存储在存储器中的用户授权数据，并且控制器可操作以基于从标识符发送的数据集合是否被授权使用外科设备来确定与便携式组件相关联的用户是否被授权接口满足存储在存储器中的条件。标准还可以是控制器应用于从标识符接收的数据集合以确定用户是否被授权使用外科装置的算法。如果确定用户未被授权使用手术装置（例如，外科医生，技术人员或患者处于错误的手术装置），则控制器可以使外科手术装置被禁用。

53. 发明申请

US20060219049A1 Footswitch operable to control a surgical system 有权
标题翻译：脚踏开关可操作以控制外科系统
公开(公告)号：US20060219049A1
公开(公告)日：2006-10-05
申请号：US11389808
申请日：2006-03-27
申请人： Christopher Horvath , Mark Buczek , T. Rowe
发明人： Christopher Horvath , Mark Buczek , T. Rowe
IPC分类号： G05G1/14
CPC分类号： G05G1/38 , A61B17/00 , A61B34/20 , A61B2017/00119 , A61B2017/00194 , A61B2017/00199 , A61B2017/00221 , A61B2017/00973 , A61C1/0023 , H01H21/26 , H01H2239/076 , H01H2300/014 , H01H2300/03 , Y02B70/3241 , Y04S20/227 , Y10T74/2054 , Y10T74/20888 , Y10T307/747
摘要： The present invention provides a surgical footswitch that includes a base, a pedal, an encoder assembly, a wireless interface, and an internal power generator. The pedal mounts upon the base and pivots. The encoder assembly couples to the pedal. As the pedal pivots, the encoder assembly translates the mechanical signal of the pedal into a control signal based on the pedals position and/or orientation. The wireless interface couples the encoder assembly to receive the control signal. The wireless interface also couples the surgical footswitch to a surgical console operable to control and direct surgical equipment. The wireless interface passes the control signal from the encoder to the surgical console, which then directs the surgical equipment based on the control signal. This wireless interface eliminates the tangle of wires or tethers, which may be a hazard in the surgical theater. The internal power generator translates footswitch movement into stored energy to eliminate potential failures of the footswitch during a procedure and overcome the need to replace batteries within the footswitch.
摘要翻译：本发明提供了一种手术脚踏开关，其包括底座，踏板，编码器组件，无线接口和内部发电机。踏板安装在底座上并枢转。编码器组件耦合到踏板。当踏板枢转时，编码器组件基于踏板位置和/或方向将踏板的机械信号转换为控制信号。无线接口耦合编码器组件以接收控制信号。无线接口还将手术脚踏开关连接到可操作以控制和引导手术设备的外科手术台。无线接口将控制信号从编码器传递到外科控制台，然后控制信号根据控制信号引导外科设备。这种无线接口消除了电线或绳索的缠结，这可能是外科手术室的危险。内部发电机将脚踏开关转换为储存的能量，以消除脚踏开关在程序期间的潜在故障，并克服了更换脚踏开关内的电池的需要。

54. 发明申请

US20060062793A1 Modified antibodies to prostate-specific membrane antigen and uses thereof 审中-公开
公开(公告)号：US20060062793A1
公开(公告)日：2006-03-23
申请号：US11218813
申请日：2005-09-02
申请人： Iain Webb , Christopher Horvath
发明人： Iain Webb , Christopher Horvath
IPC分类号： A61K39/395
CPC分类号： A61K51/1072 , A61K39/39558 , A61K47/6803 , A61K47/6869 , A61K2039/505 , A61K2039/545 , C07K16/3069 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or antigen-binding fragments thereof, have been rendered less immunogenic compared to their unmodified counterparts to a given species, e.g., a human. Pharmaceutical compositions including the aforesaid antibodies, nucleic acids, recombinant expression vectors and host cells for making such antibodies and fragments are also disclosed. Methods of using the antibodies of the invention to detect human PSMA, or to ablate or kill a PSMA-expressing cell, e.g., a PSMA-expressing cancer or prostatic cell, either in vitro or in vivo, are also provided.

55. 发明授权

US06863667B2 Ocular fixation and stabilization device for ophthalmic surgical applications 有权
标题翻译：用于眼科手术应用的眼固定和稳定装置
公开(公告)号：US06863667B2
公开(公告)日：2005-03-08
申请号：US09772539
申请日：2001-01-29
申请人： Kyle R. Webb , Michael F. Brownell , Christopher Horvath , Tibor Juhasz , Ronald M. Kurtz , Laszlo I. Nagy , Mark W. Ross , Carlos G. Suarez
发明人： Kyle R. Webb , Michael F. Brownell , Christopher Horvath , Tibor Juhasz , Ronald M. Kurtz , Laszlo I. Nagy , Mark W. Ross , Carlos G. Suarez
IPC分类号： A61B17/30 , A61F9/008 , A61F9/009 , A61F9/01 , A61B18/18
CPC分类号： A61F9/009 , A61B2017/306 , A61F9/008 , A61F2009/00846
摘要： A disposable stabilization and applanation device for reconfiguring the cornea of an eye for ophthalmic laser surgery, includes an applanation lens that is disposed in a particular spatial position with respect to an incident laser beam. The applanation lens is inserted into the central opening of an attachment ring and applanates the eye in response to pressure from a lens cone. The attachment ring is coupled to the eye and includes a skirt which surrounds the applanation lens and extends outwardly therefrom to define a chamber. The skirt is formed with a groove which defines a suction channel between the attachment ring skirt and the corneal surface of an eye. A vacuum source is connected and fluid communication with the suction channel and is selectively activated to create a partial vacuum in the channel.
摘要翻译：用于重新配置用于眼科激光手术的眼睛的角膜的一次性稳定和压扁装置包括布置在相对于入射激光束的特定空间位置的压平透镜。压平透镜被插入到附接环的中央开口中，并响应于来自透镜锥的压力而使眼睛压平。附接环联接到眼睛并且包括裙部，其围绕压扁透镜并从其向外延伸以限定腔室。裙部形成有凹槽，该凹槽限定了附接环裙与眼睛的角膜表面之间的抽吸通道。连接真空源并与抽吸通道进行流体连通并被选择性地激活以在通道中产生部分真空。

56. 发明授权

US06648877B1 Method for custom corneal corrections 有权
标题翻译：自定义角膜修正方法
公开(公告)号：US06648877B1
公开(公告)日：2003-11-18
申请号：US09609090
申请日：2000-06-30
申请人： Tibor Juhasz , Ronald M. Kurtz , Christopher Horvath , Carlos G. Suarez , J. Randy Alexander
发明人： Tibor Juhasz , Ronald M. Kurtz , Christopher Horvath , Carlos G. Suarez , J. Randy Alexander
IPC分类号： A61P9007
CPC分类号： A61F9/008 , A61F9/00829 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： A method for customizing corneal corrections includes superposing an imaginary reference field (grid) on the anterior surface of the cornea of an eye to divide the corneal surface into reference areas. Also, a diagnostically determined refractive power map for the cornea is created. An incising laser beam is then directed through an individual reference area to a focal spot. Next, movement of the focal spot along the laser beam path is selectively accomplished to photoalter a predetermined volume of stromal tissue. Subsequently, based on the refractive power map, the predetermined volume of stromal tissue that is to be photoaltered is identified for each specific reference area. Accordingly, the steps of directing the beam and moving the focal spot are then repeated using selected reference areas until the required corneal correction is achieved.
摘要翻译：用于定制角膜修正的方法包括在眼睛的角膜的前表面上叠加虚拟参考场（网格），以将角膜表面分成参考区域。此外，产生用于角膜的诊断上确定的屈光度图。然后将切割的激光束引导到单个参考区域到焦点。接下来，选择性地实现焦斑沿着激光束路径的移动，以对预定体积的基质组织进行光刻。随后，基于屈光力图，针对每个特定参考区域识别要被光老化的基质组织的预定体积。因此，然后使用选定的参考区域重复引导光束和移动焦点的步骤，直到实现所需的角膜校正。

57. 发明申请

US20200146887A1 SYSTEMS AND METHODS FOR TREATING GLAUCOMA WITH PHOTODISRUPTIVE LASER PULSES 审中-公开
公开(公告)号：US20200146887A1
公开(公告)日：2020-05-14
申请号：US16740456
申请日：2020-01-12
申请人： Christopher Horvath , Vanessa Isabella Vera
发明人： Christopher Horvath , Vanessa Isabella Vera
IPC分类号： A61F9/008 , A61F9/009 , A61F9/007
摘要： The invention relates to systems and methods for delivering highly focused photodisruptive laser pulses with pulse durations

58. 发明授权

US09033963B2 Systems and methods to deliver photodisruptive laser pulses into tissue layers of the anterior angle of the eye 有权
标题翻译：将光致破坏性激光脉冲输送到眼睛前角的组织层中的系统和方法
公开(公告)号：US09033963B2
公开(公告)日：2015-05-19
申请号：US13442854
申请日：2012-04-10
申请人： Vanessa Isabella Vera , Christopher Horvath
发明人： Vanessa Isabella Vera , Christopher Horvath
IPC分类号： A61N5/067 , A61F9/008
CPC分类号： A61F9/00821 , A61F9/00781 , A61F9/00825 , A61F2009/00868 , A61F2009/00891
摘要： The invention relates to systems and methods for measuring the angular accessibility limitations of the anterior angle of the eye, targeting one or multiple treatment zones within the anterior angle area of the eye and delivering highly focused photodisruptive laser pulses with pulse durations
摘要翻译：本发明涉及用于测量眼睛前角的角度可访问性限制的系统和方法，其针对眼睛的前角区域内的一个或多个治疗区域并且递送具有脉冲持续时间<50皮秒的高度聚焦的光破坏性激光脉冲，从而产生通道进入眼睛前角内的各种解剖结构。本发明还包括定制的前房角镜检查透镜系统，患者接口系统和用于将高度聚焦的激光束传送到眼睛的前角区域的激光输送系统。

59. 发明授权

US09023018B2 Surgical laser system with remote control functionality 有权
标题翻译：手术激光系统具有遥控功能
公开(公告)号：US09023018B2
公开(公告)日：2015-05-05
申请号：US12634150
申请日：2009-12-09
申请人： Christopher Horvath , Laszlo Otto Romoda
发明人： Christopher Horvath , Laszlo Otto Romoda
IPC分类号： A61B18/20 , A61F9/008
CPC分类号： A61F9/008 , A61F2009/00872
摘要： Embodiments of the present invention provide a laser surgical system with a basic set of functionality which is remotely controllable to implement an advanced set of functionality. According to one embodiment of the present invention, a basic laser surgical system may be coupled to an advanced control unit such that the basic laser surgical system may be controllable by the advanced control unit to implement a broader set of functionality. By moving less frequently used functionality to an advanced unit, the basic unit may be streamlined with regards to both cost and size, and the learning curve required to utilize the basic unit may be reduced relative to a more feature-ladened unit, allowing the basic unit to be utilized in myriad situations or procedures where an “all-in-one” unit would be less than desirable.
摘要翻译：本发明的实施例提供具有基本功能集的激光手术系统，其可远程控制以实现高级功能集。根据本发明的一个实施例，基本的激光手术系统可以耦合到高级控制单元，使得基本的激光手术系统可以由高级控制单元控制，以实现更广泛的功能。通过将较少使用的功能移动到高级单元，可以在成本和尺寸方面简化基本单元，并且可以相对于更特征加载的单元减少使用基本单元所需的学习曲线，从而允许基本单元单位将用于无数情况或程序中，“一体化”单位不太可取。

60. 发明申请

US20140350533A1 CONTACTLESS PHOTODISRUPTIVE LASER CATARACT SURGERY 审中-公开
标题翻译：无连续光电激光雷射手术
公开(公告)号：US20140350533A1
公开(公告)日：2014-11-27
申请号：US13877166
申请日：2011-10-02
申请人： Christopher Horvath , Vanessa I. Vera
发明人： Christopher Horvath , Vanessa I. Vera
IPC分类号： A61F9/008
CPC分类号： A61F9/00825 , A61F2009/0087 , A61F2009/00889
摘要： Method, apparatus and systems for laser surgery as part of cataract surgery. The implementation thereof includes: A means to perform incisions in the cornea and inside the eye. In particular Limbal Relaxating Incisions and an anterior or posterior capsulotomy/capsulorhexis using a rapid fire sequence of photodisruptive laser pulses, placed to open the capsule for cataract surgery. The system and methods provides the means to target and direct the laser pulse sequence into the desired region of the eye without the need of a patient interface that is locked to the laser delivery system and holds the eye in a fixed position relative to the delivery system.
摘要翻译：用于激光手术的方法，装置和系统作为白内障手术的一部分。其实现包括：在角膜和眼内进行切口的手段。特别是边缘松弛切口和使用光破坏性激光脉冲的快速火焰序列的前部或后部囊切开/撕囊术，放置以打开胶囊用于白内障手术。该系统和方法提供了将激光脉冲序列对准并将其定向到眼睛的期望区域的手段，而不需要将锁定到激光输送系统的患者界面相对于相对于输送系统保持在固定位置。

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