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51. 发明申请

US20080268528A1 Automated analyzer for use in performing nucleic Acid-based amplification reactions 有权
标题翻译：用于进行基于核酸的扩增反应的自动分析仪
公开(公告)号：US20080268528A1
公开(公告)日：2008-10-30
申请号：US11873818
申请日：2007-10-17
申请人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
发明人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
IPC分类号： C12M1/34 , C12M1/40
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译：用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，进行分析物分离程序，并确定目标分析物的存在。自动插座输送系统将反应容器从一个站移动到另一个站。分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

52. 发明授权

US06335166B1 Automated process for isolating and amplifying a target nucleic acid sequence 有权
标题翻译：用于分离和扩增靶核酸序列的自动化过程
公开(公告)号：US06335166B1
公开(公告)日：2002-01-01
申请号：US09303030
申请日：1999-04-30
申请人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
发明人： Kelly G. Ammann , Ralph E. Burns , Ernest V. Hansberry , Glenn A. Horner , Cheryl A. Jakub , John E. Kling , Donald J. Nieglos , Robert E. Schneider , Robert J. Smith
IPC分类号： C12Q168
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译：用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。分析仪包括用于自动准备标本样品，在规定温度下规定时间孵育样品，预处理分析物分离程序以及确定目标分析物的存在的站。自动插座输送系统将反应容器从一个站移动到另一个站。分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

53. 发明授权

US5541376A Switch and connector 失效
标题翻译：开关和连接器
公开(公告)号：US5541376A
公开(公告)日：1996-07-30
申请号：US218786
申请日：1994-03-28
申请人： James R. Ladtkow , Glenn A. Horner , Richard W. Petersen
发明人： James R. Ladtkow , Glenn A. Horner , Richard W. Petersen
IPC分类号： A61B18/12 , A61B18/00 , H01H1/58 , H01H9/06 , H01H11/00 , H01R43/00 , H01H1/00
CPC分类号： H01H11/0056 , H01H1/585 , H01H9/06 , A61B2018/00928 , H01H2300/014
摘要： An insulating switch base with a top, bottom and an edge has openings through the top and one edge for a conductor. A conductive switch lead frame has proximal ends with insulation displacement connectors bent in the openings. A resilient member on the frame has a moveable contact and is conductively associated with a connector. A contoured arm on the frame is distal of, but conductive with, another connector. The arm is spaced from the resilient member as an open contact capable of momentary engagement. A frangible area on each frame is between the resilient member and the arm. Recesses in the top support retain the frame. A slot and barbs on each connector receive one conductor securely in an opening after aligned installation in an opening, seating of the frame in its recess and severing the area over a passage in the base. A membrane attaches over the frame and a molding is applied about the membrane leaving the resilient member open.
摘要翻译：具有顶部，底部和边缘的绝缘开关底座具有穿过顶部的开口和用于导体的一个边缘。导电开关引线框架具有近端，绝缘位移连接器弯曲在开口中。框架上的弹性构件具有可移动的接触并且与连接器导电地相关联。框架上的轮廓臂是远端的，但是与另一个连接器导通。臂与弹性构件间隔开，作为能够瞬时接合的开放接触。每个框架上的易碎区域在弹性构件和臂之间。顶部支架中的凹槽保持框架。每个连接器上的槽和倒钩在对准安装在开口中之后牢固地接纳在开口中的一个导体，将框架放置在其凹部中并且切断基座中的通道上的区域。膜连接在框架上，并且围绕膜施加模制件，使得弹性构件打开。

55. 发明授权

US09060780B2 Methods of manufacturing shafts for surgical instruments 有权
标题翻译：手术器械轴的制造方法
公开(公告)号：US09060780B2
公开(公告)日：2015-06-23
申请号：US13249024
申请日：2011-09-29
申请人： John R. Twomey , James D. Allen, IV , Ryan C. Artale , Dennis W. Butcher , Russell D. Hempstead , Glenn A. Horner , Jessica E. C. Olson , Jeffrey R. Unger
发明人： John R. Twomey , James D. Allen, IV , Ryan C. Artale , Dennis W. Butcher , Russell D. Hempstead , Glenn A. Horner , Jessica E. C. Olson , Jeffrey R. Unger
IPC分类号： A61B18/00 , A61B18/14 , A61B17/295 , A61B17/29
CPC分类号： A61B18/1445 , A61B17/295 , A61B2017/2901 , A61B2017/2902 , A61B2018/1455 , Y10T29/49826 , Y10T29/4998
摘要： A surgical instrument includes a shaft formed via extrusion. The shaft has one or more lumens extending therethrough. The lumen(s) each define a cross-sectional configuration. An end effector assembly is coupled to a distal end of the shaft. One or more components are coupled to the end effector assembly. The component(s) extend proximally from the end effector into the lumen(s) of the shaft. One or more of the components is formed via stamping. The component(s) define a cross-sectional configuration substantially complementary to the cross-section configuration of the lumen into which they extend.
摘要翻译：手术器械包括通过挤压形成的轴。轴具有一个或多个延伸穿过其中的腔。管腔各自限定横截面构造。端部执行器组件联接到轴的远端。一个或多个部件联接到末端执行器组件。部件从末端执行器向近侧延伸到轴的内腔中。通过冲压形成一个或多个部件。部件限定了与其延伸的管腔的横截面构造基本上互补的横截面构造。

56. 发明授权

US08864795B2 Surgical forceps 有权
标题翻译：手术镊子
公开(公告)号：US08864795B2
公开(公告)日：2014-10-21
申请号：US13251380
申请日：2011-10-03
申请人： Duane E. Kerr , James D. Allen, IV , Edward M. Chojin , Allan J. Evans , Russell D. Hempstead , Glenn A. Horner , Mark J. Huseman , Daniel A. Joseph , Arlan J. Reschke , Robert M. Sharp
发明人： Duane E. Kerr , James D. Allen, IV , Edward M. Chojin , Allan J. Evans , Russell D. Hempstead , Glenn A. Horner , Mark J. Huseman , Daniel A. Joseph , Arlan J. Reschke , Robert M. Sharp
IPC分类号： A61B17/00 , A61B18/08 , A61B18/14 , A61B17/295 , A61B17/3213 , A61B17/29 , A61B18/18 , A61B18/00
CPC分类号： A61B18/1445 , A61B17/282 , A61B17/295 , A61B17/3213 , A61B18/085 , A61B18/1442 , A61B18/18 , A61B2017/0023 , A61B2017/00473 , A61B2017/2933 , A61B2017/2937 , A61B2017/2939 , A61B2017/2946 , A61B2018/00345 , A61B2018/00404 , A61B2018/00589 , A61B2018/00595 , A61B2018/0063 , A61B2018/0097 , A61B2018/1452 , A61B2018/1455 , A61B2018/1462 , Y10T29/49815
摘要： A forceps includes an end effector assembly having first and second jaw members movable between a spaced-apart position and an approximated position for grasping tissue therebetween. A knife assembly having a cutting blade disposed at a distal end thereof is also provided. The knife assembly is translatable relative to the end effector assembly between a retracted position and an extended position, wherein the cutting blade extends between the jaw members to cut tissue grasped therebetween. The knife assembly includes a proximal component and a first distal component that includes the cutting blade. The proximal and first distal components are removably coupled to one another to facilitate replacement of the first distal component while the end effector assembly remains in a substantially assembled condition, i.e., without requiring substantial disassembly of the end effector assembly.
摘要翻译：镊子包括末端执行器组件，其具有第一和第二钳口构件，该第一和第二钳口构件可以在间隔开的位置和近似位置之间移动，用于抓住它们之间的组还提供了具有设置在其远端处的切割刀片的刀组件。刀组件相对于端部执行器组件在缩回位置和延伸位置之间是可平移的，其中切割刀片在夹爪构件之间延伸以切割夹在其间的组织。刀组件包括近端部件和包括切割刀片的第一远端部件。近端和第一远侧部件可拆卸地彼此联接以有助于更换第一远端部件，同时端部执行器组件保持基本组装的状态，即不需要实际拆卸端部执行器组件。

57. 发明授权

US08591510B2 Vessel sealing instrument with cutting mechanism 有权
公开(公告)号：US08591510B2
公开(公告)日：2013-11-26
申请号：US13227220
申请日：2011-09-07
申请人： James D. Allen, IV , James S. Cunningham , Victor K. Appel , Glenn A. Horner
发明人： James D. Allen, IV , James S. Cunningham , Victor K. Appel , Glenn A. Horner
IPC分类号： A61B18/04 , A61B18/18
CPC分类号： A61B18/1445 , A61B17/2816 , A61B17/282 , A61B17/285 , A61B17/3203 , A61B2018/00345 , A61B2018/00404 , A61B2018/00601 , A61B2018/00619 , A61B2018/1412 , A61B2018/1455
摘要： An end effector assembly for use with an instrument for sealing and cutting tissue includes a pair of opposing first and second jaw members movable relative to the to grasp tissue therebetween. Each jaw member including a jaw housing and an electrically conductive surface adapted to connect to a source of electrosurgical energy such that the electrically conductive surfaces are capable of conducting electrosurgical energy through tissue held therebetween to effect a tissue seal. One of the electrically conductive surfaces including a channel defined therein and extending along a length thereof that communicates with a nozzle disposed in the jaw housing. The nozzle is configured to direct high pressure fluid from a fluid source into the channel for cutting tissue grasped between the jaw members.

58. 发明授权

US08491625B2 Apparatus for performing an electrosurgical procedure 有权
标题翻译：用于执行电外科手术的装置
公开(公告)号：US08491625B2
公开(公告)日：2013-07-23
申请号：US12792068
申请日：2010-06-02
申请人： Glenn A. Horner
发明人： Glenn A. Horner
IPC分类号： A61B17/28 , A61B18/14
CPC分类号： A61B18/1445 , A61B17/29 , A61B2017/00862 , A61B2017/2903 , A61B2017/2929 , A61B2017/2933 , A61B2017/2937 , A61B2017/2944 , A61B2018/00982 , A61B2018/145 , A61B2018/1861
摘要： An endoscopic forceps is provided. The endoscopic forceps includes a housing having a shaft that extends therefrom. A rotatable sheath operably couples to the shaft and includes a camming member. A drive assembly includes a drive rod that operably couples to the rotatable sheath. An end effector assembly operatively connected to a distal end of the shaft has a pair of first and second jaw members. One of the first and second jaw members is movable relative to the other jaw member. Actuation of the drive assembly causes the drive rod to rotate within the shaft and rotate the rotatable sheath such that the movable jaw member moves from an initial position to a subsequent position.
摘要翻译：提供内窥镜钳。内窥镜钳包括具有从其延伸的轴的壳体。可旋转的护套可操作地连接到轴并且包括凸轮构件。驱动组件包括可操作地连接到可旋转护套的驱动杆。可操作地连接到轴的远端的端部执行器组件具有一对第一和第二钳口构件。第一和第二钳口构件中的一个可相对于另一钳口构件移动。驱动组件的致动导致驱动杆在轴内旋转并使可转动的护套旋转，使得可动夹爪构件从初始位置移动到随后的位置。

59. 发明申请

US20130085516A1 Surgical Forceps 有权
标题翻译：手术镊子
公开(公告)号：US20130085516A1
公开(公告)日：2013-04-04
申请号：US13251380
申请日：2011-10-03
申请人： Duane E. Kerr , James D. Allen, IV , Edward M. Chojin , Allan J. Evans , Russell D. Hempstead , Glenn A. Horner , Mark J. Huseman , Daniel A. Joseph , Arlan J. Reschke , Robert M. Sharp
发明人： Duane E. Kerr , James D. Allen, IV , Edward M. Chojin , Allan J. Evans , Russell D. Hempstead , Glenn A. Horner , Mark J. Huseman , Daniel A. Joseph , Arlan J. Reschke , Robert M. Sharp
IPC分类号： A61B17/285 , B23P19/00
CPC分类号： A61B18/1445 , A61B17/282 , A61B17/295 , A61B17/3213 , A61B18/085 , A61B18/1442 , A61B18/18 , A61B2017/0023 , A61B2017/00473 , A61B2017/2933 , A61B2017/2937 , A61B2017/2939 , A61B2017/2946 , A61B2018/00345 , A61B2018/00404 , A61B2018/00589 , A61B2018/00595 , A61B2018/0063 , A61B2018/0097 , A61B2018/1452 , A61B2018/1455 , A61B2018/1462 , Y10T29/49815
摘要： A forceps includes an end effector assembly having first and second jaw members movable between a spaced-apart position and an approximated position for grasping tissue therebetween. A knife assembly having a cutting blade disposed at a distal end thereof is also provided. The knife assembly is translatable relative to the end effector assembly between a retracted position and an extended position, wherein the cutting blade extends between the jaw members to cut tissue grasped therebetween. The knife assembly includes a proximal component and a first distal component that includes the cutting blade. The proximal and first distal components are removably coupled to one another to facilitate replacement of the first distal component while the end effector assembly remains in a substantially assembled condition, i.e., without requiring substantial disassembly of the end effector assembly.
摘要翻译：镊子包括末端执行器组件，其具有第一和第二钳口构件，该第一和第二钳口构件可以在间隔开的位置和近似位置之间移动，用于抓住它们之间的组织。还提供了具有设置在其远端处的切割刀片的刀组件。刀组件相对于端部执行器组件在缩回位置和延伸位置之间是可平移的，其中切割刀片在夹爪构件之间延伸以切割夹在其间的组织。刀组件包括近端部件和包括切割刀片的第一远端部件。近端和第一远侧部件可拆卸地彼此联接以有助于更换第一远端部件，同时端部执行器组件保持基本组装的状态，即不需要实际拆卸端部执行器组件。

60. 发明授权

US08409247B2 Apparatus for performing an electrosurgical procedure 有权
公开(公告)号：US08409247B2
公开(公告)日：2013-04-02
申请号：US12792051
申请日：2010-06-02
申请人： David M. Garrison , Glenn A. Horner
发明人： David M. Garrison , Glenn A. Horner
IPC分类号： A61B17/28 , A61B18/14
CPC分类号： A61B17/29 , A61B18/1445 , A61B2017/00398 , A61B2017/00867 , A61B2018/0063
摘要： A surgical instrument is provided and includes a housing having a shaft. An end effector assembly is operatively connected to a distal end of the shaft and has a pair of first and second jaw members one of which is movable with respect to the other. A heat activated drive assembly operably couples to an actuation mechanism that is operably associated with the forceps and configured to supply thermal energy to the heat activated drive assembly. The heat activated drive assembly operably coupled to movable jaw member and configured to impart movement of the movable jaw member when the actuation mechanism is activated.

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