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51. 发明授权

US07915251B2 Alpha-helix mimetics and methods relating to the treatment of fibrosis 有权
标题翻译： α-螺旋模拟物和与纤维化治疗有关的方法
公开(公告)号：US07915251B2
公开(公告)日：2011-03-29
申请号：US11908961
申请日：2006-03-15
申请人： Michael Kahn , Masakatsu Eguchi
发明人： Michael Kahn , Masakatsu Eguchi
IPC分类号： A01N43/90 , A01N43/00 , A61K31/519 , A61K31/553 , A61K31/554 , C07D401/00 , C07D487/00 , C07D239/70
CPC分类号： C07K7/56
摘要： The invention provides α-helix mimetic structures of formula (I) with the definitions of A, B, D, E, G, W, R1 and R2 as set out in the description and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the treatment of diseases including fibrosis, such as pulmonary fibrosis.
摘要翻译：本发明提供式（I）的α-螺旋模拟结构，其具有如说明书中所述的A，B，D，E，G，W，R 1和R 2的定义，以及与之相关的化学文库。包含该化合物的化合物，药物组合物和使用该化合物的本发明的方法涉及治疗包括纤维化在内的疾病，例如肺纤维化。

52. 发明申请

US20100222303A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 有权
公开(公告)号：US20100222303A1
公开(公告)日：2010-09-02
申请号：US12649161
申请日：2009-12-29
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen , Soo Jin Lee
IPC分类号： A61K31/675 , C07D487/04 , A61K31/53 , A61K31/4985 , C07D413/14 , A61K31/5377 , C07D265/36 , A61K31/538 , A61P19/02
CPC分类号： C07D487/04 , A61K31/53
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

53. 发明申请

US20100120758A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 有权
公开(公告)号：US20100120758A1
公开(公告)日：2010-05-13
申请号：US12553858
申请日：2009-09-03
申请人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen
发明人： Sung Hwan Moon , Jae Uk Chung , Sung Chan Lee , Masakatsu Eguchi , Michael Kahn , Kwang Won Jeong , Cu Nguyen
IPC分类号： A61K31/53 , C07D487/04 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

54. 发明申请

US20100069333A1 ALPHA-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS 有权
标题翻译： ALPHA-HELIX相关的治疗癌症干细胞的方法和方法
公开(公告)号：US20100069333A1
公开(公告)日：2010-03-18
申请号：US12616712
申请日：2009-11-11
申请人： Michael Kahn
发明人： Michael Kahn
IPC分类号： A61K31/675 , A61K31/4985 , C07F9/02 , C07D487/04 , A61P35/00 , C12N5/00
CPC分类号： A61K31/551 , C07D487/04 , C07K5/06139 , C07K5/06191
摘要： The invention provides α-mimetic structures and a chemical library relating thereto. Additionally, the invention provides methods wherein α-mimetic compounds are used to treat cancer stem cells.
摘要翻译：本发明提供α-模拟结构和与其相关的化学文献。另外，本发明提供了使用α-模拟化合物治疗癌症干细胞的方法。

55. 发明授权

US07598253B2 Reverse-turn mimetics and methods relating thereto 有权
公开(公告)号：US07598253B2
公开(公告)日：2009-10-06
申请号：US10360549
申请日：2003-02-07
申请人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
发明人： Michael Kahn , Masakatsu Eguchi , Hwa-Ok Kim , Marcin Stasiak
IPC分类号： A61K31/519 , A61K31/495 , A61K31/33
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/06139 , C40B40/00 , Y10S514/825 , Y10S514/826 , Y10S514/903
摘要： Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.

56. 发明申请

US20080009500A1 Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders 审中-公开
标题翻译： α-螺旋模拟物和与治疗纤维化疾病有关的方法
公开(公告)号：US20080009500A1
公开(公告)日：2008-01-10
申请号：US11594575
申请日：2006-11-08
申请人： Michael Kahn
发明人： Michael Kahn
IPC分类号： A61K31/50 , A61P43/00
CPC分类号： A61K31/4985
摘要： The invention provides α-mimetic structures and a chemical library relating thereto. Additionally, the invention provides methods wherein α-mimetic compounds are used to treat fibrotic disorders.
摘要翻译：本发明提供α-模拟结构和与其相关的化学文献。另外，本发明提供了使用α-模拟化合物治疗纤维化疾病的方法。

57. 发明申请

US20070296254A1 CHILD SEAT SAFETY SYSTEM 审中-公开
标题翻译：儿童座椅安全系统
公开(公告)号：US20070296254A1
公开(公告)日：2007-12-27
申请号：US11380928
申请日：2006-04-29
申请人： Michael Kahn
发明人： Michael Kahn
IPC分类号： A47C1/11 , F21V7/04 , G08B21/00 , H02J7/00
CPC分类号： B60N2/2821 , F21W2111/00
摘要： The present invention comprises an infant carrier and a mating base which combine to form an infant carrier/car seat combination. The infant carrier has a seat belt system within it to properly secure the infant. When the infant carrier is attached to the base, and the infant carrier seat belt system is not fastened, a notification is generated. When the infant carrier is not properly fastened to the base, a notification may also be generated. Additionally, a confirmation notification may be generated when the seat belt is fastened and the infant carrier is properly fastened to the base. This notification may comprise audible, visual, or tactile indications, or a combination of the aforementioned indications. The indications may include, but are not limited to, a buzzer, a flashing light, or a vibrator in the handle of the infant carrier.
摘要翻译：本发明包括婴儿背带和组合形成婴儿背带/座椅组合的配合基座。婴儿背带有一个安全带系统，以适当地固定婴儿。当婴儿背带安装在基座上时，婴儿背带座安全带系统没有紧固，产生通知。当婴儿背带没有正确地固定在基座上时，也可能产生通知。此外，当安全带被紧固并且婴儿承载架被适当地固定到基座时，可以产生确认通知。该通知可以包括听觉，视觉或触觉指示，或上述指示的组合。所述指示可以包括但不限于在婴儿背带的手柄中的蜂鸣器，闪光灯或振动器。

58. 发明申请

US20060084655A1 Reverse-turn mimetics and method relating thereto 有权
公开(公告)号：US20060084655A1
公开(公告)日：2006-04-20
申请号：US11242653
申请日：2005-10-04
申请人： Sung Moon , Jae Chung , Sung Lee , Masakatsu Eguchi , Michael Kahn , Kwang Jeong , Cu Nguyen
发明人： Sung Moon , Jae Chung , Sung Lee , Masakatsu Eguchi , Michael Kahn , Kwang Jeong , Cu Nguyen
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D487/04
摘要： Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

59. 发明申请

US20050251410A1 Price presentation in an online e-commerce system 审中-公开
标题翻译：在线电子商务系统中的价格介绍
公开(公告)号：US20050251410A1
公开(公告)日：2005-11-10
申请号：US11120761
申请日：2005-05-03
申请人： Michael Kahn
发明人： Michael Kahn
IPC分类号： G06Q30/00 , G06F17/60
CPC分类号： G06Q30/02 , G06Q30/06 , G06Q30/0601
摘要： A method and system for information presentation in an online trading environment are described. According to one aspect of the invention, the sales price of the item, plus any applicable taxes, shipping, and any applicable payment surcharge are included in the total cost displayed for each item. The list of items may optionally be sorted according to the total cost of the item. According to another aspect of the invention, the sales price of the item plus any applicable taxes and payment surcharges are included in the total cost displayed for each item, but the shipping charges are not included, thereby providing an accurate total cost when the item will be received in-person, thereby avoiding shipping charges.
摘要翻译：描述在线交易环境中的信息呈现的方法和系统。根据本发明的一个方面，项目的销售价格加上任何适用的税金，运费和任何适用的付款附加费包括在每个项目显示的总成本中。可以根据项目的总成本来选择项目的列表。根据本发明的另一方面，项目的销售价格加上任何适用的税金和支付附加费包括在每个项目显示的总成本中，但不包括运费，从而在项目将提供准确的总成本时亲自收到，从而避免运费。

60. 发明授权

US06680753B2 Method and apparatus for skipping and repeating audio frames 有权
标题翻译：用于跳过和重复音频帧的方法和装置
公开(公告)号：US06680753B2
公开(公告)日：2004-01-20
申请号：US09800565
申请日：2001-03-07
申请人： Michael Kahn
发明人： Michael Kahn
IPC分类号： H04N9475
CPC分类号： G10L21/01 , G11B20/10527 , G11B2020/10546 , H04N21/4302 , H04N21/4305 , H04N21/4341
摘要： A method of synchronizing audio frame presentation time with a system time in an MPEG audio bit-stream decoder is provided. The method includes identifying a time disparity between an audio frame presentation time and a system time. A group of successive audio frames in the MPEG audio bit stream are then examined for an audio frame having an amplitude value less than a threshold value. An audio frame is selected from the examined bit stream for skipping or repeating. If an audio frame below the threshold value is identified, it is selected, otherwise the last frame in the group of frames is selected. The selected frame is then skipped or repeated to synchronize the audio presentation time to the system time in order to minimize the effect of audio artifacts on the listener.
摘要翻译：提供了一种将音频帧呈现时间与MPEG音频比特流解码器中的系统时间同步的方法。该方法包括识别音频帧呈现时间和系统时间之间的时间差异。然后检查MPEG音频比特流中的一组连续音频帧，其具有幅度值小于阈值的音频帧。从被检查的比特流中选择音频帧以用于跳过或重复。如果识别出低于阈值的音频帧，则选择该帧，否则选择该组帧中的最后一帧。然后跳过或重复所选择的帧以将音频呈现时间同步到系统时间，以便最小化音频伪像对收听者的影响。

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