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51. 发明授权

US07691109B2 Method of producing low profile stent and graft combination 有权
标题翻译：生产薄型支架和移植物组合的方法
公开(公告)号：US07691109B2
公开(公告)日：2010-04-06
申请号：US11230757
申请日：2005-09-19
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F11/00 , A61M29/00
CPC分类号： A61F2/07 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/954 , A61F2/97 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/9505 , A61F2002/9511 , A61F2002/9522 , A61F2220/0075 , A61F2230/0054 , Y10T29/53987
摘要： Large diameter self-expanding endoprosthetic devices, such as stents and stent grafts for delivery to large diameter vessels, such as the aorta, are disclosed having very small compacted delivery dimensions. Devices with deployed dimensions of 26 to 40 mm or more are disclosed that are compacted to extremely small dimensions of 5 mm or less, enabling percutaneous delivery of said devices without the need for surgical intervention. Compaction efficiencies are achieved by combining unique material combinations with new forms of restraining devices, compaction techniques, and delivery techniques. These inventive devices permit consistent percutaneous delivery of large vessel treatment devices. Additionally, small endoprosthetic devices are disclosed that can be compacted to extremely small dimensions for delivery through catheter tubes of less than 1 mm diameter.
摘要翻译：公开了大直径自膨胀假体内装置，例如用于输送到大直径血管，例如主动脉的支架和支架移植物，具有非常小的紧凑的输送尺寸。公开了具有26至40mm或更大的尺寸的装置，其被压实至5mm或更小的极小尺寸，能够经皮地输送所述装置，而不需要外科手术。压实效率通过将独特的材料组合与新形式的约束装置，压实技术和输送技术相结合来实现。这些本发明的装置允许大容量处理装置的一致的经皮输送。此外，公开了可以压缩至极小尺寸的小型假体内装置，以通过小于1mm直径的导管输送。

52. 发明授权

US07198636B2 Deployment system for an endoluminal device 有权
标题翻译：内窥镜装置的部署系统
公开(公告)号：US07198636B2
公开(公告)日：2007-04-03
申请号：US10346598
申请日：2003-01-17
申请人： Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61M1/00 , A61F11/00
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958
摘要： The present invention is directed to a deployment system for an endoluminal device. The deployment system includes a confining sheath placed around a compacted endoluminal device. A deployment line is provided in the system that is an integral extension of the sheath. As the deployment line is actuated, the sheath retracts from around the compacted endoluminal device. As the sheath retracts from around the endoluminal device, material from the sheath may be converted into deployment line. Once the sheath is retracted from around the compacted endoluminal device, the endoluminal device expands in configuration and repairs vascular or cardiac structures of an implant recipient. Any remaining sheath material is removed from the implantation site along with the deployment line.
摘要翻译：本发明涉及一种用于腔内装置的部署系统。部署系统包括围绕压实的腔内装置放置的限制鞘。在系统中提供了一个部署线，该线是护套的整体延伸。随着部署线被致动，护套从紧凑的腔内装置周围缩回。当护套从内腔装置周围缩回时，来自护套的材料可以被转换成展开线。一旦护套从紧凑的腔内装置周围缩回，腔内装置在构型上扩张并修复植入物接受者的血管或心脏结构。任何剩余的护套材料与植入线一起从植入部位移除。

53. 发明授权

US06827731B2 Deployment system for intraluminal devices 有权
标题翻译：管腔内装置的部署系统
公开(公告)号：US06827731B2
公开(公告)日：2004-12-07
申请号：US10054772
申请日：2002-01-22
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F206
CPC分类号： A61F2/97 , A61F2/86 , A61F2/95 , A61F2/958 , A61F2002/9511 , A61F2002/9522 , A61F2002/9583 , A61F2250/0071
摘要： A constraining sheath for use around an endoprosthesis (e.g., a stent device, with or without a graft covering), which may be a balloon expandable endoprosthesis but more preferably is a self-expanding prosthesis. The endoprosthesis is coaxially enclosed within the constraining sheath, which is an outer, disruptable, preferably implantable tubular sheath, preferably made of ePTFE. The constraining sheath and endoprosthesis are preferably mounted together as an assembly on an angioplasty balloon for delivery. Deployment of the endoprosthesis entails inflating the angioplasty balloon to a pressure sufficient to disrupt or break the constraining sheath in a prescribed fashion, thereby allowing a self-expanding endoprosthesis to spontaneously deploy. The constraining sheath of ePTFE may be attached to the endoprosthesis and implanted along with the device, or alternatively attached to the balloon catheter shaft and removed with the balloon catheter. The angioplasty balloon's working length is preferably shorter than the length of the endoprosthesis. An endoprosthesis assembly incorporating a constraining sheath according to one embodiment of the invention is also provided with an additional packaging sheath.
摘要翻译：用于内置假体周围使用的约束护套（例如，具有或不具有移植物覆盖物的支架装置），其可以是球囊可膨胀内置假体，但更优选是自膨胀假体。内置假体同轴地封闭在约束护套内，约束鞘是外部的，可破坏的，优选可植入的管状护套，优选地由ePTFE制成。约束鞘和内假体优选地作为组件安装在血管成形术气囊上用于递送。内窥镜假体的部署需要将血管成形术气囊膨胀至足以以规定的方式破坏或打破约束鞘的压力，从而允许自膨胀内置假体自发部署。 ePTFE的约束鞘可以连接到内置假体并与装置一起植入，或者替代地附接到球囊导管轴并且用球囊导管去除。血管成形术球囊的工作长度优选地短于内假体的长度。根据本发明的一个实施例的包含约束护套的假体内装配体还具有附加的包装护套。

54. 发明申请

US20120108980A1 CATHETER WITH SHAPE MEMORY ALLOY ACTUATOR 审中-公开
标题翻译：带形状记忆合金致动器的导管
公开(公告)号：US20120108980A1
公开(公告)日：2012-05-03
申请号：US13280078
申请日：2011-10-24
申请人： Thomas W. Shilling , Thomas L. Tolt , Clyde G. Oakley , Richard W. Denny , Dennis R. Dietz , Michael J. Vonesh , Craig T. Nordhausen
发明人： Thomas W. Shilling , Thomas L. Tolt , Clyde G. Oakley , Richard W. Denny , Dennis R. Dietz , Michael J. Vonesh , Craig T. Nordhausen
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/0883 , A61B8/0891 , A61B8/445 , A61B8/4461 , A61B8/483 , G01S7/52079 , G01S15/894 , G01S15/8993 , G10K11/004 , G10K11/352
摘要： Actuators employable for oscillating movement of a load. An improved actuator may include at least a first shape memory member that is actuatable to affect at least a portion of the oscillating movement of the load. The actuator may further include a second shape memory member actuatable to affect at least a second portion of the oscillating movement of the load. The utilization of one or more shape memory members facilitates the realization of controllable and reliable oscillating movement of a load in a compact manner. Such actuators may be used in imaging catheters having an ultrasound transducer disposed for oscillating movement to scan across an internal region of interest. Such imaging catheters may be used in generating three dimensional and/or real-time three dimensional (4D) images.
摘要翻译：执行器可用于摆动载荷的运动。改进的致动器可以包括至少第一形状存储器构件，其可致动以影响负载的振荡运动的至少一部分。致动器还可以包括可致动以影响负载的振荡运动的至少第二部分的第二形状存储器构件。利用一个或多个形状记忆元件有助于以紧凑的方式实现负载的可控和可靠的振荡运动。这样的致动器可以用于具有设置成用于振荡运动以超过感兴趣的内部区域扫描的超声换能器的成像导管。这样的成像导管可用于产生三维和/或实时三维（4D）图像。

55. 发明申请

US20080097401A1 Cerebral vasculature device 审中-公开
标题翻译：脑血管装置
公开(公告)号：US20080097401A1
公开(公告)日：2008-04-24
申请号：US11526269
申请日：2006-09-22
申请人： Benjamin M. Trapp , Nathan L. Friedman , Michael J. Vonesh
发明人： Benjamin M. Trapp , Nathan L. Friedman , Michael J. Vonesh
IPC分类号： A61M25/00
CPC分类号： A61B17/320725 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12172 , A61B17/221 , A61B2017/12127 , A61B2017/320716 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0078
摘要： Novel cerebral vasculature devices are disclosed, including thrombectomy removal devices that include a continuous braided structure, a proximal portion, a distal portion, and a first expandable portion located between the proximal portion and the distal portion. The braided structure includes a plurality of wires. The proximal portion and the distal portion include polymer imbedded at least partially into the braided structure. The device is useful for removing thrombus from a patient's vasculature.
摘要翻译：公开了新颖的脑血管装置，包括包括连续编织结构，近端部分，远侧部分和位于近端部分和远端部分之间的第一可扩张部分的血栓切除术去除装置。编织结构包括多根线。近端部分和远端部分包括至少部分地嵌入编织结构中的聚合物。该装置可用于从患者的脉管系统中去除血栓。

56. 发明授权

US5957950A Vascular acoustic emission analysis in a balloon angioplasty system 失效
标题翻译：球囊血管成形术系统中的血管声发射分析
公开(公告)号：US5957950A
公开(公告)日：1999-09-28
申请号：US874880
申请日：1997-06-13
申请人： Lyle F. Mockros , John M. Fildes , Krishnan B. Chandran , Michael J. Vonesh , David D. McPherson , Ashwin Nagaraj , Charles Davidson
发明人： Lyle F. Mockros , John M. Fildes , Krishnan B. Chandran , Michael J. Vonesh , David D. McPherson , Ashwin Nagaraj , Charles Davidson
IPC分类号： A61B17/00 , A61M29/02 , A61M25/10
CPC分类号： A61M25/104 , A61B2017/0011
摘要： A system and method for performing balloon angioplasty treatment on a patient. The system includes a catheter for insertion into an artery of the patient, a balloon coupled to the catheter with the balloon expandable by fluid passed through the catheter in order to apply pressure to plaque lesions deposited on vascular tissue of the artery. The balloon includes a PVDF piezoelectric transducer for sensing acoustic emission signals generated by deformation of the plaque lesions and the vascular tissue. The acoustic emission signals can be analyzed by frequency analysis, time domain analysis and wavelet analysis followed by neural net correlation evaluation.
摘要翻译：用于对患者进行气囊血管成形术治疗的系统和方法。该系统包括用于插入患者动脉的导管，气囊与导管联接，气囊可通过流经导管的流体扩张，以便对沉积在动脉血管组织上的斑块病变施加压力。气囊包括用于感测由斑块损伤和血管组织的变形产生的声发射信号的PVDF压电传感器。声发射信号可以通过频率分析，时域分析和小波分析进行分析，然后进行神经网络相关性评估。

57. 发明授权

US5612057A Acoustically reflective liposomes and methods to make and use same 失效
标题翻译：声反射脂质体和使用方法相同
公开(公告)号：US5612057A
公开(公告)日：1997-03-18
申请号：US541185
申请日：1995-10-11
申请人： Gregory M. Lanza , M. Hayat Onyuksel , Melvin E. Klegerman , Michael J. Vonesh , David L. McPherson
发明人： Gregory M. Lanza , M. Hayat Onyuksel , Melvin E. Klegerman , Michael J. Vonesh , David L. McPherson
IPC分类号： A61K49/22 , A61K9/127
CPC分类号： A61K49/227 , Y10S436/829 , Y10T428/2984
摘要： This invention relates to tissue specific acoustically reflective oligolamellar liposomes containing internally separated bilayers and methods to make and to use the same, alone as a perfusion ultrasonic contrast agent or conjugated to a ligand for tissue-specific ultrasonic image enhancement.
摘要翻译：本发明涉及包含内部分离的双层的组织特异性反射性低聚糖脂质体，以及制备和使用它们的方法，单独作为灌注超声造影剂或与用于组织特异性超声波图像增强的配体结合。

58. 发明授权

US5152293A Finger-mounted intraoperative imaging device 失效
标题翻译：手指装置术中成像装置
公开(公告)号：US5152293A
公开(公告)日：1992-10-06
申请号：US724201
申请日：1991-07-01
申请人： Michael J. Vonesh , Fouad H. Khasho
发明人： Michael J. Vonesh , Fouad H. Khasho
IPC分类号： A61B8/00 , A61B8/06
CPC分类号： A61B8/4281 , A61B8/06 , A61B8/12 , A61B8/42
摘要： A small, disposable device for use in intraoperative diagnostic imaging in the form of a finger-mounted probe having an elongated chamber along its longitudinal midline for removably receiving the distal end of an ultrasonic imaging catheter equipped with an ultrasound generator having an imaging plane normal to the probe's longitudinal midline. The probe includes a body formed of relatively rigid non-echogenic material with an upper surface of concave cross-sectional contour shaped and dimensioned to receive the underside of a user's finger and also includes an integral retention band that bridges the body and extends over the tip portion of a user's finger when the probe is worn. A Doppler generator/detector may be mounted in the distal end wall of the probe for directing, detecting, and transmitting signals representative of blood flow velocity through a vessel contacted by the smooth undersurface of the probe along the imaging plane of the ultrasonic imaging catheter extending into the probe's chamber. In one embodiment, a tubular hydrogel liner is disposed within the chamber, such liner having an axial passage for freely receiving the distal end of an imaging catheter when the hydrogel is unhydrated and for firmly engaging and retaining the distal end, and maintaining an acoustic couple, when the hydrogel is hydrated.
摘要翻译：一种用于术中诊断成像的小型一次性装置，其具有手指安装式探针的形式，其具有沿其纵向中线的细长室，用于可移除地接收配备有超声波发生器的超声波成像导管的远端，所述超声波成像导管的成像平面垂直于探头的纵向中线。探针包括由相对刚性的非回声材料形成的主体，其具有凹形横截面轮廓的上表面，该上表面的形状和尺寸适于接收使用者手指的下侧，并且还包括整体保持带，其将身体桥接并延伸到尖端使用者手指的部分，当探头佩戴时。多普勒发生器/检测器可以安装在探针的远端壁中，用于引导，检测和传输代表血流速度的信号，该血流速度通过沿着超声成像导管延伸的成像平面的探头平滑下表面接触的血管进入探针室。在一个实施例中，管状水凝胶衬套设置在腔室内，该衬套具有轴向通道，用于在水凝胶未水化时自由接收成像导管的远端，并且用于牢固地接合和保持远端，并且保持声学对当水凝胶水合时。

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