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51. 发明授权

US07314609B2 Stereoisomers of fatty acid analogs for diagnostic imaging 失效
标题翻译：用于诊断成像的脂肪酸类似物的立体异构体
公开(公告)号：US07314609B2
公开(公告)日：2008-01-01
申请号：US11274505
申请日：2005-11-16
申请人： David R. Elmaleh
发明人： David R. Elmaleh
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/0497 , A61K51/04 , A61K51/0402 , A61K2123/00
摘要： The present invention provides novel imaging agents for clinical diagnosis of injuries and diseases, in the form of a radionuclide in spatial proximity to a substantially pure stereoisomer of a fatty acid analog. The invention also provides methods for using the novel imaging agents, and kits containing one or more of the novel imaging agents of the invention.
摘要翻译：本发明提供用于临床诊断损伤和疾病的新型成像剂，其形式为空间接近脂肪酸类似物的基本上纯的立体异构体的放射性核素。本发明还提供了使用新型成像剂的方法，以及含有本发明的一种或多种新型成像剂的试剂盒。

52. 发明授权

US06835371B1 Diagnostic and therapeutic piperazine and piperidine compounds and process 失效
标题翻译：诊断和治疗哌嗪和哌啶化合物和方法
公开(公告)号：US06835371B1
公开(公告)日：2004-12-28
申请号：US09633482
申请日：2000-08-07
申请人： David R. Elmaleh , Choi Sung-Woon
发明人： David R. Elmaleh , Choi Sung-Woon
IPC分类号： A61K4900
CPC分类号： C07B59/001 , C07C217/48 , C07C233/78 , C07D211/26 , C07D211/58 , C07D241/08
摘要： Piperazine or piperidine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The piperazine or piperadine compounds are characterized by the formula:Formula I wherein: A is oxygen; n is an integer of 1 to 6; X and Y can be the same or different and are hydrogen, halogen, nitro, alkyl or halalkyl, Z is carbon or nitrogen; and &phgr; is phenyl, naphthyl, thienyl or pyridinyl. When Z is carbon, R is hydrogen, cyano, hydroxy, —COOCH3, —CH20H or —COOH; R1 is 4-fluorophenyl, 4-chlorophenyl, 4-trifluoromethyl, 3-trifluoromethyl-4 -chlorophenyl 4-bromophenyl), 4-(2-keto-1-benzimidazolinyl or 1-phenyl 1, 3, 8-triazaspiro [4,5] decan-4-one. When Z is nitrogen, R and R1 combined are wherein R3 is halo, alkyl, cyano or nitro and R2 can be hydrogen or wherein R4 is halo, alkyl, cyano, nitro, alkylnyl or alkenyl
摘要翻译：提供了可用于治疗特征在于缺乏多巴胺神经元活性或成像多巴胺神经元的神经变性疾病的哌嗪或哌啶化合物。哌嗪或哌嗪化合物的特征在于下式：其中A为氧; n为1〜6的整数。 X和Y可以相同或不同，为氢，卤素，硝基，烷基或卤代烷基，Z为碳或氮; 并且phi是苯基，萘基，噻吩基或吡啶基。当Z是碳时，R是氢，氰基，羟基，-COOCH 3，-CH 2 OH或-COOH; R1是4-氟苯基，4-氯苯基，4-三氟甲基，3-三氟甲基-4-氯苯基4-溴苯基），4-（2-酮-1-苯并咪唑啉基或1-苯基1,3,8-三氮杂螺[ 5]癸-4-酮当Z为氮时，R和R 1组合，其中R 3为卤素，烷基，氰基或硝基，R 2可为氢，或者其中R 4为卤素，烷基，氰基，硝基，烷基或烯基

53. 发明授权

US06299857B1 Cardiovascular and thrombus imaging agents, methods and kits 有权
标题翻译：心血管和血栓成像剂，方法和试剂盒
公开(公告)号：US06299857B1
公开(公告)日：2001-10-09
申请号：US09068178
申请日：1998-11-19
申请人： David R. Elmaleh , John W. Babich , Eliezer Rapaport , Paul C. Zamecnik
发明人： David R. Elmaleh , John W. Babich , Eliezer Rapaport , Paul C. Zamecnik
IPC分类号： A61K5100
CPC分类号： A61K51/0489 , A61K51/04 , A61K51/0491 , A61K2123/00
摘要： The invention provides cardiovascular imaging agents comprising a radionuclide in association with a nucleotide polyphosphate targeting molecule. Methods for using the cardiovascular imaging agents and kits containing the cardiovascular imaging agents or components suitable for production of the cardiovascular imaging agents are also provided.
摘要翻译：本发明提供包含与核苷酸聚磷酸酯靶向分子相关联的放射性核素的心血管成像剂。还提供了使用心血管成像剂和含有心血管显像剂或适合于制备心血管成像剂的组分的试剂盒的方法。

54. 发明授权

US6113971A Olive oil butter 失效
标题翻译：橄榄油黄油
公开(公告)号：US6113971A
公开(公告)日：2000-09-05
申请号：US690051
申请日：1996-07-31
申请人： David R. Elmaleh
发明人： David R. Elmaleh
IPC分类号： A23D7/00 , A23D9/00 , C11C3/00 , C11C3/12 , A23D7/005
CPC分类号： C11C3/12 , A23D7/001 , A23D9/00 , C11C3/00
摘要： Novel butters and shortenings made from monounsaturated oils such as olive oil are disclosed.
摘要翻译：公开了由单不饱和油如橄榄油制成的新颖的接头和起酥油。

55. 发明授权

US6001330A Diagnostic and therapeutic alkylenediamine compounds and process 失效
标题翻译：诊断和治疗亚烷基二胺化合物和方法
公开(公告)号：US6001330A
公开(公告)日：1999-12-14
申请号：US928246
申请日：1997-09-12
申请人： David R. Elmaleh , Robert N. Hanson , Choi Sung-Woon
发明人： David R. Elmaleh , Robert N. Hanson , Choi Sung-Woon
IPC分类号： C07B59/00 , C07C217/48 , C07C233/78 , C07D211/26 , C07D211/58 , C07D241/08 , A61K51/00 , A61M36/14
CPC分类号： C07C217/48 , C07B59/001 , C07C233/78 , C07D211/26 , C07D211/58 , C07D241/08
摘要： Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The diamine compounds or serotonin are characterized by the formula: ##STR1## wherein: l, m and n can be the same or different and are an integer of 1 to 6; X, Y and Z can be the same or different and are hydrogen, halo, haloalkyl, (C.sub.1 -C.sub.6) alkyl, aryl, (C.sub.1 -C.sub.6) alkoxy, N-alkyl, (C.sub.2 -C.sub.6) acyloxy, N-alkylene, --SH, or --SR, wherein R is from the same group as R.sub.1 and R.sub.2 and can be the same or different than R.sub.1 and R.sub.2, amino, nitro, cyano, hydroxy, --C(.dbd.O) OR.sub.6, --C(.dbd.O) NR.sub.5 R.sub.4, NR.sub.3 R.sub.2, or S(.dbd.O).sub.k R.sub.1 wherein .sub.k is 1 or 2, and R.sub.4 to R.sub.6 are independently hydrogen or (C.sub.1 -C.sub.6) alkyl;R.sub.1, and R.sub.2 can be the same or different and are hydrogen, (C.sub.1 -C.sub.6) alkyl, hydroxyalkyl or mercaptoalkyl, --C(.dbd.O) OR.sub.1, cyano, (C.sub.1 -C.sub.6) alkenyl, (C.sub.2 -C.sub.6) alkynyl, or 1, 2, 4-oxadiazol-5-yl optionally substituted at he 3-position by W wherein any (C.sub.1 -C.sub.6) alky, (C.sub.1 -C.sub.6) alkanoly, (C.sub.2 -C.sub.6) alkenyl or (C.sub.2 -C.sub.6) alkynyl (C.sub.1 -C.sub.6) alkyl, hydroxy (C.sub.1 -C.sub.6) alkyl or mercapto (C.sub.1 -C.sub.6) alkyl and optionally can be substituted by 1, 2 or 3 Z;W is (C.sub.1 -C.sub.6) alkyl or phenyl, optionally substituted by 1, 2 or 3 Z..phi. is phenyl, naphthyl, thienyl or pyridinyl.
摘要翻译：提供了可用于治疗以缺乏多巴胺神经元活性或成像多巴胺神经元为特征的神经变性疾病的二胺化合物。二胺化合物或5-羟色胺的特征在于下式：其中：l，m和n可以相同或不同，为1〜6的整数; X，Y和Z可以相同或不同，为氢，卤素，卤代烷基，（C1-C6）烷基，芳基，（C1-C6）烷氧基，N-烷基，（C2-C6）酰氧基， -SH或-SR，其中R是与R1和R2相同的基团，并且可以与R1和R2相同或不同，氨基，硝基，氰基，羟基，-C（= O）OR6，-C（= O）NR5R4，NR3R2或S（= O）kR1其中k为1或2，R4至R6独立地为氢或（C1-C6）烷基; R 1和R 2可以相同或不同，为氢，（C 1 -C 6）烷基，羟烷基或巯基烷基，-C（= O）OR 1，氰基，（C 1 -C 6）烯基，（C 2 -C 6）炔基或其中任何（C 1 -C 6）烷基，（C 1 -C 6）烷基聚，（C 2 -C 6）烯基或（C 2 -C 6）炔基（C 2 -C 6） C 1 -C 6）烷基，羟基（C 1 -C 6）烷基或巯基（C 1 -C 6）烷基，并且任选地可以被1,2或3个Z取代; W是（C1-C6）烷基或苯基，任选地被1,2或3个Z取代为苯基，萘基，噻吩基或吡啶基。

56. 发明授权

US09503899B2 System and method for access over a cable television network 有权
标题翻译：用于通过有线电视网访问的系统和方法
公开(公告)号：US09503899B2
公开(公告)日：2016-11-22
申请号：US14487174
申请日：2014-09-16
申请人： David R. Elmaleh
发明人： David R. Elmaleh
IPC分类号： H04W4/00 , H04W12/08 , H04L12/28 , H04N21/258 , H04N21/41 , H04N21/4788 , H04N21/61 , H04N21/436
CPC分类号： H04W12/08 , H04L12/2801 , H04L12/2838 , H04L2012/2841 , H04N21/25816 , H04N21/4126 , H04N21/43615 , H04N21/4788 , H04N21/6118 , H04N21/6168
摘要： A system and method for allowing a computing device to associate wirelessly with one or more access points that are connected to a cable TV network when such device is in a range of such access point, even though such wireless device would not generally be authorized to receive content or data from the access point. Signals to and from the wireless device are carried over the cable TV network and transmitted to other devices associated with other access points attached to the cable TV network.
摘要翻译：一种用于允许计算设备在这种设备处于这种接入点的范围内时与无线地与连接到有线电视网络的一个或多个接入点相关联的系统和方法，即使这样的无线设备通常不被授权接收来自接入点的内容或数据。去往和来自无线设备的信号通过有线电视网络传送并传输到与附加到有线电视网络的其他接入点相关联的其他设备。

57. 发明授权

US09173569B2 Intravascular imaging device and uses thereof 有权
标题翻译：血管内成像装置及其用途
公开(公告)号：US09173569B2
公开(公告)日：2015-11-03
申请号：US13252963
申请日：2011-10-04
申请人： David R. Elmaleh , Rick A. Rogers , Hjalmar Brismar
发明人： David R. Elmaleh , Rick A. Rogers , Hjalmar Brismar
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61B5/02 , A61K49/00
CPC分类号： A61B5/0071 , A61B5/0068 , A61B5/0084 , A61B5/0086 , A61B5/02007 , A61K49/0034
摘要： The invention is directed to a probe-type imaging device useful to visualize interior surfaces, e.g., the lumen of blood vessels. Specifically, the probe-type device is particularly useful for direct tissue imaging in the presence or absence of molecular imaging agents.
摘要翻译：本发明涉及一种用于可视化内表面（例如，血管内腔）的探针型成像装置。具体地，探针型装置在存在或不存在分子显像剂时特别适用于直接组织成像。

58. 发明申请

US20140140927A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT 有权
标题翻译：克拉莫衍生物和相关成像和处理方法
公开(公告)号：US20140140927A1
公开(公告)日：2014-05-22
申请号：US14059924
申请日：2013-10-22
申请人： David R. Elmaleh , Timothy Shoup
发明人： David R. Elmaleh , Timothy Shoup
IPC分类号： A61K51/04 , C07D311/24
CPC分类号： A61K51/0421 , C07D311/24
摘要： Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula: wherein X is OH, C1-C6 alkoxyl; Y and Z are independently selected from a C1-C6 alkyl, C1-C6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H and X is OH.
摘要翻译：公开了用作检测动脉粥样硬化斑块和治疗动脉粥样硬化和阿尔茨海默氏病的显像剂的新型色甘酸类似物，以及制备色甘酸类似物的方法。色甘酸类似物具有以下通式：其中X是OH，C 1 -C 6烷氧基; Y和Z独立地选自C 1 -C 6烷基，C 1 -C 6烷氧基，卤素，未取代或C 1 -C 6取代的胺，18 F，19 F或H; n为1,2或3; 并且其中对于结构（I），如果n均为1且Y和Z均为H且X为OH。

59. 发明授权

US08669236B2 Biotinylated compositions 有权
标题翻译：生物素化组合物
公开(公告)号：US08669236B2
公开(公告)日：2014-03-11
申请号：US11914332
申请日：2006-05-12
申请人： David R. Elmaleh , Bruce R. Zetter , Earl Weinstein , Jacqueline Banyard Bhisitkul
发明人： David R. Elmaleh , Bruce R. Zetter , Earl Weinstein , Jacqueline Banyard Bhisitkul
IPC分类号： C12N15/11
CPC分类号： C12N15/111 , A61K47/549 , A61K47/551 , A61K47/557 , C12N15/1135 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Novel biotinylated composition comprising a nucleic acid, e.g. siRNA, that are useful for targeting therapeutic and imaging agents to sites of infection and tumors are disclosed.
摘要翻译：新的生物素化组合物，其包含核酸，例如公开了可用于将治疗和成像剂靶向感染部位和肿瘤的siRNA。

60. 发明申请

US20110060138A1 Compounds and Compositions for the Detection and Treatment of Alzheimer's Disease and Related Disorders 有权
标题翻译：用于检测和治疗阿尔茨海默病和相关疾病的化合物和组合物
公开(公告)号：US20110060138A1
公开(公告)日：2011-03-10
申请号：US12933139
申请日：2009-03-23
申请人： David R. Elmaleh , Timothy M. Shoup , Hongning Fu
发明人： David R. Elmaleh , Timothy M. Shoup , Hongning Fu
IPC分类号： C07H17/02 , C07D471/10 , C07C35/16 , C07C43/196 , C07H13/02
CPC分类号： A61K51/0497 , C07C43/192 , C07C43/196 , C07C43/253 , C07D471/10 , C07H13/02 , C07H13/10 , C07H15/26
摘要： One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
摘要翻译：本发明的一个方面涉及用于诊断和/或治疗患有淀粉样变性相关病理状况的受试者的化合物，组合物和方法。在某些实施方案中，本发明的成像和/或治疗剂可以施用于受试者以鉴定和/或治疗淀粉样沉积物。具体的成像方法通过对受试者施用成像剂并检测试剂的空间分布来检测淀粉样蛋白沉积物。药剂的差异积累是AD或淀粉样变性相关病理状态的指示，并且可以通过使用PET或SPECT照相机进行监测。

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