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    • 55. 发明授权
    • Tabular grain emulsions with sensitization enhancements
    • 具增敏作用的片状颗粒乳剂
    • US5573902A
    • 1996-11-12
    • US441491
    • 1995-05-15
    • Richard L. DaubendiekJoseph C. DeatonDonald L. BlackTimothy R. GerseyJoseph G. LighthouseMyra T. OlmXin WenRobert D. Wilson
    • Richard L. DaubendiekJoseph C. DeatonDonald L. BlackTimothy R. GerseyJoseph G. LighthouseMyra T. OlmXin WenRobert D. Wilson
    • G03C1/005G03C1/035
    • G03C1/0051
    • A chemically and spectrally sensitized tabular grain emulsion is disclosed including tabular grains (a) having major faces, (b) containing greater than 70 mole percent bromide and at least 0.25 mole percent iodide, based on silver, (c) accounting for greater than 90 percent of total grain projected area, (d) exhibiting an average equivalent circular diameter of at least 0.7 .mu.m, and (f) exhibiting an average thickness in the range of from less than 0.3 .mu.m to at least 0.07 .mu.m.It has been observed that increased speed, lower granularity, increased contrast and faster rates of development can be realized when (1) the tabular grains contain less than 10 mole percent iodide and (2) the surface chemical sensitization sites include epitaxially deposited silver halide protrusions of a face centered cubic crystal lattice structure of the rock salt type forming epitaxial junctions with the tabular grains, the protrusions (a) being restricted to those portions of the tabular grains located nearest peripheral edges of and accounting for less than 50 percent of the major faces of the tabular grains, (b) containing a silver chloride concentration at least 10 mole percent higher than that of the tabular grains, and (c) including at least 1 mole percent iodide.
    • 公开了化学和光谱增感的片状颗粒乳剂,其包括具有主面的片状颗粒(a),(b)含有大于70摩尔%溴和至少0.25摩尔%碘的碘,基于银,(c)占大于90 占总颗粒投影面积的百分比,(d)平均当量圆直径至少为0.7μm,和(f)平均厚度在小于0.3μm至至少0.07μm的范围内。 已经观察到,当(1)片状颗粒含有少于10摩尔%的碘化物时,可以实现增加的速度,较低的颗粒度,增加的对比度和较快的显影速率,和(2)表面化学增感位点包括外延沉积的卤化银突起 形成与片状晶粒形成外延结的岩盐型的面心立方晶格结构,突起(a)限于位于最近周边边缘的片状颗粒的那些部分,占主要部分的50%以下 (b)含有比片状颗粒高至少10摩尔%的氯化银浓度,(c)包含至少1摩尔%的碘化物。
    • 56. 发明授权
    • Process of forming a photographic emulsion
    • 形成照相乳剂的方法
    • US5491056A
    • 1996-02-13
    • US296567
    • 1994-08-26
    • Xin WenRoger Lok
    • Xin WenRoger Lok
    • G03C1/015G03C1/035G03C1/07
    • G03C1/035G03C1/07
    • A process is disclosed for preparing a photographic emulsion utilizing an alkynylamine compound as a grain growth modifier. Specifically, the present invention provides a process of preparing a photographic emulsion comprising:introducing silver ions, halide ions and a grain growth modifier having the structure ##STR1## wherein z represents atoms necessary to complete a five to nine-membered heterocyclic ring system, R.sup.1, R.sup.2 and R.sup.3 independently represent hydrogen or a lower alkyl of from 1 to 5 carbon atoms, and R.sup.4 represents hydrogen, or an aliphatic, carbocyclic, or heterocyclic group, which may be substituted or unsubstituted, into a dispersing medium containing silver halide seed grains; andmaintaining the dispersing medium containing the seed grains, silver ions, halide ions and grain growth modifier at a pH in the range from about 4.5 to about 10, and a pAg in the range from about 6.0 to about 9.5.Also disclosed is a photographic element comprising a support having incorporated thereon a silver halide emulsion layer, the silver halide emulsion layer comprising silver halide grains internally containing a compound of the structure ##STR2## wherein Z represents atoms necessary to complete a five to nine-membered heterocyclic ring system; R.sup.1, R.sup.2 and R.sup.3 independently represent hydrogen or a lower alkyl of from 1 to 5 carbon atoms, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 be a lower alkyl of from 1 to 5 carbon atoms; and R.sup.4 represents hydrogen, or an aliphatic, carbocyclic, or heterocyclic group, which may be substituted or unsubstituted.
    • 公开了一种利用炔基胺化合物作为晶粒生长改性剂制备照相乳剂的方法。 具体地说,本发明提供一种制备照相乳剂的方法,其包括:引入银离子,卤离子和具有结构的晶粒生长改性剂,其中z表示完成五至九元杂环体系所需的原子,R1 ,R2和R3独立地表示氢或1〜5个碳原子的低级烷基,R4表示氢,或可被取代或未取代的脂族,碳环或杂环基团,形成含有卤化银种子颗粒的分散介质 ; 并且在约4.5至约10的pH范围内将含有种子晶粒,银离子,卤离子和晶粒生长调节剂的分散介质保持在约6.0至约9.5的范围内。 还公开了一种照相元件,其包括其上并入有卤化银乳剂层的载体,所述卤化银乳剂层包含卤化银颗粒,内部含有结构“IMAGE”的化合物,其中Z表示完成五至九元 杂环体系; R 1,R 2和R 3独立地表示氢或1至5个碳原子的低级烷基,条件是R 1,R 2和R 3中的至少一个为1至5个碳原子的低级烷基; 并且R 4表示氢,或可以被取代或未取代的脂族,碳环或杂环基。
    • 57. 发明授权
    • Ultrathin tabular grain emulsion
    • 超薄片状颗粒乳液
    • US5470698A
    • 1995-11-28
    • US268362
    • 1994-06-30
    • Xin Wen
    • Xin Wen
    • G03C1/00G03C1/005G03C1/035
    • G03C1/0051
    • A radiation-sensitive emulsion is disclosed in which greater than 90 percent of total grain projected area is accounted for by high aspect ratio tabular grains, the halide content of which is primarily bromide, but with a speed enhancing amount of iodide also present. The tabular grains are ultrathin and exhibit low temperature stimulated fluorescence indicative of the iodide crystal lattice modifications produced by abrupt iodide introduction known to enhance photographic speed. Tabular grain structures are present having a central region accounting for at least 5 mole percent of total silver forming the tabular grain, an annular region laterally surrounding said central region and exhibiting a maximum iodide concentration, and a peripheral region laterally surrounding the annular region and accounting for greater than 25 percent of total silver forming the tabular grain.
    • 公开了一种辐射敏感性乳剂,其中大于90%的总颗粒投影面积是由高纵横比的片状颗粒占据的,其中卤化物含量主要是溴化物,但也存在加速量的碘化物。 片状颗粒是超薄的并且表现出低温刺激的荧光,其表示由已知提高摄影速度的突然碘化物引入产生的碘化物晶格修饰。 存在片状晶粒结构,其中占据形成片状晶粒的总银的至少5摩尔%的中心区域,横向围绕所述中心区域并呈现最大碘化物浓度的环形区域以及横向环绕环形区域的周边区域和会计 大于形成片状颗粒的总银的25%。
    • 60. 发明授权
    • Therapeutic agents useful for treating pain
    • 用于治疗疼痛的治疗剂
    • US08637548B2
    • 2014-01-28
    • US12886901
    • 2010-09-21
    • Qun SunXin Wen
    • Qun SunXin Wen
    • A01N43/40A61K31/44C07D213/22C07D401/00C07D405/00C07D409/00C07D411/00
    • A61K31/444C07D401/04C07D401/14C07D413/14C07D417/04C07D417/14
    • A compound of formula: where Ar1, Ar2, X, R3, and m are as disclosed herein or a pharmaceutically acceptable salt thereof (a “Cycloheteroalkenyl Compound”); compositions comprising an effective amount of a Cycloheteroalkenyl Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cycloheteroalkenyl Compound are disclosed herein.
    • 式中的化合物:其中Ar1,Ar2,X,R3和m如本文所公开或其药学上可接受的盐(“环烯基烯基化合物”); 包含有效量的环烯基烯基化合物的组合物; 以及用于治疗或预防疼痛,UI,溃疡,IBD,IBS,成瘾性障碍,帕金森病,帕金森综合征,焦虑,癫痫,中风,癫痫发作,瘙痒症状,精神病,认知障碍,记忆缺陷,受限制 脑功能,亨廷顿舞蹈病,肌萎缩性侧索硬化,痴呆,视网膜病变,肌肉痉挛,偏头痛,呕吐,运动障碍或抑郁症,包括向有需要的动物施用有效量的环烯基烯基化合物。