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51. 发明授权

US06263249B1 Medical electrical lead having controlled texture surface and method of making same 有权
标题翻译：具有控制纹理表面的医用电线及其制造方法
公开(公告)号：US06263249B1
公开(公告)日：2001-07-17
申请号：US09258515
申请日：1999-02-26
申请人： Mark T. Stewart , Vernon B. Iverson , Kenneth W. Keeney , Catherine E. Taylor
发明人： Mark T. Stewart , Vernon B. Iverson , Kenneth W. Keeney , Catherine E. Taylor
IPC分类号： A61N105
CPC分类号： A61N1/05 , Y10T29/49002
摘要： An elongate elastomeric structure having controlled surface texture. Plasma deposition is used to create controlled features, such as ridges, on the external surface of an elongate elastomeric surface, such as the external surface of silicone tubing. The invention has particular applicability in the medical device field, such as the fabrication of implantable leads, catheters, and medical devices incorporating them.
摘要翻译：具有受控表面纹理的细长弹性体结构。等离子体沉积用于在细长弹性体表面的外表面（例如硅胶管的外表面）上产生可控特征，例如脊。本发明在诸如制造可植入引线，导管和结合它们的医疗装置之类的医疗装置领域中具有特别的适用性。

52. 发明授权

US09265557B2 Multi frequency and multi polarity complex impedance measurements to assess ablation lesions 有权
标题翻译：多频和多极性复阻抗测量来评估消融病变
公开(公告)号：US09265557B2
公开(公告)日：2016-02-23
申请号：US13017122
申请日：2011-01-31
申请人： Marshall L. Sherman , Catherine R. Condie , Mark T. Stewart
发明人： Marshall L. Sherman , Catherine R. Condie , Mark T. Stewart
IPC分类号： A61B18/12 , A61B18/02 , A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B5/4848 , A61B18/02 , A61B18/12 , A61B2017/00128 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00279 , A61B2018/00285 , A61B2018/00404 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00666 , A61B2018/00869 , A61B2018/00875 , A61B2018/0212
摘要： A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; measuring a first impedance magnitude a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.
摘要翻译：一种评估组织消融治疗的方法，包括定位邻近靶组织的医疗装置; 用所述医疗设备测量第一频率的第一阻抗幅度; 用所述医疗装置测量第二频率的第一阻抗相位; 用医疗装置切除目标组织的至少一部分; 以医疗装置在第三频率的第二阻抗幅度下测量; 用医疗装置测量第四频率的第二阻抗相位; 比较（i）第一和第二阻抗幅度和（ii）第一和第二阻抗相位中的至少一个; 以及至少部分地基于比较来提供消融治疗的功效的指示。

53. 发明授权

US09095350B2 Impedance detection of venous placement of multi-electrode catheters 有权
标题翻译：静脉放置多电极导管的阻抗检测
公开(公告)号：US09095350B2
公开(公告)日：2015-08-04
申请号：US13460877
申请日：2012-05-01
申请人： Catherine R. Condie , Marshall L. Sherman , Mark T. Stewart
发明人： Catherine R. Condie , Marshall L. Sherman , Mark T. Stewart
IPC分类号： A61B18/12 , A61B18/14 , A61B5/00 , A61B5/06 , A61B19/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B5/068 , A61B5/6856 , A61B5/6858 , A61B34/20 , A61B2018/00351 , A61B2018/00577 , A61B2018/00875 , A61B2018/1467
摘要： Systems and methods for assessing electrode position, including positioning a plurality of electrodes within a heart and proximate a pulmonary vein; obtaining an impedance measurement from each of the plurality of electrodes; determining whether any of the plurality of electrodes is located within the pulmonary vein based at least in part on the obtained impedance measurements; and generating an indication if at least one of the plurality of electrodes is determined to be located within the pulmonary vein.
摘要翻译：用于评估电极位置的系统和方法，包括将多个电极定位在心脏内并且靠近肺静脉; 从所述多个电极中的每一个获得阻抗测量; 至少部分地基于获得的阻抗测量来确定多个电极中的任何一个是否位于肺静脉内; 以及如果所述多个电极中的至少一个被确定为位于所述肺静脉内，则产生指示。

54. 发明申请

US20120310239A1 Ablation Catheters and Associated Systems and Methods 有权
标题翻译：消融导管及相关系统与方法
公开(公告)号：US20120310239A1
公开(公告)日：2012-12-06
申请号：US13560942
申请日：2012-07-27
申请人： Mark T. Stewart , James Skarda
发明人： Mark T. Stewart , James Skarda
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00065 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00375 , A61B2018/00404 , A61B2018/00898 , A61B2018/1407 , A61B2018/1435 , A61B2018/1472
摘要： An ablation catheter assembly includes an elongate catheter body having a proximal portion, a distal portion and a lumen therethrough. A helical structure associated with the catheter distal portion carries a plurality of independently operable electrodes and is transformable between a low-profile configuration wherein a straightening element is positioned in the lumen and an expanded configuration wherein the straightening element is at least partially retracted from the spiral structure. When the helical structure is in the expanded configuration, a laterally offset tip portion extends distally therefrom.
摘要翻译：消融导管组件包括细长的导管主体，其具有近端部分，远侧部分和通过其中的内腔。与导管远端部分相关联的螺旋结构携带多个可独立操作的电极，并可在其中矫正元件位于内腔中的低轮廓构型和扩张构型之间变形，其中矫正元件至少部分地从螺旋结构体。当螺旋结构处于膨胀构型时，横向偏移的尖端部分从其向远侧延伸。

55. 发明授权

US07771421B2 Ablation catheter assembly with radially decreasing helix and method of use 有权
标题翻译：消融导管组件具有径向减小的螺旋和使用方法
公开(公告)号：US07771421B2
公开(公告)日：2010-08-10
申请号：US10655197
申请日：2003-09-04
申请人： Mark T. Stewart , James R. Skarda
发明人： Mark T. Stewart , James R. Skarda
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00065 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00375 , A61B2018/00404 , A61B2018/00898 , A61B2018/1407 , A61B2018/1435 , A61B2018/1472
摘要： A catheter assembly for treatment of cardiac arrhythmia. The catheter assembly includes a catheter body and an ablative energy source. The catheter body includes a proximal portion, an intermediate portion, and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and includes an ablation section and a tip. The ablation section forms a loop defining a diameter greater than an outer dimension of a pulmonary vein ostium. The tip extends distally from the ablation section and is configured to locate a pulmonary vein. Finally, the ablative energy source is associated with the ablation section. With this configuration, upon activation of the energy source, the ablation section ablates a desired lesion pattern. In one preferred embodiment, the ablation section forms a distally decreasing radius helix, whereas the tip includes a relatively linear leader section. With this one preferred configuration, the tip readily locates a pulmonary vein and guides the ablation section to a seated relationship about a pulmonary vein ostium (or extra-ostial).
摘要翻译：用于治疗心律失常的导管组件。导管组件包括导管主体和消融能源。导管主体包括近端部分，中间部分和远端部分。中间部分从近端部分延伸并且限定纵向轴线。远侧部分从中间部分延伸并且包括消融部分和尖端。消融部分形成限定直径大于肺静脉口的外部尺寸的环。尖端从消融部分向远端延伸并且被配置为定位肺静脉。最后，烧蚀能源与消融部分相关联。利用这种配置，在激活能量源时，消融部分消除所需的损伤模式。在一个优选实施例中，消融部分形成远端减小的半径螺旋，而尖端包括相对线性的引导部分。利用这一优选的构造，尖端容易地定位肺静脉，并将消融部分引导到关于肺静脉口（或口外）的就座关系。

56. 发明申请

US20100042110A1 METHOD AND SYSTEM FOR PLACEMENT OF ELECTRICAL LEAD INSIDE HEART 有权
标题翻译：电子导管内心放置方法及系统
公开(公告)号：US20100042110A1
公开(公告)日：2010-02-18
申请号：US12570390
申请日：2009-09-30
申请人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
发明人： James F. Kelley , Zhongping C. Yang , Mark T. Stewart
IPC分类号： A61B17/00
CPC分类号： A61N1/059 , A61B17/12 , A61B17/12009 , A61B17/128 , A61B17/3468 , A61B2017/00247 , A61B2017/12018 , A61B2018/00392
摘要： A method of placing an electrical lead of an implantable cardiac device inside a heart of a patient. The method includes securing a tool to an atrial appendage of the heart to hold onto the atrial appendage, piercing the atrial appendage, and creating an aperture in the atrial appendage while holding the atrial appendage with the tool. The method also includes moving a distal end of the electrical lead into the heart through the aperture in the atrial appendage and into a ventricle of the heart. Furthermore, the method includes coupling the distal end of the electrical lead to cardiac tissue in the ventricle and delivering an electrical signal to the cardiac tissue in the ventricle of the heart to maintain a predetermined heartbeat of the heart.
摘要翻译：将可植入心脏装置的电引线放置在患者心脏内的方法。该方法包括将工具固定到心脏的心房附着物，以固定在心房附近，刺穿心房附件，以及在用该工具持有心房附件的同时创建心房附近的孔。该方法还包括通过心耳中的孔将电引线的远端移动到心脏中并进入心脏的心室。此外，该方法包括将电导线的远端耦合到心室中的心脏组织，并将电信号传送到心脏心室的心脏组织以维持心脏的预定心跳。

57. 发明授权

US07285119B2 Ablation catheter assembly and method for isolating a pulmonary vein 有权
标题翻译：消融导管装置及隔离肺静脉的方法
公开(公告)号：US07285119B2
公开(公告)日：2007-10-23
申请号：US10689112
申请日：2003-10-20
申请人： Mark T. Stewart , James R. Skarda
发明人： Mark T. Stewart , James R. Skarda
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00375 , A61B2018/1407 , A61B2018/1435
摘要： A catheter body includes a proximal portion, an intermediate portion extending from the proximal portion and defining a longitudinal axis, and a distal portion extending from the intermediate portion and terminated by a distal end of the catheter body; the distal portion forms a coil about a central loop axis, which is substantially parallel to the longitudinal axis. A first lumen extends through the proximal and intermediate portions of the catheter body and is terminated at an opening proximal to an ablation section, which is formed along the coil.
摘要翻译：导管主体包括近端部分，从近侧部分延伸并限定纵向轴线的中间部分，以及从中间部分延伸并由导管主体的远端端接的远侧部分; 远侧部分围绕基本上平行于纵向轴线的中心环轴线形成线圈。第一腔延伸穿过导管主体的近端部分和中间部分，并且在靠近沿着线圈形成的消融部分的开口处终止。

58. 发明授权

US07175734B2 Porous medical catheter and methods of manufacture 有权
标题翻译：多孔医用导管及其制造方法
公开(公告)号：US07175734B2
公开(公告)日：2007-02-13
申请号：US10264608
申请日：2002-10-04
申请人： Mark T. Stewart , James R. Skarda , Patrick R. Vettling
发明人： Mark T. Stewart , James R. Skarda , Patrick R. Vettling
IPC分类号： B29C65/52
CPC分类号： B29C65/68 , A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00065 , A61B2018/00214 , A61B2018/00375 , A61B2018/00404 , A61B2018/00898 , A61B2018/1407 , A61B2018/1435 , A61B2018/1472 , A61L29/041 , A61L29/06 , A61L29/146 , A61M25/0009 , B29C61/006 , B29C65/4815 , B29C65/483 , B29C65/484 , B29C65/4845 , B29C66/026 , B29C66/1122 , B29C66/1222 , B29C66/1224 , B29C66/12445 , B29C66/5221 , B29C66/52291 , B29C66/52293 , B29C66/63 , B29C66/636 , B29C66/71 , B29C66/727 , B29K2027/18 , B29L2023/007 , B29L2031/7542 , C08L27/18 , B29K2083/00 , B29K2081/06 , B29K2077/00 , B29K2075/00 , B29K2023/18 , B29K2023/12 , B29K2023/06 , B29K2019/00 , C08L77/12
摘要： The present invention relates to fabrication methods and apparatus for irrigating medical catheters. Such catheters include at least one section of standard thermoplastic catheter tubing coupled to a section of porous tubing (e.g., ePTFE and the like). A source of fluid couples to the porous portion of tubing to dispense diverse fluids. The manufacturing technique overcomes the inability of such porous material to liquefy and/or bond to most available adhesives by creating a mechanical-based coupling. One aspect of the present invention involves pre-treatment of a portion of a porous material such as ePTFE; that is, a “pre-imbibing” process is employed wherein the ePTFE is saturated with a solution of solvent and dissolved thermoplastic resin. After the solution evaporates a resin-based interstitial residue provides suitable structure that fuses to adjacent thermoplastic material during application of heat, such as during thermal bonding. The present may be used to prepare virtually any porous material for thermoplastic bonding.
摘要翻译：本发明涉及用于冲洗医用导管的制造方法和装置。这种导管包括与多孔管（例如ePTFE等）的一部分连接的标准热塑性导管的至少一段。流体源耦合到管道的多孔部分以分配多种流体。该制造技术克服了这种多孔材料不能通过创建基于机械的耦合来液化和/或粘合到大多数可用的粘合剂。本发明的一个方面涉及一部分多孔材料的预处理，例如ePTFE; 也就是说，使用其中ePTFE被溶剂和溶解的热塑性树脂溶液饱和的“预吸收”方法。在溶液蒸发之后，树脂基间隙残渣提供了适合的结构，其在加热期间例如在热粘合期间在相邻的热塑性材料中熔化。本发明可用于制备用于热塑性粘合的几乎任何多孔材料。

59. 发明授权

US06801809B2 Extractable implantable medical lead 有权
标题翻译：可提取植入式医用铅
公开(公告)号：US06801809B2
公开(公告)日：2004-10-05
申请号：US09854999
申请日：2001-05-14
申请人： Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
发明人： Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
IPC分类号： A61N105
CPC分类号： A61N1/056 , A61N2001/0578
摘要： A medical electrical lead with a tip-ring assembly optimized to resist damage during extraction. The lead includes an elongated plastic tube and at least two elongated conductors mounted in the plastic tube. A tip-ring assembly is mounted to the distal end of the tube, the tip-ring assembly including a ring electrode coupled to one of the conductors, a tip electrode located distal to the ring electrode and coupled to another of the conductors and two molded plastic components separately fabricated of a plastic harder than the plastic tube, adhered to one another and together defining a circumferential groove in which the ring electrode is located and mechanically coupled to the tip electrode. The tip electrode may be provided with a proximally extending electrode shank covered by a tine sleeve which is fabricated of a plastic softer than the molded plastic components and is adhered to more distally located molded plastic component. The more distally located molded plastic component preferably overlaps the electrode shank to provide a stronger structure.
摘要翻译：具有尖端环组件的医疗电气引线，优化以防止在提取期间的损坏。引线包括细长塑料管和安装在塑料管中的至少两根细长导体。尖端环组件安装到管的远端，尖端环组件包括耦合到一个导体的环形电极，位于环形电极远侧并连接到另一个导体的尖端电极，以及两个模制分别由比塑料管更硬的塑料制成的塑料部件彼此粘合在一起并且一起形成环形电极所在的并且机械地联接到尖端电极的周向槽。尖端电极可以设置有由齿形套筒覆盖的近端延伸的电极柄，其由比模制的塑料部件更软的塑料制成并且被粘附到更远端定位的模制塑料部件上。更远端定位的模制塑料部件优选地与电极柄重叠以提供更强的结构。

60. 发明授权

US06549811B2 Medical electrical lead having controlled texture surface and method of making same 失效
标题翻译：具有控制纹理表面的医用电线及其制造方法
公开(公告)号：US06549811B2
公开(公告)日：2003-04-15
申请号：US09760077
申请日：2001-01-12
申请人： Mark T. Stewart , Vernon B. Iverson , Kenneth W. Keeney , Catherine E. Taylor
发明人： Mark T. Stewart , Vernon B. Iverson , Kenneth W. Keeney , Catherine E. Taylor
IPC分类号： A61N105
CPC分类号： A61N1/05 , Y10T29/49002
摘要： An elongate elastomeric structure having controlled surface texture. Plasma deposition is used to create controlled features, such as ridges, on the external surface of an elongate elastomeric surface, such as the external surface of silicone tubing. The invention has particular applicability in the medical device field, such as the fabrication of implantable leads, catheters, and medical devices incorporating them.
摘要翻译：具有受控表面纹理的细长弹性体结构。等离子体沉积用于在细长弹性体表面的外表面（例如硅胶管的外表面）上产生可控特征，例如脊。本发明在诸如制造可植入引线，导管和结合它们的医疗装置之类的医疗装置领域中具有特别的适用性。

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